公开(公告)号：US07943901B2

公开(公告)日：2011-05-17

申请号：US11946679

申请日：2007-11-28

Applicant: Ching Wu

Inventor： Ching Wu

IPC: H01J49/04 ,  H01J49/40 ,  H01J49/10

CPC classification number: G01N27/622 ,  H01J49/004

Abstract: This invention describes an ion mobility spectrometer system for chemical detection in the field. The system allows: a high throughput operation, an interface to new ionization methods, and an interface to a mass spectrometer.

Abstract translation: 本发明描述了一种用于现场化学检测的离子迁移谱仪系统。 该系统允许：高通量操作，与新离子化方法的接口以及与质谱仪的接口。

公开(公告)号：US07576321B2

公开(公告)日：2009-08-18

申请号：US11618430

申请日：2006-12-29

Applicant: Ching Wu

Inventor： Ching Wu

IPC: G01N27/64 ,  H01J49/06 ,  H01J49/40

CPC classification number: G01N27/622

Abstract: Various embodiments of a multi-dimensional ion mobility analyzer are disclosed that have more than one drift chamber and can acquire multi-dimensional ion mobility profiles of substances. The drift chambers of this device can, for example, be operated under independent operational conditions to separate charged particles based on their distinguishable chemical/physical properties. The first dimension drift chamber of this device can be used either as a storage device, a reaction chamber, and/or a drift chamber according to the operational mode of the analyzer. Also presented are various methods of operating an ion mobility spectrometer including, but not limited to, a continuous first dimension ionization methods that can enable ionization of all chemical components in the sample regardless their charge affinity.

Abstract translation: 公开了具有多于一个漂移室的多维离子迁移率分析仪的各种实施方案，并且可以获得物质的多维离子迁移谱。 该装置的漂移室可以例如在独立操作条件下操作，以根据其可区分的化学/物理性质分离带电粒子。 该装置的第一尺寸漂移室可以根据分析仪的操作模式用作存储装置，反应室和/或漂移室。 还提出了操作离子迁移谱仪的各种方法，包括但不限于连续的第一维电离方法，其能够使得样品中的所有化学组分电离，而不管其电荷亲和力如何。

公开(公告)号：US20080121797A1

公开(公告)日：2008-05-29

申请号：US11946679

申请日：2007-11-28

Applicant: Ching Wu

Inventor： Ching Wu

IPC: H01J49/04 ,  H01J49/40 ,  H01J49/10

CPC classification number: G01N27/622 ,  H01J49/004

Abstract: This invention describes an ion mobility spectrometer system for chemical detection in the field. The system allows: a high throughput operation, an interface to new ionization methods, and an interface to a mass spectrometer.

Abstract translation: 本发明描述了一种用于现场化学检测的离子迁移谱仪系统。 该系统允许：高通量操作，与新离子化方法的接口以及与质谱仪的接口。

公开(公告)号：US20210223204A1

公开(公告)日：2021-07-22

申请号：US17063636

申请日：2020-10-05

Applicant: Ching Wu

Inventor： Ching Wu

IPC: G01N27/622 ,  H01J49/00 ,  H01J49/06 ,  H01J49/04

Abstract: The present invention relates to a preconcentrator for vapors and particles collected from air. The vapor preconcentrator is made from plural layer of coils. The coil is made of resistance alloy. The pitch size of the coil is made to precisely trap/filter out certain size of the particles during preconcentration. Multiple coils could be made with different pitch sizes to achieve multiple step filtrations. When the sample flow enters the preconcentrator chamber, it passes through the coils. The particles of different sizes are trapped on different layer of coils. The vapor sample can be trapped on any coils when interacted with the coil surface. They could be trapped without any affinitive coating as the preconcentrator is at relatively low temperature. Different coils or different sections of the coil can be coated with different material to trap chemicals of different classes. During the desorption process, the coils are flash heated with controlled temperature ramping speed to evaporate the trapped chemicals. Various configurations, constructions, and methods of operation are presented.

公开(公告)号：US20180372684A1

公开(公告)日：2018-12-27

申请号：US16055038

申请日：2018-08-04

Applicant: Ching Wu

Inventor： Ching Wu

IPC: G01N27/62 ,  H01J49/00 ,  H01J49/04 ,  H01J49/06

Abstract: The present invention relates to drift tubes for ion mobility spectrometers. In one embodiment, the drift tube of the present invention uses a simplified design having helical resistive material to form substantially constant electric fields that guide ion movements. The drift tube for ion mobility spectrometers described herein is constructed with a non-conductive structure. This configuration provides a robust ion mobility spectrometer that is simple to build. One feature of the present invention is that the drift tube design described herein enables the ion mobility spectrometer to be built with a lower weight, lower power consumption, lower manufacturing cost, and free of sealants.

公开(公告)号：US10073056B2

公开(公告)日：2018-09-11

申请号：US15383736

申请日：2016-12-19

Applicant: Ching Wu

Inventor： Ching Wu

IPC: G01N27/62 ,  H01J49/06 ,  H01J49/04

Abstract: The present invention relates to ion mobility spectrometers. In one embodiment, the ion mobility spectrometer of the present invention uses a simplified ion mobility spectrometer design having helical resistive material to form substantially constant electric fields that guide ion movements. The drift tube for ion mobility spectrometers described herein is constructed with a non-conductive structure. This configuration provides a robust ion mobility spectrometer that is simple to build. One feature of the present invention is that the drift tube design described herein enables the ion mobility spectrometer to be built with a lower weight, lower power consumption, lower manufacturing cost, and free of sealants.

公开(公告)号：US09508536B2

公开(公告)日：2016-11-29

申请号：US14283499

申请日：2014-05-21

Applicant: Ching Wu

Inventor： Ching Wu

IPC: H01J49/04

CPC classification number: H01J49/049

Abstract: This invention describes a sample collection and desorption device and method that collects residues of explosives and other chemicals from a surface and then introduces them into a detector. The desorption method and device include introducing additional chemicals while heating up the sample collector, thus, the collected sample may be converted via a chemical reaction or a catalytic process. The detector can be an ion mobility spectrometer or mass spectrometer.

Abstract translation: 本发明描述了从表面收集炸药和其他化学物质的残留物并随后将其引入检测器的样品收集和解吸装置和方法。 解吸方法和装置包括在加热样品收集器的同时引入额外的化学品，因此，可以通过化学反应或催化过程转化收集的样品。 检测器可以是离子迁移谱仪或质谱仪。

公开(公告)号：US09236234B2

公开(公告)日：2016-01-12

申请号：US14214558

申请日：2014-03-14

Applicant: Ching Wu ,  Mark A Osgood

Inventor： Ching Wu ,  Mark A Osgood

IPC: H01J49/40 ,  H01J49/06 ,  C07B63/00 ,  G01N27/62

CPC classification number: H01J49/061 ,  C07B63/00 ,  G01N27/622 ,  H01J49/0027

Abstract: The present invention uses an AC voltage instead of DC voltage on an ion gate to filter/selectively pass ions. The ions that pass through the AC ion gate can be further separated in a spectrometric instrument. An ion mobility spectrometer using the AC ion gate can achieve better gating performance. For a time of flight ion mobility spectrometer with an AC ion gate, a narrow pulse of selected ions can be passed into a drift tube where they are separated based on their low field ion mobility. Moreover, when the AC voltage at the AC ion gate has a waveform as used for differential ion mobility spectrometry, the time of flight ion mobility spectrometer is converted into a two dimensional separation spectrometer, where ions are first separated based on their high field ion mobility and then further separated based on their low field ion mobility.

Abstract translation: 本发明在离子浇口上使用交流电压而不是直流电压来过滤/选择性地通过离子。 通过AC离子浇口的离子可以在光谱仪器中进一步分离。 使用AC离子浇口的离子迁移谱仪可以获得更好的门控性能。 对于具有AC离子浇口的飞行时间离子迁移谱仪，选择的离子的窄脉冲可以被传送到漂移管中，基于它们的低场离子迁移率，它们被分离。 此外，当AC离子浇口处的AC电压具有用于差示离子迁移率光谱法的波形时，将飞行时间离子迁移谱仪转换成二维分离光谱仪，其中离子首先基于它们的高场离子迁移率而被分离 然后基于它们的低场离子迁移率进一步分离。

公开(公告)号：US08884221B2

公开(公告)日：2014-11-11

申请号：US13475993

申请日：2012-05-20

Applicant: Ching Wu ,  Clinton Alawn Krueger ,  Anthony Joseph Midey ,  Mark A Osgood

Inventor： Ching Wu ,  Clinton Alawn Krueger ,  Anthony Joseph Midey ,  Mark A Osgood

IPC: G01N27/62 ,  H01J49/00

CPC classification number: G01N27/622

Abstract: An ion mobility spectrometer wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. An ion mobility spectrometer and operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation.

Abstract translation: 离子迁移谱仪，其中离子沿着漂移轴线分离，同时在基本上不是在漂移轴线的方向上也不与漂移轴线相反的方向提供漂移气流。 离子迁移谱仪和操作方法在漂移管和/或分段漂移管中使用横向气流用于预分离。

公开(公告)号：US08618476B2

公开(公告)日：2013-12-31

申请号：US13293317

申请日：2011-11-10

Applicant: Ching Wu ,  Clinton Alawn Krueger

Inventor： Ching Wu ,  Clinton Alawn Krueger

IPC: H01J49/26 ,  H01J49/00 ,  B01D59/44

CPC classification number: G01N27/622

Abstract: The present invention describes separating components in a sample in an ion mobility based spectrometer using at least one matching property of the components other than the molecular properties in conventional ion mobility measurements in noble drift gases to enhance separation and resolution of the sample. Separation based on the matching property is realized by altering the drift media of the IMS. Besides altering drift media, energy level of ions and/or drift media are also controlled during the separation process. This invention describes an ion mobility apparatus wherein an energy source is added to the IMS that provides additional energy to the ions and/or drift media and tuning methods that involve selecting drift media and optimizing the energy level in order to achieve optimal performance.

Abstract translation: 本发明描述了使用离子迁移率光谱仪中的样品中的组分，其使用除贵族漂移气体中的常规离子迁移率测量中的分子特性以外的组分的至少一个匹配性质以增强样品的分离和分离。 通过改变IMS的漂移介质来实现基于匹配特性的分离。 除了改变漂移介质之外，还可以在分离过程中控制离子和/或漂移介质的能级。 本发明描述了一种离子迁移率装置，其中向IMS提供能量源，其为离子和/或漂移介质提供额外的能量以及涉及选择漂移介质并优化能级以便实现最佳性能的调谐方法。