公开(公告)号：US10548851B2

公开(公告)日：2020-02-04

申请号：US16255020

申请日：2019-01-23

Applicant: InCube Labs, LLC

Inventor： Mir Imran ,  Joel Harris

IPC: A61K9/48 ,  A61K35/12 ,  A61K9/00 ,  A61B5/00 ,  A61B5/145 ,  A61M31/00 ,  A61K35/28 ,  A61K35/30 ,  A61K35/39 ,  A61K9/06 ,  A61M25/10

Abstract: Embodiments provide swallowable devices, preparations and methods for delivering viable cells (VC) into the GI tract including GI wall tissue or other tissue site. Particular embodiments provide a swallowable device such as a capsule for delivering VC into an intestinal wall or other site. The VC can be contained within a tissue-penetrating shell disposed in the capsule that protects the VC as they pass through the GI tract until they are inserted into GI tract tissue or other location. The shell desirably has shape, size and material consistency to be contained in a swallowable capsule, delivered from the capsule into solid tissue by the application of force on the shell and biodegrade within the solid tissue to release the VC into the tissue. Within the shell or other structure the VC can be maintained in a viability-sustaining gel that preserves the viability of the VC for selected time periods.

公开(公告)号：US10531206B2

公开(公告)日：2020-01-07

申请号：US15890185

申请日：2018-02-06

Applicant: Earlens Corporation

Inventor： Daniel J. Freed ,  Sunil Puria

IPC: H04R25/00 ,  H04B10/50 ,  H04B10/114

Abstract: A processor comprises instructions to adjust a bias of an input signal in order to decrease a duty cycle of a pulse modulated optical signal. The bias can be increased, decreased, or maintained in response to one or more measured values of the signal. In many embodiments, a gain of the signal is adjusted with the bias in order to inhibit distortion. The bias can be adjusted slowly in order to inhibit audible noise, and the gain can be adjusted faster than the bias in order to inhibit clipping of the signal. In many embodiments, one or more of the bias or the gain is adjusted in response to a value of the signal traversing a threshold amount. The value may comprise a trough of the signal traversing the threshold.

公开(公告)号：US10520505B2

公开(公告)日：2019-12-31

申请号：US15910610

申请日：2018-03-02

Applicant: BioCardia, Inc.

Inventor： Peter Altman ,  Cheryl Wong Po Foo

IPC: G01N33/569 ,  A61K35/28

Abstract: Autologous bone marrow cells (BMC) are transplanted to a heterologous site in a patient after a sample of the patient's BMC has been tested and found to have a phenotypic profile which meets minimum criteria for transplantation. The phenotypic profile may be obtained by screening a sample of bone marrow cells (BMC) from the patient for the phenotypic profile, such as a CD profile, the phenotype profile may be assessed to determine the likelihood that the BMC will be suitable for transplantation to the heterologous tissue site without enriching particular phenotypic population(s) of the BMC.

公开(公告)号：US10507313B2

公开(公告)日：2019-12-17

申请号：US13827468

申请日：2013-03-14

Applicant: InCube Labs, LLC

Inventor： Mir Imran ,  Phillip Morgan ,  Ben Tranchina ,  Paul Spehr ,  Kyle Horlen

IPC: A61M37/00 ,  A61M5/142 ,  A61B5/04 ,  A61B5/0478 ,  A61B5/053 ,  A61B5/00 ,  A61N1/05 ,  A61N1/36 ,  A61B5/055

Abstract: Various embodiments provide an apparatus, system method for treating neurological conditions by delivering solid form medication to the ventricles or other areas of the brain. Particular embodiments provide an apparatus and method for treating epilepsy and other neurological conditions by delivering solid form medication to ventricles in the brain wherein the medication is contained in a diffusion chamber so as to allow the medication to dissolve in the cerebrospinal fluid of the brain and then diffuse out of the diffusion chamber to be delivered to the ventricles and brain tissue. In one or more embodiments, portions of apparatus have sufficient flexibility to conform to the shape of the ventricles of the brain when advanced into them and/or to not cause deformation of the ventricle sufficient to cause a significant physiologic effect.

公开(公告)号：US10478396B2

公开(公告)日：2019-11-19

申请号：US15879308

申请日：2018-01-24

Applicant: Rani Therapeutics, LLC

Inventor： Mir Imran

IPC: A61K9/48 ,  A61K9/00 ,  A61M25/10 ,  A61M5/00 ,  A61K38/29 ,  A61K31/155 ,  A61M31/00 ,  A61M37/00

Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

公开(公告)号：US10456136B2

公开(公告)日：2019-10-29

申请号：US15369293

申请日：2016-12-05

Applicant: Zipline Medical, Inc.

Inventor： Amir Belson ,  Eric Storne ,  Alan Schaer ,  Pankaj Rathi ,  Keiichiro Ichiryu ,  Peter D'Aquanni ,  Luke Clauson ,  Chris Feezor

IPC: A61B17/08 ,  A61B17/04 ,  A61B17/00 ,  A61B17/02

Abstract: An apparatus for closing a surgical incision comprises left and right base panels, a plurality of closure components, and a plurality of left and right axial supports coupled to the respective base panels. The closure components couple the left and right base panels to each other laterally and have left and right ends coupled to the respective base panels. The closure components are positioned laterally across the left and right panels, the left axial supports are disposed between pairs of left closure component ends, the right axial supports are disposed between pairs of right closure component ends, and the left and right axial supports are offset from one another such that a serpentine arrangement of consecutive closure components and axial supports is formed. The apparatus can be made of antimicrobial materials or materials impregnated with antimicrobial agents. A flexible adhesive cover can be provided over the apparatus when in use.

公开(公告)号：US10314892B2

公开(公告)日：2019-06-11

申请号：US15716259

申请日：2017-09-26

Applicant: Rani Therapeutics, LLC

Inventor： Mir Imran

IPC: A61K38/31 ,  A61K9/00 ,  A61M25/10 ,  A61M5/00 ,  A61K31/155 ,  A61M31/00 ,  A61K9/48

Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

公开(公告)号：US10307579B2

公开(公告)日：2019-06-04

申请号：US15832464

申请日：2017-12-05

Applicant: Rani Therapeutics, LLC

Inventor： Mir Imran

IPC: A61M5/00 ,  A61M37/00 ,  C07K16/18 ,  A61M25/10 ,  A61K38/27 ,  A61M29/02 ,  C07K16/28 ,  A61M31/00 ,  A61K9/48

Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

公开(公告)号：US10292601B2

公开(公告)日：2019-05-21

申请号：US15282570

申请日：2016-09-30

Applicant: EARLENS CORPORATION

Inventor： Rodney Perkins ,  William Facteau ,  Brent Edwards ,  Paul Rucker ,  Kulbir Sandhu ,  Cem Shaquer ,  Lakshman Rathnam

IPC: A61B5/0205 ,  A61B5/145 ,  H04R25/02 ,  A61B5/0488 ,  A61B5/1455 ,  A61N1/30 ,  A61B5/11 ,  A61B5/0452 ,  A61B5/0476 ,  A61M31/00 ,  A61B5/00 ,  A61B5/026 ,  A61B5/0408 ,  A61B5/0478 ,  A61B5/0492 ,  H04R25/00 ,  H04R1/02 ,  A61B5/021 ,  A61B5/024 ,  A61B5/08

Abstract: The present invention is directed to a wearable system wherein elements of the system, including various sensors adapted to detect biometric and other data and/or to deliver drugs, are positioned proximal to, on the ear or in the ear canal of a person. In embodiments of the invention, elements of the system are positioned on the ear or in the ear canal for extended periods of time. For example, an element of the system may be positioned on the tympanic membrane of a user and left there overnight, for multiple days, months, or years. Because of the position and longevity of the system elements in the ear canal, the present invention has many advantages over prior wearable biometric and drug delivery devices.

公开(公告)号：US10238868B2

公开(公告)日：2019-03-26

申请号：US15410712

申请日：2017-01-19

Applicant: Incube Labs, LLC

Inventor： Mir Imran

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/05 ,  A61N1/372

Abstract: A system for controlling urination in a patient includes an implantable controller and an external device. The implantable controller includes circuitry and electrodes for stimulating the pudenal nerves in order to control urination. In addition, the implantable controller includes sensors for determining information on bladder fullness and for transmitting such information to an external device which is used for controlling the implanted controller. The external device will display when bladder filling exceeds a safe threshold level, allowing the patient and a caregiver to take appropriate steps to allow the patient to urinate.