公开(公告)号：US07483141B2

公开(公告)日：2009-01-27

申请号：US11981941

申请日：2007-11-01

Applicant: Andrew J. Dosmann ,  Mohammad A. Kheiri

Inventor： Andrew J. Dosmann ,  Mohammad A. Kheiri

IPC: G01N21/47 ,  G01N21/55

CPC classification number: G01N21/474 ,  G01N21/3151 ,  G01N2021/478 ,  G01N2201/0642

Abstract: A glucose monitoring system comprising a readhead positioned a predetermined distance from a sample aperture. The readhead comprises first and second LEDs adapted to emit intersecting paths of light. A beam splitter is positioned at the intersection of the light paths. The beam splitter comprises a band pass filter for controlling the center wavelength of a resulting coaxial emitted light for illuminating a sample on the sample aperture. The readhead further comprises a detector which comprises a detector aperture and a molded lens over the detector aperture. A light-scattering section upstream of the lens comprises a plurality of steps having angles greater than 90 degrees to reduce internal stray light.

Abstract translation: 一种葡萄糖监测系统，包括位于距样本孔预定距离的读取头。 读取头包括适于发射相交光线的第一和第二LED。 分束器位于光路的交叉处。 分束器包括带通滤波器，用于控制所产生的同轴发射光的中心波长，用于照射样品孔上的样品。 读取头还包括检测器，其包括检测器孔和在检测器孔上的模制透镜。 透镜上游的光散射部分包括具有大于90度的角度的多个台阶以减少内部杂散光。

公开(公告)号：US07304743B2

公开(公告)日：2007-12-04

申请号：US10739227

申请日：2003-10-27

Applicant: Andrew J. Dosmann ,  Mohammad A. Kheiri

Inventor： Andrew J. Dosmann ,  Mohammad A. Kheiri

IPC: G01N21/47 ,  G01N21/55

CPC classification number: G01N21/474 ,  G01N21/3151 ,  G01N2021/478 ,  G01N2201/0642

Abstract: A glucose monitoring system comprising a readhead positioned a predetermined distance from a sample aperture. The readhead comprises first and second LEDs adapted to emit intersecting paths of light. A beam splitter is positioned at the intersection of the light paths. The beam splitter comprises a band pass filter for controlling the center wavelength of a resulting coaxial emitted light for illuminating a sample on the sample aperture. The readhead further comprises a detector which comprises a detector aperture and a molded lens over the detector aperture. A light-scattering section upstream of the lens comprises a plurality of steps having angles greater than 90 degrees to reduce internal stray light.

Abstract translation: 一种葡萄糖监测系统，包括位于距样本孔预定距离的读取头。 读取头包括适于发射相交光线的第一和第二LED。 分束器位于光路的交叉处。 分束器包括带通滤波器，用于控制所产生的同轴发射光的中心波长，用于照射样品孔上的样品。 读取头还包括检测器，其包括检测器孔和在检测器孔上的模制透镜。 透镜上游的光散射部分包括具有大于90度的角度的多个台阶以减少内部杂散光。

公开(公告)号：US07268881B2

公开(公告)日：2007-09-11

申请号：US10780278

申请日：2004-02-17

Applicant: David W. Larsen ,  Zhi Xu

Inventor： David W. Larsen ,  Zhi Xu

IPC: G01N21/00

CPC classification number: G01N30/74 ,  G01N21/0303 ,  G01N21/53 ,  G01N2030/847 ,  G01N2030/8494 ,  G01N2201/0642 ,  G01N21/47

Abstract: The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.

Abstract translation: 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器，使得光束在滤光片上的入射角近似于布鲁斯特角，并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元，并且参考单元包括透镜和球面镜，以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号，其以电压或电流模式工作，以减少采样信号中的光源噪声。

公开(公告)号：US07220389B2

公开(公告)日：2007-05-22

申请号：US10147826

申请日：2002-05-20

Applicant: Keiko Neriishi ,  Yuichi Hosoi ,  Katsuhiro Kohda ,  Masahiro Eto ,  Akifumi Kato ,  Kenji Nakajima

Inventor： Keiko Neriishi ,  Yuichi Hosoi ,  Katsuhiro Kohda ,  Masahiro Eto ,  Akifumi Kato ,  Kenji Nakajima

IPC: B01L11/00

CPC classification number: G01N23/04 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01L3/02 ,  B01L3/5085 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/168 ,  C40B60/14 ,  G01N21/0303 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/76 ,  G01N2201/0642

Abstract: The biochemical analysis unit has a base plate and absorptive regions. The absorptive regions are surrounded by the base plate formed of materials which shield a radioactive ray and a light. In the absorptive regions are applied and absorbed specific binding substances to be bound with substances derived from a living organism that are labeled with labeling substances for generating the radioactive ray or the light. The base plate prevents the specific binding substances from penetrating in the other absorptive regions. When an analysis of data of the radioactive ray and the light is carried out, an image of the radioactive ray and the light is generated without noises.

Abstract translation: 生化分析装置具有底板和吸收区。 吸收区被由屏蔽放射线和光的材料形成的基板包围。 在吸收区域中应用和吸收的特定结合物质与被生物体标记的生物体衍生的物质结合，以产生放射线或光。 底板防止特定的结合物质渗入另一个吸收区域。 当进行放射线和光的数据分析时，产生放射线和光的图像而没有噪声。

公开(公告)号：US07190445B2

公开(公告)日：2007-03-13

申请号：US11165129

申请日：2005-06-24

Applicant: Arthur E. Colvin, Jr. ,  Steven J. Walters

Inventor： Arthur E. Colvin, Jr. ,  Steven J. Walters

IPC: G01J1/42 ,  G01N21/01

CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2201/0642

Abstract: An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.

Abstract translation: 用于确定分析物的存在或浓度的光学传感器装置包含设置在光源上的波导和安装在基板的表面上并由内部挡板隔开的光检测器，其中波导具有对应于远的 由光源和光检测器之间的遮光挡板确定的光源的场发射点。 分析物指示矩阵设置在波导的外表面上。 传感器装置的几何形状仅利用指示矩阵的直接照明，并且直接收集指示矩阵照明，而不会被所述波导的任何明显的反射。 由光源产生的不良光线噪声通过波导直接从器件中流出。

公开(公告)号：US20050237518A1

公开(公告)日：2005-10-27

申请号：US11165129

申请日：2005-06-24

Applicant: Arthur Colvin ,  Steven Walters

Inventor： Arthur Colvin ,  Steven Walters

IPC: G01N21/64 ,  G01N21/77 ,  G01J1/42

CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2201/0642

Abstract: An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.

公开(公告)号：US20050179904A1

公开(公告)日：2005-08-18

申请号：US10780278

申请日：2004-02-17

Applicant: David Larsen ,  Zhi Xu

Inventor： David Larsen ,  Zhi Xu

IPC: G01N21/00 ,  G01N21/03 ,  G01N21/53 ,  G01N30/74 ,  G01N30/84

CPC classification number: G01N30/74 ,  G01N21/0303 ,  G01N21/53 ,  G01N2030/847 ,  G01N2030/8494 ,  G01N2201/0642 ,  G01N21/47

Abstract: The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.

Abstract translation: 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器，使得光束在滤光片上的入射角近似于布鲁斯特角，并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元，并且参考单元包括透镜和球面镜，以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号，其以电压或电流模式工作，以减少采样信号中的光源噪声。

公开(公告)号：US20050134853A1

公开(公告)日：2005-06-23

申请号：US11016033

申请日：2004-12-17

Applicant: Alan Ingleson ,  David Slocum ,  Michael Brill

Inventor： Alan Ingleson ,  David Slocum ,  Michael Brill

IPC: G01J3/50 ,  G01N21/25 ,  G01N21/27 ,  G01N21/57 ,  G06T7/40 ,  G01J3/46

CPC classification number: G01N21/255 ,  G01J3/0251 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/50 ,  G01N21/274 ,  G01N21/57 ,  G01N2201/0642 ,  G01N2201/065 ,  G06T7/90

Abstract: Systems, methodologies, media, and other embodiments associated with color measuring are described. One exemplary system embodiment includes a spectrophotometer, one or more light sources for illuminating an interior of the spectrophotometer, and a digital camera configured at a port of the spectrophotometer and being configured to measure light components from a sample. In the present invention, segmentation logic is provided for the spectrophotometer that is configured to employ computational image segmentation to characterize specular reflection from a sample and to characterize a selected patch or portion from the test sample, such as a selected color in a multicolor pattern. In accordance with the present invention, the spectrophotometer and the included digital camera may be color-characterized in situ.

Abstract translation: 描述了与颜色测量相关联的系统，方法，介质和其它实施例。 一个示例性系统实施例包括分光光度计，用于照亮分光光度计内部的一个或多个光源，以及配置在分光光度计的端口处并被配置为测量来自样品的光分量的数字照相机。 在本发明中，为分光光度计提供分割逻辑，其被配置为采用计算图像分割来表征来自样本的镜面反射并且从所述测试样品（例如多色图案中的所选颜色）表征所选择的贴片或部分。 根据本发明，分光光度计和所附的数码相机可以原位进行颜色表征。

公开(公告)号：US20040090615A1

公开(公告)日：2004-05-13

申请号：US10739227

申请日：2003-10-27

Inventor： Andrew J. Dosmann ,  Mohammad A. Kheiri

IPC: G01N033/48

CPC classification number: G01N21/474 ,  G01N21/3151 ,  G01N2021/478 ,  G01N2201/0642

Abstract: A glucose monitoring system comprising a readhead positioned a predetermined distance from a sample aperture. The readhead comprises first and second LEDs adapted to emit intersecting paths of light. A beam splitter is positioned at the intersection of the light paths. The beam splitter comprises a band pass filter for controlling the center wavelength of a resulting coaxial emitted light for illuminating a sample on the sample aperture. The readhead further comprises a detector which comprises a detector aperture and a molded lens over the detector aperture. A light-scattering section upstream of the lens comprises a plurality of steps having angles greater than 90 degrees to reduce internal stray light.

Abstract translation: 一种葡萄糖监测系统，包括位于距样本孔预定距离的读取头。 读取头包括适于发射相交光线的第一和第二LED。 分束器位于光路的交叉处。 分束器包括带通滤波器，用于控制所产生的同轴发射光的中心波长，用于照射样品孔上的样品。 读取头还包括检测器，其包括检测器孔和在检测器孔上的模制透镜。 透镜上游的光散射部分包括具有大于90度的角度的多个台阶以减少内部杂散光。

公开(公告)号：US06664113B2

公开(公告)日：2003-12-16

申请号：US10126629

申请日：2002-04-22

Applicant: Yoshifumi Kurihara ,  Toshinori Hayashi ,  Juichi Saitoh ,  Takahiko Ishiguro

Inventor： Yoshifumi Kurihara ,  Toshinori Hayashi ,  Juichi Saitoh ,  Takahiko Ishiguro

IPC: G01N2164

CPC classification number: G01N21/6452 ,  G01N2201/0642 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A method for detecting fluorescence from a liquid sample housed in a transparent or translucent sample container includes providing a sample container in a sample holder, which is opaque except for a sample container introduction opening and incoming and outgoing openings for excitation light; layering a liquid sample and a shielding liquid unmixable therewith to prevent external light from entering through the sample container introduction opening; introducing excitation light from such a direction that the excitation light can irradiate the liquid sample before irradiating the shielding liquid; and detecting fluorescence, which emits in a direction of avoiding absorption by the shielding liquid.

Abstract translation: 用于检测容纳在透明或半透明样品容器中的液体样品的荧光的方法包括：将样品容器放置在样品保持器中，样品容器除了样品容器引入开口和用于激发光的入射和出射开口外是不透明的; 层叠液体样品和与其不可混合的屏蔽液体，以防止外部光线通过样品容器引入口; 在照射所述屏蔽液体之前，从所述激发光可以照射所述液体样品的方向引入激发光; 并检测荧光，其沿避开被屏蔽液体吸收的方向发射。