公开(公告)号：US20190151511A1

公开(公告)日：2019-05-23

申请号：US15539475

申请日：2016-12-05

Applicant: Colorado State University Research Foundation

Inventor： Travis S. Bailey ,  Kristine Fischenich ,  Jackson T. Lewis ,  Tammy Haut Donahue ,  Chen Guo

IPC: A61L27/52 ,  C08J3/075 ,  A61L27/26 ,  C08L53/00 ,  C08G81/02

Abstract: Provided herein is a soft tissue mimetic formed from a block copolymer hydrogel and methods of making such. The hydrogel comprises a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO-SOS by weight. The soft tissue mimetic has a fatigue resistance to at least 500,000 compression cycles.

公开(公告)号：US10167387B2

公开(公告)日：2019-01-01

申请号：US14917795

申请日：2014-09-10

Applicant: Colorado State University Research Foundation

Inventor： Susan P. James ,  Travis S. Bailey ,  Ketul C. Popat ,  David A. Prawel ,  Jackson T. Lewis ,  Richard L. Koch

IPC: A61F2/16 ,  A61L27/44 ,  A61L27/48 ,  C08G77/388 ,  C08G77/14 ,  C08L43/04 ,  G02B1/04 ,  G02C7/04

Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.