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    CARBOHYDRATE-LIGAND CONJUGATES AND THEIR APPLICATION FOR THE ANALYSIS OF CARBOHYDRATE-PROTEIN INTERACTION
    92.
    发明申请
    CARBOHYDRATE-LIGAND CONJUGATES AND THEIR APPLICATION FOR THE ANALYSIS OF CARBOHYDRATE-PROTEIN INTERACTION 审中-公开
    碳水化合物 - 配体结合物及其应用于碳水化合物 - 蛋​​白质相互作用的分析

    公开(公告)号：US20140295566A1

    公开(公告)日：2014-10-02

    申请号：US14274521

    申请日：2014-05-09

    Applicant: Japan Science and Technology Agency ,  National University Corporation Kagoshima University

    Inventor： Yasuo SUDA

    IPC: G01N33/52 ,  C07H15/04

    CPC classification number: G01N33/52 ,  C07H15/04 ,  G01N33/531 ,  G01N2400/00

    Abstract: A novel ligand conjugate which is effectively utilizable for analyzing a function of a protein; a ligand-supporting object; and a method of analyzing a protein. The ligand conjugate has a structure which comprises: a linker compound having a structure represented by the following General Formula (1): (wherein n and p each is an integer of 0 to 6) in which X is a structure comprising one, two, or three hydrocarbon derivative chains which have an aromatic amino group at the end and may have a carbon-nitrogen bond in the main chain, Y is a hydro-carbon structure containing one or more sulfur atoms, and Z is a straight-chain structure comprising a carbon-carbon bond or carbon-oxygen bond; and a sugar which has a reducing end and is bonded to the linker compound through the aromatic amino group.

    Abstract translation: 一种新颖的配体结合物，可有效用于分析蛋白质的功能; 配体支持物; 和分析蛋白质的方法。 配体缀合物具有以下结构：包含具有以下通式（1）表示的结构的连接体化合物：（其中n和p各自为0〜6的整数），其中，X为包含1〜 或在末端具有芳香族氨基并且在主链中可具有碳 - 氮键的三个烃衍生物链，Y是含有一个或多个硫原子的氢碳结构，Z是直链结构，包括 碳 - 碳键或碳 - 氧键; 和具有还原性末端并通过芳香族氨基与连接体化合物键合的糖。

    PROCESS FOR THE ISOLATION OF RHAMNOLIPIDS
    93.
    发明申请
    PROCESS FOR THE ISOLATION OF RHAMNOLIPIDS 有权
    RHAMNOLIPIDS的分离方法

    公开(公告)号：US20140148588A1

    公开(公告)日：2014-05-29

    申请号：US14089168

    申请日：2013-11-25

    Applicant: Martin Schilling ,  Marius Ruetering ,  Verena Dahl ,  Fabien Cabirol

    Inventor： Martin Schilling ,  Marius Ruetering ,  Verena Dahl ,  Fabien Cabirol

    IPC: C07H15/04

    CPC classification number: C07H15/04 ,  C11B1/10 ,  C11B1/108

    Abstract: A process for isolating rhamnolipids is provided. The process includes providing an aqueous medium containing at least one rhamnolipid and having a pH of less than 6. Next, the aqueous medium is brought into contact with at least one organic solvent to provide a multiphase system and then the aqueous phase is separated off. The pH is then increased to a value of 6 or more to provide a multiphase organic system. Next, a rhamnolipid-enriched organic phase is separated off. An optional step of further purifying the rhamnolipid may be performed.

    Abstract translation: 提供了分离鼠李糖脂的方法。 该方法包括提供含有至少一种鼠李糖脂并且pH小于6的水性介质。接下来，使水性介质与至少一种有机溶剂接触以提供多相体系，然后分离出水相。 然后将pH增加至6以上的值以提供多相有机体系。 接下来，分离出富含鼠李糖脂的有机相。 可以进行进一步纯化鼠李糖脂的任选步骤。

    MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS
    94.
    发明申请
    MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS 审中-公开
    用于治疗细菌感染的MANNOSE衍生物

    公开(公告)号：US20140107049A1

    公开(公告)日：2014-04-17

    申请号：US14042817

    申请日：2013-10-01

    Applicant: Vertex Pharmaceuticals Incorporated

    Inventor： Youssef Laafiret Bennani ,  Bingcan Liu

    IPC: C07H15/20 ,  C07H15/26 ,  C07H15/04

    CPC classification number: C07H15/20 ,  C07H15/04 ,  C07H15/203 ,  C07H15/26

    Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. The invention also provides processes for making the compounds of the invention.The compounds of the present invention are represented by the following structure of Formula A: wherein the variables are as described herein.

    Abstract translation: 本发明涉及可用于治疗或预防细菌感染的化合物。 本发明还提供含有化合物的药学上可接受的组合物和使用该组合物治疗细菌感染的方法。 本发明还提供了制备本发明化合物的方法。 本发明的化合物由式A的以下结构表示：其中变量如本文所述。

    Process for producing 1,2-trans-glycoside compound
    95.
    发明授权
    Process for producing 1,2-trans-glycoside compound 失效
    1,2-反式糖苷化合物的制备方法

    公开(公告)号：US08664372B2

    公开(公告)日：2014-03-04

    申请号：US13477950

    申请日：2012-05-22

    Applicant: Shigeru Yamago

    Inventor： Shigeru Yamago

    IPC: C07H11/04 ,  C07H15/04 ,  C07H15/10 ,  C07H15/14 ,  A61K31/7024 ,  A61K31/7028

    CPC classification number: C07H17/04

    Abstract: In preparing a glycoside compound from (a) a furanose compound or pyranose compound, and (b) an alcohol compound, a process for preparing a glycoside compound in which glycosidic bond locates selectively trans form relative to C-2 hydroxyl group, the process comprising using a furanose compound wherein the hydroxyl at the 2-position may have a substituent protected with a group A, or a pyranose compound which may have a substituent wherein R2 and R3 are the same or different and are each alkyl having 1 to 4 carbon atoms or aryl having or not having a substituent, or R2 and R3 are combined to form alkylene having 2 to 4 carbon atoms (the alkylene may be substituted with alkyl having 1 to 4 carbon atoms, or may have intervening phenylene), and m and n are each an integer of 0 or 1.

    Abstract translation: 在从（a）呋喃糖化合物或吡喃糖化合物制备糖苷化合物和（b）醇化合物时，制备糖苷键相对于C-2羟基选择性反式定位的糖苷化合物的方法，该方法包括 使用其中2-位的羟基可以具有被A基团保护的取代基的呋喃糖化合物，或者可以具有取代基的吡喃糖化合物，其中R 2和R 3相同或不同，并且各自是具有1至4个碳原子的烷基 或具有或不具有取代基的芳基，或R 2和R 3结合形成具有2至4个碳原子的亚烷基（亚烷基可以被具有1至4个碳原子的烷基取代，或可以具有中间亚苯基），m和n 分别为0或1的整数。

    METHOD FOR PREPARING PRECURSOR USED FOR LABELING HEPATOCYTE RECEPTOR AND CONTAINING TRISACCHARIDE AND DTPA LIGAND
    97.
    发明申请
    METHOD FOR PREPARING PRECURSOR USED FOR LABELING HEPATOCYTE RECEPTOR AND CONTAINING TRISACCHARIDE AND DTPA LIGAND 有权
    制备用于标记肝细胞受体和含有TRISACCHARIDE和DTPA配体的前体的方法

    公开(公告)号：US20140046045A1

    公开(公告)日：2014-02-13

    申请号：US13571731

    申请日：2012-08-10

    Applicant: CHIH-YUAN LIN ,  YU CHANG ,  JEN-TSUNG WANG ,  CHENG-FANG HSU ,  WEI-TI KUO ,  HUNG-WEN YU ,  WUU-JYH LIN ,  MEI-HUI WANG

    Inventor： CHIH-YUAN LIN ,  YU CHANG ,  JEN-TSUNG WANG ,  CHENG-FANG HSU ,  WEI-TI KUO ,  HUNG-WEN YU ,  WUU-JYH LIN ,  MEI-HUI WANG

    IPC: C07H15/04 ,  C07H1/06

    CPC classification number: C07H1/06 ,  C07H15/04 ,  C07K1/13

    Abstract: A method for preparing a precursor used to label hepatocyte receptors is revealed. The precursor contains a bifunctional structure including trisaccharide and DTPA ligand. During synthesis processes of the precursor, silica gel columns and Reverse phase-18 (RP-18) columns are used for purification. Thus both the purification times and cost of each purification are reduced. Moreover, use diethyl ether to facilitate precipitation of products and remove a part of coupling reagent. Removing the coupling reagent helps purification of products. Furthermore, Nα,Nα-bis(carboxymethyl)-L-lysine hydrate and benzyl chloroformate are coupled to form a trisaccharide skeleton so as to ensure the yield rate of trisaccharide structure.

    Abstract translation: 揭示了制备用于标记肝细胞受体的前体的方法。 该前体含有包括三糖和DTPA配体的双功能结构。 在前体的合成过程中，使用硅胶柱和反相18（RP-18）柱进行纯化。 因此，每次纯化的纯化时间和成本均降低。 此外，使用乙醚促进产物沉淀并除去一部分偶联剂。 去除偶联剂有助于净化产品。 此外，Nalpha，Nalpha-双（羧甲基）-L-赖氨酸水合物和氯甲酸苄酯偶联形成三糖骨架，以确保三糖结构的产率。

    SOPHOROLIPID ANALOG COMPOSITIONS
    98.
    发明申请
    SOPHOROLIPID ANALOG COMPOSITIONS 审中-公开
    SOPHOROLIPID类似物组合物

    公开(公告)号：US20140024816A1

    公开(公告)日：2014-01-23

    申请号：US14031696

    申请日：2013-09-19

    Applicant: Synthezyme, LLC

    Inventor： Richard A. Gross ,  Mark H. Schofield

    IPC: C07H15/10 ,  C07H9/02 ,  C07H15/04

    CPC classification number: C07H15/10 ,  A01N25/30 ,  A01N43/16 ,  A01N43/90 ,  A61K8/602 ,  A61K31/7028 ,  A61K2800/10 ,  A61Q17/005 ,  A61Q19/00 ,  C07H9/02 ,  C07H15/04

    Abstract: A composition of matter comprising sophorolipids as antimicrobial agents, antifungal agents, biopesticides, for uses as drugs to treat HIV, septic shock, cancer, asthma, dermatological conditions, as spermicidal agents, as anti-inflammatory drugs, as ingredients in cosmetics and building blocks for monomers and polymers and self-assembled templates for further chemical elaboration.

    Abstract translation: 包含作为抗微生物剂的槐糖脂，抗真菌剂，生物杀虫剂，用作药物治疗HIV，败血性休克，癌症，哮喘，皮肤病学条件的杀螨剂作为抗炎药物的物质组合物，作为化妆品和构件中的成分 用于单体和聚合物以及自组装模板，用于进一步的化学处理。

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