公开(公告)号：US11898193B2

公开(公告)日：2024-02-13

申请号：US16565773

申请日：2019-09-10

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Benjamin J. Miller ,  Qun Zhong ,  Darren Roy Link

IPC: C12Q1/6806 ,  B05B1/08 ,  B01L3/00 ,  B05B1/26 ,  B05B7/00 ,  B01F23/41 ,  B01F33/3011 ,  B01F35/221 ,  B05B1/02 ,  B01L7/00

CPC classification number: C12Q1/6806 ,  B01F23/41 ,  B01F33/3011 ,  B01F35/2213 ,  B01L3/502761 ,  B01L3/502784 ,  B05B1/02 ,  B05B1/08 ,  B05B1/26 ,  B05B7/0012 ,  B01L7/525 ,  B01L2200/025 ,  B01L2200/0647 ,  B01L2200/141 ,  B01L2200/143 ,  B01L2200/148 ,  B01L2300/0867 ,  B01L2300/14 ,  B01L2400/0487 ,  Y10T436/2575

Abstract: The invention generally relates to methods and systems for manipulating droplet size. In certain aspects, the invention provides methods for manipulating droplet size that include forming droplets of aqueous fluid surrounded by an immiscible carrier fluid, and manipulating droplet size during the forming step by adjusting pressure exerted on the aqueous fluid or the carrier fluid.

公开(公告)号：US20200225129A1

公开(公告)日：2020-07-16

申请号：US16733137

申请日：2020-01-02

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Benjamin Miller ,  Brian Hutchison ,  Andrew Wilson ,  Jonathan William Larson ,  Qun Zhong ,  Yevgeny Yurkovetsky ,  Darren Roy Link ,  Mark Weary

IPC: G01N1/38 ,  B01L3/02 ,  B01L3/00 ,  B01F15/00 ,  B01F13/00 ,  F17D3/01 ,  G01N27/447 ,  F16K99/00

Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.

公开(公告)号：US20240150813A1

公开(公告)日：2024-05-09

申请号：US18400468

申请日：2023-12-29

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Benjamin J. Miller ,  Qun Zhong ,  Darren Roy Link

IPC: C12Q1/6806 ,  B01F23/41 ,  B01F33/3011 ,  B01F35/221 ,  B01L3/00 ,  B05B1/02 ,  B05B1/08 ,  B05B1/26 ,  B05B7/00

CPC classification number: C12Q1/6806 ,  B01F23/41 ,  B01F33/3011 ,  B01F35/2213 ,  B01L3/502761 ,  B01L3/502784 ,  B05B1/02 ,  B05B1/08 ,  B05B1/26 ,  B05B7/0012 ,  B01L7/525 ,  B01L2200/0647 ,  B01L2300/14 ,  B01L2400/0487 ,  Y10T436/2575

Abstract: The invention generally relates to methods and systems for manipulating droplet size. In certain aspects, the invention provides methods for manipulating droplet size that include forming droplets of aqueous fluid surrounded by an immiscible carrier fluid, and manipulating droplet size during the forming step by adjusting pressure exerted on the aqueous fluid or the carrier fluid.

公开(公告)号：US11268887B2

公开(公告)日：2022-03-08

申请号：US16733137

申请日：2020-01-02

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Benjamin Miller ,  Brian Hutchison ,  Andrew Wilson ,  Jonathan William Larson ,  Qun Zhong ,  Yevgeny Yurkovetsky ,  Darren Roy Link ,  Mark Weary

IPC: G01N1/38 ,  F16K99/00 ,  B01L3/02 ,  B01L3/00 ,  B01F15/00 ,  B01F13/00 ,  F17D3/01 ,  G01N27/447 ,  G01N21/03 ,  G01N21/17

Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.

公开(公告)号：US10527529B2

公开(公告)日：2020-01-07

申请号：US15674074

申请日：2017-08-10

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Benjamin J. Miller ,  Brian Hutchison ,  Andrew Wilson ,  Jonathan William Larson ,  Qun Zhong ,  Yevgeny Yurkovetsky ,  Darren Roy Link ,  Mark Weary

IPC: B01L3/02 ,  G01N1/38 ,  B01L3/00 ,  F17D3/01 ,  G01N27/447 ,  F16K99/00 ,  G01N21/03 ,  G01N21/17

Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.

公开(公告)号：US20200002748A1

公开(公告)日：2020-01-02

申请号：US16565773

申请日：2019-09-10

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Benjamin J. Miller ,  Qun Zhong ,  Darren Roy Link

IPC: C12Q1/6806 ,  B05B1/08 ,  B01F13/00 ,  B01F3/08 ,  B05B1/02 ,  B01L3/00

Abstract: The invention generally relates to methods and systems for manipulating droplet size. In certain aspects, the invention provides methods for manipulating droplet size that include forming droplets of aqueous fluid surrounded by an immiscible carrier fluid, and manipulating droplet size during the forming step by adjusting pressure exerted on the aqueous fluid or the carrier fluid.