公开(公告)号：US5196588A

公开(公告)日：1993-03-23

申请号：US528879

申请日：1990-05-25

Applicant: Lloyd M. Burgess ,  Charles A. Gibson ,  David J. Schreck

Inventor： Lloyd M. Burgess ,  Charles A. Gibson ,  David J. Schreck

IPC: C07C209/16 ,  C07D295/023 ,  C07D295/13

CPC classification number: C07D295/023 ,  C07C209/16 ,  C07D295/13

Abstract: A continuously generated alkyleneamines producers composition comprising, based on 100% of the moles of the composition and exclusive of any MEA and water present,a) about 14 to about 20 mole % DETA,b) about 45 to about 75 mole % EDA (net generated),c) about 4 to about 10 mole % AEEA,d) about 3 to about 25 mole % of the combination of PIP, AEP and HEP,e) about 0.5 to about 5 mole % of one or more of TETAs and TEPAs,f) less than about 1 mole % of other polyalkylene polymines,g) an EDA to DETA mole ratio greater than about 2.60,h) a DETA to AEEA mole ratio greater than about 1.35, andi) an EDA to AEEA mole ratio greater than about 8,and a process of manufacturing it which comprises feeding hydrogen, ammonia, MEA and EDA, preferably provided from a recycle stream, to a reaction zone containing a fixed bed of a reductive amination catalyst in a tubular reactor, wherein the hydrogen comprises about 1 to about 30 mole percent of the feed in the reaction zone, the mole ratio of EDA to MEA is less than about 0.25 and the mole ratio of ammonia to MEA is about 1 to about 15, the temperature of the reaction zone is about 120.degree. C. to about 300.degree. C., the pressure of the reaction zone is about 1800 to about 2500 psig., the conversion of MEA is about 20 to about 60 weight percent, and recovering said producers composition from the reaction zone.

Abstract translation: 连续生成的亚烷基胺生产商组合物包含基于组合物摩尔数的100％，不包含存在的任何MEA和水，a）约14至约20摩尔％DETA，b）约45至约75摩尔％EDA（净 产生），c）约4至约10摩尔％的AEEA，d）PIP，AEP和HEP的组合约3至约25摩尔％，e）约0.5至约5摩尔％的一种或多种TETA和TEPAs ，f）小于约1摩尔％的其它聚亚烷基多胺，g）EDA与DETA摩尔比大于约2.60，h）DETA与AEEA摩尔比大于约1.35，和i）EDA与AEEA摩尔比大于 比例大约为8，其制造方法包括将优选从再循环流提供的氢，氨，MEA和EDA进料到管式反应器中含有还原胺化催化剂固定床的反应区，其中氢包括 反应区中约1至约30摩尔％的进料，EDA的摩尔比 至MEA小于约0.25，氨与MEA的摩尔比为约1至约15，反应区的温度为约120℃至约300℃，反应区的压力为约1800 至约2500psig，MEA的转化率为约20至约60重量％，并从反应区回收所述生产者组合物。

公开(公告)号：US5068330A

公开(公告)日：1991-11-26

申请号：US576987

申请日：1990-09-04

Applicant: Lloyd M. Burgess ,  Charles A. Gibson

Inventor： Lloyd M. Burgess ,  Charles A. Gibson

IPC: C07C209/16 ,  C07C213/02 ,  C07D295/023

CPC classification number: C07D295/023 ,  C07C209/16 ,  C07C213/02

Abstract: A continuously generated alkyleneamines producers composition comprising, based on 100% of the moles of the composition and exclusive of any MEA and water present,a) about 15 to about 50 mole % AEEA,b) about 15 to about 55 mole % EDA,c) about 10 to about 20 mole % DETA,d) about 5 to about 20 mole % of the combination of PIP,AEP and HEP,3) about 3 to about 10 mole % of one or more of TETAs and TEPAs,f) less than about 1 mole % of other polyalkylene polyamines,g) an DETA to AEEA mole ratio less than 0.77, andh) an EDA to AEEA mole ratio less than 8;and a process of manufacturing the same, which comprises feeding hydrogen, ammonia and MEA to a reaction zone containing a fixed bed of a reductive amination catalyst, wherein the hydrogen comprises about 20 to about 60 mole percent of the feed in the reaction zone and the mole ratio of ammonia to MEA is about 1 to about 5, the temperature of the reaction zone is about 120.degree. C. to about 300.degree. C., the pressure of the reaction zone is about 400 to about 1400 psig., the conversion of MEA is about 20 to about 45 weight percent, and recovering said producers composition from the reaction zone.

Abstract translation: 连续生成的亚烷基胺生产商组合物包含基于组合物摩尔数的100％而不存在任何MEA和水，a）约15至约50摩尔％的AEEA，b）约15至约55摩尔％的EDA，c ）约10至约20摩尔％DETA，d）PIP，AEP和HEP的组合约5至约20摩尔％，3）约3至约10摩尔％的一种或多种TETA和TEPAs，f）较少 约1摩尔％的其它聚亚烷基多胺，g）DETA与AEEA摩尔比小于0.77，和h）EDA与AEEA摩尔比小于8; 以及其制造方法，其包括将氢，氨和MEA进料到含有还原胺化催化剂固定床的反应区中，其中氢包含反应区中约20至约60摩尔％的进料和 氨与MEA的摩尔比为约1至约5，反应区的温度为约120℃至约300℃，反应区的压力为约400至约1400psig，转化率 MEA为约20至约45重量％，并从反应区回收所述生产者组合物。

公开(公告)号：US4647701A

公开(公告)日：1987-03-03

申请号：US613473

申请日：1984-05-23

Applicant: Charles A. Gibson

Inventor： Charles A. Gibson

IPC: C07C85/06

CPC classification number: C07C209/16

Abstract: Ethanolamine is subjected to reductive amination in a continuous process to produce diethylenetriamine with less than 10 weight percent piperazine contained in the reaction products. The reductive amination conditions include the use of a catalyst, an ethanolamine feed rate of at least about 400 kilograms of ethanolamine per hour per cubic meter of catalyst, and a temperature sufficient to react between about 35 and 60 percent of the ethanolamine fed.

Abstract translation: 将乙醇胺在连续方法中进行还原胺化以制备反应产物中含有少于10重量％的哌嗪的二亚乙基三胺。 还原胺化条件包括使用催化剂，每小时每立方米催化剂至少约400千克乙醇胺的乙醇胺进料速率，以及足以在进料的乙醇胺的约35％至60％之间反应的温度。

公开(公告)号：US08529504B2

公开(公告)日：2013-09-10

申请号：US13185488

申请日：2011-07-18

Applicant: Charles A. Gibson ,  Gary O'Boyle ,  Gary S. Falwell

Inventor： Charles A. Gibson ,  Gary O'Boyle ,  Gary S. Falwell

IPC: A61M31/00 ,  A61M37/00 ,  A61M25/00

CPC classification number: A61M25/0147 ,  A61M25/0041 ,  A61M25/0054 ,  A61M25/0108 ,  A61M25/0141 ,  A61M25/0144 ,  A61M2025/0161

Abstract: Methods and apparatuses for manipulating an elongated flexible shaft of a catheter provide ease and reliability of positioning electrodes against or near tissue. Dual-bend flexible distal tips may be used in combination with flat wires. In some embodiments, flat wires which are free to rotate upon initial bending of shaft segments are employed. In some embodiments, one or more transition segments are used to relocate the satellite lumen-to-main lumen transition of pull wires away from a change in shaft stiffness.

Abstract translation: 用于操纵导管的细长柔性轴的方法和装置提供了将电极定位在组织附近或附近的便利性和可靠性。 双弯曲柔性远端可与扁平线组合使用。 在一些实施例中，采用在轴段的初始弯曲时自由旋转的扁平线。 在一些实施例中，使用一个或多个过渡段来重新定位拉线的卫星管腔到主腔的转变远离轴刚度的变化。

公开(公告)号：US20120165815A1

公开(公告)日：2012-06-28

申请号：US13414018

申请日：2012-03-07

Applicant: Russell F. Collins ,  Gary S. Falwell ,  Eric A. Bene ,  Steven J. Burns ,  Denyse M. Collins ,  Charles A. Gibson ,  Ding Sheng He ,  Paul E. LeClair ,  Donald F. Patterson ,  Stephen W. Sagon ,  Pierre Jais

Inventor： Russell F. Collins ,  Gary S. Falwell ,  Eric A. Bene ,  Steven J. Burns ,  Denyse M. Collins ,  Charles A. Gibson ,  Ding Sheng He ,  Paul E. LeClair ,  Donald F. Patterson ,  Stephen W. Sagon ,  Pierre Jais

IPC: A61B18/00

CPC classification number: A61B18/1492 ,  A61B2017/003 ,  A61B2018/00029 ,  A61B2018/00083 ,  A61B2018/0016 ,  A61B2018/00196 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00577 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/00946 ,  A61B2018/1497

Abstract: Embodiments described herein relate to methods of using a catheter having a braided conductive member. One embodiment relates to a method for treating a condition of a patient that involves contacting an exterior wall of a blood vessel with the braided conductive member. Another embodiment relates to a method that involves contacting a wall of a blood vessel with the braided conductive member and controlling energy delivery to the braided conductive member based on at least one sensed temperature.

Abstract translation: 本文所述的实施例涉及使用具有编织导电构件的导管的方法。 一个实施方案涉及用于治疗患者的状况的方法，其涉及使血管的外壁与编织的导电构件接触。 另一实施例涉及一种方法，其包括使血管的壁与编织的导电构件接触，并且基于至少一个感测到的温度控制向编织导电构件的能量传递。

公开(公告)号：US20110270173A1

公开(公告)日：2011-11-03

申请号：US13185488

申请日：2011-07-18

Applicant: Charles A. Gibson ,  Gary O'Boyle ,  Gary S. Falwell

Inventor： Charles A. Gibson ,  Gary O'Boyle ,  Gary S. Falwell

IPC: A61M25/092

CPC classification number: A61M25/0147 ,  A61M25/0041 ,  A61M25/0054 ,  A61M25/0108 ,  A61M25/0141 ,  A61M25/0144 ,  A61M2025/0161

Abstract: Methods and apparatuses for manipulating an elongated flexible shaft of a catheter provide ease and reliability of positioning electrodes against or near tissue. Dual-bend flexible distal tips may be used in combination with flat wires. In some embodiments, flat wires which are free to rotate upon initial bending of shaft segments are employed. In some embodiments, one or more transition segments are used to relocate the satellite lumen-to-main lumen transition of pull wires away from a change in shaft stiffness.

Abstract translation: 用于操纵导管的细长柔性轴的方法和装置提供了将电极定位在组织附近或附近的便利性和可靠性。 双弯曲柔性远端可与扁平线组合使用。 在一些实施例中，采用在轴段的初始弯曲时自由旋转的扁平线。 在一些实施例中，使用一个或多个过渡段来重新定位拉线的卫星管腔到主腔的转变远离轴刚度的变化。

公开(公告)号：US5611777A

公开(公告)日：1997-03-18

申请号：US518521

申请日：1995-08-23

Applicant: Russell W. Bowden ,  Gary S. Falwell ,  Charles A. Gibson ,  Richard B. Stevens ,  Debbie E. Stevens-Wright

Inventor： Russell W. Bowden ,  Gary S. Falwell ,  Charles A. Gibson ,  Richard B. Stevens ,  Debbie E. Stevens-Wright

IPC: A61B5/0402 ,  A61M25/01 ,  A61M25/092 ,  A61M37/00 ,  A61B5/042 ,  A61M25/00

CPC classification number: A61M25/0144 ,  A61M25/0136 ,  A61M25/0147 ,  A61B18/1815 ,  A61B2017/003 ,  A61B2018/0016 ,  A61B2018/00916 ,  A61B2018/00946 ,  A61B2018/00952 ,  A61M25/0141

Abstract: A steerable catheter includes control handle having a generally tubular housing with a longitudinal slot therein in which an axially or longitudinally movable two-part slideblock resides, and a generally cylindrical, rotatably mounted thumbwheel surrounding a distal portion of the tubular housing, for controlling the axial translation of the slideblock. The pullwire passes into the distal end of the control handle and is only secured to the proximal part of the two-part slideblock so as to prevent the user from placing the pullwire under compression. A tip radius adjusting wire is attached to and extends distally from a slide actuator in the control handle into and through the main catheter shaft portion. The free distal end of the tip radius adjusting wire is selectably Iocatable at different positions. The radius of curvature of the tip portion, when deflected, depends upon how far distally into the deflectable tip portion the radius adjusting wire has been advanced by the user. The electrode catheter thus has a deflectable tip whose radius of curvature is adjustable over a relatively wide range.

Abstract translation: 可导向的导管包括控制手柄，其具有大致管状的壳体，其中纵向狭槽在其中，轴向或纵向可移动的两部分滑块位于其中，以及围绕管状壳体的远端部分的大致圆柱形可旋转地安装的指轮，用于控制轴向 幻灯片的翻译。 拉线进入控制手柄的远端，并且仅固定到两部分滑块的近端部分，以防止使用者将拉线放置在压缩状态。 尖端半径调节线附接到控制手柄中的滑块致动器并远离其延伸并且穿过主导管轴部分。 尖端半径调整线的自由端可选地位于不同的位置。 尖端部分的弯曲半径在偏转时取决于使用者已经使半径调节线前进到可偏转尖端部分的远端。 因此，电极导管具有可偏转的尖端，其弯曲半径在相对宽的范围内是可调节的。

公开(公告)号：US5202491A

公开(公告)日：1993-04-13

申请号：US528554

申请日：1990-05-25

Applicant: Lloyd M. Burgess ,  Charles A. Gibson ,  David J. Schreck

Inventor： Lloyd M. Burgess ,  Charles A. Gibson ,  David J. Schreck

IPC: C07C209/16 ,  C07C213/02

CPC classification number: C07C209/16 ,  C07C213/02

Abstract: A continuously generated alkyleneamines producers composition comprising, based on 100% of the moles of the composition and exclusive of any MEA and water present,a) about 20 to about 40 mole % DETA,b) about 15 to about 60 mole % EDA (net generated),c) about 5 to about 18 mole % AEEA,d) about 3 to about 25 mole % of the combination of PIP, AEP and HEP,e) less than about 1 to about 5 mole % of one or more of TETAs and TEPAs,f) less than about 1 mole % of other polyalkylene polyamines,g) a DETA to AEEA mole ratio greater than about 1.35, andh) an EDA to DETA mole ratio less than 2.60,and the process of manufacturing it which comprises feeding hydrogen, ammonia, MEA and EDA, preferably provided from a recycle stream, to a reaction zone containing a fixed bed of a reductive amination catalyst in a tubular reactor, wherein the hydrogen comprises about 1 to about 30 mole percent of the feed in the reaction zone, the mole ratio of EDA to MEA is greater than 0.25 and the mole ratio of ammonia to MEA is about 1 to about 15, the temperature of the reaction zone is about 120.degree. C. to about 300.degree. C., the pressure of the reaction zone is about 1800 to about 2500 psig., the conversion of MEA is about 20 to about 60 weight percent, and recovering said producers composition from the reaction zone.

Abstract translation: 连续生成的亚烷基胺生产者组合物，其包含基于组合物的摩尔数的100％，不包含存在的任何MEA和水，a）约20至约40摩尔％的DETA，b）约15至约60摩尔％的EDA（净 产生），c）约5至约18摩尔％的AEEA，d）PIP，AEP和HEP的组合的约3至约25摩尔％，e）小于约1至约5摩尔％的一种或多种TETA 和tEPA，f）小于约1摩尔％的其它多亚烷基多胺，g）DETA与AEEA摩尔比大于约1.35，和h）EDA与DETA摩尔比小于2.60，其制备方法包括 将优选从再循环流提供的氢气，氨，MEA和EDA进料到管式反应器中含有还原胺化催化剂固定床的反应区，其中氢包括约1至约30摩尔％ 反应区，EDA与MEA的摩尔比大于0.25，摩尔比为 氨至MEA为约1至约15，反应区的温度为约120℃至约300℃，反应区的压力为约1800至约2500psig，MEA的转化率为约 20至约60重量％，并从反应区回收所述生产者组合物。

公开(公告)号：US5202490A

公开(公告)日：1993-04-13

申请号：US528555

申请日：1990-05-25

Applicant: Lloyd M. Burgess ,  Charles A. Gibson ,  David J. Schreck

Inventor： Lloyd M. Burgess ,  Charles A. Gibson ,  David J. Schreck

IPC: C07C209/16 ,  C07C213/02

CPC classification number: C07C209/16 ,  C07C213/02

Abstract: A continuously generated alkyleneamines producers composition comprising based on 100% of the moles of the compostion and exclusive of any MEA and water present,a) about 15 to about 35 mole % DETA,b) about 15 to about 55 mole % EDA (net generated),c) about 10 to about 35 mole % AEEA,d) about 3 to about 25 mole % of the combination of PIP, AEP and HEP,e) about 3 to about 10 mole % of one or more of TETAs and TEPAs,f) less than about 1 mole % of other polyalkylene polyamines, andg) a DETA to AEEA mole ratio greater than about 0.77 to less than 1.35,and the process of producing the same, which comprises feeding hydrogen, ammonia, MEA and EDA, preferably provided from a recycle stream, to a reaction zone containing a fixed bed of a reductive amination catalyst in a tubular reactor, wherein the hydrogen comprises about 10 to about 50 mole percent of the feed in the reaction zone, the mole ratio of EDA to MEA is less than about 0.25 and the mole ratio of ammonia to MEA is about 1 to about 10, the temperature of the reaction zone is about 120.degree. C. to about 300.degree. C., the pressure of the reaction zone is about 1000 to about 1800 psig, the conversion of MEA is about 20 to about 50 weight percent, and recovering said producers composition from the reaction zone.

Abstract translation: 连续生成的亚烷基胺生产者组合物包含基于组合物的摩尔数的100％，不包含存在的任何MEA和水，a）约15至约35摩尔％DETA，b）约15至约55摩尔％EDA（净产生 ），c）约10至约35摩尔％的AEEA，d）PIP，AEP和HEP的组合约3至约25摩尔％，e）约3至约10摩尔％的一种或多种TETA和TEPAs， f）小于约1摩尔％的其它多亚烷基多胺，以及g）DETA与AEEA摩尔比大于约0.77至小于1.35，其制备方法包括进料氢气，氨气，MEA和EDA， 优选从再循环流提供到在管式反应器中含有还原胺化催化剂固定床的反应区，其中氢包含反应区中进料的约10至约50摩尔％，EDA与 MEA小于约0.25，氨与MEA的摩尔比为约1至约1 约10℃，反应区的温度为约120℃至约300℃，反应区的压力为约1000至约1800psig，MEA的转化率为约20至约50重量％，和 从反应区回收所述生产者组合物。

公开(公告)号：US4381223A

公开(公告)日：1983-04-26

申请号：US307223

申请日：1981-09-30

Applicant: Charles A. Gibson ,  Moinuddin Ahmed ,  Michael Habenschuss

Inventor： Charles A. Gibson ,  Moinuddin Ahmed ,  Michael Habenschuss

IPC: C07C67/00 ,  C07C209/00 ,  C07C209/86 ,  C07C211/14 ,  C07C213/00 ,  C07C213/10 ,  C07C215/06 ,  C07C215/08 ,  C07C215/12 ,  B01D3/00

CPC classification number: C07C215/08 ,  C07C213/10 ,  C07C215/12

Abstract: This invention provides for the separation of an amine composition undergoing processing at high temperatures and pressures which amine composition contains volatile components and less volatile components where the volatile components are desirable for further processing and/or utilization and the less volatile components are less desirable for further processing and/or utilization. The separation serves to divide the amine composition into two streams, one which is enriched in the volatile components and the other which is enriched in the less volatile components.

Abstract translation: 本发明提供了在高温和高压下进行加工的胺组合物的分离，该胺组合物含有挥发性组分和较不易挥发的组分，其中挥发性组分对于进一步处理和/或利用是理想的，并且较不易挥发的组分对于进一步的 处理和/或利用。 该分离用于将胺组合物分成两股，其中富含挥发性组分的物质和富含较不易挥发组分的另一种。