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34 条记录 (耗时 0.015 秒)

    Adamantyl phenyl .beta.-alanines
    13.
    发明授权
    Adamantyl phenyl .beta.-alanines 失效
    金刚烷基苯基β-丙氨酸

    公开(公告)号：US4691051A

    公开(公告)日：1987-09-01

    申请号：US870553

    申请日：1986-06-04

    申请人： Vassil S. Georgiev ,  George B. Mullen

    发明人： Vassil S. Georgiev ,  George B. Mullen

    IPC分类号： C07D205/12 ,  C07C101/08

    CPC分类号： C07D205/12

    摘要： Adamantyl phenyl .beta.-alanines having the structure: ##STR1## wherein R is phenyl or substituted phenyl and one of R.sup.1 and R.sup.2 is NH.sub.2 and the other is CO.sub.2 H, are disclosed herein.

    摘要翻译： 具有以下结构的金刚烷基苯基β-丙氨酸：其中R是苯基或取代的苯基，R 1和R 2之一是NH 2，另一个是CO 2 H。

    Arylkylamine spirofuropyridines useful in therapy
    14.
    发明授权
    Arylkylamine spirofuropyridines useful in therapy 失效
    可用于治疗的芳烷基螺呋喃吡啶

    公开(公告)号：US06995167B2

    公开(公告)日：2006-02-07

    申请号：US09529654

    申请日：1999-12-23

    申请人： James T Loch, III ,  George B Mullen ,  Eifion D Phillips

    发明人： James T Loch, III ,  George B Mullen ,  Eifion D Phillips

    IPC分类号： A61K31/439 ,  C07D221/22

    CPC分类号： C07D491/22

    摘要： A compound of formula I, wherein NRR1 is attached at the 5- or 6-position of the furopyridine ring; R is hydrogen, C1–C4 alkyl, or COR2; R1 is (CH2)nAr, CH2CH═CHAr, or CH2C≡CAr; n is 0 to 3; A is N or NO; Ar is a 5- or 6-membered aromatic or heteroaromatic ring which contains zero to four nitrogen atoms, zero to one oxygen atoms, and zero to one sulfur atoms; or an 8-, 9- or 10-membered fused aromatic or heteroaromatic ring system containing zero to four nitrogen atoms, zero to one oxygen atoms, and zero to one sulfur, any of which may optionally be substituted with one to two substitutents independently selected from: halogen, trifluoromethyl, or C1–C4 alkyl; R2 is hydrogen, C1–C4 alkyl, C1–C4 alkoxy or phenyl ring optionally substituted with one to three of the following substituents: halogen, C1–C4 alkyl, C2–C4 alkenyl, C2–C4 alkynyl, OH; OC1–C4 alkyl, CO2R5, —CN, —NO2, —NR3R4, or —CF3; R3, R4 and R5 may be hydrogen, C1–C4 alkyl, or phenyl ring optionally substituted with one to three of the following substituents: halogen, C1–C4 alkyl, C2–C4 alkenyl, C2–C4 alkynyl, OH; OC1–C4 alkyl, —CN, —NO2, or —CF3; and enantiomers thereof, and pharmaceutically acceptable salts thereof, processes for preparing them, composition containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.

    摘要翻译： 式I的化合物，化学式id =“CHEM-US-00001”num =“000

    3,5-diphenyl-3-[(1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl)]- 2
    15.
    发明授权
    3,5-diphenyl-3-[(1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl)]- 2 失效
    3,5-二苯基-3 - [（1H-咪唑-1-基甲基）或（1H-1,2,4-三唑-1-基甲基）] - 2-甲基-4-异恶唑啉

    公开(公告)号：US4835283A

    公开(公告)日：1989-05-30

    申请号：US167673

    申请日：1988-03-07

    申请人： Vassil S. Georgiev ,  George B. Mullen

    发明人： Vassil S. Georgiev ,  George B. Mullen

    IPC分类号： C07D413/06

    CPC分类号： C07D413/06

    摘要： This invention pertains generally to substituted 2-methylisoxazolines and more specifically to 3,5-diphenyl-3-[(1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-yl-methyl)]-2-methyl-4-isoxazoline derivatives which are useful as antifungal agents.

    摘要翻译： 本发明一般涉及取代的2-甲基异恶唑啉，更具体地涉及3,5-二苯基-3 - [（1H-咪唑-1-基甲基）或（1H-1,2,4-三唑-1-基 - 甲基）] -2-甲基-4-异恶唑啉衍生物，其可用作抗真菌剂。

    Substituted alpha-(2-tricyclo(3.3.1.13,7)-decylidene)benzeneacetamide derivatives
    20.
    发明授权
    Substituted alpha-(2-tricyclo(3.3.1.13,7)-decylidene)benzeneacetamide derivatives 失效
    取代的α-（2-三环（3.3.1.13,7） - 十一烷基）苯乙酰胺衍生物

    公开(公告)号：US4745220A

    公开(公告)日：1988-05-17

    申请号：US866840

    申请日：1986-05-27

    申请人： Vassil S. Georgiev ,  George B. Mullen

    发明人： Vassil S. Georgiev ,  George B. Mullen

    IPC分类号： A61K31/165 ,  C07C233/00 ,  C07C103/26 ,  C07C103/22

    CPC分类号： A61K31/165 ,  C07C233/00

    摘要： Substituted .alpha.-[2'-tricyclo[3.3.1.1.sup.3,7 ]decylidene]-benzenacetamide derivatives of the formula: ##STR1## where the R.sup.1, R.sup.2 and R.sup.3 substitutents are independently selected from hydrogen, lower alkyl, lower alkoxy, halogen and trifluoromethyl, provided that at least one of such substitutents is hydrogen, have antihypoxia, antiparkinson, and/or anticonvulsant activities.

    摘要翻译： 取代的下式的其中R1，R2和R3取代基独立地选自氢，低级烷基，低级烷氧基，卤素和三氟甲基的α-[2-三环[3.3.1.13,7]癸基] - 苯乙酰胺衍生物 条件是至少一种这样的取代基是氢，具有抗缺氧，抗帕金森和/或抗惊厥活性。