公开(公告)号：US5733890A

公开(公告)日：1998-03-31

申请号：US727292

申请日：1996-10-09

Applicant: Jih Ru Hwu ,  Gholam H. Hakimelahi ,  Shwu-Chen Tsay ,  Ali A. Moosavi-Movahedi ,  Majid M. Sadeghi

Inventor： Jih Ru Hwu ,  Gholam H. Hakimelahi ,  Shwu-Chen Tsay ,  Ali A. Moosavi-Movahedi ,  Majid M. Sadeghi

IPC: C07H19/16 ,  A61K31/70 ,  C07H19/19 ,  C07H19/20

CPC classification number: C07H19/16

Abstract: Novel adenylate analogs having the following formula are synthesized in the present invention, which are found active against herpes simplex viruses: ##STR1## wherein R.sup.1 is hydroxyl, C.sub.1 -C.sub.4 alkoxy, an amino ester radical of --NHR.sup.3 COOR.sup.4, wherein R.sup.3 is a bivalent C.sub.1 -C.sub.4 saturated hydrocarbon and R.sup.4 is C.sub.1 -C.sub.4 alkyl; and R.sup.2 is hydroxyl, --O.sup.+ NH.sub.4 or ##STR2##

Abstract translation: 在本发明中合成具有下列结构式的新型腺苷酸类似物，其被发现针对单纯疱疹病毒具有活性：-NHR3COOR4的氨基酯基，其中R3是二价C1-C4饱和烃，R4是C1-C4烷基; 并且R 2是羟基，-O + NH 4或

公开(公告)号：US20090098098A1

公开(公告)日：2009-04-16

申请号：US12240755

申请日：2008-09-29

Applicant: Jih-Ru Hwu ,  Shwu-Chen Tsay

Inventor： Jih-Ru Hwu ,  Shwu-Chen Tsay

IPC: A01N59/20 ,  A01N59/16 ,  A01N55/02 ,  A01N43/14 ,  A01P1/00 ,  A01P3/00

CPC classification number: A61L2/22 ,  A61K31/28 ,  A61K33/24 ,  A61K45/06 ,  A61L2/186 ,  A61K2300/00

Abstract: The present invention relates to an anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having a catalytic function; (B) a mixture of a coenzyme having reducing ability and quinones, and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard. Additionally, the present composition can be applied to human being such as applying to hand, foot, genital organs, oral cavity, and the like in a lower dose to attain the effect of destroying of bacteria, viruses, and fungi.

Abstract translation: 本发明涉及抗菌，抗病毒和抗真菌组合物，其制备和应用。 本发明的组合物主要包括足够比例的以下三种成分：（A）具有催化功能的金属化合物; （B）具有还原能力的辅酶和醌类的混合物，和（C）添加剂。 本发明的抗细菌，抗病毒和抗真菌组合物能够破坏病毒以及杀死细菌和真菌。 因此，该组合物可以配制成用于应用于诸如呼吸器，面罩，手套，过滤器，避孕套等保护装置的气雾剂和膜。本发明组合物还可以用于家庭，车辆，医院，学校，餐厅， 酒店，互联网咖啡店，适用于空调，水龙头，凳子，电梯内部及其键盘。 此外，本发明的组合物可以以较低剂量施用于人，例如施用于手，脚，生殖器，口腔等，以达到破坏细菌，病毒和真菌的效果。

公开(公告)号：US20080234158A1

公开(公告)日：2008-09-25

申请号：US11726703

申请日：2007-03-22

Applicant: Jih Ru Hwu ,  Shwu-Chen Tsay

Inventor： Jih Ru Hwu ,  Shwu-Chen Tsay

IPC: A62D3/30 ,  A62D101/04

CPC classification number: A62D3/38 ,  A61L9/01 ,  A62D2101/04 ,  Y10S71/903

Abstract: This invention relates to compositions that counteract chemicals such as pesticides and malodorants. Also disclosed are a method for preparing such compositions and a method for applying such compositions to counteract pesticides or malordorants.

Abstract translation: 本发明涉及抵抗诸如杀虫剂和恶臭剂的化学物质的组合物。 还公开了制备这种组合物的方法以及用于施用这样的组合物以抵抗农药或恶臭剂的方法。

公开(公告)号：US07387799B2

公开(公告)日：2008-06-17

申请号：US10628259

申请日：2003-07-29

Applicant: Jih-Ru Hwu ,  Shwu-Chen Tsay

Inventor： Jih-Ru Hwu ,  Shwu-Chen Tsay

IPC: A01N59/00 ,  A01N59/08 ,  A01N59/16 ,  A01N55/02 ,  A61K33/26 ,  A61K33/30 ,  A61K33/00 ,  A61K31/295 ,  A61K31/315 ,  A61K33/24

CPC classification number: A61L2/22 ,  A61K31/28 ,  A61K33/24 ,  A61K45/06 ,  A61L2/186 ,  A61K2300/00

Abstract: The present invention relates to an anti-bacterial, anti-viral, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having catalytic function; (B) ionic compound, and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard. Additionally, the present composition can be applied to human being such as applying to hand, foot, genital organs, oral cavity, and the like in a lower dose to attain the effect of destroying bacteria, viruses, and fungi.

Abstract translation: 本发明涉及抗细菌，抗病毒和抗真菌组合物，其制备和应用。 本发明的组合物主要包括以下三种成分：（A）具有催化功能的金属化合物; （B）离子化合物，（C）添加剂。 本发明的抗细菌，抗病毒和抗真菌组合物能够破坏病毒以及杀死细菌和真菌。 因此，该组合物可以配制成用于应用于诸如呼吸器，面罩，手套，过滤器，避孕套等保护装置的气雾剂和膜。本发明组合物还可以用于家庭，车辆，医院，学校，餐厅， 酒店，互联网咖啡店，适用于空调，水龙头，凳子，电梯内部及其键盘。 此外，本发明的组合物可以以较低剂量施用于人体，例如施用于手，脚，生殖器，口腔等，以达到破坏细菌，病毒和真菌的效果。

公开(公告)号：US07282606B2

公开(公告)日：2007-10-16

申请号：US11179568

申请日：2005-07-13

Applicant: Ru Hwu Jih ,  Shwu Chen Tsay ,  Balaachary Magendran ,  Subhasish K. Chakraborty ,  Asish R. Das ,  Kuen Wang Sheu ,  Chun Mei Shu ,  Chin Kun Lu ,  Wei Min Chang

Inventor： Ru Hwu Jih ,  Shwu Chen Tsay ,  Balaachary Magendran ,  Subhasish K. Chakraborty ,  Asish R. Das ,  Kuen Wang Sheu ,  Chun Mei Shu ,  Chin Kun Lu ,  Wei Min Chang

IPC: C07C307/10

CPC classification number: C07C303/40 ,  C07C303/08 ,  C07C303/38 ,  C07C309/51 ,  C07C311/37

Abstract: The present invention discloses a new process for the synthesis of tamsulosin and its aralkylamine derivatives, especially (R)-(−)-5-{2-[2-(2-alkoxyphenoxy) ethylamino]propyl}-2-alkoxybenzenesulfonamides having the following formula 1 (where R1 and R2 represent C1-C4 alkyl groups) and their hydrochloride thereof, and other various pharmaceutical used salts. Tamsulosin hydrochloride (R1=Et, R2=Me, in its hydrochloride salt form) is an antagonist of α-A adrenoceptors in the prostate. Tamsulosin•HCl occurs as white crystals, which melt with decomposition at approximately 230° C. It is sparingly soluble in water and in methanol, slightly soluble in glacial acetic acid and in ethanol, and practically insoluble in ether.

Abstract translation: 本发明公开了一种合成坦索罗辛及其芳烷基胺衍生物，特别是（R） - （ - ） - 5- {2- [2-（2-烷氧基苯氧基）乙基氨基]丙基} -2-烷氧基苯磺酰胺的新方法， 式1（其中R 1和R 2代表C 1 -C 4烷基）及其盐酸盐 ，和其他各种药物用盐。 盐酸坦索罗辛（R 1 = Et，R 2 = Me，其盐酸盐形式）是前列腺中α-A肾上腺素受体的拮抗剂。 淡黄色素HCl以白色晶体的形式发生，其在约230℃下分解熔融。它微溶于水和甲醇，微溶于冰醋酸和乙醇，几乎不溶于乙醚。

公开(公告)号：US20060246148A1

公开(公告)日：2006-11-02

申请号：US11344235

申请日：2006-02-01

Applicant: Jih-Ru Hwu ,  Shwu-Chen Tsay

Inventor： Jih-Ru Hwu ,  Shwu-Chen Tsay

IPC: A61K38/43 ,  A61K31/28 ,  A61K31/315 ,  A61K33/42 ,  A61K33/40 ,  A61K33/24 ,  A61K33/26 ,  A61K31/12

CPC classification number: A61K31/12 ,  A01N59/16 ,  A01N59/20 ,  A61K31/28 ,  A61K31/315 ,  A61K31/7084 ,  A61K33/00 ,  A61K33/24 ,  A61K33/40 ,  A61K45/06 ,  C11D3/38654 ,  C11D3/3947 ,  C11D3/48 ,  C11D7/10 ,  A01N57/16 ,  A01N59/00 ,  A01N59/02 ,  A01N59/04 ,  A01N59/06 ,  A01N59/08 ,  A01N59/26 ,  A01N61/00 ,  A01N2300/00

Abstract: The present invention relates to an anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having a catalytic function; (B) a mixture of a coenzyme having reducing ability and an agent having oxidizing ability; and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard. Additionally, the present composition can be applied to human being such as applying to hand, foot, genital organs, oral cavity, and the like in a lower dose to attain the effect of destroying of bacteria, viruses, and fungi.

Abstract translation: 本发明涉及抗菌，抗病毒和抗真菌组合物，其制备和应用。 本发明的组合物主要包括足够比例的以下三种成分：（A）具有催化功能的金属化合物; （B）具有还原能力的辅酶和具有氧化能力的试剂的混合物; 和（C）添加剂。 本发明的抗细菌，抗病毒和抗真菌组合物能够破坏病毒以及杀死细菌和真菌。 因此，该组合物可以配制成用于应用于诸如呼吸器，面罩，手套，过滤器，避孕套等保护装置的气雾剂和膜。本发明组合物还可以用于家庭，车辆，医院，学校，餐厅， 酒店，互联网咖啡店，适用于空调，水龙头，凳子，电梯内部及其键盘。 此外，本发明的组合物可以以较低剂量施用于人，例如施用于手，脚，生殖器，口腔等，以达到破坏细菌，病毒和真菌的效果。

公开(公告)号：US6121255A

公开(公告)日：2000-09-19

申请号：US72191

申请日：1998-05-04

Applicant: Jih Ru Hwu ,  Shwu-Chen Tsay ,  Gholam H. Hakimelahi ,  Chun Chieh Lin ,  Wen Nan Tseng ,  Ali A. Moshfegh ,  Abdolmajid Azaripour ,  Hasan Mottaghian

Inventor： Jih Ru Hwu ,  Shwu-Chen Tsay ,  Gholam H. Hakimelahi ,  Chun Chieh Lin ,  Wen Nan Tseng ,  Ali A. Moshfegh ,  Abdolmajid Azaripour ,  Hasan Mottaghian

IPC: C07D501/00 ,  C07D501/26 ,  C07D501/28 ,  A61K31/545 ,  C07C65/40 ,  C07C69/94

CPC classification number: C07D501/00

Abstract: A phloroglucide derivative having the following formula: ##STR1## wherein Q is halogen; X is CH.sub.2 or C.dbd.O; Y is cephalosporin having a formula of ##STR2## wherein Ph is phenyl, Ac is acetoxy, or pharmaceutically acceptable salts thereof, and an antibacterial pharmaceutical composition derived thereof.

Abstract translation: 具有下式的间苯二酚衍生物：其中Q是卤素; X是CH 2或C = O; Y是具有下式的头孢菌素，其中Ph是苯基，Ac是乙酰氧基，或其药学上可接受的盐，以及衍生自其的抗菌药物组合物。

公开(公告)号：US5760013A

公开(公告)日：1998-06-02

申请号：US700795

申请日：1996-08-21

Applicant: Jih Ru Hwu ,  Gholam H. Hakimelahi ,  Shwu-Chen Tsay

Inventor： Jih Ru Hwu ,  Gholam H. Hakimelahi ,  Shwu-Chen Tsay

IPC: C07H19/10 ,  C07H21/00 ,  A61K31/70

CPC classification number: C07H19/10 ,  C07H21/00 ,  Y10S514/885

Abstract: Novel thymidylate analogs having the following formula are synthesized in the present invention, which are found active against human immunodeficiency virus type 1 (HIV-1): ##STR1## wherein R.sup.1 is hydrogen, cyano (--CN), halogen or azido (--N.sub.3); R.sup.2 is hydroxyl or an amino ester radical having a formula of --NHR.sup.4 COOR.sup.5, wherein R.sup.4 is a bivalent C.sub.1 -C.sub.4 saturated hydrocarbon and R.sup.5 is C.sub.1 -C.sub.4 alkyl; Me is methyl; and R.sup.3 is hydroxyl or thymidinyl having a formula as follows: ##STR2##

Abstract translation: 具有下式的新型胸苷酸类似物在本发明中合成，其被发现对人类免疫缺陷病毒1型（HIV-1）具有活性：其中R 1是氢，氰基（-CN），卤素或叠氮基（-N 3 ）; R2是羟基或具有式-NHR4COOR5的氨基酯基，其中R4是二价C1-C4饱和烃，R5是C1-C4烷基; 我是甲基; 并且R3是具有如下公式的羟基或胸腺嘧啶：

公开(公告)号：US5527683A

公开(公告)日：1996-06-18

申请号：US407582

申请日：1995-03-20

Applicant: Jih R. Hwu ,  Shwu-Chen Tsay ,  Buh-Luen Chen ,  Himatkumar V. Patel ,  Wan-Lin Chen ,  Chun C. Lin ,  Ching-Tai Chou

Inventor： Jih R. Hwu ,  Shwu-Chen Tsay ,  Buh-Luen Chen ,  Himatkumar V. Patel ,  Wan-Lin Chen ,  Chun C. Lin ,  Ching-Tai Chou

IPC: C07H21/00 ,  C12N15/10 ,  C12Q1/68 ,  C07H19/04 ,  C12P19/34 ,  C12Q1/70

CPC classification number: C07H21/00 ,  C12N15/10 ,  C12Q1/68

Abstract: The present invention discloses a photo-induced DNA-cleaving agent composition comprises N-aryl-N-(alkyl or arylalkyl)hydroxylamine having the following formula: ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, phenyl, C.sub.1 -C.sub.6 alkoxy, phenoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, halogen or halo(C.sub.1 -C.sub.6 alkyl)wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, halogen or halo(C.sub.1 -C.sub.6 alkyl); R.sub.2 is hydrogen; R.sub.3 is hydrogen or phenyl; R.sub.4 is hydrogen, phenyl, hydroxylphenyl, methoxyphenyl, dimethoxyphenyl, dimethylaminophenyl or naphthyl. The present N-aryl-N-(alkyl or arylalkyl)hydroxylamine is stable in dark, but it can react with O.sub.2 to form HO. radicals under irradiation of UV light for a period of 2-3 hours. The HO. radicals then react with DNA to accomplish cleavage of DNA.

Abstract translation: 本发明公开了一种光致DNA切割剂组合物，其包含具有下式的N-芳基-N-（烷基或芳烷基）羟胺：其中R是C1-C6烷基，苯基，C1-C6 烷氧基，苯氧基，C1-C6烷氧基羰基，卤素或卤素（C1-C6烷基），其中R1是氢，C1-C6烷基，苯基，C1-C6烷氧基，C1-C6烷氧基羰基，卤素或卤素（C1-C6烷基） R2是氢; R3是氢或苯基; R4是氢，苯基，羟基苯基，甲氧基苯基，二甲氧基苯基，二甲基氨基苯基或萘基。 本发明N-芳基-N-（烷基或芳基烷基）羟胺在黑暗中稳定，但可与O 2反应形成HO。 紫外线照射下的自由基2-3小时。 HO。 然后自由基与DNA反应以完成DNA的切割。