公开(公告)号：US20230221217A1

公开(公告)日：2023-07-13

申请号：US18008701

申请日：2021-06-14

Applicant: Consejo Superior de Investigaciones Cientificas (CSIC)

Inventor： Antonio ALCAMI PERTEJO ,  Alberto RASTROJO LASTRAS

IPC: G01N1/22 ,  C12Q1/689 ,  C12Q1/6895 ,  C12Q1/70

CPC classification number: G01N1/2205 ,  C12Q1/689 ,  C12Q1/6895 ,  C12Q1/70

Abstract: The present invention refers to a device comprising polytetrafluorethylene (PTFE) filters and the use of the same for collecting, detecting and identifying organisms present in air ecosystems. The invention also provides a method suitable for the capture, detection and identification of whole airborne biological particles, including viruses and other important air pathogens, which involves the use of the device. This method allows toperform organism, preferably viral, metagenomics to sequence all DNA and RNA organisms captured in the filters. This methodology may be used to detect, for instance, SARS-CoV2 particles in air samples.

公开(公告)号：US20220002380A1

公开(公告)日：2022-01-06

申请号：US17294582

申请日：2019-10-29

Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Inventor： Antonio ALCAMI PERTEJO ,  Sergio MARTÍN PONTEJO ,  Carolina SÁNCHEZ FERNÁNDEZ

IPC: C07K14/705 ,  A61K39/00

Abstract: The present invention provides improved Etanercept variants which comprise one (A105E), preferably two (A105E/L106F), amino acid substitutions regarding the Etanercept original amino acid sequence of SEQ ID NO: 3. These variants inhibit TNF activity but fail to neutralize human LTα (hLTα). Thus, they are proposed herein as a great alternative to be used in the clinic for the treatment of autoimmune or inflammatory diseases in which an exacerbated TNF activity is involved, since they prevent the side effects associated to the use of the original Etanercept molecule while retaining the TNF blocking activity.