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公开(公告)号：US11383238B2
公开(公告)日：2022-07-12
申请号：US16626490
申请日：2019-07-26
Inventor： Nan Zhao , Peizhi Cai , Haochen Cui , Yuelei Xiao , Fengchun Pang , Le Gu , Yingying Zhao , Hui Liao , Yue Geng , Wenliang Yao
Abstract: A microfluidic apparatus is provided. The microfluidic apparatus includes an electrochromic layer including a plurality of individually independently addressable regions; a microfluidic layer defining a microfluidic channel for allowing a microfluid to pass therethrough; and a plurality of photodetectors configured to detect light transmit through the microfluid. The electrochromic layer is configured to be switched between a first state in which the plurality of individually independently addressable regions of the electrochromic layer are substantially transmissive, and a second state in which at least a first one of the plurality of individually independently addressable regions of the electrochromic layer in a region corresponding to a position of the microfluid is substantially transmissive, at least a second one of the plurality of individually independently addressable regions of the electrochromic layer outside the region corresponding to the position of the microfluid is substantially non-transmissive.
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公开(公告)号：US11344891B2
公开(公告)日：2022-05-31
申请号：US16768558
申请日：2019-11-13
Inventor： Yingying Zhao , Peizhi Cai , Le Gu , Fengchun Pang , Yue Geng , Yuelei Xiao , Haochen Cui , Nan Zhao , Hui Liao , Wenliang Yao , Chuncheng Che
IPC: B01L3/00
Abstract: The present disclosure provides a microfluidic chip, including: first base substrate and a second base substrate opposite to each other; first electrode and second electrode between the first base substrate and the second base substrate and configured to control droplet to move between the first base substrate and the second base substrate according to voltages applied on the first electrode and the second electrode; light guide component configured to guide light propagating in the first base substrate to the droplet; shading component and detection component, shading component having light transmission regions spaced from each other, light transmission regions being configured to transmit light passing through the droplet to the detection component, wherein detection component is on second base substrate and is configured to obtain property of the droplet according to an intensity of the light passing through droplet and received from the light transmission regions.
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公开(公告)号：US11344889B2
公开(公告)日：2022-05-31
申请号：US16603648
申请日：2019-04-26
Inventor： Haochen Cui , Peizhi Cai , Chuncheng Che , Fengchun Pang , Yingying Zhao , Yue Geng , Le Gu , Nan Zhao , Yuelei Xiao , Hui Liao
Abstract: The embodiments of the present disclosure relate to a microfluidic chip. The microfluidic chip may include a substrate. The substrate may include an electrode layer on a base substrate, a dielectric layer on the electrode layer, and a lyophobic layer on the dielectric layer. The electrode layer may include a plurality of electrode units. Each of the plurality of electrode units may be configured to realize both droplet detection and droplet driving in response to a detection signal and a driving signal respectively.
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公开(公告)号：US20210322973A1
公开(公告)日：2021-10-21
申请号：US16603648
申请日：2019-04-26
Inventor： Haochen Cui , Peizhi Cai , Chuncheng Che , Fengchun Pang , Yingying Zhao , Yue Geng , Le Gu , Nan Zhao , Yuelei Xiao , Hui Liao
Abstract: The embodiments of the present disclosure relate to a microfluidic chip. The microfluidic chip may include a substrate. The substrate may include an electrode layer on a base substrate, a dielectric layer on the electrode layer, and a lyophobic layer on the dielectric layer. The electrode layer may include a plurality of electrode units. Each of the plurality of electrode units may be configured to realize both droplet detection and droplet driving in response to a detection signal and a driving signal respectively.
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公开(公告)号：US11053539B2
公开(公告)日：2021-07-06
申请号：US15750907
申请日：2017-07-12
Inventor： Fengchun Pang , Peizhi Cai , Yue Geng
IPC: B01L3/00 , C12Q1/6869 , C12Q1/6825
Abstract: A detection substrate and a manufacturing method thereof, and a nucleic acid detecting method are provided. The detection substrate includes at least one detection unit disposed on a base substrate, the detection unit including a first electrode, a second electrode and a colloid layer, the second electrode disposed on a side of the first electrode away from the base substrate, the second electrode including at least one hollowed structure, the second electrode and the first electrode being insulated from each other, and the first electrode and the second electrode being configured to be applied with voltages respectively; the colloid layer at least disposed on the at least one hollowed structure of the second electrode, the colloid layer including a linker configured to be paired with a target nucleic acid.
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Patent Agency Ranking
公开(公告)号：US10146362B2
公开(公告)日：2018-12-04
申请号：US15209575
申请日：2016-07-13
Inventor： Rui Xu , Xiaochuan Chen , Xi Chen , Lei Ma , Peizhi Cai , Xue Cao , Jinyu Li , Yanchen Li , Fengchun Pang , Xingyou Luo
Abstract: The disclosure provides a shift register unit, a shift register, a driving method and an array substrate. The shift register unit may comprise a touch-controlled circuit comprising a touch-controlled turning-on module and a touch-controlled turning-off module, wherein a control of the touch-controlled turning-on module is connected to a touch-controlled turning-on signal, an input is connected to a negative power supply signal, and an output is connected to an output terminal, and the touch-controlled turning-on signal is a pulse signal at a start of a touch controlling period; and a control of the touch-controlled turning-off module is connected to a touch-controlled turning-off signal, an input of the touch-controlled turning-off module is connected to a positive power supply signal, and an output of the touch-controlled turning-off module is connected to the output terminal, wherein the touch-controlled turning-off signal is a pulse signal at an end of the touch controlling period.
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17.发明公开公开(公告)号：US20240278236A1
公开(公告)日：2024-08-22
申请号：US18654383
申请日：2024-05-03
Inventor： Fengchun Pang
CPC classification number: B01L3/502707 , G09G3/34
Abstract: Provided are a microfluidic chip and a manufacturing method thereof, and a microfluidic device. The microfluidic chip comprises a first substrate structure comprising a plurality of pin areas comprising a first and a second pin area, a detection area, and a grounding trace. The detection area comprises a plurality of first scan lines extending along a first direction, each of which being connected to the first pin area through a corresponding first scan trace; a plurality of first data lines extending along a second direction, each of which being connected to the second pin area through a corresponding first data trace; a plurality of detection units, each of which comprising a first switching transistor connected to a corresponding first scan line and data line, a driving electrode, and a first hydrophobic layer. The grounding trace is connected to at least one detection unit and one of the pin areas.
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公开(公告)号：US12061386B2
公开(公告)日：2024-08-13
申请号：US17626472
申请日：2021-03-10
Inventor： Yuelei Xiao , Yue Li , Fengchun Pang , Xue Cao , Na Li , Juan Chen , Sikai Zhang , Yifan Wu , Wenbo Chang
IPC: G02F1/1333 , G02F1/1337 , G02F1/1343
CPC classification number: G02F1/133382 , G02F1/1337 , G02F1/1343
Abstract: The present disclosure provides dimming glass, a dimming module and an operating method thereof. The dimming glass includes: a first glass substrate and a second glass substrate arranged opposite to each other; a first electrode and a second electrode arranged between the first glass substrate and the second glass substrate; a liquid crystal dimming layer arranged between the first glass substrate and the second glass substrate; and a heating layer arranged between the liquid crystal dimming layer and the first glass substrate, and configured to heat the liquid crystal dimming layer upon the receipt of an electric signal.
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公开(公告)号：US11291970B2
公开(公告)日：2022-04-05
申请号：US16071932
申请日：2018-01-02
Inventor： Yue Geng , Fengchun Pang , Peizhi Cai , Le Gu
IPC: B01L3/00 , B01J19/00 , C12Q1/6874 , C12Q1/6869
Abstract: A gene sequencing chip is provided, which includes: an upper substrate including a plurality of liquid inlets for inletting liquid drops; a lower substrate opposite to the upper substrate and spaced therefrom by a gap, the gap being provided for allowing the liquid drops to move therein, the lower substrate including a liquid drop operation region, the liquid drop operation region including a manipulation electrode array. The manipulation electrode array includes multiple first sub-arrays for preparing a gene library, multiple second sub-arrays for sequencing the gene library which is prepared, each first sub-array being adjacent to one of the multiple second sub-arrays. Based on the gene sequencing chip provided in this disclosure, operations to tiny liquid drops such as movement, fusion and splitting can be accurately manipulated by using digital microfluidic techniques, and all steps of the gene sequencing from library preparation to gene sequencing can be completed on one chip.
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公开(公告)号：US11103868B2
公开(公告)日：2021-08-31
申请号：US16338042
申请日：2018-10-11
Inventor： Fengchun Pang , Peizhi Cai , Yue Geng , Le Gu , Yingying Zhao , Haochen Cui , Nan Zhao , Yuelei Xiao , Hui Liao , Chuncheng Che
IPC: B01L3/00
Abstract: The present disclosure provides a microfluidic chip, a biological detection device and a method. The microfluidic chip includes: a first substrate and a second substrate that are oppositely disposed; a first electrode and a second electrode that are oppositely disposed between the first substrate and the second substrate, the first electrode including a plurality of spaced first electrode units, and the second electrode including a plurality of spaced second electrode units, wherein the first electrode units are disposed oppositely to the second electrode units in one-to-one correspondence; a first dielectric layer and a second dielectric layer between the first electrode and the second electrode; a first hydrophobic layer and a second hydrophobic layer between the first dielectric layer and the second dielectric layer, wherein a gap is between the first hydrophobic layer and the second hydrophobic layer.
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