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11.发明授权Integrin binding motif containing peptides and methods of treating skeletal diseases 有权含有肽的整合素结合基序和治疗骨骼疾病的方法公开(公告)号：US07160862B2
公开(公告)日：2007-01-09
申请号：US11042492
申请日：2005-01-24
CPC分类号： A61K8/64 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/16 , A61K38/1709 , A61Q11/00 , C07K14/47 , C07K14/4705 , C07K14/4728 , C07K14/705 , C07K14/78
摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
摘要翻译： 公开了包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，糖胺聚糖结合基序和钙结合基序中的至少一种，并且与基质细胞外磷酸糖蛋白中的RGD序列连续的氨基酸的其余部分。 这些序列可以配制用于注射或分散在牙膏或漱口剂或牙龈贴片中并且被施用以增强骨/牙齿生长和/或减少体内过量的尿中磷酸盐的损失。
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公开(公告)号：US20060210493A1
公开(公告)日：2006-09-21
申请号：US11379316
申请日：2006-04-19
IPC分类号： A61K8/96 , C07K14/475
CPC分类号： A61Q11/00 , A61K8/64 , A61K38/1709 , Y10S514/899 , Y10S514/90 , Y10S514/901
摘要： Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.
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公开(公告)号：US20050002875A1
公开(公告)日：2005-01-06
申请号：US10344046
申请日：2001-08-09
IPC分类号： A61K8/00 , A61K8/64 , A61K38/00 , A61K38/16 , A61K38/17 , A61P1/02 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K17/00 , A61K7/28 , C07K14/47
CPC分类号： A61Q11/00 , A61K8/64 , A61K38/1709 , Y10S514/899 , Y10S514/90 , Y10S514/901
摘要： Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.
摘要翻译： 公开了牙膏，漱口剂和牙线等牙科产品，通过溶解，分散或涂覆促进骨生长的化合物来增强产品。 优选的化合物是包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，并且在基质细胞外磷酸糖蛋白中与RGD序列连续的氨基酸残基。 可以将这些序列配制成用于分散在牙膏或漱口剂中并施用以增强骨/牙齿生长。 当牙科产品随着时间的推移被多次使用时，它们可以提高牙齿健康。
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公开(公告)号：US5837674A
公开(公告)日：1998-11-17
申请号：US675031
申请日：1996-07-03
申请人： Yoshinari Kumagai , Akira Otaka
发明人： Yoshinari Kumagai , Akira Otaka
IPC分类号： A61K31/80 , A61K38/00 , A61K38/04 , A61K38/16 , A61P19/00 , A61P19/08 , A61P19/10 , C07K5/00 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K17/00 , C08G69/10 , A01N57/10
CPC分类号： C07K7/06 , C07K7/08 , A61K38/00 , Y10T436/16
摘要： Phosphopeptides which significantly reduce bone loss or weakening are provided by the invention. Also provided is a method for treating or preventing any condition associated with bone loss or weakening by administering the phosphopeptides by oral or injectable means.
摘要翻译： 通过本发明提供显着减少骨丢失或减弱的磷酸肽。 还提供了通过口服或注射方式施用磷酸肽来治疗或预防与骨丢失或减弱有关的任何病状的方法。
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公开(公告)号：US07498021B2
公开(公告)日：2009-03-03
申请号：US11379316
申请日：2006-04-19
CPC分类号： A61Q11/00 , A61K8/64 , A61K38/1709 , Y10S514/899 , Y10S514/90 , Y10S514/901
摘要： Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.
摘要翻译： 公开了牙膏，漱口剂和牙线等牙科产品，其中通过溶解，分散或涂覆促进骨生长的化合物来增强产品。 优选的化合物是包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，并且在基质细胞外磷酸糖蛋白中与RGD序列连续的氨基酸残基。 可以将这些序列配制成用于分散在牙膏或漱口剂中并施用以增强骨/牙齿生长。 当牙科产品随着时间的推移被多次使用时，它们可以提高牙齿健康。
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公开(公告)号：US20050163728A1
公开(公告)日：2005-07-28
申请号：US11042492
申请日：2005-01-24
IPC分类号： A61K9/08 , A61K8/00 , A61K8/64 , A61K9/70 , A61K38/00 , A61K47/04 , A61P3/00 , A61P19/08 , A61P19/10 , A61Q11/00 , C07K14/00 , C07K14/47 , C07K14/705 , C07K14/78 , A61K38/10 , A61K7/28 , A61K38/08
CPC分类号： A61K8/64 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/16 , A61K38/1709 , A61Q11/00 , C07K14/47 , C07K14/4705 , C07K14/4728 , C07K14/705 , C07K14/78
摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
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公开(公告)号：US20220226433A1
公开(公告)日：2022-07-21
申请号：US17486551
申请日：2021-09-27
申请人： Yoshinari Kumagai , Dawn McGuire , Meghan Miller , David Rosen
发明人： Yoshinari Kumagai , Dawn McGuire , Meghan Miller , David Rosen
摘要： A diagnostic and a method of treatment are disclosed whereby the diagnostic identifies patients more likely to respond to a therapeutic intervention thereby improving clinical benefits including improved joint function, reduced pain, and other clinical symptoms.
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公开(公告)号：US20110251124A1
公开(公告)日：2011-10-13
申请号：US12967888
申请日：2010-12-14
CPC分类号： A61K38/1703 , Y02A50/473
摘要： A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.
摘要翻译： 公开了一种在患者体内测量钙，磷酸盐和甲状旁腺激素水平的方法。 用包含具有磷酸肌醇蛋白活性的化合物的制剂治疗患者，然后再次进行测量。 基于测量，根据需要，连续重复测量，施用和调整剂量来调节配方的剂量。
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公开(公告)号：US20090023633A1
公开(公告)日：2009-01-22
申请号：US11926719
申请日：2007-10-29
CPC分类号： A61K38/1703 , Y02A50/473
摘要： A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.
摘要翻译： 公开了一种在患者体内测量钙，磷酸盐和甲状旁腺激素水平的方法。 用包含具有磷酸肌醇蛋白活性的化合物的制剂治疗患者，然后再次进行测量。 基于测量，根据需要，连续重复测量，施用和调整剂量来调节配方的剂量。
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公开(公告)号：US20060193916A1
公开(公告)日：2006-08-31
申请号：US11327153
申请日：2006-01-05
申请人： Mirella Lazarova , David Rosen , Yoshinari Kumagai
发明人： Mirella Lazarova , David Rosen , Yoshinari Kumagai
IPC分类号： A61K38/10 , A61K9/14 , A61K31/728 , A61K33/42
CPC分类号： A61K38/1841 , A61K9/0063 , A61K31/728 , A61K33/42 , A61K38/10 , A61K2300/00
摘要： Methods to treat the defects in skeletal tissues characterized by protecting the marrow cells adjacent to the defects from apoptotic and/or necrotic cell death are disclosed. The methods provide additional benefits which are to reduce inflammation and irritation in the marrow tissues and assist promoting new skeletal tissue formation to an application of a simple skeletal formation or regeneration activity such as a bone growth factor. The methods may involve application of pharmacologically active peptidic compounds comprising about 15 to about 28 amino acids in their sequences characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan attachment motif, and/or a calcium binding motif. The sequence may be a 23 amino acid sequence formulated for injection, topical application, or dispersed in a matrix such as collagen or a tooth filling composition or gum patch and administered to enhance bone/tooth growth or prevent loss.
摘要翻译： 公开了治疗特征在于保护与缺陷相邻的骨髓细胞凋亡和/或坏死细胞死亡的骨骼组织中的缺陷的方法。 所述方法提供额外的益处，其是减少骨髓组织中的炎症和刺激，并且有助于促进新的骨骼组织形成以应用简单的骨骼形成或再生活性，例如骨生长因子。 所述方法可以包括在其序列中应用包含约15至约28个氨基酸的药理学活性肽化合物，其特征在于含有整联蛋白结合基序如RGD序列，糖胺聚糖附着基序和/或钙结合基序 。 序列可以是配制用于注射，局部施用或分散在基质如胶原或牙齿填充组合物或牙龈贴片中的23个氨基酸序列，并且用于增强骨/牙齿生长或防止损失。
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