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公开(公告)号：US11365208B2
公开(公告)日：2022-06-21
申请号：US16465536
申请日：2017-11-23
Inventor： Juan Carlos Morales Sánchez , Pablo Peñalver Puente , Efres Belmonte Reche , Elena González Rey , Maria Luisa Mateos Martin
Abstract: The present invention relates to a group of compounds derived from resveratrol having as substituents at least one silyl group which, in turn, can be substituted by different groups. The invention also relates to the therapeutic use of these compounds in inflammatory, neurological, and neurodegenerative diseases.
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公开(公告)号：US11332739B2
公开(公告)日：2022-05-17
申请号：US16322316
申请日：2017-07-31
Inventor： Xavier Gibert Pérez , Marta Sitjà Arnau , Maria Mar Fenech Martínez , Santiago Francisco Elena Fito , Susana Martín García
Abstract: The present invention relates to a method for preparing cDNA infectious clones based on the genome of an attenuated Porcine Reproductive and Respiratory Syndrome virus (PRRSV) and uses thereof for preparing efficacious and safety-enhanced vaccines against PRRSV. The invention further comprises an infectious cDNA clone obtainable by such method. The invention further provides an attenuated modified PRRSV, and immunogenic compositions and vaccines comprising that attenuated PRRSV. The present invention further provides the attenuated PRRSV for use in the prophylaxis and/or the treatment of PRRSV infections, and the attenuated PRRSV for use as vaccine or medicament in the prophylaxis and/or the treatment of PRRSV infections.
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公开(公告)号：US11300344B2
公开(公告)日：2022-04-12
申请号：US16283261
申请日：2019-02-22
Inventor： Michel Galvin , Albert Verdaguer
Abstract: Disclosed is a snow making method incorporating nucleation agent particles into water and in spraying the water containing the nucleation agent particles onto a surface or into an ambiance whose temperature is lower than 0° C., by way of a device for producing snow or ice. The nucleation agent particles consist in silicate particles whose unit equivalent spherical diameter is lower than 15 μm, and preferably lower than 5 μm. Also disclosed is the powdery product for implementing the method.
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公开(公告)号：US20220009091A1
公开(公告)日：2022-01-13
申请号：US17341970
申请日：2021-06-08
Applicant: Naver France , Consejo Superior de Investigaciones Cientificas (CSIC) , Universitatpolitècnica De Catalunya Plaça d'Eusebi Güell 6 Edifici Vertex, Planta 1
Inventor： Francesc Moreno Noguer , Guillem Alenyà Ribas , Enric Corona Puyane , Albert Pumarola Peris , Grégory Rogez
IPC: B25J9/16
Abstract: Method for determining a grasping hand model suitable for grasping an object by obtaining a first RGB image including at least one object; obtaining an object model estimating a pose and shape of said object from the first image of the object; selecting a grasp taxonomy from a set of grasp taxonomies by means of a Convolutional Neural Network, with a cross entropy loss, thus, obtaining a set of parameters defining a coarse grasping hand model; refining the coarse grasping hand model, by minimizing loss functions referring to the parameters of the hand model for obtaining an operable grasping hand model while minimizing the distance between the finger of the hand model and the surface of the object and preventing interpenetration; and obtaining a mesh of the hand represented by the enhanced set of parameters.
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公开(公告)号：US20220002380A1
公开(公告)日：2022-01-06
申请号：US17294582
申请日：2019-10-29
IPC: C07K14/705 , A61K39/00
Abstract: The present invention provides improved Etanercept variants which comprise one (A105E), preferably two (A105E/L106F), amino acid substitutions regarding the Etanercept original amino acid sequence of SEQ ID NO: 3. These variants inhibit TNF activity but fail to neutralize human LTα (hLTα). Thus, they are proposed herein as a great alternative to be used in the clinic for the treatment of autoimmune or inflammatory diseases in which an exacerbated TNF activity is involved, since they prevent the side effects associated to the use of the original Etanercept molecule while retaining the TNF blocking activity.
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Patent Agency Ranking
公开(公告)号：US20220000942A1
公开(公告)日：2022-01-06
申请号：US17297629
申请日：2019-11-27
Inventor： Yolanda SANZ HERRANZ , Eva Maria GOMEZ DEL PULGAR VILLANUEVA , Ana AGUSTI FELIU , Maria Carmen CENIT LAGUNA
IPC: A61K35/741 , C12N1/20 , A61K35/744 , A61P25/24 , A23L33/135
Abstract: The present invention relates to Christensenellaceae bacteria including Christensenella minuta strain DSM 32891, to the cellular components, metabolites and secreted molecules thereof, and to compositions that comprise the above products, and also to the use of said strain for the prevention and/or treatment of mood or affective disorders, such as depression, stress disorders, anxiety disorders and migraine.
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公开(公告)号：US20210388108A1
公开(公告)日：2021-12-16
申请号：US17287777
申请日：2019-10-23
Applicant: GLYCARDIAL DIAGNOSTICS, S.L. , Fundacio Institut De Recerca De L'Hospital De La Santa Creu l Sant Pau , CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Inventor： Lina BADIMON MAESTRO , Judit CUBEDO RAFOLS , Teresa PADRO CAPMANY
Abstract: The invention relates to new antibodies against specific glycosylation sites within the ApoJ protein as well as their application thereof in the diagnosis and prognosis of ischemia and the determination of the risk of a recurrent ischemic event.
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公开(公告)号：US20210340080A1
公开(公告)日：2021-11-04
申请号：US17374021
申请日：2021-07-13
Applicant: Saudi Arabian Oil Company , Universitat Politecnica De Valencia , Consejo Superior De Investigaciones Cientificas
Inventor： Raed Hasan Abudawoud , Avelino Corma Canos , M. Teresa Portilla Ovejero , Vicente J. Margarit Benavent , M. Teresa Navarro Villalba , M. Cristina Martinez Sanchez , Ibrahim M. Al-Zahrani
IPC: C07C6/12 , B01J29/26 , B01J29/48 , B01J35/10 , C07C4/18 , B01J29/80 , B01J29/46 , B01J35/00 , B01J35/02 , B01J29/24 , B01J29/44 , B01J29/22
Abstract: Method of making BTX compounds including benzene, toluene, and xylene, including feeding heavy reformate to a reactor containing a composite zeolite catalyst. The composite zeolite catalyst includes a mixture of layered mordenite (MOR-L) comprising a layered or rod-type morphology with a layer thickness less than 30 nm and ZSM-5. The MOR-L, the ZSM-5, or both include one or more impregnated metals. The method further includes producing the BTX compounds by simultaneously performing transalkylation and dealkylation of the heavy reformate in the reactor. The composite zeolite catalyst is able to simultaneously catalyze both the transalkylation and dealkylation reactions.
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公开(公告)号：US20210215421A1
公开(公告)日：2021-07-15
申请号：US17056171
申请日：2019-05-17
Inventor： Javier SESE MONCLUS , Conrado RILLO MILLAN
Abstract: The present invention relates to a cryocooler suitable for gas liquefaction applications, that comprises a coldhead (1) with one or more refrigeration stages (2, 3); further comprising: a refrigerator compressor (4) for distributing compressed gas-phase cryogen inside the coldhead (1); a heat exchanging coil (9) arranged at least partially around the external region of the coldhead (1); at least one extraction orifice (8) communicating a gas circulation circuit (5) inside the coldhead (1) with the heat exchanging coil (9); acting said extraction orifice/s (8) as pass-through port/s which allow the gas inside the coldhead (1) to flow through the inside of the heat exchanger coil (9) for exchanging heat with the exterior thereof, and wherein the heat exchanging coil (9) is adapted to connect and redirect the gas to one return port (8′) connected to the gas circulation circuit (5). Another object of the invention relates to a cryogen-gas liquefaction system (11) and a method for liquefaction of gases that comprises said system (11).
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公开(公告)号：US10894785B2
公开(公告)日：2021-01-19
申请号：US16323473
申请日：2017-08-04
Applicant: CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CHUV , CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
Inventor： Pierre Vogel , Michel Duchosal , Nahimana Aimable , Inmaculada Robina , Faustino Mollinedo , Alessio Nencioni
IPC: C07D401/12 , C07D401/14 , C07D409/14 , C07D407/14 , A61P35/00 , C07D405/14
Abstract: The present invention relates to novel piperidine derivatives having better cell growth inhibitory activities toward cancer cell cultures and, more particularly, PANC-1 cancer cell cultures than FK866. Accordingly, the present invention relates to compounds of formula I, wherein Ar1 is aryl or heteroaryl, which are optionally substituted by one, two or three substituents selected from lower alkyl; lower alkoxy; formyl; hydroxyl; lower alkyl substituted by lower alkoxy or hydroxyl; A is CnH2n, CnH2n-2 or CnH2n-4, wherein n=4,5,6,7; B is ═N—CN, oxo (═O), thio (═S); D is NH, —CH═CH—; Ar2 is aryl or heteroaryl which are optionally substituted by one, two or three halogen substituents; wherein, if B is oxo (═O), Ar1 and Ar2 are not simultaneously phenyl and pyridine-3-yl; B and D are not simultaneously ═N—CN and —CH═CH—, or a pharmaceutically acceptable salt, a racemic mixture or its corresponding enantiomers and/or optical isomers. The compounds of formula I and their pharmaceutically usable addition salts possess valuable pharmacological properties. Specifically, it has been found that the compounds of the present invention, alone or in combination with other therapeutic active compounds, have an activity as chemotherapeutic agents against cancer and, more particularly, pancreatic cancers.
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