公开(公告)号：US11098028B2

公开(公告)日：2021-08-24

申请号：US16535752

申请日：2019-08-08

Applicant: Genentech, Inc.

Inventor： Jinguang Lin ,  Alexandra Chestakova ,  Wei Gu ,  Hans Iding ,  Jing Li ,  Xin Linghu ,  Patrik Meier ,  Chunbo Sha ,  Jeffrey Stults ,  Youchu Wang ,  Haiming Zhang ,  Jianqian Zhang ,  Tao Zhang

IPC: C07D401/14 ,  C07D401/04 ,  C12P17/16 ,  A61P35/00 ,  A61P25/00 ,  A61P29/00

Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid

公开(公告)号：US20180134685A1

公开(公告)日：2018-05-17

申请号：US15866899

申请日：2018-01-10

Applicant: Genentech, Inc.

Inventor： Jinguang Lin ,  Alexandra Chestakova ,  Wei Gu ,  Hans Iding ,  Jing Li ,  Xin Linghu ,  Patrik Meier ,  Chunbo Sha ,  Jeffrey Stults ,  Youchu Wang ,  Haiming Zhang ,  Jianqian Zhang ,  Tao Zhang

IPC: C07D401/14 ,  C07D401/04 ,  C12P17/16

CPC classification number: C07D401/14 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C12P17/165

Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid

公开(公告)号：US20170247338A1

公开(公告)日：2017-08-31

申请号：US15514188

申请日：2015-09-25

Applicant: F. HOFFMANN-LA ROCHE AG ,  GENENTECH, INC.

Inventor： Francis Gosselin ,  Chong Han ,  Hans Iding ,  Reinhard Reents ,  Scott Savage ,  Beat Wirz

IPC: C07D239/70 ,  C07C253/30 ,  C07C255/22 ,  C12N9/78 ,  C07D239/54 ,  C07D239/42 ,  C12P41/00 ,  C07B57/00 ,  C07C253/34

Abstract: The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.

公开(公告)号：US20170022183A1

公开(公告)日：2017-01-26

申请号：US15285781

申请日：2016-10-05

Applicant: Genentech, Inc.

Inventor： Jinguang Lin ,  Alexandra Chestakova ,  Wei Gu ,  Hans Iding ,  Jing Li ,  Xin Linghu ,  Patrik Meier ,  Chunbo Sha ,  Jeffrey Stults ,  Youchu Wang ,  Haiming Zhang ,  Jianqian Zhang ,  Tao Zhang

IPC: C07D401/14 ,  C12P17/16 ,  C07D401/04

CPC classification number: C07D401/14 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C12P17/165

Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid

Abstract translation: 本发明提供了制备式（Ⅷa）化合物和（Ⅷa）盐形式的方法，其中Rc是芳基磺酸。