公开(公告)号：USD295196S

公开(公告)日：1988-04-12

申请号：US734882

申请日：1985-05-16

申请人： Paul D. Davis

设计人： Paul D. Davis

公开(公告)号：US20140134651A1

公开(公告)日：2014-05-15

申请号：US14074521

申请日：2013-12-03

申请人： Paul D. Davis ,  Alexander R. Pokora

发明人： Paul D. Davis ,  Alexander R. Pokora

IPC分类号： G01N33/58 ,  C12Q1/28

CPC分类号： G01N33/581 ,  C12Q1/28 ,  G01N33/54353

摘要： Disclosed is an analytical composition of a peroxidase discrete polyethylene glycol (PEG) conjugate, which conjugate is capable of providing a detectable condition in the presence of peroxidase and hydrogen peroxide.

摘要翻译： 公开了过氧化物酶离散聚乙二醇（PEG）缀合物的分析组合物，该缀合物能够在过氧化物酶和过氧化氢存在下提供可检测的条件。

公开(公告)号：US07888536B2

公开(公告)日：2011-02-15

申请号：US11203950

申请日：2005-08-15

申请人： Paul D. Davis ,  Edward C. Crapps

发明人： Paul D. Davis ,  Edward C. Crapps

IPC分类号： C07C43/11

CPC分类号： C07C41/16 ,  C07C247/04 ,  C07C319/12 ,  C08G65/331 ,  C08L71/02 ,  Y02P20/55 ,  C07C323/12 ,  C07C43/164 ,  C07C43/1785 ,  C07C43/11

摘要： Aspects of the present invention are directed to novel methods for making discrete polyethylene compounds selectively and specifically to a predetermined number of ethylene oxide units. Methods which can be used to build up larger dPEG compounds (a) containing a wider range of utility to make useful homo- and heterofunctional and branched species, and (b) under reaction configurations and conditions that are milder, more efficient, more diverse in terms of incorporating useful functionality, more controllable, and more versatile then any conventional method reported in the art to date. In addition, the embodiments of the invention allow for processes that allow for significantly improving the ability to purify the intermediates or final product mixtures, making these methods useful for commerial manufacturing dPEGs. Protecting groups and functional groups can be designed to make purification at large scale a practical reality. The novel dPEG products form the compositional and material basis for making other novel compounds of valuable application in the fields of diagnostics and therapeutics, amongst others.

摘要翻译： 本发明的方面涉及选择性地且具体地制备离散聚乙烯化合物至预定数量的环氧乙烷单元的新方法。 可用于建立较大的dPEG化合物的方法（a），其具有更广泛的用途以实现有用的同功和异功能和支链物质，以及（b）在温和，更有效，更多样化的反应配置和条件下 迄今为止本领域所报道的任何常规方法，结合有用的功能，更可控和更通用的术语。 此外，本发明的实施方案允许允许显着提高纯化中间体或最终产物混合物的能力的方法，使得这些方法对于商业制造dPEG有用。 保护群体和功能团体可以设计成大规模净化实际的现实。 新型dPEG产品形成了其他新型化合物在诊断和治疗领域的有价值应用的组成和物质基础。

公开(公告)号：US06432662B1

公开(公告)日：2002-08-13

申请号：US09171334

申请日：1999-05-20

申请人： Paul D. Davis ,  Kelli D. Feather-Henigan ,  Kimberly Hines

发明人： Paul D. Davis ,  Kelli D. Feather-Henigan ,  Kimberly Hines

IPC分类号： C12Q128

CPC分类号： C12Q1/28

摘要： Chemiluminescent detection of molecules of synthetic or natural origin such as proteins and nucleic acids (DNA and RNA), as well as other biologic molecules, is increasingly replacing radioactive detection as the method of choice where sensitivity is critical. In such assays, luminescence is customarily achieved by the oxidation of a luminol or isoluminol substrate in the presence of an oxidizing agent such as hydrogen peroxide or hydrogen peroxide source, such as perborate, and a peroxidase catalyst such as horseradish peroxidase. To obtain useful levels of luminescence (e.g., detectable levels) by customary techniques, a luminescent enhancer is also present during oxidation. It has been found in the practice of the present invention that azine enhancers have contained an impurity which reduces the properties of the chemiluminescent assay working solutions. The present invention describes a working solution, a process of using the working solution, and kits containing solutions which can be mixed to form the working solutions comprising a solution which is useful for the chemiluminescent assay of peroxidase activity comprising: a) at least one chemiluminescent cyclic diacylhydrazide, b) at least one azine enhancer, and c) at least one oxidizine agent wherein said azine enhancer comprises less than 0.005 parts mole/mole total basis of azine compounds having a hydrogen atom bonded to a nitrogen atom of the azine ring. It has generally been found that this hydrogen containing azine is a poisoning agent for the performance of the azine enhancer.

摘要翻译： 化学发光检测合成或天然来源的分子，如蛋白质和核酸（DNA和RNA）以及其他生物分子，正在越来越多地将放射性检测替代为灵敏度至关重要的选择方法。 在这种测定中，通常在氧化剂如过氧化氢或过氧化氢源（例如过硼酸盐）和过氧化物酶催化剂如辣根过氧化物酶的存在下氧化鲁米诺或异鲁米酚底物来实现发光。 为了通过常规技术获得有用的发光水平（例如可检测水平），在氧化期间也存在发光增强剂。 在本发明的实践中已经发现，吖嗪增强剂含有降低化学发光测定工作溶液性质的杂质。 本发明描述了工作解决方案，使用工作溶液的方法以及包含可混合以形成包含可用于过氧化物酶活性的化学发光测定的溶液的工作溶液的试剂盒，所述方法包括：a）至少一种化学发光 环二酰基酰肼，b）至少一种吖嗪增效剂，和c）至少一种氧化剂，其中所述吖嗪增强剂包含具有与吖嗪环的氮原子键合的氢原子的吖嗪化合物的总计基于0.005摩尔/摩尔。 通常已经发现，该含氢吖嗪是用于实施吖嗪增强剂的中毒剂。

公开(公告)号：US4086504A

公开(公告)日：1978-04-25

申请号：US410938

申请日：1973-10-29

申请人： George D. Ezell ,  Marvin L. Murphy, Jr. ,  Paul D. Davis, Jr.

发明人： George D. Ezell ,  Marvin L. Murphy, Jr. ,  Paul D. Davis, Jr.

IPC分类号： G01V1/22

CPC分类号： G01V1/223

摘要： In operations such as seismic exploration seismic waves are generated at a shot point. The amplitudes of successive samples of seismic waves appearing at a plurality of detector stations variously spaced from said shot point in the wake of generation thereof are converted to digital codes. The codes from all the detectors are transmitted in sequence and on a real time basis by spread spectrum radio pulses to a master station.A plurality of data acquisition units each including a radio transponder and a seismic detector are located at each of a plurality of spaced seismic detector stations in a seismic prospect. A master radio station means is located in or adjacent to the prospect. Means in the acquisition units and in the master station means interrogates and sequentially polls the transponder units in real time to secure and store digital samples at the master station of analog signals from the detectors at a fixed sample interval the duration of which is selected in relation to the frequencies of the signals whereby samples portray the time amplitude variations of the signals.

摘要翻译： 在诸如地震勘探的操作中，在射击点产生地震波。 出现在与所述拍摄点不同的多个检测站的地震波的连续样本在其生成之后的振幅被转换成数字码。 来自所有检测器的代码通过扩频无线电脉冲按顺序和实时地发送到主站。