公开(公告)号：US20150299751A1

公开(公告)日：2015-10-22

申请号：US14405791

申请日：2013-06-07

Applicant: INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE ,  CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIOAMBIENTALES Y TECNOLOGICAS ,  UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO

Inventor： Gerard VILAREM ,  Luc RIGAL ,  Virginie VANDENBOSSCHE ,  Julien BRAULT ,  Martin HERNANDEZ LUNA ,  Oscar HERNANDEZ MELENDEZ ,  Eduardo VIVALDO LIMA ,  Eduardo BARZANA GARCIA ,  Mercedes BALLESTEROS ,  Aleta DUQUE ,  Paloma MANZANARES ,  Matti Samuel SIIKA-AHO ,  Jaana Maria UUSITALO ,  Julio MATA-SEGREDA ,  Stephane GUILLOUET ,  Eric LOMBARD ,  Xavier CAMELEYRE

IPC: C12P19/14 ,  C12P7/10 ,  C12P19/02

CPC classification number: C12P19/14 ,  C12P7/10 ,  C12P19/02 ,  C12P2201/00 ,  C12P2203/00 ,  C13K1/02 ,  Y02E50/16

Abstract: A method of treating a solid lignocellulosic material (10) in which the solid lignocellulosic material (10) is subjected to a treatment, called a mechano-chemical treatment (1), of mixing and chemical degradation of the solid lignocellulosic material (10) so as to form an intermediate composition having a hydrated lignocellulosic material whose enzymatic digestibility is increased relative to the digestibility of the solid lignocellulosic starting material (10), then; the hydrated lignocellulosic material is subjected to a treatment, called a mechano-chemical treatment (2), in which a dispersion is formed, called an aqueous dispersion, of the hydrated lignocellulosic material (10) in an aqueous composition, the aqueous dispersion including at least one enzyme for degrading the hydrated lignocellulosic material (10).

Abstract translation: 一种处理固体木质纤维素材料（10）的方法，其中将固体木质纤维素材料（10）进行称为机械化学处理（1）的处理，使固体木质纤维素材料（10）的混合和化学降解所以 为了形成具有水解的木质纤维素材料的中间组合物，其相对于固体木质纤维素原料（10）的消化率的酶消化率增加; 将水合木质纤维素材料进行处理，称为机械化学处理（2），其中在水性组合物中形成水合木质纤维素材料（10）的分散体（称为水分散体），水分散体包含在 用于降解水合木质纤维素材料（10）的至少一种酶。

公开(公告)号：US20240182853A1

公开(公告)日：2024-06-06

申请号：US18439208

申请日：2024-02-12

Applicant: UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO

Inventor： Maria Gloria SOLDEVILA MELGAREJO ,  Evelyn Katy ALVAREZ SALAZAR ,  Josefina ALBERU GOMEZ ,  Arimelek CORTES HERNANDEZ

IPC: C12N5/0783 ,  A61K35/17

CPC classification number: C12N5/0637 ,  A61K35/17 ,  C12N2501/2306 ,  C12N2501/25 ,  C12N2501/515 ,  C12N2502/1121

Abstract: A methodology to obtain in vitro large numbers of human induced regulatory T cells with specificity to the donor antigen, with a phenotype and stable suppressor function in the presence of pro-inflammatory cytokines, through of co-cultures of monocyte-derived dendritic cells and T cells “naïve”, both from genetically unrelated individuals (donor and recipient) is disclosed. The cells obtained with the present method are of CD4, CD25, CTLA-4 and FOXP3+ phenotype and show a specific suppressor function on donor antigen-specific T lymphocytes. These cells maintain their phenotype and stable suppressive function in presence of pro-inflammatory cytokines TNF-α and IL-6. The stability and the number obtained make them candidates as therapeutic tools for transplantation.

公开(公告)号：US20180282758A1

公开(公告)日：2018-10-04

申请号：US15949840

申请日：2018-04-10

Applicant: UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO ,  ARIZONA BOARD OF REGENTS ON BEHALF OF UNIVERSITY OF ARIZONA

Inventor： LILIANA PARDO-LOPEZ ,  BRUCE ELLIOT TABASHNIK ,  MARIO SOBERON-CHAVEZ ,  MARIA ALEJANDRA BRAVO DE LA PARRA

IPC: C12N15/82 ,  C07K14/325

Abstract: The present invention provides a method to obtain DNA constructs that encode 3-domain Cry toxins (also called Cry toxins, Bt toxins, or β-endotoxins) lacking helix α-1. These DNA constructs have been modified to encode proteins that kill insects that are resistant to the corresponding unmodified Cry toxins. The DNA constructs encoding the Modified 3-Domain Cry Toxins and the encoded Modified 3-Domain Cry Toxins are provided together with the molecular vectors and the host cell comprising said constructs and the recombinant methods to produce the Modified 3-Domain Cry Toxins. Additionally, compositions comprising the Modified 3-Domain Cry Toxins are disclosed. The resistance of the insects to unmodified Cry toxins is due to reduced toxin binding to the insects' midgut receptors. The invention further provides methods to overcome resistance in crop pests.

公开(公告)号：US20170172928A1

公开(公告)日：2017-06-22

申请号：US15129714

申请日：2015-03-25

Applicant: UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO

Inventor： David QUINTANAR GUERRERO ,  Laura Elizabeth HERNANDEZ RIZO

IPC: A61K9/28 ,  B05D5/00

CPC classification number: A61K9/284 ,  A61K9/2072 ,  A61K9/2826 ,  A61K9/2853 ,  A61K9/2866 ,  A61K2121/00 ,  B05D1/02 ,  B05D5/00 ,  B05D2258/02

Abstract: The present invention specifically refers to a pharmaceutical system for preparation of solid pharmaceutical forms for administering therapeutic substances improving their bioavailability; said system is particularly suitable for administering sensitive active principles by their proteinaceous nature or by being nucleic acids since polymeric excipients with good matrix and bioadhesion properties are used which together with the impermeability conferred by the applied coating make the prepared system a delivery form with excellent performance.

公开(公告)号：US20160376500A1

公开(公告)日：2016-12-29

申请号：US15188142

申请日：2016-06-21

Applicant: Instituto Potosino de Investigación Científica y Tecnológica A.C. ,  UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO

Inventor： Alejando Ricardo FEMAT FLORES ,  David RIOS JARA ,  Larissa ALEXANDROVA ,  César Augusto FERNÁNDEZ GIJÓN ,  Guillermo SANTANA RODRIGUEZ

IPC: C09K11/06 ,  C08F220/14 ,  C07D487/06

CPC classification number: C09K11/06 ,  C07D487/06 ,  C08F220/14 ,  C09K2211/1044 ,  C09K2211/1048 ,  C09K2211/1466 ,  Y02B20/181

Abstract: The instant invention is related with new perimidine derivatives synthesized via direct condensation between naphthalene-1,8-diamine and itaconic or citraconic anhydrides at low temperature. The targeting itaco-perinone (IP) molecule formed via double low temperature cyclization has fluorescence properties emitting white light intensively. Besides, 9-methylene-8H-pyrrolo[1,2-a]perimidin-10(9H)-one is copolymerizable with several kind of organic monomer compounds via free radical mechanism maintaining the ability to emit white light even within the polymer film.

Abstract translation: 本发明涉及通过萘-1,8-二胺和衣康酸或柠康酸酐在低温下直接缩合合成的新的二嘧啶衍生物。 通过双低温环化形成的靶向itaco-百草酮（IP）分子具有发射白光的荧光特性。 此外，9-亚甲基-8H-吡咯并[1,2-a]伴侣苷-10（9H） - 酮可通过自由基机理与几种有机单体化合物共聚，即使在聚合物膜内也能保持发出白光的能力。

公开(公告)号：US20150225351A1

公开(公告)日：2015-08-13

申请号：US14220596

申请日：2014-03-20

Applicant: UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO ,  CORROSION Y PROTECCION SA DE CV

Inventor： Jose Ignacio Regla CONTRERAS ,  Maria Patricia Shirley Demare NEGRETE ,  Jorge Antonio Ascencio GUTIERREZ ,  Lorenzo Martinez GOMEZ ,  Lorenzo Martinez Martinez DE LA ESCALERA ,  Jorge Joaquin Canto IBANEZ ,  Irene Carrillo SALGADO

IPC: C07D233/06 ,  C23F11/14 ,  C05F5/00 ,  C07D233/14

CPC classification number: C07D233/06 ,  C05F5/006 ,  C07D233/14 ,  C23F11/149 ,  Y02A40/211 ,  Y02E50/343 ,  Y02W30/47

Abstract: The biphasic extraction from coffee waste without a prior drying process, to obtain coffee oil, which is transesterified with KOH catalyzed methanol to produce mixtures of glycerol free methylic esters, also known as coffee oil biodiesel, which is subjected to an aminolysis reaction with aminoethylethanolamine (AEEA) by heating to 140-160° C. at atmospheric pressure with a subsequent dehydration reaction at the same temperature but at a reduced pressure of 200 to 300 mmHg, in order to achieve cyclization of the intermediary amides into the corresponding imidazolines. Alternatively process, coffee oil can be submitted to the same aminolysis procedure with aminoethylethanolamine (AEEA) at 140 to 160° C. and atmospheric pressure with a subsequent dehydration reaction at the same temperature but at a reduced pressure of 200 to 300 mmHg, to produce imidazolines that contain the residual glycerol of the original triglycerides.

Abstract translation: 在没有先前干燥过程的情况下从咖啡废物中双相提取，以获得咖啡油，其用KOH催化的甲醇酯交换，以产生甘油游离甲基酯（也称为咖啡油生物柴油）的混合物，其与氨基乙基乙醇胺进行氨解反应 AEEA）通过在大气压下加热至140-160℃，随后在相同温度下，但在200至300mmHg的减压下进行脱水反应，以使中间体酰胺环化成相应的咪唑啉。 或者，咖啡油可以在140至160℃的氨基乙基乙醇胺（AEEA）和大气压下进行相同的氨解过程，随后在相同温度下，但在200至300mmHg的减压下进行脱水反应，以产生 含有原始甘油三酯的残留甘油的咪唑啉。

公开(公告)号：US08979698B2

公开(公告)日：2015-03-17

申请号：US13760744

申请日：2013-02-06

Applicant: Universidad Nacional Autonoma de Mexico

Inventor： Ricardo Chicurel Uziel ,  Luis Alberto Vazquez Perez ,  Gabriel Ascanio Gasca

IPC: F16H1/32 ,  F16F15/14 ,  H02K49/10

CPC classification number: F16F15/14 ,  F16F15/1478 ,  F16H1/32 ,  F16H2001/325 ,  F16H2001/328 ,  H02K49/102 ,  Y10T74/2121

Abstract: The present invention refers to a conventional spur gear transmission or magnetic gear transmission, with a cycloidal configuration. The magnetic gears include contact points such that the mobile gear rolls on the fixed gear. Alternatively, a balance wheel is incorporated, which generates a centrifugal force opposite to the one associated with the mobile gear, of equal magnitude and on the same plane as this latter one, thereby completely eliminating the unbalancing of the mechanism. The balance wheel is mounted on the high-speed shaft in a manner similar to the mobile gear, and has the freedom to displace itself radially through centrifugal effect in the opposite direction to the eccentric position of the center of the mobile gear until it presses against a fixed track over which it rolls, concentric with the fixed gear with an equal force, opposite and collinear with that produced by the mobile gear.

Abstract translation: 本发明涉及具有摆线构造的常规正齿轮传动装置或磁齿轮传动装置。 磁齿轮包括接触点，使得移动齿轮在固定齿轮上滚动。 或者，结合了平衡轮，其产生与可移动齿轮相关的离心力相等的离心力，并且在与之相同的平面上产生离心力，从而完全消除了机构的不平衡。 平衡轮以类似于移动齿轮的方式安装在高速轴上，并且具有通过离心效应在与可移动齿轮的中心的偏心位置相反的方向上径向移动的自由，直到其抵抗 一个固定的轨道，它在其上滚动，与固定的齿轮同等的力，与由移动齿轮产生的相反和共线。

公开(公告)号：US20220127572A1

公开(公告)日：2022-04-28

申请号：US17510902

申请日：2021-10-26

Applicant: UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO

Inventor： Maria Gloria SOLDEVILA MELGAREJO ,  Saul ARTEAGA CRUZ ,  Evelyn Katy ALVAREZ SALAZAR ,  Arimelek CORTES HERNANDEZ ,  Josefina ALBERU GOMEZ

IPC: C12N5/0783 ,  A61K9/00 ,  A61K39/00 ,  A61P37/06 ,  C12N5/0784

Abstract: A methodology to obtain large numbers of allospecific human Tr1 lymphocytes in vitro differentiated with phenotype and suppressive function stability in presence of proinflammatory cytokines, by using donor tolerogenic dendritic cells (DC10) derived from donor monocytes and from a not related receptor (allogeneic) naîve T cells cocultures. The obtained cells with the present methodology are characterized by the expression of a Tr1 regulatory phenotype (CD4+, CD49b+, LAG-3+), being high IL-10 producers, and also they express additional co-inhibitory molecules as PD1, TIM-3, CD39, CTLA-4 y TIGIT. Moreover, the cellular product obtained by this methodology is able to maintain a stable phenotype and suppressive function in presence of proinflammatory cytokines (IL-1β, IL-6, IFN-γ y TNF-α). The numbers, purity, and stability of the Tr1 obtained by this methodology, make them great candidates for their use as therapeutic tools in transplantation.

公开(公告)号：US20160367580A1

公开(公告)日：2016-12-22

申请号：US14890827

申请日：2015-02-18

Applicant: UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO

Inventor： Hector Salvador SUMANO LOPEZ ,  Lilia GUTIERREZ OLVERA

IPC: A61K31/706 ,  A61K47/10

Abstract: The invention relates to an improved long-acting or extended-release tilmicosin formulation comprising: tilmicosin phosphate in a concentration between 35 and 50% by weight of the total composition; a first co-solvent in a concentration between 8 and 20% by volume, said first co-solvent being propylene glycol; a second co-solvent in a concentration between 5 and 15% by volume, said second co-solvent being ethyl alcohol; and an emulsifier in a concentration between 1.5 and 15% by weight of the total composition, said emulsifier being poloxamer. The invention also relates to the method for producing said improved long-acting tilmicosin formulation.

Abstract translation: 本发明涉及一种改进的长效或延长释放的替米考星制剂，其包含：总组合物重量的35-50％浓度的替米考星磷酸盐; 浓度为8至20体积％的第一共溶剂，所述第一助溶剂为丙二醇; 浓度为5至15体积％的第二共溶剂，所述第二助溶剂为乙醇; 和浓度为总组合物重量的1.5至15％的乳化剂，所述乳化剂是泊洛沙姆。 本发明还涉及生产所述改进的长效替米考星制剂的方法。

公开(公告)号：US20160008792A1

公开(公告)日：2016-01-14

申请号：US14742000

申请日：2015-06-17

Applicant: INSTITUTO MEXICANO DEL PETROLEO ,  UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO

Inventor： Maria Antonia CORTES JACOME ,  Jose Antonio TOLEDO ANTONIO ,  Jose ESCOBAR AGUILAR ,  Esteban LOPEZ SALINAS ,  Carlos ANGELES CHAVEZ ,  Enelio TORRES GARCIA ,  Jose Gonzalo HERNANDEZ CORTEZ ,  Maria de Lourdes Araceli MOSQUEIRA MONDRAGON ,  Miguel PEREZ LUNA ,  Gerardo FERRAT TORRES ,  Jorge Fernando RAMIREZ SOLIS ,  Aida GUTIERREZ ALEJANDRE

IPC: B01J23/85 ,  C10L1/08 ,  B01J31/22 ,  B01J35/02 ,  B01J37/08 ,  B01J37/02 ,  B01J37/20 ,  C10G45/08 ,  B01J37/00

CPC classification number: B01J23/85 ,  B01J23/883 ,  B01J27/19 ,  B01J31/22 ,  B01J35/026 ,  B01J35/1019 ,  B01J35/1042 ,  B01J35/1047 ,  B01J35/1061 ,  B01J37/0009 ,  B01J37/0207 ,  B01J37/0209 ,  B01J37/0213 ,  B01J37/024 ,  B01J37/08 ,  B01J37/20 ,  B01J2531/60 ,  C10G45/06 ,  C10G45/08 ,  C10G2300/1044 ,  C10G2300/1048 ,  C10G2300/70 ,  C10G2400/04 ,  C10L1/08 ,  C10L2200/0438 ,  C10L2200/0446 ,  C10L2270/026

Abstract: The present invention relates to a catalytic formulation used in the hydroprocessing of light and middle oil fractions, preferably in hydrodesulfurization and hydrodenitrogenation reactions to obtain diesel with ultra low sulfur content less than or equal to 15 ppm in weight. The catalytic formulation, object of the present invention, consists of at least one metal of Group VI B and at least one metal of Group VIII B and one element of Group V A of the periodic table deposited on a support based on surface modified alumina with an inorganic oxide of a metal of Group II A, IV A and/or IV B. And containing an impregnated organic compound containing at least one hydroxyl group and at least one carboxyl group and that can contain or not at least one sulfide group in its structure. The catalytic formulation, object of the present invention, allows processing of the oil fractions with initial and final boiling temperatures between 150 and 450° C., with initial nitrogen and sulfur content between 1 and 3% by weight and 200 to 600 ppm, respectively, reducing sulfur content to concentrations lower or equal to 15 ppm and nitrogen concentrations to lower than 1 ppm.

Abstract translation: 本发明涉及用于轻质和中间油馏分加氢处理的催化剂，优选在加氢脱硫和加氢脱氮反应中，以获得重量小于或等于15ppm的超低硫含量的柴油。 本发明目的的催化剂配方由至少一种第ⅥB族金属和至少一种第ⅧB族金属和元素周期表第VA族元素的一种元素组成，所述元素沉积在基于表面改性氧化铝的载体上， IIA，IVA和/或IVB族金属的无机氧化物。并且含有含有至少一个羟基和至少一个羧基的浸渍有机化合物，并且其结构中可含有至少一个硫化物基团 。 本发明目的的催化剂配方允许在初始和最终沸腾温度为150-450℃之间加工油馏分，其初始氮和硫含量分别为1至3重量％和200至600ppm ，将硫含量降低至等于或低于15ppm，氮浓度低于1ppm。