-
11.
公开(公告)号:US11642280B2
公开(公告)日:2023-05-09
申请号:US17213922
申请日:2021-03-26
Applicant: CORNING INCORPORATED
CPC classification number: A61J1/065 , A61J1/1412 , B32B17/06 , B65B7/161 , B65D39/0052 , C03C15/02 , A61J2200/44 , Y10T428/13 , Y10T428/131 , Y10T428/1328 , Y10T428/1331 , Y10T428/1352 , Y10T428/1355 , Y10T428/1397
Abstract: A sealed pharmaceutical container includes a shoulder, a neck extending from the shoulder, and a flange extending from the neck. The flange includes an inclined sealing surface defining an opening in the sealed pharmaceutical container. The sealed pharmaceutical container also includes a sealing assembly including a stopper extending over the sealing surface of the flange and a cap securing the stopper to the flange. The stopper has a glass transition temperature (Tg) that is greater than or equal to −70° C. and less than or equal to −45° C. The sealing assembly maintains a helium leakage rate of the sealed pharmaceutical container of less than or equal to 1.4×10−6 cm3/s as the sealed pharmaceutical container is cooled to a temperature of less than or equal to −45° C.
-
12.
公开(公告)号:US20220339067A1
公开(公告)日:2022-10-27
申请号:US17728337
申请日:2022-04-25
Applicant: CORNING INCORPORATED
Inventor: Dane Alphanso Christie , Adam Robert Sarafian , Jiangtao Wu
IPC: A61J1/14
Abstract: A sealed pharmaceutical container comprises a shoulder, a neck extending from the shoulder, and a flange extending from the neck. The flange comprises an outer surface extending from the underside surface and a contact surface extending between the outer surface and an inner surface defining an opening in the sealed pharmaceutical container. The contact surface comprises an outer peripheral edge disposed proximate to the outer surface of the flange. The sealed pharmaceutical container comprises a sealing assembly comprising a stopper extending over the contact surface of the flange and covering the opening, and a cap securing the stopper to the flange. The stopper comprises a sealing surface that is secured in contact with the contact surface of the flange to form a seal between the flange and the stopper. An outer peripheral edge of the sealing surface is disposed at or radially inward of the outer peripheral edge.
-
公开(公告)号:US12186267B2
公开(公告)日:2025-01-07
申请号:US18310956
申请日:2023-05-02
Applicant: CORNING INCORPORATED
Inventor: Christy Lynn Chapman , Sinue Gomez-Mower , Weirong Jiang , Joseph Michael Matusick , Christie Leigh McCarthy , Connor Thomas O'Malley , John Stephen Peanasky , Shivani Rao Polasani , James Ernest Webb , Michael Clement Ruotolo, Jr. , Bryan James Musk , Jared Seaman Aaldenberg , Eric Lewis Allington , Douglas Miles Noni, Jr. , Amber Leigh Tremper , Kristen Dae Waight , Kevin Patrick McNelis , Patrick Joseph Cimo , Steven Edward DeMartino , Robert Anthony Schaut , Adam Robert Sarafian
Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.
-
公开(公告)号:US12076296B2
公开(公告)日:2024-09-03
申请号:US17957964
申请日:2022-09-30
Applicant: CORNING INCORPORATED
Inventor: Steven Edward DeMartino , Sinue Gomez-Mower , Weirong Jiang , Joseph Michael Matusick , Christie Leigh McCarthy , Connor Thomas O'Malley , John Stephen Peanasky , Shivani Rao Polasani , James Ernest Webb , Michael Clement Ruotolo, Jr. , Bryan James Musk , Jared Seaman Aaldenberg , Eric Lewis Allington , Douglas Miles Noni, Jr. , Amber Leigh Tremper , Kristen Dae Waight , Kevin Patrick McNelis , Patrick Joseph Cimo , Christy Lynn Chapman , Robert Anthony Schaut , Adam Robert Sarafian
CPC classification number: A61J1/1468 , B65D23/0821
Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.
-
公开(公告)号:US20240285471A1
公开(公告)日:2024-08-29
申请号:US18628329
申请日:2024-04-05
Applicant: CORNING INCORPORATED
Inventor: Connor Thomas O'Malley , Sinue Gomez-Mower , Weirong Jiang , Joseph Michael Matusick , Christie Leigh McCarthy , Christy Lynn Chapman , John Stephen Peanasky , Shivani Rao Polasani , James Ernest Webb , Michael Clement Ruotolo, Jr. , Bryan James Musk , Jared Seaman Aaldenberg , Eric Lewis Allington , Douglas Miles Noni, Jr. , Amber Leigh Tremper , Kristen Dae Waight , Kevin Patrick McNelis , Patrick Joseph Cimo , Steven Edward DeMartino , Robert Anthony Schaut , Adam Robert Sarafian , Alicia Marie Gallagher
CPC classification number: A61J1/1468 , B65D23/0821
Abstract: A glass cartridge comprises a cylindrical body portion comprising an outer diameter Dc and an average sidewall thickness Tc, the cylindrical body portion having a first end and a second end opposite the first end; an opening at the first end of the cylindrical body portion; a shoulder extending radially inward from the second end of the cylindrical body portion; and a neck extending from the shoulder and comprising an outer neck diameter NOD that is less than the outer diameter Dc of the cylindrical body portion. The average wall thickness Tc is less than or equal to 0.85*s1, wherein s1 is a wall thickness of a standard glass cartridge defined by ISO 13926-1:2004 having an outer diameter d1 that is closer to the outer diameter Dc than the outer diameter d1 of any other standard glass cartridge defined by ISO 13926-1:2004.
-
公开(公告)号:US20240067560A1
公开(公告)日:2024-02-29
申请号:US18237733
申请日:2023-08-24
Applicant: CORNING INCORPORATED
Inventor: Gabriel Pierce Agnello , Dane Alphanso Christie , Richard Michael Fiacco , Eric Emil Leonhardt , Adam Robert Sarafian , Bryan Henry Smith
CPC classification number: C03C15/00 , C03C17/005 , C03C17/25 , C03C2217/213 , C03C2218/11
Abstract: An aqueous treating medium may include water; an acid selected from the group consisting of: HCl, HBr, HNO3, H2SO4, H2SO3, H3PO4, H3PO2, HOAc, citric acid, tartaric acid, ascorbic acid, EDTA, methanesulfonic acid, toluenesulfonic acid, and combinations thereof, wherein a concentration of the acid in the aqueous treating medium is from 0.5 M to 1.5 M; a salt, wherein a concentration of the salt in the aqueous treating medium is from greater than 0 M to 2 M; a fluoride-containing compound selected from the group consisting of: HF, NaF, NH4HF2, and combinations thereof, wherein a concentration of the fluoride-containing compound in the aqueous treating medium is from 0.026 M to 0.26 M; and silica, wherein the aqueous treating medium is saturated with silica.
-
公开(公告)号:US20230391667A1
公开(公告)日:2023-12-07
申请号:US18237537
申请日:2023-08-24
Applicant: CORNING INCORPORATED
Inventor: Timothy Michael Gross , Adam Robert Sarafian , Jingshi Wu , Zheming Zheng
CPC classification number: C03C21/007 , C03C3/097
Abstract: Glass-based articles that include a compresive stress layer extending from a surface of the glass-based article to a depth of compression are formed by exposing glass-based substrates to water vapor containing environments. The methods of forming the glass-based articles may include elevated pressures and/or multiple exposures to water vapor containing environments.
-
公开(公告)号:US20230157927A1
公开(公告)日:2023-05-25
申请号:US17992412
申请日:2022-11-22
Applicant: CORNING INCORPORATED
Inventor: Dane Alphanso Christie , Adam Robert Sarafian , Jiangtao Wu
CPC classification number: A61J1/1412 , A61J1/065 , A61J1/1468 , B65B7/2821 , B65D41/28
Abstract: Caps for sealing assemblies for sealing glass containers and maintaining container closure integrity at −80° C. or less are disclosed. The caps include a cap skirt having an annular body and a crimp region. The crimp region is a crimpable metal. The annular body of the cap skirt has a coefficient of thermal expansion (CTE) greater than a CTE of a metal consisting of aluminum, a stiffness greater than or equal to 2 times a stiffness of the crimp region, or both. The greater CTE, stiffness, or both of the cap skirt increase the seal pressure and contact area between the stopper and glass container when cooled to −80° C. or less. The caps enable the sealing assemblies to maintain a helium leakage rate of the sealed glass container of less than or equal to 1.4×10−6 cm3/s at −80° C. or less.
-
19.
公开(公告)号:US20230145946A1
公开(公告)日:2023-05-11
申请号:US17982088
申请日:2022-11-07
Applicant: CORNING INCORPORATED
Inventor: Michael Patrick Carson , Dane Alphanso Christie , Galan Gregory Moore , Connor Thomas O'Malley , Adam Robert Sarafian , Robert Anthony Schaut , Mark Owen Weller , Jiangtao Wu
CPC classification number: A61J1/1412 , A61J1/065
Abstract: A sealed pharmaceutical container includes a shoulder, a neck extending from the shoulder, a flange extending from the neck, and a sealing assembly. The flange includes an underside surface extending from the neck, an outer surface extending from the underside surface, the outer surface defining an outer diameter of the flange, and an upper sealing surface extending between the outer surface and an inner surface defining an opening in the sealed pharmaceutical container. The sealing assembly includes a stopper and a metal-containing cap securing the stopper to the flange. The stopper includes a sealing portion extending over the upper sealing surface of the flange and covering the opening, and a rim extending at least partially along the outer surface of the flange.
-
20.
公开(公告)号:US20210212893A1
公开(公告)日:2021-07-15
申请号:US17213922
申请日:2021-03-26
Applicant: CORNING INCORPORATED
Abstract: A sealed pharmaceutical container includes a shoulder, a neck extending from the shoulder, and a flange extending from the neck. The flange includes an inclined sealing surface defining an opening in the sealed pharmaceutical container. The sealed pharmaceutical container also includes a sealing assembly including a stopper extending over the sealing surface of the flange and a cap securing the stopper to the flange. The stopper has a glass transition temperature (Tg) that is greater than or equal to −70° C. and less than or equal to −45° C. The sealing assembly maintains a helium leakage rate of the sealed pharmaceutical container of less than or equal to 1.4×10−6 cm3/s as the sealed pharmaceutical container is cooled to a temperature of less than or equal to −45° C.
-
-
-
-
-
-
-
-
-