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公开(公告)号：US20130115869A1
公开(公告)日：2013-05-09
申请号：US13289435
申请日：2011-11-04
CPC分类号： H05K7/20736
摘要： A user-customizable air guide comprises a duct having four side panels, an open front end, an open back end, and a flange extending from at least two of the side panels at the front end. The four side panels have a plurality of frangible links that are generally parallel and spaced apart along the rectangular duct between the front end and the back end, wherein each frangible link extends around the four side panels of the rectangular duct. The frangible links are manually breakable to customize the length of the duct extending from the open front end.
摘要翻译： 用户可定制的空气引导件包括具有四个侧板，敞开的前端，敞开的后端以及从前端的至少两个侧板延伸的凸缘的管道。 四个侧板具有多个易碎连杆，它们在前端和后端之间沿着矩形管道大致平行且间隔开，其中每个易碎连杆围绕矩形管道的四个侧板延伸。 易碎的链接是手动破坏的，以便定制从开放的前端延伸的管道的长度。
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公开(公告)号：US20130042778A1
公开(公告)日：2013-02-21
申请号：US13213128
申请日：2011-08-19
CPC分类号： B41J11/0095 , B41J11/008
摘要： A method of printing on a sheet of paper comprises drawing a first sheet of paper from a first paper source into a printer having an optical scanner and a print head, scanning a first face of the first sheet to determine the presence or absence of print thereon. In response to detecting print on the first face, the print head is caused to print an obstruction on the first face. In response to detecting no print on the first face, the print head is caused to print new matter on the first face. The method enables a printer to accept used paper while eliminating confusion over which face contains the new matter.
摘要翻译： 一种在一张纸上打印的方法包括将第一张纸从第一纸张来源拉入具有光学扫描仪和打印头的打印机中，扫描第一张纸的第一面以确定其上是否有印刷 。 响应于检测到第一面上的打印，使得打印头在第一面上印刷障碍物。 响应于在第一面上没有检测到打印，使打印头在第一面上印刷新物质。 该方法使得打印机能够接受使用过的纸张，同时消除对包含新物质的面部的混淆。
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公开(公告)号：US20110254367A1
公开(公告)日：2011-10-20
申请号：US12762568
申请日：2010-04-19
CPC分类号： G06F1/263 , G06F1/30 , Y10T307/25 , Y10T307/615 , Y10T307/696 , Y10T307/832
摘要： Redundant power delivery including a power cable comprising a first plug including contacts for hot, neutral, and ground and a plurality of power lines, each power line electrically connected independently to the hot, neutral, and ground contacts of the first plug at a first end and each power line having a second plug at a second end providing contacts for hot, neutral, and ground; a selectable redundant power module, the selectable redundant power module comprising a plurality of input connectors, each input connector comprising a hot, neutral, and ground contacts and adapted to engage each second plug of each power line; and a switch to select one or more of the input connectors of the selectable redundant power module for receiving power.
摘要翻译： 冗余电力输送，包括电力电缆，其包括包括用于热，中性和接地的触点的第一插头和多个电力线，每个电力线在第一端独立于第一插头的热，中性和接地触点电连接 并且每个电源线具有在第二端处的第二插头，其提供用于热，中立和接地的触点; 可选择的冗余电源模块，所述可选择的冗余电源模块包括多个输入连接器，每个输入连接器包括热，中性线和接地触头，并且适于接合每个电力线的每个第二插头; 以及用于选择用于接收功率的可选择冗余电力模块的一个或多个输入连接器的开关。
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14.发明申请公开(公告)号：US20100143976A1
公开(公告)日：2010-06-10
申请号：US12614976
申请日：2009-11-09
摘要： A method of increasing production of a methylmalonyl-CoA derivative in a bacterium is disclosed that includes providing a bacterium that produces a methylmalonyl-CoA derivative in which methylmalonyl-CoA mutase function has been inhibited and culturing the bacterium in a medium containing an effective amount of methylmalonyl-CoA or a precursor thereof to increase the production of the methylmalonyl-CoA derivative by the bacterium. The production of the methylmalonyl-CoA derivative is increased when compared to production of the methylmalonyl-CoA derivative by the bacterium when cultured in a medium without the effective amount of methylmalonyl-CoA or a precursor thereof.
摘要翻译： 公开了增加细菌中甲基丙二酰辅酶A衍生物生产的方法，其包括提供产生甲基丙二酰基-CoA变位酶功能被抑制的甲基丙二酰辅酶A衍生物的细菌，并在含有有效量的 甲基丙二酰辅酶A或其前体，以增加细菌产生的甲基丙二酰辅酶A衍生物。 与在没有有效量的甲基丙二酰辅酶A或其前体的培养基中培养时，细菌相比，甲基丙二酰-CoA衍生物的生产增加。
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公开(公告)号：US5976836A
公开(公告)日：1999-11-02
申请号：US852401
申请日：1997-05-07
申请人： J. Mark Weber , Paul E. Hessler , Peter E. Larsen , Minh B. Luu
发明人： J. Mark Weber , Paul E. Hessler , Peter E. Larsen , Minh B. Luu
CPC分类号： C12P19/62 , C07K14/395
摘要： The present invention provides isolated and purified polypeptides that increase antibiotic production, polynucleotides that encode those polypeptides, expression vectors containing those polynucleotides, host cells transformed with those expression vectors, a process of making the polypeptides using those polynucleotides and vectors, and processes using those polypeptides and polynucleotides.
摘要翻译： 本发明提供增加抗生素产生的分离和纯化的多肽，编码那些多肽的多核苷酸，含有这些多核苷酸的表达载体，用那些表达载体转化的宿主细胞，使用这些多核苷酸和载体制备多肽的方法，以及使用这些多肽 和多核苷酸。
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公开(公告)号：US5786174A
公开(公告)日：1998-07-28
申请号：US790309
申请日：1997-01-28
申请人： J. Mark Weber , David C. Demirjian , Malcolm J. Casadaban , Nikos C. Pagratis , Veronika Vonstein
发明人： J. Mark Weber , David C. Demirjian , Malcolm J. Casadaban , Nikos C. Pagratis , Veronika Vonstein
CPC分类号： C12N9/0006 , C12N15/74 , C12N15/902 , C12N9/1077
摘要： We have developed a new gene transfer system for extreme thermophiles of the genus Thermus, including Thermus flavus., using a chromosomal gene, and a thermostable derivative of the kanamycin-resistance gene (kan.sup.tr2). A plasmid mediated gene-replacement process is used to insert it into the chromosome resulting in the production of Leu.sup.- Km.sup.r transformants. This system not only allows stable, single-copy gene insertion into the chromosome of an extreme thermophile, but can be used in the thermo-genetic process described here to generate thermo-stabilized enzymes and proteins for industrial processes. This host-vector environment makes it possible to generate further thermo-stabilizing mutations in the kan gene beyond those levels previously reported.
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公开(公告)号：US5141926A
公开(公告)日：1992-08-25
申请号：US510483
申请日：1990-04-18
申请人： J. Mark Weber , James B. McAlpine
发明人： J. Mark Weber , James B. McAlpine
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08 , C12N1/20 , C12N1/21 , C12N15/09 , C12N15/52 , C12P19/62 , C12R1/01
CPC分类号： C07H17/08 , C12N15/52 , C12P19/62 , Y10S435/882
摘要： Novel 6-deoxyerythromycin derivatives are disclosed, as are methods for their preparation and use as antiinfective agents. The compounds of the invention include 6-deoxyerythromycins and 6-deoxy-15-norerythromycins which are represented by the structural formula ##STR1## in which R.sub.1 is selected from OH and H, and R.sub.2 and R.sub.3 are independently selected from H and CH.sub.3, as well as the pharmaceutically acceptable salts and esters of the above compounds. Additionally disclosed are genetically modified microorganisms which produce the compounds of the invention and means for the preparation of those microorganisms.
摘要翻译： 公开了新型6-脱氧红霉素衍生物，以及它们的制备方法和用作抗感染剂的方法。 本发明的化合物包括由结构式“IMAGE”表示的6-脱氧红霉素和6-脱氧-15-重氮霉素，其中R1选自OH和H，R2和R3独立地选自H和CH3，作为 以及上述化合物的药学上可接受的盐和酯。 另外公开了产生本发明化合物的遗传修饰的微生物和用于制备这些微生物的方法。
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公开(公告)号：US09367106B2
公开(公告)日：2016-06-14
申请号：US13542714
申请日：2012-07-06
IPC分类号： G06F9/00 , G06F9/24 , G06F15/177 , G06F1/22 , G06F1/18
摘要： A unit of information technology equipment (ITE), such as a compute node or a network switch, comprises a system board in communication with network connectors that selectively connect to a network interconnect, a gravity sensor for detecting a first orientation and a second orientation of the system board, and a basic input/output system (BIOS) in communication with the gravity sensor to receive a signal identifying whether the system board is in the first or second orientation. The ITE further comprises a network ASIC (application specific integrated circuit) that inverts the pinout of transmit and receive signals in the network connectors in response to a command from the BIOS indicating that the system board is in the second orientation. A system may comprise a first ITE in a first orientation that interlocks with a second ITE in a second orientation that is inverted 180 degrees from the first orientation.
摘要翻译： 诸如计算节点或网络交换机的信息技术设备（ITE）的单元包括与网络连接器通信的系统板，网络连接器选择性地连接到网络互连，重力传感器用于检测第一取向和第二取向 系统板和与重力传感器通信的基本输入/输出系统（BIOS），以接收识别系统板是处于第一还是第二方向的信号。 ITE还包括网络ASIC（专用集成电路），其响应于来自BIOS的来自BIOS的指示系统板处于第二方向的命令，反转网络连接器中的发送和接收信号的引脚分布。 系统可以包括处于第一取向的第一ITE，其以与第一取向相反180度的第二取向互锁于第二ITE。
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公开(公告)号：US06350591B1
公开(公告)日：2002-02-26
申请号：US09250585
申请日：1999-02-16
申请人： J. Mark Weber , David C. Demirjian , Malcolm J. Casadaban , Veronika Vonstein , Nikos C. Pagratis
发明人： J. Mark Weber , David C. Demirjian , Malcolm J. Casadaban , Veronika Vonstein , Nikos C. Pagratis
IPC分类号： C12N1574
CPC分类号： C12N9/0006 , C12N9/1077 , C12N15/74 , C12N15/902
摘要： We have developed a new gene transfer system for extreme thermophiles of the genus Thermus, including Thermus flavus., using a chromosomal gene, and a thermostable derivative of the kanamycin-resistance gene (kantr2). A plasmid mediated gene-replacement process is used to insert it into the chromosome resulting in the production of Leu−Kmr transformants. This system not only allows stable, single-copy gene insertion into the chromosome of an extreme thermophile, but can be used in the thermo-genetic process described here to generate thermo-stabilized enzymes and proteins for industrial processes. This host-vector environment makes it possible to generate further thermo-stabilizing mutations in the kan gene beyond those levels previously reported.
摘要翻译： 我们开发了一种新的基因转移系统，用于嗜热栖热菌（Thermus）的嗜热菌（Thermus flavus），使用染色体基因，以及卡那霉素抗性基因（kantr2）的热稳定衍生物。 使用质粒介导的基因置换方法将其插入染色体，导致产生Leu-Kmr转化体。 该系统不仅允许稳定的单拷贝基因插入到极端嗜热菌的染色体中，而且可用于本文所述的热遗传过程中以产生用于工业过程的热稳定的酶和蛋白质。 这种宿主载体环境使得可能在以前报道的那些水平之外在kan基因中产生进一步的热稳定突变。
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公开(公告)号：US5872238A
公开(公告)日：1999-02-16
申请号：US912794
申请日：1997-08-18
申请人： J. Mark Weber , David C. Demirjian , Malcolm J. Casadaban , Veronika Vonstein , Nikos C. Pagratis
发明人： J. Mark Weber , David C. Demirjian , Malcolm J. Casadaban , Veronika Vonstein , Nikos C. Pagratis
CPC分类号： C12N9/0006 , C12N15/74 , C12N15/902 , C12N9/1077
摘要： We have developed a new gene transfer system for extreme thermophiles of the genus Thermus, including Thermus flavus., using a chromosomal gene, and a thermostable derivative of the kanamycin-resistance gene (kan.sup.tr2). A plasmid mediated gene-replacement process is used to insert it into the chromosome resulting in the production of Leu.sup.- Km.sup.r transformants. This system not only allows stable, single-copy gene insertion into the chromosome of an extreme thermophile, but can be used in the thermo-genetic process described here to generate thermo-stabilized enzymes and proteins for industrial processes. This host-vector environment makes it possible to generate further thermo-stabilizing mutations in the kan gene beyond those levels previously reported.
摘要翻译： 我们开发了一种新的基因转移系统，用于嗜热栖热菌（Thermus）的嗜热菌（Thermus flavus），使用染色体基因，以及卡那霉素抗性基因（kantr2）的热稳定衍生物。 使用质粒介导的基因替换过程将其插入染色体，导致Leu- Kmr转化体的产生。 该系统不仅允许稳定的单拷贝基因插入到极端嗜热菌的染色体中，而且可用于本文所述的热遗传过程中以产生用于工业过程的热稳定的酶和蛋白质。 这种宿主载体环境使得可能在以前报道的那些水平之外在kan基因中产生进一步的热稳定突变。
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