公开(公告)号：US4072696A

公开(公告)日：1978-02-07

申请号：US434656

申请日：1974-01-18

Applicant: Colin C. Beard ,  John A. Edwards ,  John H. Fried

Inventor： Colin C. Beard ,  John A. Edwards ,  John H. Fried

IPC: C07C335/28 ,  C07C147/00 ,  C07C147/06 ,  C07C149/40

CPC classification number: C07C335/28

Abstract: Carbalkoxythioureidobenzene derivatives represented by the following formula: ##STR1## where R is a lower alkyl group having 1 to 4 carbon atoms; R.sup.1 is --SR.sup.2, --SOR.sup.2, --SO.sub.2 R.sup.2, --OR.sup.2, --SCN, --SC(O)NR.sup.3 R.sup.4, or --M'(CH.sub.2).sub.n MR.sup.7 where n is 1-4; R.sup.2 is lower alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, lower alkenyl or lower alkynyl having 3 to 6 carbon atoms, aralkyl or aryl, provided that when R.sup.1 is --SO.sub.2 R.sup.2, R.sup.2 is not aralkyl or phenyl; R.sup.3 and R.sup.4 are independently hydrogen or lower alkyl having 1 to 6 carbon atoms; Y is amino, nitro, acylamino where the acyl portion has 1 to 6 carbon atoms, --NHC(O) (CH.sub.2).sub.m COOH where m is 1-6, or --NHC(S)NHCOOR; M and M' are independently O, S or ##STR2## and R.sup.7 is lower alkyl having 1 to 4 carbon atoms or aryl. The R.sup.1 substitution is either at the 4- or 5-position.The compounds are useful as pesticides, particularly as anthelmintic and antifungal agents.

Abstract translation: 由下式表示的碳烷氧基硫代脲基苯衍生物：其中R是具有1至4个碳原子的低级烷基; R1是-SR2，-SOR2，-SO2R2，-OR2，-SCN，-SC（O）NR3R4或-M'（CH2）nMR7，其中n是1-4; R2是具有1至6个碳原子的低级烷基，具有3至7个碳原子的环烷基，具有3至6个碳原子的低级链烯基或低级炔基，芳烷基或芳基，条件是当R 1是-SO 2 R 2时，R 2不是芳烷基或苯基; R3和R4独立地是氢或具有1至6个碳原子的低级烷基; Y是酰基部分具有1-6个碳原子的氨基，硝基，酰基氨基，-NHC（O）（CH 2）m COOH，其中m是1-6，或-NHC（S）NHCOOR; M和M'独立地为O，S或，并且R 7为具有1至4个碳原子的低级烷基或芳基。 R1取代在4-或5-位。

公开(公告)号：US3935209A

公开(公告)日：1976-01-27

申请号：US441222

申请日：1974-02-11

Applicant: Colin C. Beard ,  John A. Edwards ,  John H. Fried

Inventor： Colin C. Beard ,  John A. Edwards ,  John H. Fried

IPC: C07D235/32 ,  A23K1/16 ,  C07D213/64 ,  C07D213/643 ,  C07D213/70 ,  C07D233/84 ,  C07D239/38 ,  C07D241/18 ,  C07D249/12 ,  C07D277/34 ,  C07D277/36 ,  C07D333/34

CPC classification number: C07D213/643 ,  C07D213/70 ,  C07D233/84 ,  C07D239/38 ,  C07D241/18 ,  C07D249/12 ,  C07D277/34 ,  C07D277/36 ,  C07D333/34

Abstract: Benzene ring substituted benzimidazole-2-carbamate derivatives represented by the formula: ##SPC1##Where R is a lower alkyl group having 1 to 4 carbon atoms; R.sup.1 is a heterocyclic ring having 1-4 hetero atoms; and M is O, S, or ##EQU1## The R.sup.1 M-substitution is at the 5(6)-position. The compounds are useful as pesticides, particularly as anthelmintic and antifungal agents.

公开(公告)号：US07198314B1

公开(公告)日：2007-04-03

申请号：US10171530

申请日：2002-06-11

Applicant: John A. Edwards

Inventor： John A. Edwards

IPC: B60P3/34

CPC classification number: B60P3/34

Abstract: FIGS. 3a and 3b show two side elevation views of a vehicle passenger cabin defining a passenger space wherein are featured an actuation device, generally designated 2, balancing gas springs, generally designated 65, pivoting hinge member 4, inner weather seal 50, outer weather seal 51 and draught proof brush seal 62. In view generally designated 3a, a pivoting extension member 3 is shown in the retracted position for on-road driving. In view generally designated 3b, a pivoting extension member 3 is shown in the extended position for passenger access and use.

Abstract translation: 图 图3a和3b示出了限定乘客空间的车辆客舱的两个侧视图，其特征在于具有致动装置，总体标记为2，平衡气弹簧，总体上标示为65，枢转铰链构件4，内部天气密封件50，外部天气 密封件51和防风刷刷密封件62。 在通常标示为3a的视图中，枢转延伸构件3被示出处于缩回位置以用于道路行驶。 在总体上标示为3b的视图中，枢转延伸构件3被示出处于用于乘客进入和使用的延伸位置。

公开(公告)号：US06325144B1

公开(公告)日：2001-12-04

申请号：US09590926

申请日：2000-06-09

Applicant: Rocky A. Turley ,  Greg C. Badke ,  John A. Edwards

Inventor： Rocky A. Turley ,  Greg C. Badke ,  John A. Edwards

IPC: E21B2304

CPC classification number: E21B17/025 ,  E21B17/1035 ,  E21B33/1285

Abstract: An expandible packer provides a crescent-shaped cross-sectional area for more and larger diameter data cable and fluid control conduits by eccentrically offsetting the packer mandrel relative to the expandable element. The expandible element of the packer eccentrically surrounds the mandrel to provide an eccentric volume zone between the packer collars. One or more data cable or fluid carrier conduits may be laid between the collars within this eccentric zone, all of greater diameter than would be possible within an annulus between two concentric mandrels. The eccentric zone conduits are secured and protected by a compliant filler material such as rubber or other elastomer that is applied around and between the control conduits within the eccentric zone. This filler material is trimmed or cast to a substantially cylindrical surface about an axis that is substantially coextensive with the expandable element axis.

Abstract translation: 可扩展封隔器通过使封隔器心轴相对于可膨胀元件偏心偏移，为越来越大直径的数据电缆和流体控制管道提供月牙形横截面面积。 封隔器的可膨胀元件偏心地围绕心轴以在封隔器套环之间提供偏心的容积区域。 一个或多个数据电缆或流体载体导管可以放置在该偏心区域内的套环之间，其全部直径大于在两个同心心轴之间的环形空间内的直径。 偏心区域导管由柔性填充材料（例如橡胶或其它弹性体）固定和保护，该弹性体围绕和偏置在偏心区域内的控制导管之间。 该填充材料被修剪或者铸造成围绕与可膨胀元件轴基本上共同延伸的轴线的基本上圆柱形的表面。

公开(公告)号：US4198404A

公开(公告)日：1980-04-15

申请号：US893386

申请日：1978-04-05

Applicant: John A. Edwards ,  Francisco S. Alvarez

Inventor： John A. Edwards ,  Francisco S. Alvarez

IPC: C07J3/00 ,  C07J5/00 ,  A61K31/56

CPC classification number: C07J3/005 ,  C07J5/0076

Abstract: Certain 3-ketoandrost-4-ene and 3-ketoandrosta-1,4-diene 17 beta-carboxylic acids and esters substituted at the 6 alpha and 6 beta positions with fluorine substituents are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 9 alpha position with fluoro, chloro or bromo; substituted at the 11 with a keto, a beta-hydroxy or a beta-chloro (the latter only when there is a 9 alpha-chloro); substituted at 16 alpha (or 16 beta) with methyl or hydrogen when there is a 17 alpha-hydroxy (or an ester).

Abstract translation: 某些3-酮基雄甾-4-烯和3-酮基雄性-1,4-二烯17β-羧酸和在具有氟取代基的6α和6β位置取代的酯可用作抗炎类固醇。 这些化合物任选在9α位被氟，氯或溴取代; 在11处用酮，β-羟基或β-氯取代（后者仅在存在9α-氯时）; 当存在17α-羟基（或酯）时，以16α（或16β）与甲基或氢原子取代。

公开(公告)号：US4187301A

公开(公告)日：1980-02-05

申请号：US893389

申请日：1978-04-05

Applicant: John A. Edwards

Inventor： John A. Edwards

IPC: C07J3/00 ,  C07J5/00 ,  C07J31/00 ,  C07J71/00 ,  A61K31/58

CPC classification number: C07J5/0076 ,  C07J3/005 ,  C07J31/006 ,  C07J71/0031

Abstract: Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 6 alpha, 6 beta-positions with fluorine substituents are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 9 alpha position with fluoro, chloro or bromo; substituted at the 11 with a keto-, a beta-hydroxy or a beta-chloro (the latter only when there is a 9 alpha-chloro); substituted at 16 alpha, 17 alpha-positions with isopropylidenedioxy; and substituted at 16 alpha (or 16 beta) with methyl or hydrogen when there is a 17 alpha-hydroxy (or an ester).

Abstract translation: 在具有氟取代基的6α，6β位置取代的某些3-氧代雄甾-4-烯和3-氧代雄甾-1,4-二烯17β-硫代羧酸酯可用作抗炎类固醇。 这些化合物任选在9α位被氟，氯或溴取代; 在11处用酮 - ，β-羟基或β-氯取代（后者仅在存在9α-氯时）; 在16个α，17个α位被异丙二烯基取代; 并且当存在17α-羟基（或酯）时，以16α（或16β）与甲基或氢原子取代。

公开(公告)号：US3993768A

公开(公告)日：1976-11-23

申请号：US604502

申请日：1975-08-13

Applicant: Colin C. Beard ,  John A. Edwards ,  John H. Fried

Inventor： Colin C. Beard ,  John A. Edwards ,  John H. Fried

IPC: C07D235/32

CPC classification number: C07D235/32

Abstract: This application describes further species embraced by the following generic formula: ##SPC1##Where R is a lower alkyl group having 1 to 4 carbon atoms; R.sup.1 is --SOR.sup.2, --SO.sub.2 R.sup.2, --SCN, --SR.sup.5, --OR.sup.5 or M'(CH.sub.2).sub.n MR.sup.7 where M and M' are independently ##EQU1## R.sup.7 is lower alkyl having 1 to 4 carbon atoms or aryl, and n is 1-4; R.sup.2 is lower alkyl having from 1 to 6 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, lower alkenyl or lower alkynyl having 3 to 6 carbon atoms, or aralkyl or aryl; R.sup.5 is lower alkenyl, lower alkynyl, or aralkyl; and the R.sup.1 substitution is at the 5(6)-position. The above compounds can also be substituted at the 1-position.

Abstract translation: 本申请描述了由以下通式表示的其它物质：+ q，10，其中R是具有1至4个碳原子的低级烷基; R 1是-SOR 2，-SO 2 R 2，-SCN，-SR 5，-OR 5或M'（CH 2）nMR 7，其中M和M'独立地为O和R a，O，S，S，S和R d' 4个碳原子或芳基，n为1-4; R2是具有1至6个碳原子的低级烷基，具有3至7个碳原子的环烷基，具有3至6个碳原子的低级链烯基或低级炔基，或芳烷基或芳基; R5是低级烯基，低级炔基或芳烷基; 而R1取代位于5（6）位。 上述化合物也可以在1-位取代。

公开(公告)号：US3982010A

公开(公告)日：1976-09-21

申请号：US507651

申请日：1974-09-19

Applicant: John A. Edwards

Inventor： John A. Edwards

IPC: A61K31/425 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D277/40 ,  C07D277/46 ,  C07D277/48 ,  C07D277/56 ,  C07D277/58 ,  C07D417/12

CPC classification number: A61K31/425 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D277/40 ,  C07D277/46 ,  C07D277/48 ,  C07D277/56 ,  C07D277/58 ,  C07D417/12

Abstract: 1-Amino-3-[2-thiazoloxy]-2-propanol and substituted 1-amino derivatives thereof; 3-[2-thiazoloxy]-1,2-epoxypropane 5-[thiazol-2-oxymethylene]-oxazolidine and/or N-substituted and/or 2-substituted oxazolidine, derivatives thereof and methods of preparing such compounds. The above 1-amino-3-[2-thiazoloxy]-2-propanol and derivatives exhibit .beta.-adrenergic stimulating cardiovascular activity and are useful for the treatment of abnormal heart conditions in mammals. The above 3-[2-thiazoloxy]-1,2-epoxypropane and derivatives are useful as intermediates for the aforementioned cardiovascular agents. The 5-[thiazol-2-oxymethylene]-oxazolidine and derivatives are intermediates for aforementioned cardiovascular agents. The 1-amino-3-[2-thiazoloxy]-2-propanol and derivatives can be prepared by base or acid hydrolysis of the corresponding 5-[thiazol-2-oxymethylene]-oxazolidine or derivatives; or by treatment of the corresponding 3-[2-thiazoloxy]-2,3-epoxypropane or derivative with the desired amine or amino-derivative.

Abstract translation: 1-氨基-3- [2-噻唑氧基] -2-丙醇及其取代的1-氨基衍生物; 3- [2-噻唑氧基] -1,2-环氧丙烷5- [噻唑-2-甲醛] - 恶唑烷和/或N-取代的和/或2-取代的恶唑烷及其衍生物和制备这些化合物的方法。 上述1-氨基-3- [2-噻唑氧基] -2-丙醇及其衍生物表现出β-肾上腺素能刺激心血管活性，可用于治疗哺乳动物异常心脏病症。 上述3- [2-噻唑氧基] -1,2-环氧丙烷及其衍生物可用作上述心血管药物的中间体。 5- [噻唑-2-甲醛]恶唑烷及其衍生物是上述心血管药物的中间体。 1-氨基-3- [2-噻唑氧基] -2-丙醇及其衍生物可以通过相应的5- [噻唑-2-甲醛] - 恶唑烷或其衍生物的碱或酸水解来制备。 或通过用所需的胺或氨基衍生物处理相应的3- [2-噻唑氧基] -2,3-环氧丙烷或衍生物。

公开(公告)号：US4263289A

公开(公告)日：1981-04-21

申请号：US71635

申请日：1979-08-31

Applicant: John A. Edwards

Inventor： John A. Edwards

IPC: C07J3/00 ,  C07J31/00 ,  C07J71/00 ,  A61K31/56

CPC classification number: C07J71/0031 ,  C07J3/005 ,  C07J31/006

Abstract: Certain 16.beta.-methyl-3-oxoandrost-4-ene and 16.beta.-methyl-3-oxoandrosta-1,4-diene 17.beta.-thiocarboxylic acid esters are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 6.alpha.-position with fluoro or chloro; optionally substituted at the 9.alpha. position with fluoro, chloro or bromo; substituted at the 11 position with a keto, a .beta.-hydroxy or a .beta.-chloro (the latter only when there is a 9.alpha.-chloro); and substituted with 17.alpha.-hydroxy (or an ester thereof).

Abstract translation: 某些16个β-甲基-3-氧代雄甾-4-烯和16个β-甲基-3-氧代雄甾-1,4-二烯17β-硫代羧酸酯可用作抗炎类固醇。 这些化合物任选在6位上被氟或氯取代; 任选在9α位被氟，氯或溴取代; 在11位置用酮，β-羟基或β-氯代替（后者仅在存在9α-氯的情况下）; 并用17α-羟基（或其酯）取代。

公开(公告)号：US4188385A

公开(公告)日：1980-02-12

申请号：US893388

申请日：1978-04-05

Applicant: John A. Edwards

Inventor： John A. Edwards

IPC: A61K31/56 ,  A61K31/568 ,  A61K31/58 ,  A61P5/38 ,  A61P29/00 ,  C07J1/00 ,  C07J3/00 ,  C07J31/00 ,  C07J71/00

CPC classification number: C07J31/006 ,  C07J3/005 ,  C07J71/0031

Abstract: Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters are useful as antiinflammatory steroids. These compounds are optionally substituted at the 6 alpha-position with fluoro, or chloro; optionally substituted at the 9 alpha position with fluoro, chloro or bromo; substituted at the 11 position with a keto, a beta-hydroxy on a beta-chloro (the latter only when there is a 9 alpha-chloro); substituted at 16 alpha, 17 alpha-positions with isopropylidenedioxy; and substituted at 16 alpha (or 16 beta) with methyl or hydrogen when there is a 17 alpha-hydroxy (or an ester).

Abstract translation: 某些3-氧代雄甾-4-烯和3-氧代雄甾-1,4-二烯17β-硫代羧酸酯可用作抗炎类固醇。 这些化合物任选在6α-位被氟或氯取代; 任选在9α位被氟，氯或溴取代; 在11位上用酮，在β-氯代替β-羟基（仅当存在9α-氯时）; 在16个α，17个α位被异丙二烯基取代; 并且当存在17α-羟基（或酯）时，以16α（或16β）与甲基或氢原子取代。