公开(公告)号：US20160367580A1

公开(公告)日：2016-12-22

申请号：US14890827

申请日：2015-02-18

Applicant: UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO

Inventor： Hector Salvador SUMANO LOPEZ ,  Lilia GUTIERREZ OLVERA

IPC: A61K31/706 ,  A61K47/10

Abstract: The invention relates to an improved long-acting or extended-release tilmicosin formulation comprising: tilmicosin phosphate in a concentration between 35 and 50% by weight of the total composition; a first co-solvent in a concentration between 8 and 20% by volume, said first co-solvent being propylene glycol; a second co-solvent in a concentration between 5 and 15% by volume, said second co-solvent being ethyl alcohol; and an emulsifier in a concentration between 1.5 and 15% by weight of the total composition, said emulsifier being poloxamer. The invention also relates to the method for producing said improved long-acting tilmicosin formulation.

Abstract translation: 本发明涉及一种改进的长效或延长释放的替米考星制剂，其包含：总组合物重量的35-50％浓度的替米考星磷酸盐; 浓度为8至20体积％的第一共溶剂，所述第一助溶剂为丙二醇; 浓度为5至15体积％的第二共溶剂，所述第二助溶剂为乙醇; 和浓度为总组合物重量的1.5至15％的乳化剂，所述乳化剂是泊洛沙姆。 本发明还涉及生产所述改进的长效替米考星制剂的方法。