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19 条记录 (耗时 0.029 秒)

    System and software of enhanced pharmaceutical operations in long-term care facilities and related methods
    11.
    发明申请
    System and software of enhanced pharmaceutical operations in long-term care facilities and related methods 有权
    长期护理设施加强制药业务的制度和软件及相关方法

    公开(公告)号：US20070250210A1

    公开(公告)日：2007-10-25

    申请号：US11818416

    申请日：2007-06-14

    申请人： James Moncrief ,  James Martin

    发明人： James Moncrief ,  James Martin

    IPC分类号： G06F17/00

    CPC分类号： G06F19/3462 ,  B65B1/30 ,  G06F19/00 ,  G06F19/328 ,  G06F19/3418 ,  G06F19/3456 ,  G06Q10/08 ,  G06Q40/08 ,  G06Q50/22 ,  G06Q50/24 ,  G16H10/60 ,  G16H40/20

    摘要： A system, software and related methods of enhanced pharmaceutical operations in long term care facilities are provided. An embodiment of a system includes a long-term care facility pharmacy group management server, long-term care facility pharmacy management software associated with the long-term care facility pharmacy group management server to manage pharmacological operations in a plurality of long-term care facilities, a plurality of pharmaceutical storage and electronic dispensing carts each positioned in a long-term care facility remote from the long-term care facility pharmacy group management server and in communication therewith, a remote pharmacy group server in communication with the long-term care facility pharmacy group management server, and a plurality of pharmaceutical prescription document processors each positioned in a long-term care facility and in communication with the remote pharmacy group server or the long-term care facility pharmacy group management server.

    摘要翻译： 提供了长期护理设施中增强药物操作的系统，软件和相关方法。 系统的实施例包括长期护理设施药房组管理服务器，与长期护理设施药房组管理服务器相关联的长期护理设施药房管理软件，用于管理多个长期护理设施中的药理作用 ，多个药物储存和电子分配车，每个药物储存和电子分配车每个定位在远离护理设施药房组管理服务器的远程护理设施中，并与之通信，与长期护理设施通信的远程药房组服务器 药剂组管理服务器和多个处方文件处理器，每个处理文件处理器分别位于长期护理设施中并与远程药房组服务器或长期护理设施药房组管理服务器通信。

    Carbohydrate conjugates to prevent abuse of controlled substances
    12.
    发明申请
    Carbohydrate conjugates to prevent abuse of controlled substances 有权
    碳水化合物缀合物，以防止受控物质的滥用

    公开(公告)号：US20070197451A1

    公开(公告)日：2007-08-23

    申请号：US11179801

    申请日：2005-07-13

    申请人： Travis Mickle ,  Thomas Piccariello ,  James Moncrief ,  Nancy Boerth ,  Barney Bishop

    发明人： Travis Mickle ,  Thomas Piccariello ,  James Moncrief ,  Nancy Boerth ,  Barney Bishop

    IPC分类号： A61K31/485 ,  A61K9/22

    CPC分类号： A61K9/0019 ,  A61K31/706 ,  A61K47/549

    摘要： The invention provides a “street-safe” version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or eliminating the euphoric effects that lead to substance abuse. The invention provides pharmaceutical compositions comprising a controlled substance and a carbohydrate covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive or substantially diminishes its activity and methods of using the same.

    摘要翻译： 本发明提供了一种“街道安全”的受控物质版本，其允许物质的治疗有益效果，同时减少或消除导致药物滥用的欣快效应。 本发明提供药物组合物，其包含受控物质和与所述受控物质共价结合的碳水化合物，使得所述受控物质在药理学上无活性或显着降低其活性及其使用方法。

    Abuse-resistant hydrocodone compounds
    14.
    发明申请
    Abuse-resistant hydrocodone compounds 有权
    滥用抗氢可可酮化合物

    公开(公告)号：US20050266070A1

    公开(公告)日：2005-12-01

    申请号：US10953110

    申请日：2004-09-30

    申请人： Travis Mickle ,  Suma Krishnan ,  James Moncrief ,  Christopher Lauderback ,  Christal Miller

    发明人： Travis Mickle ,  Suma Krishnan ,  James Moncrief ,  Christopher Lauderback ,  Christal Miller

    IPC分类号： A61K9/48 ,  A61K38/08 ,  A61K47/48

    CPC分类号： A61K38/08 ,  A61K47/64

    摘要： The present invention decreases the potential for abuse of opioids, particularly hydrocodone, by covalent modification. The invention provides methods of delivering hydrocodone as conjugates that release the hydrocodone following oral administration while being resistant to abuse by circuitous routes such as intravenous (“shooting”) injection and intranasal administration (“snorting”). Further, hydrocodone compositions of the invention are resistant to oral abuse as well, since release of the hydrocodone at suprapharmacological doses reaches saturation.

    摘要翻译： 本发明通过共价修饰降低了阿片样物质，特别是氢可酮的滥用的可能性。 本发明提供了递送氢可酮作为缀合物的方法，其在口服给药之后释放氢可酮，同时抵抗诸如静脉内（“射击”）注射和鼻内给药（“嗅觉”）等迂回途径的滥用。 此外，本发明的氢可酮组合物也耐口服滥用，因为以超药物剂量的氢可酮的释放达到饱和。

    Abuse-resistant amphetamine compounds
    18.
    发明申请
    Abuse-resistant amphetamine compounds 有权
    滥用安非他明类化合物

    公开(公告)号：US20050054561A1

    公开(公告)日：2005-03-10

    申请号：US10858526

    申请日：2004-06-01

    申请人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    发明人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    IPC分类号： A61K31/165 ,  A61K31/7008 ,  A61K38/16 ,  A61K47/48 ,  A61K48/00

    CPC分类号： A61K31/165 ,  A61K47/542

    摘要： The invention describes compounds, compositions and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

    摘要翻译： 本发明描述了使用其的化合物，组合物和方法，其包含与苯丙胺共价连接的化学部分。 这些化合物和组合物可用于减少或预防滥用和过量安非他明。 这些化合物和组合物特别用于提供某些障碍（例如注意力缺陷多动障碍（ADHD），ADD，发作性睡病和肥胖）的耐药性替代治疗。 苯丙胺的口服生物利用度维持在治疗有用的剂量。 在较高剂量下，生物利用度显着降低，从而提供减少口服滥用责任的方法。 此外，本发明的化合物和组合物通过肠胃外途径（例如静脉内或鼻内给药）降低苯丙胺的生物利用度，进一步限制其滥用责任。

    Abuse resistant lysine amphetamine compounds
    19.
    发明申请
    Abuse resistant lysine amphetamine compounds 有权
    滥用抗性赖氨酸苯丙胺化合物

    公开(公告)号：US20050038121A1

    公开(公告)日：2005-02-17

    申请号：US10857619

    申请日：2004-06-01

    申请人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    发明人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    IPC分类号： A61K31/165 ,  A61K31/198 ,  A61K38/00 ,  A61K47/48

    CPC分类号： A61K31/165 ,  A61K47/542 ,  C07C237/06 ,  Y02A50/415 ,  Y10S436/901 ,  Y10T436/173845

    摘要： The present invention describes compounds, compositions and methods of using the same comprising lysine covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

    摘要翻译： 本发明描述了使用其包含与苯丙胺共价连接的赖氨酸的化合物，组合物和方法。 这些化合物和组合物可用于减少或预防滥用和过量安非他明。 这些化合物和组合物特别用于提供某些障碍（例如注意力缺陷多动障碍（ADHD），ADD，发作性睡病和肥胖）的耐药性替代治疗。 苯丙胺的口服生物利用度维持在治疗有用的剂量。 在较高剂量下，生物利用度显着降低，从而提供减少口服滥用责任的方法。 此外，本发明的化合物和组合物通过肠胃外途径（例如静脉内或鼻内给药）降低苯丙胺的生物利用度，进一步限制其滥用责任。