公开(公告)号：US20190282685A1

公开(公告)日：2019-09-19

申请号：US16260554

申请日：2019-01-29

申请人： GLAXOSMITHKLINE BIOLOGICALS, S.A.

发明人： Guido GRANDI ,  Renata Maria GRIFANTINI ,  Oretta FINCO

IPC分类号： A61K39/118 ,  G01N33/569 ,  A61K39/395 ,  C07K14/295 ,  C07K16/12

摘要： The invention provides Chlamydia antigens for use in the treatment, prevention and/or diagnosis of Chlamydia infection. In particular, the invention provides antigens CT733, CTI 53, CT601, CT279, CT443, CT372, CT456, CT381, CT255, CT341, CT716, CT745, CT387, CT812, CT869, CT166, CT175, CT163, CT214, CT721, CT127, CT043, CT823 and/or CT600 from C. trachomatis for the treatment, prevention or diagnosis of Chlamydia infection.

公开(公告)号：US20190275141A1

公开(公告)日：2019-09-12

申请号：US16423507

申请日：2019-05-28

申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.

发明人： Philip DORMITZER

IPC分类号： A61K39/155 ,  A61K39/12

摘要： The invention relates to an immunization regimen whereby an infant is protected against respiratory syncytial virus (RSV) through administration of a first anti-RSV immune response inducing composition to his or her mother during pregnancy, followed by administration of a second anti-RSV immune response inducing composition to the infant after birth.

公开(公告)号：US20190211064A1

公开(公告)日：2019-07-11

申请号：US16363127

申请日：2019-03-25

申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.

发明人： Andrea CARFI ,  Yingxia WEN

IPC分类号： C07K14/005 ,  C12N7/00 ,  A61K39/245 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55588 ,  A61K2039/572 ,  C12N7/00 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16151

摘要： An isolated human cytomegalovirus (HCMV) membrane protein complex that comprises gH, gL and at least one more HCMV glycoprotein is provided. In some embodiments the complex consists of gH, gL and gO. In other embodiments the complex consists of gH, gL, pUL128, pUL130 and pUL131A. Processes for expressing and purifying such complexes, and subsequent uses of such complexes in immunogenic compositions and vaccines, are also provided.

公开(公告)号：US10245317B2

公开(公告)日：2019-04-02

申请号：US15265597

申请日：2016-09-14

申请人： GlaxoSmithKline Biologicals s.a.

发明人： Ralph Leon Biemans ,  Dominique Boutriau ,  Carine Capiau ,  Philippe Denoel ,  Pierre Duvivier ,  Jan Poolman

IPC分类号： A61K39/00 ,  A61K39/02 ,  C07H3/00 ,  C12N7/00 ,  A61K39/08 ,  A61K39/09 ,  A61K39/385 ,  A61K39/095 ,  A61K39/102 ,  A61K39/116 ,  A61K39/05 ,  A61K39/29 ,  A61K39/145 ,  A61K39/12

摘要： The present application discloses an immunogenic composition comprising at least 2 different N. meningitidis capsular saccharides, wherein one or more is/are selected from a first group consisting of MenA, MenC, MenY and MenW which is/are conjugated through a linker to a carrier protein(s), and one or more different saccharides is/are selected from a second group consisting of MenA, MenC, MenY and MenW which is/are directly conjugated to a carrier protein(s).

公开(公告)号：US20190078064A1

公开(公告)日：2019-03-14

申请号：US16177562

申请日：2018-11-01

申请人： GLAXOSMITHKLINE BIOLOGICALS, S.A.

发明人： Jurgen Haas ,  Julian Ihssen ,  Michael Thomas Kowarik ,  Torsten Franz Schwede ,  Linda Christiane Thöny-Meyer

IPC分类号： C12N9/10 ,  C12P21/00

CPC分类号： C12N9/1081 ,  C12P21/005

摘要： Described herein are oligosaccharyl transferases for use in N-glycosylating proteins of interest in vitro and in host cells. Methods for using such oligosaccharyl transferases, nucleic acids encoding such oligosaccharyl transferases, and host cells comprising such oligosaccharyl transferases are also provided herein. Glycoconjugates generated by using such oligosaccharyl transferases are also provided herein.

公开(公告)号：US20190076519A1

公开(公告)日：2019-03-14

申请号：US16104226

申请日：2018-08-17

申请人： GlaxoSmithKline Biologicals S.A.

发明人： Guy BAUDOUX ,  Mathieu BOXUS ,  Brigitte COLAU ,  Martine MARCHAND

IPC分类号： A61K39/125 ,  A61K39/12 ,  C12N7/00 ,  C07K14/005 ,  C07K7/08 ,  A61K39/39 ,  C07K14/085 ,  A61K39/00

摘要： Fusion proteins comprising a carrier protein and a Human Rhinovirus (HRV) peptide, and immunogenic compositions containing such fusion proteins.

公开(公告)号：US20190054163A1

公开(公告)日：2019-02-21

申请号：US16078196

申请日：2017-03-02

申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.

发明人： Ventzislav Bojidarov VASSILEV

IPC分类号： A61K39/145 ,  C07K14/005 ,  C12N15/62 ,  A61P31/16

摘要： The present invention relates to novel influenza antigens, novel immunogenic or vaccine compositions, as well as to uses of and to methods for producing said antigens and compositions. In particular, the invention relates to recombinant forms of hemagglutinin (HA) and their use in vaccine compositions for the prevention of influenza virus infections.

公开(公告)号：US20190049390A1

公开(公告)日：2019-02-14

申请号：US16074900

申请日：2017-02-01

申请人： GlaxoSmithKline Biologicals S.A.

发明人： Romain Marie VEILLON

IPC分类号： G01N21/88 ,  G01N21/90

摘要： Apparatus for detecting cracks in optically transparent articles e.g vials, comprising a mount for the article, a light source to direct light at a mounted article, an optical detector positioned to receive light from the light source passed through the article and to generate an electronic signal responsive to received light, first and second (analyzer) polarizers such that light from the light source passes through the first polarizer then through the article, then through the second polarizer on its path to the optical detector, with an optical wave plate positioned between the mount and the second polarizer, and an image processing system to process the electronic signal generated by the optical detector and to indicate the presence or absence of a crack in the article supported on the mount. A method of crack detection using the apparatus is also provided.

公开(公告)号：US20180303940A1

公开(公告)日：2018-10-25

申请号：US16019984

申请日：2018-06-27

申请人： GLAXOSMITHKLINE BIOLOGICALS, S.A.

发明人： Carine DE KESEL ,  Vincent MANCUSO

IPC分类号： A61K47/24 ,  A61K9/127 ,  A61K47/28 ,  A61K47/36

CPC分类号： A61K47/24 ,  A61K9/127 ,  A61K9/1272 ,  A61K9/1277 ,  A61K47/28 ,  A61K47/36 ,  Y02A50/411

摘要： Provided are compositions and methods for producing a lipidic film. The method comprises the steps of: (i) dissolving a lipid mix in isopropanol to form a homogeneous mix; and (ii) removing the solvent from the homogeneous mix to form a lipidic film, wherein the lipid mix comprises a lipid and cholesterol.

公开(公告)号：US10060928B2

公开(公告)日：2018-08-28

申请号：US14896473

申请日：2014-06-05

申请人： GlaxoSmithKline Biologicals S.A.

发明人： Clementine Mascaux

IPC分类号： G01N33/579 ,  G01N33/20 ,  G01N33/569 ,  A61K39/00

CPC分类号： G01N33/579 ,  A61K2039/55505 ,  G01N33/20 ,  G01N33/56911 ,  G01N2400/50 ,  Y10T436/25375

摘要： Methods for determining the endotoxin content of an aluminum salt preparation for use in medicine are provided. The methods include mixing the aluminum salt with a desorption buffer and separating the aluminum salt from the endotoxin.