公开(公告)号：US07199584B2

公开(公告)日：2007-04-03

申请号：US11147716

申请日：2005-06-07

申请人： Carlos Meriles

发明人： Carlos Meriles

IPC分类号： G01V3/00

CPC分类号： G01R33/0385 ,  G01Q60/52 ,  G01R33/281 ,  G01R33/282 ,  G01R33/323 ,  G01R33/44

摘要： A probe, device, and methods for performing nuclear magnetic resonance (NMR) measurements on a suitable sample are provided. The probe includes a hyper polarized tip positioned to cause a dipolar interaction between the tip and sample. The nuclear magnetic spin of a selected portion of the sample induces a modulation of tip magnetization, which is proportional to the local magnetization of the selected portion. An NMR device includes the probe, a radio frequency (RF) coil for manipulating spins in the sample and tip, and a means for detecting the modulation of tip magnetization. An RF pulse sequence selects the selected portion and allows detection of the modulation. The method for obtaining NMR data includes positioning the tip to induce the dipolar interaction; selecting the sample portion; modulating the tip magnetization in response thereto; and detecting the tip modulation. The device and method may be adapted to obtain NMR images and spectroscopy.

摘要翻译： 提供了用于在合适样品上进行核磁共振（NMR）测量的探针，装置和方法。 探针包括超极化尖端，定位成引起尖端和样品之间的偶极相互作用。 样品的选定部分的核磁自旋引起尖端磁化的调制，其与所选择的部分的局部磁化成正比。 NMR装置包括探针，用于操纵样品和尖端中的自旋的射频（RF）线圈，以及用于检测尖端磁化的调制的装置。 RF脉冲序列选择所选择的部分并允许检测调制。 获得NMR数据的方法包括定位尖端以引起偶极相互作用; 选择样品部分; 响应于此调制尖端磁化强度; 并检测尖端调制。 该装置和方法可以适于获得NMR图像和光谱。

公开(公告)号：US20070194788A1

公开(公告)日：2007-08-23

申请号：US11625209

申请日：2007-01-19

申请人： Alexander Pines ,  Daniel Topgaard ,  Dimitrios Sakellariou ,  Rachel Martin ,  Carlos Meriles

发明人： Alexander Pines ,  Daniel Topgaard ,  Dimitrios Sakellariou ,  Rachel Martin ,  Carlos Meriles

IPC分类号： G01V3/00

CPC分类号： G01R33/36 ,  G01R33/3808 ,  G01R33/385 ,  G01R33/445 ,  G01R33/4616 ,  G01R33/56563

摘要： Methods and systems for compensating for static magnetic field inhomogeneities during nuclear magnetic resonance detection are disclosed. Application of radio frequency pulses and/or magnetic field gradients may be used to correct for spin dephasing caused by the inhomogeneities. The methods and system may be used to improve signal-to-noise ratios in NMR and MRI systems where magnetic field inhomogeneity may have an effect.

摘要翻译： 公开了用于在核磁共振检测期间补偿静态磁场不均匀性的方法和系统。 可以使用射频脉冲和/或磁场梯度来校正由不均匀性引起的自旋去相位。 该方法和系统可用于提高NMR和MRI系统中的磁场不均匀性可能具有影响的信噪比。

公开(公告)号：US20060273794A1

公开(公告)日：2006-12-07

申请号：US11147716

申请日：2005-06-07

申请人： Carlos Meriles

发明人： Carlos Meriles

IPC分类号： G01V3/00

CPC分类号： G01R33/0385 ,  G01Q60/52 ,  G01R33/281 ,  G01R33/282 ,  G01R33/323 ,  G01R33/44

摘要： A probe, device, and methods for performing nuclear magnetic resonance (NMR) measurements on a suitable sample are provided. The probe includes a hyperpolarized tip positioned to cause a dipolar interaction between the tip and sample. The nuclear magnetic spin of a selected portion of the sample induces a modulation of tip magnetization, which is proportional to the local magnetization of the selected portion. An NMR device includes the probe, a radio frequency (RF) coil for manipulating spins in the sample and tip, and a means for detecting the modulation of tip magnetization. An RF pulse sequence selects the selected portion and allows detection of the modulation. The method for obtaining NMR data includes positioning the tip to induce the dipolar interaction; selecting the sample portion; modulating the tip magnetization in response thereto; and detecting the tip modulation. The device and method may be adapted to obtain NMR images and spectroscopy.

摘要翻译： 提供了用于在合适样品上进行核磁共振（NMR）测量的探针，装置和方法。 探针包括一个超极化尖端，其位于尖端和样品之间的偶极相互作用。 样品的选定部分的核磁自旋引起尖端磁化的调制，其与所选择的部分的局部磁化成正比。 NMR装置包括探针，用于操纵样品和尖端中的自旋的射频（RF）线圈，以及用于检测尖端磁化的调制的装置。 RF脉冲序列选择所选择的部分并允许检测调制。 获得NMR数据的方法包括定位尖端以引起偶极相互作用; 选择样品部分; 响应于此调制尖端磁化强度; 并检测尖端调制。 该装置和方法可以适于获得NMR图像和光谱。