公开(公告)号：US08586154B2

公开(公告)日：2013-11-19

申请号：US12528636

申请日：2008-03-03

Applicant: Bryan V. Hunt ,  Kyle J. Lindstrom ,  Judith M. Invie ,  David B. Olson ,  Anthony M. Renstrom

Inventor： Bryan V. Hunt ,  Kyle J. Lindstrom ,  Judith M. Invie ,  David B. Olson ,  Anthony M. Renstrom

IPC: C09K19/00

CPC classification number: G02B1/10 ,  C07C43/23 ,  C07C69/734 ,  C07C69/78 ,  C08F32/06 ,  C08J5/18 ,  C08J2335/02 ,  G02B1/04 ,  G02B5/0231 ,  G02B5/045 ,  G02F1/133504 ,  G02F2001/133507 ,  Y10T428/10 ,  Y10T428/1036 ,  Y10T428/1041 ,  Y10T428/105

Abstract: Optical films are described having a polymerized microstructured surface that comprises the reaction product of a polymerizable resin composition comprising at least one polymerizable ethylenically unsaturated triphenyl monomer. Also described are certain triphenyl (meth)acrylate monomers and polymerizable resin compositions.

Abstract translation: 描述了具有聚合的微结构化表面的光学膜，其包含包含至少一个可聚合烯属不饱和三苯基单体的可聚合树脂组合物的反应产物。 还描述了某些三苯基（甲基）丙烯酸酯单体和可聚合树脂组合物。

公开(公告)号：US08263594B2

公开(公告)日：2012-09-11

申请号：US13008453

申请日：2011-01-18

Applicant: Kyle J. Lindstrom ,  Hugues M. H. Martin ,  Bryon A. Merrill ,  Michael J. Rice ,  Joshua R. Wurst ,  Chad A. Haraldson ,  Philip D. Heppner ,  Shri Niwas ,  Matthew R. Radmer

Inventor： Kyle J. Lindstrom ,  Hugues M. H. Martin ,  Bryon A. Merrill ,  Michael J. Rice ,  Joshua R. Wurst ,  Chad A. Haraldson ,  Philip D. Heppner ,  Shri Niwas ,  Matthew R. Radmer

IPC: A61K31/5377 ,  A61K31/437 ,  A61K31/497 ,  C07D471/04 ,  C07D413/14 ,  A61P31/12 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 含有芳香氧基或芳基亚烷氧基取代基的6,7,8或9位的咪唑并喹啉化合物含有这些化合物作为免疫调节剂的化合物，中间体和使用方法，用于调节动物中的细胞因子生物合成和治疗 公开了包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：US20110086972A1

公开(公告)日：2011-04-14

申请号：US12936552

申请日：2009-05-19

Applicant: Bryan V. Hunt ,  Kyle J. Lindstrom ,  James P. DiZio

Inventor： Bryan V. Hunt ,  Kyle J. Lindstrom ,  James P. DiZio

IPC: C08L33/10 ,  C08F20/30 ,  C08F20/10 ,  C08L33/08 ,  B82Y20/00

CPC classification number: C08F220/40 ,  B29K2033/12 ,  Y10S977/773

Abstract: Presently described are (e.g. microstructured) optical films and polymerizable resin compositions comprising at least one (meth)acrylate monomer comprising an unsubstituted or substituted phenyl ethylene group referred to as phenyl ethylene (meth)acrylate monomers.

Abstract translation: 目前描述的是（例如微结构的）光学薄膜和包含至少一种（甲基）丙烯酸酯单体的可聚合树脂组合物，所述单体包含被称为苯乙烯（甲基）丙烯酸酯单体的未取代或取代的苯基亚乙基。

公开(公告)号：US07897609B2

公开(公告)日：2011-03-01

申请号：US11570703

申请日：2005-06-17

Applicant: Shri Niwas ,  Bryon A. Merrill ,  Philip D. Heppner ,  Tushar A. Kshirsagar ,  Gregory D. Lundquist, Jr. ,  David T. Amos ,  Kyle J. Lindstrom

Inventor： Shri Niwas ,  Bryon A. Merrill ,  Philip D. Heppner ,  Tushar A. Kshirsagar ,  Gregory D. Lundquist, Jr. ,  David T. Amos ,  Kyle J. Lindstrom

IPC: C07D215/38 ,  A61K31/02

CPC classification number: C07D471/14

Abstract: Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 公开了用芳基取代基取代的咪唑并萘啶环体系，含有这些化合物的药物组合物，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：US20090270576A1

公开(公告)日：2009-10-29

申请号：US12111235

申请日：2008-04-29

Applicant: Bryan V. Hunt ,  Kyle J. Lindstrom

Inventor： Bryan V. Hunt ,  Kyle J. Lindstrom

IPC: C08F118/16

CPC classification number: C08F220/30 ,  C08F222/10 ,  C08F2220/306

Abstract: Microstructured optical films and polymerizable resin compositions comprising at one aromatic monomer or oligomer having at least two polymerizable (meth)acrylate groups and a fluorenol (meth)acrylate monomer.

Abstract translation: 微结构光学膜和可聚合树脂组合物，其包含一种具有至少两个可聚合（甲基）丙烯酸酯基团的芳族单体或低聚物和芴醇（甲基）丙烯酸酯单体。

公开(公告)号：US20080221291A1

公开(公告)日：2008-09-11

申请号：US12041238

申请日：2008-03-03

Applicant: Judith M. Invie ,  Bryan V. Hunt ,  Kyle J. Lindstrom ,  David B. Olson ,  Anthony M. Renstrom ,  Clinton L. Jones

Inventor： Judith M. Invie ,  Bryan V. Hunt ,  Kyle J. Lindstrom ,  David B. Olson ,  Anthony M. Renstrom ,  Clinton L. Jones

IPC: C08F20/06

CPC classification number: G02B1/04 ,  C08F20/06 ,  C08F20/30 ,  C08F20/38 ,  C08K3/22 ,  C08K2201/011 ,  Y10T428/24355

Abstract: Optical films having a polymerized microstructured surface are described. The polymerized microstructured surface comprises the reaction product of a polymerizable resin composition comprising 10% to 100 wt-% of at least one biphenyl di(meth)acrylate monomer. The di(meth)acrylate monomer comprises a core biphenyl structure having two aromatic rings connected with a C—C bond. The biphenyl di(meth)acrylate monomer preferably comprises a sufficient amount of ortho and/or meta(meth)acrylate substituents such that the monomer is a liquid at 25° C.

Abstract translation: 描述具有聚合微结构化表面的光学膜。 聚合的微结构表面包含含有10％至100％重量的至少一种二（甲基）丙烯酸联苯酯单体的可聚合树脂组合物的反应产物。 二（甲基）丙烯酸酯单体包括具有两个与C-C键连接的芳环的核心联苯结构。 联苯二（甲基）丙烯酸酯单体优选包含足够量的邻位和/或间位（甲基）丙烯酸酯取代基使得单体在25℃下为液体。

公开(公告)号：US06924293B2

公开(公告)日：2005-08-02

申请号：US10669051

申请日：2003-09-23

Applicant: Kyle J. Lindstrom

Inventor： Kyle J. Lindstrom

IPC: A61K31/4745 ,  A61K31/541 ,  A61P37/02 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04

CPC classification number: A61K31/4745 ,  C07D471/04 ,  Y02A50/409

Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract translation: 在1位含有磺酰胺或磺酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫反应调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：US06747040B2

公开(公告)日：2004-06-08

申请号：US10405321

申请日：2003-04-02

Applicant: Kyle J. Lindstrom ,  Michael J. Rice

Inventor： Kyle J. Lindstrom ,  Michael J. Rice

IPC: A61K31437

CPC classification number: C07D471/04 ,  A61K31/4745 ,  A61K45/06 ,  C07D471/14 ,  A61K2300/00

Abstract: Imidazonaphthyridine compounds that are unsubstituted at the 2-position induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

Abstract translation: 在2-位未被取代的咪唑并萘啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 还公开了制备可用于制备化合物的化合物和中间体的方法。

公开(公告)号：US06743920B2

公开(公告)日：2004-06-01

申请号：US10436488

申请日：2003-05-12

Applicant: Kyle J. Lindstrom ,  Luke T. Dressel

Inventor： Kyle J. Lindstrom ,  Luke T. Dressel

IPC: C07D47102

CPC classification number: C07D471/04

Abstract: A process and intermediates for preparing 1H-imidazo[4,5-c]pyridin-4-amines are disclosed. The process includes providing a 4-phenoxy-1H-imidazo[4,5-c]pyridine and aminating the 4-phenoxy-1H-imidazo[4,5-c]pyridine to provide a 1H-imidazo[4,5-c]pyridin-4-amine.

Abstract translation: 公开了制备1H-咪唑并[4,5-c]吡啶-4-胺的方法和中间体。 该方法包括提供4-苯氧基-1H-咪唑并[4,5-c]吡啶并胺化4-苯氧基-1H-咪唑并[4,5-c]吡啶，得到1H-咪唑并[4,5-c ]吡啶-4-胺。

公开(公告)号：US06720334B2

公开(公告)日：2004-04-13

申请号：US10358017

申请日：2003-02-04

Applicant: Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

Inventor： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC: A61K31437

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract translation: 在1位含有脲或硫脲官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。