公开(公告)号：US20220095933A1

公开(公告)日：2022-03-31

申请号：US17507297

申请日：2021-10-21

Applicant: LightLab Imaging, Inc.

Inventor： Joseph M. Schmitt ,  Joel M. Friedman ,  Christopher Petroff ,  Amr Elbasiony

IPC: A61B5/02 ,  A61B5/00

Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

公开(公告)号：US20220095932A1

公开(公告)日：2022-03-31

申请号：US17507259

申请日：2021-10-21

Applicant: LightLab Imaging, Inc.

Inventor： Joseph M. Schmitt ,  Joel M. Friedman ,  Christopher Petroff ,  Amr Elbasiony

IPC: A61B5/02 ,  A61B5/00

Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

公开(公告)号：US11020078B2

公开(公告)日：2021-06-01

申请号：US16437587

申请日：2019-06-11

Applicant: LightLab Imaging, Inc.

Inventor： Lorina Dascal ,  Itai Winkler

IPC: G06K9/00 ,  A61B6/00 ,  G06T7/00 ,  A61B5/00 ,  A61B8/12 ,  G06T5/50

Abstract: The disclosure relates generally to the field of vascular system and peripheral vascular system data collection, imaging, image processing and feature detection relating thereto. In part, the disclosure more specifically relates to methods for detecting position and size of contrast cloud in an x-ray image including with respect to a sequence of x-ray images during intravascular imaging. Methods of detecting and extracting metallic wires from x-ray images are also described herein such as guidewires used in coronary procedures. Further, methods for of registering vascular trees for one or more images, such as in sequences of x-ray images, are disclosed. In part, the disclosure relates to processing, tracking and registering angiography images and elements in such images. The registration can be performed relative to images from an intravascular imaging modality such as, for example, optical coherence tomography (OCT) or intravascular ultrasound (IVUS).

公开(公告)号：US10687777B2

公开(公告)日：2020-06-23

申请号：US15911749

申请日：2018-03-05

Applicant: LightLab Imaging, Inc.

Inventor： Lorina Dascal ,  Itai Winkler ,  Stavit Cohen ,  Amit Cohen ,  Desmond C. Adler

IPC: A61B6/00 ,  G06T7/11 ,  A61B6/12 ,  A61B8/12 ,  A61B5/00 ,  G06T7/00 ,  A61B8/00 ,  A61B6/03 ,  A61B5/055 ,  A61B90/00 ,  A61M25/10

Abstract: In part, the invention relates to processing, tracking and registering angiography images and elements in such images relative to images from an intravascular imaging modality such as, for example, optical coherence tomography (OCT). Registration between such imaging modalities is facilitated by tracking of a marker of the intravascular imaging probe performed on the angiography images obtained during a pullback. Further, detecting and tracking vessel centerlines is used to perform a continuous registration between OCT and angiography images in one embodiment.

公开(公告)号：US10453196B2

公开(公告)日：2019-10-22

申请号：US16199109

申请日：2018-11-23

Applicant: LightLab Imaging, Inc.

Inventor： Sonal Ambwani

IPC: G06T7/00 ,  A61B5/00

Abstract: In part, the disclosure relates to methods of stent strut detection relative to a side branch region using intravascular data. In one embodiment, detecting stent struts relative to jailed side branches is performed using a scan line-based peak analysis. In one embodiment, false positive determinations relating to stent struts are analyzed using a model strut.

公开(公告)号：US10453190B2

公开(公告)日：2019-10-22

申请号：US15359237

申请日：2016-11-22

Applicant: LightLab Imaging, Inc.

Inventor： Christopher E. Griffin

IPC: G06K9/00 ,  G06T7/00 ,  A61B5/00 ,  A61B8/08 ,  A61B8/12 ,  G06T7/136 ,  G06T7/13 ,  A61B5/06

Abstract: In part, the disclosure relates to shadow detection and shadow validation relative to data sets obtained from an intravascular imaging data collection session. The methods can use locally adaptive thresholds and scan line level analysis relative to candidate shadow regions to determine a set of candidate shadows for validation or rejection. In one embodiment, the shadows are stent strut shadows, guidewire shadows, side branch shadows or other shadows.

公开(公告)号：US10109058B2

公开(公告)日：2018-10-23

申请号：US15157340

申请日：2016-05-17

Applicant: LightLab Imaging, Inc.

Inventor： Sonal Ambwani ,  Christopher E. Griffin ,  James G. Peterson ,  Satish Kaveti ,  Joel M. Friedman

IPC: G06T7/00 ,  A61B34/20 ,  G06T7/11 ,  G06T7/174 ,  G06K9/46

Abstract: The disclosure relates, in part, to computer-based visualization of stent position within a blood vessel. A stent can be visualized using intravascular data and subsequently displayed as stent struts or portions of a stent as a part of a one or more graphic user interface(s) (GUI). In one embodiment, the method includes steps to distinguish stented region(s) from background noise using an amalgamation of angular stent strut information for a given neighborhood of frames. The GUI can include views of a blood vessel generated using distance measurements and demarcating the actual stented region(s), which provides visualization of the stented region. The disclosure also relates to display of intravascular diagnostic information such as indicators. An indicator can be generated and displayed with images generated using an intravascular data collection system. The indicators can include one or more viewable graphical elements suitable for indicating diagnostic information such as stent information.

公开(公告)号：US20180225830A1

公开(公告)日：2018-08-09

申请号：US15948084

申请日：2018-04-09

Applicant: LightLab Imaging, Inc.

Inventor： Ajay Gopinath ,  Desmond Adler

IPC: G06T7/13 ,  A61B5/00 ,  A61B5/02 ,  G06T5/50 ,  G06T7/12 ,  G06T11/60 ,  G06T19/20

CPC classification number: G06T7/13 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B6/504 ,  A61B6/5217 ,  G06T5/50 ,  G06T7/12 ,  G06T11/60 ,  G06T19/20 ,  G06T2200/08 ,  G06T2207/10101 ,  G06T2207/20104 ,  G06T2207/20224 ,  G06T2207/30101 ,  G06T2210/41 ,  G06T2211/404 ,  G06T2219/2012

Abstract: In part, the disclosure relates to method for identifying regions of interest in a blood vessel. The method includes the steps of: providing OCT image data of the blood vessel; applying a plurality of different edge detection filters to the OCT image data to generate a filter response for each edge detection filter; identifying in each edge detection filter response any response maxima; combining the response maxima for each edge detection filter response while maintaining the spatial relationship of the response maxima, to thereby create edge filtered OCT data; and analyzing the edge filtered OCT data to identify a region of interest, the region of interest defined as a local cluster of response maxima. In one embodiment, one or more indicia are positioned in one or more panels to emphasize a reference vessel profile as part of a user interface.

公开(公告)号：US09983356B2

公开(公告)日：2018-05-29

申请号：US14853078

申请日：2015-09-14

Applicant: LightLab Imaging, Inc.

Inventor： Joseph M. Schmitt ,  Desmond Adler

IPC: G02B6/28 ,  G01B9/02 ,  G02B6/35

CPC classification number: G02B6/2861 ,  G01B9/02004 ,  G01B9/02091 ,  G02B6/2808 ,  G02B6/3502

Abstract: In one embodiment, the invention relates to an apparatus for increasing the repetition rate in a light source. The apparatus includes a first optical coupler comprising a first arm, a second arm and a third arm; a first mirror in optical communication with the second arm of the first optical coupler; and a first optical delay line having a first end in optical communication with the third arm of the first optical coupler and a second end in optical communication with a second mirror, wherein light entering the first arm of the first optical coupler leaves the first arm of the first optical coupler either delayed by an amount (τ) or substantially undelayed.

公开(公告)号：US20180085095A1

公开(公告)日：2018-03-29

申请号：US15830640

申请日：2017-12-04

Applicant: LightLab Imaging, Inc.

Inventor： Christopher Hutchins ,  Alexander Ship

IPC: A61B8/08 ,  A61B8/00 ,  A61B8/12 ,  A61B5/00

CPC classification number: A61B8/5261 ,  A61B5/0066 ,  A61B5/0084 ,  A61B8/12 ,  A61B8/4416

Abstract: A method for bringing an IVUS and an OCT image into register. In one embodiment, the method includes obtaining an IVUS image of an area of a lumen; obtaining an OCT image of the same area of the lumen; determining the same asymmetry in each of the IVUS and OCT images; and overlaying the IVUS and OCT images and rotating them with respect to one another until the asymmetry in each of the IVUS and OCT images are in register, and determining the angle of rotation that resulted in the registration. In another aspect, the invention relates to a probe for OCT and IVUS imaging. In one embodiment, the probe includes a sheath having a first end and a second end defining a lumen; a marker that is opaque to light and ultrasound located between the first end and second end; and an IVUS/OCT probe head positioned within the sheath.