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    PROCESS OF INCREASING CELLULAR PRODUCTION OF BIOLOGICALLY ACTIVE COMPOUNDS
    1.
    发明申请
    PROCESS OF INCREASING CELLULAR PRODUCTION OF BIOLOGICALLY ACTIVE COMPOUNDS 审中-公开
    增加生物活性化合物细胞生产的过程

    公开(公告)号：US20100143976A1

    公开(公告)日：2010-06-10

    申请号：US12614976

    申请日：2009-11-09

    申请人： J. Mark WEBER ,  Andrew R. Reeves ,  Igor A. Brikun ,  William Henry Cernota

    发明人： J. Mark WEBER ,  Andrew R. Reeves ,  Igor A. Brikun ,  William Henry Cernota

    IPC分类号： C12P19/60 ,  C12N1/21 ,  C12N1/20

    CPC分类号： C12P19/62 ,  C12N1/18 ,  C12N9/12 ,  C12N9/90

    摘要： A method of increasing production of a methylmalonyl-CoA derivative in a bacterium is disclosed that includes providing a bacterium that produces a methylmalonyl-CoA derivative in which methylmalonyl-CoA mutase function has been inhibited and culturing the bacterium in a medium containing an effective amount of methylmalonyl-CoA or a precursor thereof to increase the production of the methylmalonyl-CoA derivative by the bacterium. The production of the methylmalonyl-CoA derivative is increased when compared to production of the methylmalonyl-CoA derivative by the bacterium when cultured in a medium without the effective amount of methylmalonyl-CoA or a precursor thereof.

    摘要翻译： 公开了增加细菌中甲基丙二酰辅酶A衍生物生产的方法，其包括提供产生甲基丙二酰基-CoA变位酶功能被抑制的甲基丙二酰辅酶A衍生物的细菌，并在含有有效量的 甲基丙二酰辅酶A或其前体，以增加细菌产生的甲基丙二酰辅酶A衍生物。 与在没有有效量的甲基丙二酰辅酶A或其前体的培养基中培养时，细菌相比，甲基丙二酰-CoA衍生物的生产增加。