公开(公告)号：US20220169649A1

公开(公告)日：2022-06-02

申请号：US17365789

申请日：2021-07-01

申请人： Incyte Corporation

发明人： Yanran Ai ,  Onur Atasoylu ,  Yu Bai ,  Joseph Barbosa ,  David M. Burns ,  Daniel Levy ,  Brent Douty ,  Hao Feng ,  Leah C. Konkol ,  Cheng-Tsung Lai ,  Xun Liu ,  Song Mei ,  Jun Pan ,  Haisheng Wang ,  Liangxing Wu ,  Wenqing Yao ,  Eddy W. Yue

IPC分类号： C07D471/14 ,  C07D519/00

摘要： The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US20220135570A1

公开(公告)日：2022-05-05

申请号：US17500140

申请日：2021-10-13

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Peter Niels Carlsen ,  Pei Gan ,  Gia Hoang ,  Yong Li ,  Chao Qi ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Wenyu Zhu

IPC分类号： C07D487/04 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20220089588A1

公开(公告)日：2022-03-24

申请号：US17307547

申请日：2021-05-04

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Fenglei Zhang ,  Song Mei ,  Wenqing Yao

IPC分类号： C07D417/14 ,  C07D403/06 ,  C07D231/14 ,  C07D233/90 ,  C07D263/34 ,  C07D277/56 ,  C07D401/06 ,  C07D403/12 ,  C07D405/12 ,  C07D417/06

摘要： Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US20220056049A1

公开(公告)日：2022-02-24

申请号：US17421179

申请日：2020-01-06

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Neil Lajkiewicz ,  Wenqing Yao

IPC分类号： C07D519/00

摘要： The present application provides heteroaryl amide compounds that activate the STING pathway to produce interferons, which are useful in the treatment of various diseases including infectious diseases and cancer.

公开(公告)号：US11242343B2

公开(公告)日：2022-02-08

申请号：US16786169

申请日：2020-02-10

申请人： Incyte Corporation

发明人： Kai Liu ,  Jun Pan ,  Alexander Sokolsky ,  Oleg Vechorkin ,  Hai Fen Ye ,  Qinda Ye ,  Wenqing Yao

IPC分类号： C07D471/04 ,  C07D519/00

摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

公开(公告)号：US20210380584A1

公开(公告)日：2021-12-09

申请号：US17405204

申请日：2021-08-18

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Jingwei Li ,  Wenqing Yao

IPC分类号： C07D471/04 ,  A61P37/04 ,  C07D413/14

摘要： Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US11111247B2

公开(公告)日：2021-09-07

申请号：US16580766

申请日：2019-09-24

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Minh Nguyen ,  Chao Qi ,  Anlai Wang ,  Liangxing Wu ,  Wenqing Yao ,  Peng Zhao

IPC分类号： C07D487/04 ,  C07D487/02 ,  A61P35/00 ,  C07D519/00 ,  A61K45/06

摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and/or FGFR activity, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity and/or FGFR activity, such as cancer.

公开(公告)号：US20210230162A1

公开(公告)日：2021-07-29

申请号：US17153065

申请日：2021-01-20

申请人： Incyte Corporation

发明人： Le Zhao ,  Xiaozhao Wang ,  Wenyu Zhu ,  Haolin Yin ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/20 ,  C07D491/20 ,  C07D471/22 ,  C07D498/20

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US20210171535A1

公开(公告)日：2021-06-10

申请号：US17110740

申请日：2020-12-03

申请人： Incyte Corporation

发明人： Matthew S. McCammant ,  Evan Styduhar ,  Oleg Vechorkin ,  Robert Swyka ,  Wenqing Yao

IPC分类号： C07D487/14

摘要： The present disclosure relates to tricyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

公开(公告)号：US11008344B2

公开(公告)日：2021-05-18

申请号：US16528181

申请日：2019-07-31

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Yingda Ye ,  Wenqing Yao

IPC分类号： A61K31/437 ,  A61K31/519 ,  A61K31/5025 ,  A61K31/4985 ,  A61P31/00 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K45/06

摘要： The present application provides tricyclic heteroaryl compounds that activate the STING pathway to produce interferons, which are useful in the treatment of various diseases including infectious diseases and cancer.