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公开(公告)号：US20230203010A1
公开(公告)日：2023-06-29
申请号：US18073782
申请日：2022-12-02
申请人： Incyte Corporation
发明人： Xin Li , Michael Liang , Evan Styduhar , Robert Swyka , Oleg Vechorkin , Anlai Wang , Lin You , Peng Zhao , Ke Zhang , Minh Nguyen
IPC分类号： C07D401/14 , C07D487/04 , C07D405/14 , C07D409/14
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D487/04
摘要： The present application provides bicyclic amines that are inhibitors of cyclin-dependent kinase 12 (CDK12), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
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公开(公告)号：US20210094934A1
公开(公告)日：2021-04-01
申请号：US17015797
申请日：2020-09-09
申请人： Incyte Corporation
发明人： Oleg Vechorkin , Jun Pan , Alexander Sokolsky , Evan Styduhar , Qinda Ye , Wenqing Yao
IPC分类号： C07D403/14 , C07D239/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D487/04 , C07D487/08
摘要： Disclosed are compounds of Formula (I′) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US20240317744A1
公开(公告)日：2024-09-26
申请号：US18602434
申请日：2024-03-12
申请人： Incyte Corporation
发明人： Xin Li , Oleg Vechorkin , Yanran Ai , Onur Atasoylu , Hang Thi Dang , Brent Douty , Chunhong He , Peng He , Michael Liang , Minh Nguyen , Evan Styduhar , Anlai Wang , Xiaozhao Wang , Hai Fen Ye , Eddy W. Yue , Ke Zhang , Peng Zhao
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present application provides bicyclic urea compounds that modulate the activity of JAK2, which are useful in the treatment of various diseases, including cancer.
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公开(公告)号：US11731958B2
公开(公告)日：2023-08-22
申请号：US17015797
申请日：2020-09-09
申请人： Incyte Corporation
发明人： Oleg Vechorkin , Jun Pan , Alexander Sokolsky , Evan Styduhar , Wenqing Yao
IPC分类号： C07D403/14 , C07D239/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D487/04 , C07D487/08
CPC分类号： C07D403/14 , C07D239/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D487/04 , C07D487/08
摘要： Disclosed are compounds of Formula (I′) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US20210171535A1
公开(公告)日：2021-06-10
申请号：US17110740
申请日：2020-12-03
申请人： Incyte Corporation
IPC分类号： C07D487/14
摘要： The present disclosure relates to tricyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US11939331B2
公开(公告)日：2024-03-26
申请号：US17835331
申请日：2022-06-08
申请人： Incyte Corporation
发明人： Xin Li , Evan Styduhar , Robert Swyka , Oleg Vechorkin , Wenqing Yao
IPC分类号： C07D471/14 , A61K31/4375 , A61K31/439 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P35/00 , C07D519/00
CPC分类号： C07D471/14 , A61K31/4375 , A61K31/439 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P35/00 , C07D519/00
摘要： The present disclosure relates to tricyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US11897891B2
公开(公告)日：2024-02-13
申请号：US17110740
申请日：2020-12-03
申请人： Incyte Corporation
IPC分类号： C07D471/14 , C07D487/14 , A61P35/00
CPC分类号： C07D487/14 , A61P35/00 , C07D471/14
摘要： The present disclosure relates to tricyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US10800761B2
公开(公告)日：2020-10-13
申请号：US16278865
申请日：2019-02-19
申请人： Incyte Corporation
发明人： Oleg Vechorkin , Jun Pan , Alexander Sokolsky , Evan Styduhar , Wenqing Yao
IPC分类号： C07D403/14 , C07D239/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D487/04 , C07D487/08
摘要： Disclosed are compounds of Formula (I′) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US20240287086A1
公开(公告)日：2024-08-29
申请号：US18545487
申请日：2023-12-19
申请人： Incyte Corporation
IPC分类号： C07D487/14 , A61P35/00 , C07D471/14
CPC分类号： C07D487/14 , A61P35/00 , C07D471/14
摘要： The present disclosure relates to tricyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US20240150326A1
公开(公告)日：2024-05-09
申请号：US18212444
申请日：2023-06-21
申请人： Incyte Corporation
发明人： Oleg Vechorkin , Jun Pan , Alexander Sokolsky , Evan Styduhar , Qinda Ye , Wenqing Yao
IPC分类号： C07D403/14 , C07D239/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D487/04 , C07D487/08
CPC分类号： C07D403/14 , C07D239/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D487/04 , C07D487/08
摘要： Disclosed are compounds of Formula (I′) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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