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16 条记录 (耗时 0.037 秒)

    Method of producing nanoparticle-in-oil dispersion
    11.
    发明授权
    Method of producing nanoparticle-in-oil dispersion 有权

    公开(公告)号：US10441935B2

    公开(公告)日：2019-10-15

    申请号：US15546462

    申请日：2016-01-17

    申请人： MIYAZAKI PREFECTURE

    发明人： Masataka Shimizu ,  Kenji Yamamoto ,  Shingo Hamayama

    IPC分类号： B01J13/00 ,  A61K9/107 ,  A61K8/04 ,  A61K9/10

    摘要： Provided is a method suitable for industrial-scale production of a dispersion in which nano-sized particles are dispersed. Specifically, a method for producing a nanoparticle-in-oil dispersion in which fine particles made up of a solid component, an aqueous liquid component or a mixture thereof are dispersed in an oil phase, includes: (1) a step of preparing a W/O emulsion-type precursor in which an aqueous phase in the form of droplets of an aqueous solution having a water-soluble substance dissolved therein is dispersed in an oil phase; and (2) a step of boiling the aqueous phase of the W/O emulsion-type precursor, to obtain a nanoparticle-in-oil dispersion in which the fine particles are dispersed in the oil phase.

    AGENT FOR INHIBITING PRODUCTION OF HEPATITIS C VIRUS AND ITS USE
    12.
    发明申请
    AGENT FOR INHIBITING PRODUCTION OF HEPATITIS C VIRUS AND ITS USE 有权
    禁止生产乙型肝炎病毒及其使用的药剂

    公开(公告)号：US20110288164A1

    公开(公告)日：2011-11-24

    申请号：US13204219

    申请日：2011-08-05

    申请人： Masahiko TAKESHITA ,  Hirohito TSUBOUCHI ,  Hirofumi UTO ,  Hiroaki KATAOKA ,  Takanori KAI ,  Hideaki HIRABARU ,  Miho SAKAI ,  Ena AKAMATSU

    发明人： Masahiko TAKESHITA ,  Hirohito TSUBOUCHI ,  Hirofumi UTO ,  Hiroaki KATAOKA ,  Takanori KAI ,  Hideaki HIRABARU ,  Miho SAKAI ,  Ena AKAMATSU

    IPC分类号： A61K31/353 ,  A61P31/14

    CPC分类号： A61K31/74 ,  A61K36/45 ,  C07D311/62

    摘要： This invention provides an agent for inhibiting production of hepatitis C virus with notable anti-HCV activity and without side-effects. The agent comprises a proanthocyanidin polymer composition illustrated in the following the general formula (1), wherein R1 is hydrogen or hydroxyl, R2 is hydroxyl, R3 is hydrogen when R1 is either hydrogen or hydroxyl, but R3 is possibly hydroxyl when R1 is either hydrogen or hydroxyl to the extent that both R1 and R3 being hydroxyl is at most 40 percents in the proanthocyanidin polymer composition said units of flavan-3-ol being bonded each other in any one of three patterns as follows; (i) a bond between carbon at the position 4 and carbon at the position 8, (ii) a bond between carbon at the position 4 and carbon at the position 6, (iii) a bond between carbon at the position 4 and carbon at the position 8, and between carbon, at the position 2 and oxygen at the position 7.

    摘要翻译： 本发明提供用于抑制具有显着的抗HCV活性并且没有副作用的丙型肝炎病毒生产的药剂。 该试剂包含如下通式（1）所示的原花青素聚合物组合物，其中R 1为氢或羟基，R 2为羟基，R 3为氢时，R 1为氢或羟基，但当R 1为氢时，R 3为羟基 或羟基，其中R 1和R 3为羟基在原花色素聚合物组合物中至多为40％的程度，所述黄烷-3-醇单元以如下三种模式中的任一种彼此结合; （i）位置4的碳和位置8的碳之间的键，（ii）位置4的碳与位置6的碳之间的键;（iii）位置4的碳与碳之间的键 位置8，碳之间，位置2和位置7处的氧。

    Method and apparatus for manufacturing low melting point metal fine particles
    13.
    发明授权
    Method and apparatus for manufacturing low melting point metal fine particles 有权
    制造低熔点金属微粒的方法和装置

    公开(公告)号：US07976608B2

    公开(公告)日：2011-07-12

    申请号：US11885677

    申请日：2005-03-09

    申请人： Kiyoshi Torigoe ,  Masataka Shimizu ,  Kenji Yamamoto ,  Mitsuhiro Mizozoe ,  Hoshiro Takahashi ,  Tomohide Suzuki ,  Motohiro Murase

    发明人： Kiyoshi Torigoe ,  Masataka Shimizu ,  Kenji Yamamoto ,  Mitsuhiro Mizozoe ,  Hoshiro Takahashi ,  Tomohide Suzuki ,  Motohiro Murase

    IPC分类号： B22F9/06

    CPC分类号： B22F9/08 ,  B22F2009/0808 ,  B23K35/0244 ,  B23K35/40

    摘要： In a solder paste which is a mixture of a flux and low melting point metal particles, low melting point metal fine particles manufactured by a conventional method or apparatus therefor include particles having widely varying particle diameters. Accordingly, the solder paste could not completely fill the minute holes in a mask for application to minute solder portions by printing, or mask removability was poor. According to the present invention, a mixture of a heat resistant continuous phase liquid and coarse metal particles in molten state is passed through a porous membrane to form the coarse low melting point metal particles into fine particles with a predetermined diameter. An apparatus according to the present invention comprise a porous membrane between a heating and dispersing mechanism and a cooling mechanism, and a pressure vessel connected to the heating and dispersing mechanism for applying a high pressure to the heating and dispersing mechanism.

    摘要翻译： 在焊剂和低熔点金属颗粒的混合物的焊膏中，通过常规方法或设备制造的低熔点金属微粒包括粒径变化很大的颗粒。 因此，焊膏不能完全填充掩模中的微孔，以通过印刷施加到微小的焊料部分，或者掩模可移除性差。 根据本发明，将耐热连续相液体和熔融状态的粗大金属粒子的混合物通过多孔膜，将粗低熔点金属粒子形成为规定直径的微粒。 根据本发明的装置包括加热和分散机构和冷却机构之间的多孔膜，以及连接到加热和分散机构的压力容器，用于向加热和分散机构施加高压。

    Method of preventing or treating liver disease
    15.
    发明申请
    Method of preventing or treating liver disease 审中-公开
    预防或治疗肝病的方法

    公开(公告)号：US20060094679A1

    公开(公告)日：2006-05-04

    申请号：US11208544

    申请日：2005-08-23

    申请人： Hirohito Tsubouchi ,  Satoru Hasuike

    发明人： Hirohito Tsubouchi ,  Satoru Hasuike

    IPC分类号： A61K48/00 ,  A61K38/17

    CPC分类号： A61K38/1709 ,  A61K48/00 ,  C07K14/575

    摘要： An object of the present invention is to provide a method of preventing or treating liver disease, particularly non-alcoholic fatty liver disease, hepatic fibrosis, cirrhosis, or liver cancer. The present invention is directed to a method of preventing or treating liver disease comprising administering to a patient in need thereof an effective amount of an osteoactivin-like protein or a fragment thereof having liver disease-suppressing activity similar to that of osteoactivin or a gene comprising a DNA encoding such a protein or fragment.

    摘要翻译： 本发明的目的是提供一种预防或治疗肝病，特别是非酒精性脂肪肝疾病，肝纤维化，肝硬化或肝癌的方法。 本发明涉及一种预防或治疗肝脏疾病的方法，包括向有需要的患者施用有效量的具有类似于骨质疏植蛋白的肝脏疾病抑制活性的类骨质疏松素样蛋白或其片段或包含 编码这种蛋白质或片段的DNA。