公开(公告)号：US20170326248A1

公开(公告)日：2017-11-16

申请号：US15497636

申请日：2017-04-26

Applicant: GENENTECH, INC

Inventor： Paul Polakis ,  Andrew G. Polson ,  Susan Diane Spencer ,  Shang-Fan Yu ,  Bing Zheng

IPC: A61K47/68 ,  A61K45/06 ,  A61K31/706

CPC classification number: A61K47/6807 ,  A61K31/706 ,  A61K45/06 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6867

Abstract: The invention provides anti-CD22 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20170002086A1

公开(公告)日：2017-01-05

申请号：US15181618

申请日：2016-06-14

Applicant: Genentech, Inc.

Inventor： Paul Polakis ,  Peter Dragovich ,  Thomas Harden Pillow ,  Shang-Fan Yu

IPC: C07K16/30 ,  A61K47/48 ,  C07K16/32 ,  C07K16/28 ,  C07K16/40

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3092 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/515

Abstract: The invention provides immunoconjugates and methods of using the same.

Abstract translation: 本发明提供了免疫缀合物及其使用方法。

公开(公告)号：US08968741B2

公开(公告)日：2015-03-03

申请号：US13760751

申请日：2013-02-06

Applicant: Genentech, Inc.

Inventor： Allen J. Ebens ,  Alane M. Gray ,  Wei-Ching Liang ,  Yan Wu ,  Shang-Fan Yu

IPC: C07K16/28 ,  A61K47/48 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/3061 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6855 ,  C07K16/2803 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/77 ,  C07K2317/92

Abstract: Anti-CD22 antibodies and immunoconjugates thereof are provided. Methods of using anti-CD22 antibodies and immunoconjugates thereof are provided.

Abstract translation: 提供抗CD22抗体及其免疫偶联物。 提供了使用抗CD22抗体及其免疫偶联物的方法。

公开(公告)号：US20140030279A1

公开(公告)日：2014-01-30

申请号：US13936279

申请日：2013-07-08

Applicant: Spirogen Sari ,  Genentech, Inc.

Inventor： Paul Polakis ,  Andrew Polson ,  Susan Diane Spencer ,  Shang-Fan Yu ,  John A. Flygare ,  Janet L. Gunzner-Toste ,  Thomas Harden Pillow ,  Philip Wilson Howard ,  Luke Masterson

IPC: A61K47/48 ,  A61K45/06 ,  A61K31/551

CPC classification number: A61K31/5517 ,  A61K31/551 ,  A61K45/06 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6867 ,  A61K47/6877 ,  A61K2300/00

Abstract: The invention provides anti-CD22 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US11000510B2

公开(公告)日：2021-05-11

申请号：US16358410

申请日：2019-03-19

Applicant: Genentech, Inc.

Inventor： Andrew Polson ,  Shang-Fan Yu ,  Yu-Waye Chu ,  Michael Wenger ,  Jamie Harue Hirata ,  Dan Lu

IPC: A61K39/00 ,  A61K31/4184 ,  A61K39/395 ,  A61K47/68 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  A61K31/553 ,  A61K31/454 ,  A61K31/635

Abstract: Provided herein are methods of treating B-cell proliferative disorders in particular Follicular Lymphoma and/or Diffuse Large B-Cell Lymphoma using immunoconjugates comprising anti-CD79b antibodies in combination with additional therapeutic agents.

公开(公告)号：US10556951B2

公开(公告)日：2020-02-11

申请号：US15918842

申请日：2018-03-12

Applicant: GENENTECH, INC.

Inventor： Shang-Fan Yu ,  Wei-Ching Liang ,  Yan Wu ,  Steven Leong ,  Andrew Polson

IPC: A61K39/395 ,  C07K16/28 ,  G01N33/574 ,  A61K47/68 ,  A61K39/00

Abstract: The invention provides anti-CD33 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US09951133B2

公开(公告)日：2018-04-24

申请号：US15171128

申请日：2016-06-02

Applicant: GENENTECH, INC.

Inventor： Shang-Fan Yu ,  Wei-Ching Liang ,  Yan Wu ,  Steven Leong ,  Andrew Polson

IPC: A61K39/395 ,  C07K16/28 ,  A61K47/48 ,  G01N33/574 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K47/6809 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57492 ,  G01N2333/70596 ,  G01N2458/00

Abstract: The invention provides anti-CD33 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20170304438A1

公开(公告)日：2017-10-26

申请号：US15440917

申请日：2017-02-23

Applicant: Genentech, Inc.

Inventor： Andrew Polson ,  Shang-Fan Yu ,  Yu-Waye Chu ,  Michael Wenger

IPC: A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  A61K31/4184 ,  C07K16/30 ,  A61K39/00

CPC classification number: A61K31/4184 ,  A61K31/454 ,  A61K31/553 ,  A61K31/635 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6867 ,  A61K47/6889 ,  A61K2039/507 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2300/00 ,  C07K16/2803 ,  C07K16/2887 ,  C07K16/3061 ,  C07K2317/24

Abstract: Provided herein are methods of treating B-cell proliferative disorders in particular Follicular Lymphoma and/or Diffuse Large B-Cell Lymphoma using immunoconjugates comprising anti-CD79b antibodies in combination with additional therapeutic agents.

公开(公告)号：US20170290920A1

公开(公告)日：2017-10-12

申请号：US15497656

申请日：2017-04-26

Applicant: MEDIMMUNE LIMITED ,  GENENTECH, INC.

Inventor： Paul Polakis ,  Andrew Polson ,  Susan Diane Spencer ,  Shang-Fan Yu ,  John A. Flygare ,  Janet L. Gunzner-Toste ,  Thomas H. Pillow ,  Philip Wilson Howard ,  Luke Masterson

IPC: A61K47/48 ,  A61K31/5517 ,  C07D487/16 ,  C07K19/00

CPC classification number: A61K31/5517 ,  A61K31/551 ,  A61K45/06 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6867 ,  A61K47/6877 ,  A61K2300/00

Abstract: The invention provides anti-CD22 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US09580514B2

公开(公告)日：2017-02-28

申请号：US14400684

申请日：2013-03-14

Applicant: Genentech, Inc.

Inventor： Sunil Bhakta ,  Meredith Hazen ,  Jo-Anne S Hongo ,  Jagath R Junutula ,  Isidro Hotzel ,  Yonglei Shang ,  Shang-Fan Yu

IPC: A61K39/395 ,  C07K16/30 ,  A61K47/48 ,  A61K51/10 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6817 ,  A61K47/6855 ,  A61K51/1051 ,  A61K2039/505 ,  A61K2039/6037 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/77 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415 ,  G01N33/57423 ,  G01N2333/47 ,  G01N2500/02

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. In certain aspects, the isolated nucleic acid molecule comprises a nucleotide sequence having at least about 80% nucleic acid sequence identity, alternatively at least about 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% nucleic acid sequence identity, to (a) a DNA molecule encoding a full-length TAT polypeptide having an amino acid sequence as disclosed herein, a TAT polypeptide amino acid sequence lacking the signal peptide as disclosed herein, an extracellular domain of a transmembrane TAT polypeptide, with or without the signal peptide, as disclosed herein.

Abstract translation: 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。 在某些方面，分离的核酸分子包含具有至少约80％核酸序列同一性，或至少约81％，82％，83％，84％，85％，86％，87％，88 ％，89％，90％，91％，92％，93％，94％，95％，96％，97％，98％，99％或100％的核酸序列同一性。 如本文公开的具有本文公开的氨基酸序列的全长TAT多肽，缺乏本文公开的信号肽的TAT多肽氨基酸序列，跨膜TAT多肽的胞外结构域，具有或不具有信号肽。