公开(公告)号：US20060273794A1

公开(公告)日：2006-12-07

申请号：US11147716

申请日：2005-06-07

申请人： Carlos Meriles

发明人： Carlos Meriles

IPC分类号： G01V3/00

CPC分类号： G01R33/0385 ,  G01Q60/52 ,  G01R33/281 ,  G01R33/282 ,  G01R33/323 ,  G01R33/44

摘要： A probe, device, and methods for performing nuclear magnetic resonance (NMR) measurements on a suitable sample are provided. The probe includes a hyperpolarized tip positioned to cause a dipolar interaction between the tip and sample. The nuclear magnetic spin of a selected portion of the sample induces a modulation of tip magnetization, which is proportional to the local magnetization of the selected portion. An NMR device includes the probe, a radio frequency (RF) coil for manipulating spins in the sample and tip, and a means for detecting the modulation of tip magnetization. An RF pulse sequence selects the selected portion and allows detection of the modulation. The method for obtaining NMR data includes positioning the tip to induce the dipolar interaction; selecting the sample portion; modulating the tip magnetization in response thereto; and detecting the tip modulation. The device and method may be adapted to obtain NMR images and spectroscopy.

摘要翻译： 提供了用于在合适样品上进行核磁共振（NMR）测量的探针，装置和方法。 探针包括一个超极化尖端，其位于尖端和样品之间的偶极相互作用。 样品的选定部分的核磁自旋引起尖端磁化的调制，其与所选择的部分的局部磁化成正比。 NMR装置包括探针，用于操纵样品和尖端中的自旋的射频（RF）线圈，以及用于检测尖端磁化的调制的装置。 RF脉冲序列选择所选择的部分并允许检测调制。 获得NMR数据的方法包括定位尖端以引起偶极相互作用; 选择样品部分; 响应于此调制尖端磁化强度; 并检测尖端调制。 该装置和方法可以适于获得NMR图像和光谱。

公开(公告)号：US20050177042A1

公开(公告)日：2005-08-11

申请号：US10517102

申请日：2003-06-05

申请人： Takayuki Abe ,  Shigeru Watanabe

发明人： Takayuki Abe ,  Shigeru Watanabe

IPC分类号： A61B5/055 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/05 ,  A61B6/00

CPC分类号： G01R33/563 ,  A61B5/055 ,  G01R33/281 ,  G01R33/56308

摘要： An MRI apparatus having a pulse sequence of dynamic MRA performs a pulse sequence for monitoring arrival of a contrast agent at a blood vessel of interest. The pulse sequence is substantially the same as the imaging sequence except that the phase-encode number and/or the slice-encode number is small. A time-series image reconstructed by using data measured under the condition of applying gradient magnetic fields with a low spatial resolution is displayed to ascertain that the contrast agent has arrived at the blood vessel of interest. When the contrast agent arrives at the blood vessel of interest, the phase-encode and slice-encode are added to continue the substantial measurement pulse sequence without changing the pulse sequence itself. The first image of the substantial measurement is produced by using the data acquired at the time of arrival of the contrast agent in monitoring. Thus, the arrival time of the contrast agent can be reliably monitored with high time-resolution and the substantial measurement can be performed with most suitable timing to obtain an excellent blood vessel image.

摘要翻译： 具有动态MRA的脉冲序列的MRI装置执行用于监视造影剂到感兴趣的血管的到达的脉冲序列。 除了相位编码数和/或片编码数小之外，脉冲序列与成像序列基本相同。 显示通过使用在施加具有低空间分辨率的梯度磁场的条件下测量的数据重建的时间序列图像，以确定造影剂已到达感兴趣的血管。 当造影剂到达感兴趣的血管时，添加相位编码和切片编码以继续实质的测量脉冲序列而不改变脉冲序列本身。 通过使用在造影剂到达时获取的数据进行监测来产生实质测量的第一图像。 因此，可以以高时间分辨率可靠地监视造影剂的到达时间，并且可以以最合适的时间进行实质测量以获得优异的血管图像。

公开(公告)号：US06903548B2

公开(公告)日：2005-06-07

申请号：US10605703

申请日：2003-10-21

申请人： Thomas K. F. Foo

发明人： Thomas K. F. Foo

IPC分类号： G01R33/28 ,  A61B5/055 ,  G01R33/48 ,  G01R33/54 ,  G01R33/563 ,  G01R33/567 ,  G01V3/00

CPC分类号： G01R33/56366 ,  G01R33/281 ,  G01R33/56308

摘要： A non-selective saturation pulse together with a series of notched RF saturation pulses are used to acquire MR perfusion data. The non-selective saturation recovery RF pulse is non-selective and is designed to be effective at blood pool suppression for a first slice as well as a next slice in a series of slice locations. The first slice. location may be placed at an angle or plane that is not necessarily coaxial with the other slice locations to be imaged. The present invention supports the acquisition of MR data with efficient spatial coverage and a calibration slice of data that provides a linear measure of signal intensity versus contrast concentration in a blood pool.

摘要翻译： 使用非选择性饱和脉冲和一系列缺陷RF饱和脉冲来获取MR灌注数据。 非选择性饱和恢复RF脉冲是非选择性的，并且被设计为对于第一切片的血液池抑制以及一系列切片位置中的下一切片有效。 第一片。 位置可以放置在不一定与要成像的其它切片位置同轴的角度或平面上。 本发明支持采用有效空间覆盖的MR数据采集和数据的校准切片，其提供信号强度对血液浓度对比浓度的线性测量。

公开(公告)号：US06867591B2

公开(公告)日：2005-03-15

申请号：US10741610

申请日：2003-12-19

申请人： Ian Nelson

发明人： Ian Nelson

IPC分类号： G01R33/28 ,  G01R33/58 ,  G01V3/00

CPC分类号： G01R33/583 ,  G01R33/281

摘要： A device for simulating a sample of gas having a specific level of polarization when measured by a NMR pickup coil includes an active circuit loosely coupled to the NMR pickup coil. The active circuit responds as a hyperpolarized gas having the specific level of polarization when measured by the NMR pickup coil.

摘要翻译： 一种用于模拟具有特定极化水平的气体样本的装置，其通过NMR拾取线圈测量时包括松散耦合到NMR拾取线圈的有源电路。 当由NMR拾取线圈测量时，有源电路作为具有特定极化水平的超极化气体作出响应。

公开(公告)号：US20050033159A1

公开(公告)日：2005-02-10

申请号：US10485433

申请日：2001-03-16

申请人： Charles Mistretta ,  Yousef Tehrani ,  Timothy Carroll ,  Jiang Du

发明人： Charles Mistretta ,  Yousef Tehrani ,  Timothy Carroll ,  Jiang Du

IPC分类号： G01R33/28 ,  A61B5/055 ,  G01R33/54 ,  G01R33/563 ,  A61B5/05

CPC分类号： G01R33/563 ,  G01R33/281

摘要： A magnetic resonance angiogram (MRA) is acquired using a contrast enhancement method in which a series of NMR images are rapidly acquired during a time resolved phase of the examination in which the contrast bolus makes a first pass through the arteries and veins. Arterial and venous voxels are automatically identified in the images using either of two disclosed methods. The signals from identified arterial voxels are used to produce an arterial contrast enhancement reference curve that is used to segment arterial voxels by a correlation process. Venous voxels are segmented in the same manner using a calculated venous contrast enhancement reference curve.

摘要翻译： 使用对比度增强方法获得磁共振血管造影（MRA），其中在检查的时间分辨阶段期间快速获取一系列NMR图像，其中对比剂推注首先通过动脉和静脉。 使用两种公开的方法之一，在图像中自动识别动脉和静脉体素。 来自确定的动脉体素的信号用于产生用于通过相关过程分割动脉体素的动脉造影增强参考曲线。 使用计算的静脉造影增强参考曲线以相同的方式分割静脉体素。

公开(公告)号：US20040210129A1

公开(公告)日：2004-10-21

申请号：US10795044

申请日：2004-03-05

发明人： Stephen J. Riederer ,  David G. Kruger ,  Ananth J. Madhuranthakam

IPC分类号： A61B005/055

CPC分类号： G01R33/4824 ,  G01R33/281 ,  G01R33/561 ,  G01R33/5619 ,  G01R33/56308 ,  G01R33/56375

摘要： MRA data is acquired from an extended field of view by translating the patient through the bore of the MRI system as three-dimensional MRA data sets are acquired and time-resolved images reconstructed. The leading edge of a contrast bolus can be tracked in these images and parameters such as bolus velocity and bolus arrival time can be calculated to provide functional information in addition to anatomical information. Temporal resolution is improved by undersampling peripheral k-space and sampling the center of k-space at a higher temporal rate.

摘要翻译： 通过在获取三维MRA数据集并重建时间分辨图像的情况下通过MRI系统的孔翻译患者，从扩展视野获取MRA数据。 可以在这些图像中跟踪造影剂的前沿，并且可以计算参数，例如推注速度和推注到达时间，以提供除了解剖信息之外的功能信息。 通过对外围k空间进行欠采样并以更高的时间速率对k空间的中心进行采样来改进时间分辨率。

公开(公告)号：US06807441B2

公开(公告)日：2004-10-19

申请号：US09861220

申请日：2001-05-18

申请人： Kathleen M. Schmainda

发明人： Kathleen M. Schmainda

IPC分类号： A61B503

CPC分类号： G01R33/5615 ,  A61B5/055 ,  G01R33/281 ,  G01R33/50

摘要： Two sets of time course NMR data are acquired using an EPI pulse sequence in which both gradient recalled echo NMR signals and spin-echo NMR signals are acquired after bolus injection of a contrast agent. The gradient-echo signals and spin-echo NMR signals are employed to calculate rCBV maps which are corrected for contrast leakage and used as a measure of tumor angiogenesis. Both the gradient echo and spin echo signals are employed to calculate a &Dgr;R2 weighting ratio which is also a measure of tumor angiogenesis.

摘要翻译： 使用EPI脉冲序列获取两组时程NMR数据，其中在推注造影剂之后获得梯度回波NMR信号和自旋回波NMR信号。 梯度回波信号和自旋回波NMR信号用于计算校正对比渗漏的rCBV图，并用作肿瘤血管生成的量度。 采用梯度回波和自旋回波信号来计算DeltaR2加权比，其也是肿瘤血管生成的量度。

公开(公告)号：US20040143449A1

公开(公告)日：2004-07-22

申请号：US10734655

申请日：2003-12-11

申请人： Mirada Solutions Limited

发明人： Christian Peter Behrenbruch ,  John Michael Brady ,  Jerome Marie Joseph Declerck

IPC分类号： G06F017/60

CPC分类号： G06F19/3468 ,  A61B5/055 ,  G01R33/281 ,  G06F19/321 ,  G06T7/0012

摘要： A processing system which comprises a processing apparatus and a processing agent which is administered to a processing subject. The processing agent has a primary behaviour which provides the desired process result in conjunction with the apparatus, but also has a distinctive signature characteristic which is detected by test functionality in the processing system. The behaviour of the processing system can be modified in response to the test result. In an example such as a contrast enhanced medical imaging, the full functionality of the imaging equipment may be available only if a contrast agent having the particular distinctive signature characteristic is used, thus tying use of the apparatus to use of a particular agent.

摘要翻译： 一种处理系统，包括对处理对象施加的处理装置和处理剂。 处理代理具有与设备一起提供期望的处理结果的主要行为，而且具有由处理系统中的测试功能检测到的特征性特征。 可以根据测试结果修改处理系统的行为。 在诸如对比度增强的医学成像的例子中，成像设备的全部功能仅在使用具有特定特征性特征的造影剂时可用，因此使用该装置来使用特定的药剂。

公开(公告)号：US06754521B2

公开(公告)日：2004-06-22

申请号：US10375825

申请日：2003-02-27

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61B5055

CPC分类号： A61K49/18 ,  A61B5/201 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308 ,  G01R33/5635

摘要： The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

摘要翻译： 本发明是一种通过将磁共振对比度增强的动脉期期间的磁共振对比度图像的预定部分数据的收集相关联来提供相对于相邻静脉和背景组织的感兴趣的动脉的优先增强的技术和装置 。 对比度增强的动脉期可以描述为相对于相邻静脉的感兴趣动脉中的最大，基本升高或升高的对比浓度的周期。 本发明包括用于监测和检测造影剂到动脉和感兴趣组织的检测系统。 当感兴趣区域的动脉中的造影剂的浓度最大时，基本升高或升高（例如，在给予磁性之前一系列磁共振脉冲的感兴趣区域的响应大约20-50％ 共振造影剂），可以获取磁共振图像数据的预定部分（例如，表示k空间的中心的数据）。 因此，本发明有助于将k空间图像数据的中心部分与对比度增强的动脉相位之间的同步。 k空间的中心对应于支配图像对比度的最低空间频率数据。

公开(公告)号：US20040061496A1

公开(公告)日：2004-04-01

申请号：US10606933

申请日：2003-06-27

发明人： Masashi Ookawa

IPC分类号： G01V003/00

CPC分类号： G01R33/563 ,  G01R33/281 ,  G01R33/5611 ,  G01R33/56308

摘要： Magnetic resonance imaging uses a pulse sequence formed to include a pre-pulse, an RF excitation pulse, an encoding gradient pulse, and a reading gradient pulse. The encoding gradient pulse has an encoding amount determined to allow a data acquisition position in a k-space to be directed outward from a center of the k-space. A train of pulses including the RF excitation pulse, the encoding gradient pulse, and the reading gradient pulse is repeated to allow the number of times of data acquisition in the k-space to become larger as approaching to a central region of the k-space. The pre-pulse is formed to be reduced in an application rate to the RF excitation pulse as approaching to an outward position in the k-space. By way of example, this pulse sequence is used for contrast enhanced MRA carried out under a dynamic scan.

摘要翻译： 磁共振成像使用形成为包括预脉冲，RF激励脉冲，编码梯度脉冲和读取梯度脉冲的脉冲序列。 编码梯度脉冲具有被确定为允许k空间中的数据获取位置从k空间的中心向外指向的编码量。 重复包括RF激励脉冲，编码梯度脉冲和读取梯度脉冲的一串脉冲，以允许k空间中的数据采集次数随着接近k空间的中心区域而变大 。 形成预脉冲以在接近k空间中的向外位置时以RF激励脉冲的施加速率减小。 作为示例，该脉冲序列用于在动态扫描下进行的造影增强MRA。