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公开(公告)号：US20180144916A1
公开(公告)日：2018-05-24
申请号：US15578990
申请日：2016-06-01
申请人： Micromass UK Limited
IPC分类号： H01J49/00
CPC分类号： H01J49/0009 , H01J49/0004 , H01J49/0036
摘要： A method of calibrating or optimising an analytical instrument is disclosed that comprises analysing analyte from a sample using an analytical instrument, determining a sample type of the sample based on analysis of analyte from the sample, identifying one or more species of the analyte that are known to be endogenous to the determined sample type, and calibrating or optimising the analytical instrument using the one or more identified endogenous species.
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公开(公告)号：US09928999B2
公开(公告)日：2018-03-27
申请号：US15317049
申请日：2015-06-11
申请人： Micromass UK Limited
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed comprising digitising at least one individual signal or transient, determining in relation to the digitized signal or transient an indication of overlap and/or coalescence of ion arrivals in the digitized signal or transient, or one or more ion arrival envelopes in the digitized signal or transient, and marking or flagging the digitized signal or transient as suffering from overlap or coalescence of ion arrivals based on the indication.
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公开(公告)号：US09818589B2
公开(公告)日：2017-11-14
申请号：US15410327
申请日：2017-01-19
申请人： Micromass UK Limited
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/401
摘要： A method of analyzing ions is disclosed comprising: (i) separating ions according to a physico-chemical property in a separator; (ii) transmitting ions which emerge from the separator through a transfer device with a first transit time t1, energizing a pusher electrode or orthogonal acceleration electrode and obtaining first data; (iii) transmitting ions which subsequently emerge from the separator through the transfer device with a second greater transit time t2, energizing the pusher electrode or orthogonal acceleration electrode and obtaining second data; and (iv) repeating steps (ii) and (iii) one or more times. The pusher electrode or orthogonal acceleration electrode is energized with a period t3, wherein t2−t1 is arranged to equal t3/2. The first and second data are combined to form a composite data set.
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公开(公告)号：US20170250062A1
公开(公告)日：2017-08-31
申请号：US15125350
申请日：2015-03-10
申请人： Micromass UK Limited
CPC分类号： H01J49/0036 , G01N27/622 , H01J49/0031 , H01J49/004 , H01J49/005
摘要： A method of mass spectrometry is disclosed comprising experimentally determining or measuring one or more first ion mobility values, collision cross sections or interaction cross sections collision cross sections or first ion mobility parameters and one or more mass or mass to charge ratios of one or more analyte ions, generating a first list of possible candidate compounds which correspond to said one or more analyte ions on the basis of the one or more determined or measured masses or mass to charge ratios, and calculating, estimating or determining one or more second ion mobility values, collision cross sections or interaction cross sections collision cross sections or second ion mobility parameters of at least some of the candidate compounds in the first list. The method further comprises a step of either: (i) generating a second reduced list of possible candidate compounds by filtering or removing candidate compounds from the first list if the difference between said one or more experimentally determined or measured first ion mobility values, collision cross sections or interaction cross sections collision cross sections or first ion mobility parameters and the one or more calculated, estimated or determined second ion mobility values, collision cross sections or interaction cross sections collision cross sections or second ion mobility parameters is greater than a predetermined amount; and/or (ii) reducing a likelihood value associated with one or more possible candidate compounds in the first list if the difference between said one or more experimentally determined or measured first ion mobility values, collision cross sections or interaction cross sections collision cross sections or first ion mobility parameters and the one or more calculated, estimated or determined second ion mobility values, collision cross sections or interaction cross sections collision cross sections or second ion mobility parameters is greater than a predetermined amount.
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公开(公告)号：US09721780B2
公开(公告)日：2017-08-01
申请号：US14847574
申请日：2015-09-08
申请人： Micromass UK Limited
发明人： Keith Richardson
CPC分类号： H01J49/401 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/40
摘要： A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a Time of Flight mass analyzer are controlled by attenuating ions which would otherwise be transmitted to the Time of Flight mass analyzer and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity.
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公开(公告)号：US20170133211A1
公开(公告)日：2017-05-11
申请号：US15410327
申请日：2017-01-19
申请人： Micromass UK Limited
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/401
摘要： A method of analysing ions is disclosed comprising: (i) separating ions according to a physico-chemical property in a separator; (ii) transmitting ions which emerge from the separator through a transfer device with a first transit time t1, energising a pusher electrode or orthogonal acceleration electrode and obtaining first data; (iii) transmitting ions which subsequently emerge from the separator through the transfer device with a second greater transit time t2, energising the pusher electrode or orthogonal acceleration electrode and obtaining second data; and (iv) repeating steps (ii) and (iii) one or more times. The pusher electrode or orthogonal acceleration electrode is energised with a period t3, wherein t2−t1 is arranged to equal t3/2. The first and second data are combined to form a composite data set.
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公开(公告)号：US20170131238A1
公开(公告)日：2017-05-11
申请号：US15125363
申请日：2015-03-10
申请人： Micromass UK Limited
CPC分类号： H01J49/0036 , G01N27/622 , H01J49/0031 , H01J49/004 , H01J49/005
摘要： A method of identifying ions or confirming the identity of ions is disclosed comprising determining a physico-chemical or other property of first ions under first conditions, determining the physico-chemical or other property of the first ions or second ions derived from the first ions under second different conditions, and identifying or confirming the identity of the first ions or determining a class of the first or the second ions on the basis of the physico-chemical or other property of the first ions as determined under the first conditions and on the basis of the physico-chemical or other property of the first ions or second ions derived from the first ions as determined under the second conditions.
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公开(公告)号：US20170011899A1
公开(公告)日：2017-01-12
申请号：US15301172
申请日：2015-04-01
申请人： Micromass UK Limited
CPC分类号： H01J49/0036 , G01N27/622 , H01J49/0031 , H01J49/0045 , H01J49/40
摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises: providing a plurality of species of ions; analysing the ions during a plurality of sequential acquisition periods so as to obtain spectral data relating to the ions; varying the value of an operational parameter of the spectrometer such that it has different values during the different acquisition periods, wherein the spectral data obtained for a given ion varies depending on the value of the operational parameter; storing the spectral data obtained during the different acquisition periods separately; selecting a target ion; and then interrogating the spectral data so as to identify a set of first acquisition periods that include data corresponding to said target ion. Selecting spectral data from only a subset of the first acquisition periods allows the selection of the optimal spectral data for the target ion, whilst discarding less optimal data.
摘要翻译： 公开了一种质谱法或离子迁移光谱法。 该方法包括：提供多种离子; 在多个顺序采集周期期间分析离子，以便获得与离子有关的光谱数据; 改变光谱仪的操作参数的值，使得其在不同采集周期期间具有不同的值，其中为给定离子获得的光谱数据根据操作参数的值而变化; 分别存储在不同采集周期期间获得的光谱数据; 选择目标离子; 然后询问光谱数据，以便识别包括对应于所述目标离子的数据的一组第一采集周期。 从第一采集周期的子集中选择光谱数据允许选择目标离子的最佳光谱数据，同时丢弃较不优化的数据。
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129.发明申请Data Dependent Control of the Intensity of Ions Separated in Multiple Dimensions 有权多维分离离子强度的数据依赖性控制公开(公告)号：US20160035551A1
公开(公告)日：2016-02-04
申请号：US14774981
申请日：2014-03-14
申请人： MICROMASS UK LIMITED
CPC分类号： H01J49/0036 , H01J49/0031 , H01J49/40 , H01J49/4215
摘要： A method of mass spectrometry is disclosed comprising setting an attenuation factor of an attenuation device to a first value and then separating or filtering ions according to a first physico-chemical property and separating or filtering ions according to a second physico-chemical property and obtaining a multi-dimensional array of data. The most intense ion peak within one or more subsets of the multi-dimensional array of data is determined. If it is determined that the most intense ion peak would cause saturation of an ion detector or ion detection system then the method further comprises adjusting the attenuation factor of the attenuation device to a second value and obtaining mass spectral data wherein the adjustment of the attenuation factor substantially alters the intensity of all ions which are detected by the ion detector or ion detection system equally and irrespective of the mass to charge ratio of the ions. The intensity of the mass spectral data is then scaled based upon the degree to which the attenuation factor of the attenuation device was increased or reduced.
摘要翻译： 公开了一种质谱方法，其包括将衰减装置的衰减因子设定为第一值，然后根据第一物理化学性质分离或过滤离子，并根据第二物理化学性质分离或过滤离子，并获得 数据的多维数组。 确定多维数据阵列的一个或多个子集内的最强离子峰。 如果确定最强离子峰将导致离子检测器或离子检测系统的饱和，则该方法还包括将衰减器件的衰减因子调整到第二值并获得质谱数据，其中调整衰减因子 基本上改变由离子检测器或离子检测系统检测到的所有离子的强度，并且与离子的质荷比无关。 然后基于衰减装置的衰减因子增加或减小的程度来缩放质谱数据的强度。
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公开(公告)号：US20160035548A1
公开(公告)日：2016-02-04
申请号：US14774756
申请日：2014-03-10
申请人： MICROMASS UK LIMITED
发明人： Jeffery Mark Brown , Kevin Giles , Martin Raymond Green , John Brian Hoyes , Christopher Jones , Michael Raymond Morris , Steven Derek Pringle , Keith Richardson , Farnoush Salarzaei , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/005 , G01N27/622 , H01J49/0031 , H01J49/0045 , H01J49/0072
摘要： A method of mass spectrometry is disclosed comprising:performing a survey scan of a plurality of different types of parent or precursor ions, wherein said survey scan comprises analysing the ion mobilities of the ions and mass analysing the ions;determining the charge states of parent or precursor ions analysed in the survey scan based on their determined combinations of ion mobility and mass to charge ratio;selecting a parent or precursor ion for fragmentation or reaction; andfragmenting or reacting said selected ion, wherein the fragmentation or reaction conditions are selected from a plurality of different fragmentation or reaction conditions based upon the determined charge state of the selected ion.
摘要翻译： 公开了一种质谱方法，包括：对多种不同类型的母体或前体离子进行测量扫描，其中所述测量扫描包括分析离子的离子迁移率和大量分析离子; 基于它们确定的离子迁移率和质荷比的组合来确定在测量扫描中分析的母体或前体离子的电荷状态; 选择母体或前体离子进行碎裂或反应; 并且使所述选择的离子断裂或反应，其中基于所选离子的确定的电荷状态，所述断裂或反应条件选自多个不同的断裂或反应条件。
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