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公开(公告)号：US07561920B2
公开(公告)日：2009-07-14
申请号：US11097611
申请日：2005-03-31
IPC分类号： A61N1/18
CPC分类号： H04R25/70 , A61N1/36036
摘要： Methods and systems for modifying the parameters of at least one hearing device for a patient with residual hearing provide needed orchestration of acoustic and electric stimulation of patients wearing such devices.
摘要翻译： 用于修改具有残留听力的患者的至少一个听力装置的参数的方法和系统为佩戴这种装置的患者提供对声学和电刺激的所需编排。
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12.发明申请Multi-electrode stimulation to elicit electrically-evoked compound action potential 审中-公开多电极刺激引发电诱发复合动作电位公开(公告)号：US20080221640A1
公开(公告)日：2008-09-11
申请号：US10698097
申请日：2003-10-31
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/36036
摘要： A multichannel neurostimulation device spatially spreads the excitation pattern in the target neural tissue by either: (1) rapid sequential stimulation of a small group of electrodes, or (2) simultaneously stimulating a small group of electrodes. Such multi-electrode stimulation stimulates a greater number of neurons in a synchronous manner, thereby increasing the amplitude of the extra-cellular voltage fluctuation and facilitating its recording. The electrical stimuli are applied simultaneously (or sequentially at a rapid rate) on selected small groups of electrodes while monitoring the evoked compound action potential (ECAP) on a nearby electrode. The presence of an observable ECAP not only validates operation of the implant device at a time when the patient may be unconscious or otherwise unable to provide subjective feedback, but also provides a way for the magnitude of the observed ECAP to be recorded as a function of the amplitude of the applied stimulus. From this data, a safe, efficacious and comfortable threshold level can be obtained which may be used thereafter as the initial setting of the stimulation parameters of the neurostimulation device, or to guide the setting of the stimulation parameters of the neurostimulation device.
摘要翻译： 多通道神经刺激装置通过以下方式之一将目标神经组织中的激发图案空间扩展：（1）快速连续刺激小组电极，或（2）同时刺激小组电极。 这种多电极刺激以同步方式刺激更多数量的神经元，从而增加细胞外电压波动的幅度并促进其记录。 电刺激同时（或以快速顺序）施加在选定的小组电极上，同时监测附近电极上的诱发化合物动作电位（ECAP）。 可观察到的ECAP的存在不仅在患者无意识或不能提供主观反馈的时候验证植入装置的操作，而且还提供了将所观察到的ECAP的大小记录为作为 施加的刺激的幅度。 从该数据可以获得安全，有效和舒适的阈值水平，其可以随后用作神经刺激装置的刺激参数的初始设置，或者指导神经刺激装置的刺激参数的设置。
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13.发明授权System and method for using a multi-contact electrode to stimulate the cochlear nerve or other body tissue 有权使用多接触电极刺激耳蜗神经或其他身体组织的系统和方法公开(公告)号：US07317944B1
公开(公告)日：2008-01-08
申请号：US10886801
申请日：2004-07-08
申请人： Edward H Overstreet
发明人： Edward H Overstreet
CPC分类号： A61N1/36036 , A61N1/0541
摘要： A system and method for preserving temporal and spatial resolution in complex sounds for poor performing patients having high stimulation thresholds is described. The system and method employs two or more adjacent electrode contacts to deliver concurrent stimulation. This concurrent delivery of stimuli creates a high current field intensity that overlaps between individual current fields generated by the two or more adjacent electrodes and which individual fields are summed to create an overlapping field that has a higher current field intensity than a single current emanating from an individual electrode. The use of this method reduces or eliminates the need to increase either the stimulus current amplitude or to increase the pulse width, both of which may cause loss of system resolution, i.e., loss of fine structure information that is used to resolve complex sounds such as music.
摘要翻译： 描述了用于在具有高刺激阈值的不良表现的患者中保持复杂声音中的时间和空间分辨率的系统和方法。 该系统和方法采用两个或更多个相邻的电极触点来传送并发刺激。 这种并发传播的刺激产生了高电流场强度，其在由两个或更多个相邻电极产生的各个电流场之间重叠，并且将各个场相加以产生具有比单个电流发射的单个电流更高的电流场强度的重叠场 单个电极。 使用这种方法减少或消除了增加刺激电流幅度或增加脉冲宽度的需要，这两者都可能导致系统分辨率的损失，即用于解决复杂声音的精细结构信息的丢失，例如 音乐。
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14.发明授权公开(公告)号：US07277759B2
公开(公告)日：2007-10-02
申请号：US10771819
申请日：2004-02-04
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61B5/0488 , A61B5/4041
摘要： A method of recording neural responses reduces the inaccuracy of the recordings caused by nerve adaptation to repeated exposure of stimuli. In one embodiment, a maximum set of X number of successive stimuli are delivered through an electrode and the resulting neural response recorded and, afterwards, the next stimulation must occur through another electrode. This stimulation sequence prevents the same set of nerves from being stimulated too often, which can result in stimulus adaptation and cause measurement inaccuracy. In one embodiment of the invention, a smart software can be employed to provide visual plots of “growth curves”, including real-time calculated datapoints and their confidence intervals, and automatically terminate the recording session upon reaching a pre-set trigger. Alternatively, a human operator can terminate a recording session, based on visual feedback of growth curves, including their real-time calculated datapoints and confidence intervals.
摘要翻译： 记录神经反应的方法减少了神经适应对刺激反复暴露引起的记录的不准确性。 在一个实施例中，通过电极传送X个连续刺激的最大集合，并记录所得到的神经反应，然后，下一个刺激必须通过另一个电极发生。 该刺激序列防止相同的神经组被频繁地刺激，这可能导致刺激适应并导致测量不准确。 在本发明的一个实施例中，智能软件可用于提供“生长曲线”的视觉图，包括实时计算的数据点及其置信区间，并且在达到预置触发时自动终止记录会话。 或者，人类操作者可以基于生长曲线的视觉反馈（包括其实时计算的数据点和置信区间）来终止记录会话。
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15.发明授权Method and system for obtaining stapedial reflexes in cochlear implant users using multiband stimuli 有权在使用多频带刺激的耳蜗植入物使用者中获得吻合反射的方法和系统公开(公告)号：US07117038B1
公开(公告)日：2006-10-03
申请号：US10662615
申请日：2003-09-15
申请人： Edward H Overstreet
发明人： Edward H Overstreet
IPC分类号： A61B1/10
CPC分类号： A61N1/36036
摘要： A method and system for fitting a multichannel cochlear implant system to a patient increases the percentage of patients for which stapedial reflexes can be obtained, and increases the accuracy of predicting the “live speech” comfort levels of the patient's fitting programs from the stapedial reflex. Electrical stimuli are applied on multiple electrodes at “live speech” pulse rates. The neural excitation patterns elicited from such stimulation more closely resemble that which occurs when the system is subjected to normal speech patterns. By progressively setting threshold levels in bands, e.g., groups of electrodes, either overlapping or non-overlapping, as well as with a final check by globally adjusting the band obtained contour to the stapedial reflex, such values more closely resemble actual “live speech” program levels than those obtained with traditional methods. Further, broader excitation patterns produced by the activation of multiple electrodes increases the probability of obtaining reflex measurements where single electrode stimulation fails due to sparse neural survival.
摘要翻译： 用于将多声道人工耳蜗植入系统装配到患者的方法和系统增加了可以获得吻合反射的患者的百分比，并且增加了从吻合反射预测患者装配程序的“实况语音”舒适度的准确性。 电刺激以“实时语音”脉冲速率施加在多个电极上。 从这种刺激引起的神经激励模式更接近于当系统经受正常语音模式时发生的神经激励模式。 通过逐渐设置频带中的阈值水平，例如重叠或不重叠的电极组，以及通过将获得的频带全局调整为吻合反射的最终检查，这些值更接近实际的“实时语音” 程序水平高于传统方法。 此外，通过多个电极的激活产生的更广泛的激励模式增加了由于稀疏神经存活而获得单电极刺激失败的反射测量的可能性。
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16.发明授权Enhanced methods for determining iso-loudness contours for fitting cochlear implant sound processors 失效用于确定用于拟合人工耳蜗声音处理器的等响度轮廓的增强方法公开(公告)号：US07043303B1
公开(公告)日：2006-05-09
申请号：US10647372
申请日：2003-08-25
申请人： Edward H. Overstreet
发明人： Edward H. Overstreet
IPC分类号： A61N1/36
CPC分类号： A61N1/36036
摘要： Methods are taught to simplify the cochlear implant fitting process for various cochlear prostheses and stimulation strategies, including high rate stimulation strategies. For instance, patient self-programming is made possible. In addition, auto-fitting is made possible (particularly useful for very young patients and other patients for whom it is challenging to obtain feedback) using iso-neural response contours which can be linearly transposed to arrive at iso-loudness contours. Furthermore, M iso-loudness contours (or iso-neural contours) can be linearly transposed to determine T iso-loudness contours. In addition, wider pulse widths can be used to generate an iso-loudness contour whose shape can be used (via linear transposition) to program high-rate, narrow pulse width stimulation.
摘要翻译： 教导了简化用于各种耳蜗假体和刺激策略的人工耳蜗植入装配过程的方法，包括高速率刺激策略。 例如，患者自我编程成为可能。 此外，使用可以线性转置以达到等响度轮廓的等神经反应轮廓，自动拟合成为可能（对于非常年轻的患者和其他具有挑战性的获得反馈的患者特别有用）。 此外，M等响度轮廓（或等神经轮廓）可以被线性转置以确定T等响度轮廓。 此外，可以使用更宽的脉冲宽度来产生等响度轮廓，其形状可以被使用（通过线性位移）来编程高速率，窄脉冲宽度的刺激。
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公开(公告)号：US08594799B2
公开(公告)日：2013-11-26
申请号：US12610000
申请日：2009-10-30
IPC分类号： A61N1/00
CPC分类号： A61B17/3468 , A61B34/30 , A61B34/76 , A61B34/77 , A61B2034/742 , A61B2090/064 , A61N1/0541 , A61N1/36036
摘要： A system for mechanically assisted insertion of an electrode includes: an insertion tool configured to insert the electrode into biological tissues; and a controller configured to control the insertion tool, in which the controller is further configured to select operating parameters comprising a maximum allowable force profile from a library of operating parameters, in which the maximum allowable force profile is generated from data recorded during a number of previous successful operations. Also, a method for insertion of a cochlear lead, includes: selecting operating parameters comprising a maximum allowable force profile from a library of operating parameters; inserting the cochlear lead while sensing real time force and position; and continuing the insertion while the real time force is below the maximum allowable force profile, in which the maximum allowable force profile is generated from data recorded during a number of previous successful operations.
摘要翻译： 用于机械辅助插入电极的系统包括：插入工具，其构造成将电极插入生物组织中; 以及控制器，其被配置为控制所述插入工具，其中所述控制器还被配置为从来自操作参数库的所述操作参数库中选择包括最大容许力分布的操作参数，其中从在多个 以前的成功操作。 另外，用于插入耳蜗导线的方法包括：从操作参数库中选择包括最大容许力分布的操作参数; 插入耳蜗线，同时感测实时力和位置; 并且当实时力低于最大允许力分布时继续插入，其中最大允许力分布由在多个先前成功操作期间记录的数据产生。
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公开(公告)号：US08150527B2
公开(公告)日：2012-04-03
申请号：US12495593
申请日：2009-06-30
IPC分类号： H04R25/00
CPC分类号： H04R25/70 , A61N1/36036
摘要： Methods and systems for modifying the parameters of at least one hearing device for a patient with residual hearing provide needed orchestration of acoustic and electric stimulation of patients wearing such devices.
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19.发明授权Methods and systems for automatically identifying whether a neural recording signal includes a neural response signal 有权用于自动识别神经记录信号是否包括神经反应信号的方法和系统公开(公告)号：US07818052B2
公开(公告)日：2010-10-19
申请号：US11142152
申请日：2005-06-01
IPC分类号： A61B5/04
CPC分类号： A61B5/04001 , A61B5/4041 , A61B5/7217 , A61N1/36036
摘要： Methods of automatically identifying whether a neural recording signal includes a neural response signal include fitting an artifact model to a neural recording signal to produce a fitted artifact model signal, determining a strength-of-response metric that describes a distance of the neural recording signal from the fitted artifact model signal, and identifying the neural recording signal as including a neural response signal if the strength-of-response metric is above a pre-determined threshold. Corresponding systems are also described.
摘要翻译： 自动识别神经记录信号是否包括神经反应信号的方法包括将伪像模型拟合到神经记录信号以产生拟合的伪像模型信号，确定描述神经记录信号距离的距离强度的度量度量 拟合假象模型信号，并且如果响应强度度量高于预定阈值，则将神经记录信号识别为包括神经响应信号。 还描述了相应的系统。
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20.发明申请METHODS AND SYSTEMS OF CONVEYING FINE STRUCTURE INFORMATION TO A COCHLEAR IMPLANT PATIENT 有权将精细结构信息传送给海绵体植入物的方法和系统公开(公告)号：US20100070000A1
公开(公告)日：2010-03-18
申请号：US12559759
申请日：2009-09-15
CPC分类号： A61N1/36032 , A61N1/0541 , A61N1/323 , A61N1/36036 , A61N1/36185
摘要： An exemplary method of conveying fine structure information to a cochlear implant patient includes dividing an audio signal into a plurality of analysis channels, generating electrical stimulation in accordance with the information contained within each of the analysis channels, applying the electrical stimulation to at least one stimulation site within a patient via a plurality of stimulation channels, and at least partially isolating one of the stimulation channels from a rest of the stimulation channels, wherein fine structure information is conveyed to the patient via the isolated stimulation channel. Corresponding methods and systems are also disclosed.
摘要翻译： 将精细结构信息传送到耳蜗植入患者的示例性方法包括将音频信号划分成多个分析通道，根据包含在每个分析通道内的信息产生电刺激，将电刺激应用于至少一个刺激 通过多个刺激通道在患者体内的位置，并且至少部分地将刺激通道中的一个与其余刺激通道隔离，其中精细结构信息经由隔离的刺激通道传送给患者。 还公开了相应的方法和系统。
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