-
公开(公告)号：US20210342232A1
公开(公告)日：2021-11-04
申请号：US17242508
申请日：2021-04-28
发明人： Kartik Gopalan , Ping Yang , Dinuni K. Fernando , Jonathan Terner
摘要： Post-copy is one of the two key techniques (besides pre-copy) for live migration of virtual machines in data centers. Post-copy provides deterministic total migration time and low downtime for write-intensive VMs. However, if post-copy migration fails for any reason, the migrating VM is lost because the VM's latest consistent state is split between the source and destination nodes during migration. PostCopyFT provides a new approach to recover a VM after a destination or network failure during post-copy live migration using an efficient reverse incremental checkpointing mechanism. PostCopyFT was implemented and evaluated in the KVM/QEMU platform. Experimental results show that the total migration time of post-copy remains unchanged while maintaining low failover time, downtime, and application performance overhead.
-
公开(公告)号：US20210332331A1
公开(公告)日：2021-10-28
申请号：US17167743
申请日：2021-02-04
IPC分类号： C12N7/00 , C07K14/005 , C12N15/86 , C12Q1/6897 , C12N9/22 , A61K38/46 , C12N9/16
摘要： The invention provides adeno-associated virus (AAV) replication (Rep) sequences. In one embodiment, the invention provides nucleotide sequences encoding a chimeric protein, wherein the encoded chimeric protein contains a wild type AAV Rep inhibitory amino acid sequence, and wherein the nucleotide sequences contain a scrambled and/or deoptimized polynucleotide sequence encoding the wild type AAV Rep inhibitory amino acid sequence. The invention provides vectors, cells, and viruses containing the invention's sequences. Also provided are methods for detecting portions of the AAV Rep inhibitory amino acid sequence, which reduce replication and/or infection and/or productive infection by viruses. The invention's compositions and methods are useful for site-specific integration and/or expression of heterologous sequences by recombinant adeno-associated virus (rAAV) vectors and by rAAV virus particles, such as hybrid viruses (e.g., Ad-AAV) comprising such vectors. The invention's compositions and methods find application in, for example, gene therapy and/or vaccines.
-
公开(公告)号：US20210325848A1
公开(公告)日：2021-10-21
申请号：US17267430
申请日：2019-08-09
发明人： Rahul RAI , Prakhar JAISWAL
IPC分类号： G05B19/4099 , G06T7/50 , B33Y50/02 , B22F10/85
摘要： Shape diameter-based approaches to identifying and correcting 2D slices of 3D models (or the 3D models themselves) are provided for improved manufacturability. Using the present approaches, critical error-prone regions in 2D slices or 3D models can be identified, including thin extrusions and bridges, sharp corners, small holes, and narrow intrusions. The areas of these regions can be computed and used to quantify the printability of the slices or models. The boundaries of slices or models can be modeled as mass-spring-damper systems for performing local deformations to correct error-prone regions. External forces, that are a function of shape diameters and interior angles, can be imposed on the modeled systems for this purpose.
-
公开(公告)号：US20210290859A1
公开(公告)日：2021-09-23
申请号：US17258918
申请日：2019-07-10
发明人： Allan KUCINE
摘要： The present disclosure is directed to a dental tool and methods for using the same. The dental tool includes a handle; a tip operably attached to a first end of the handle; and an alignment element that is substantially parallel with the handle.
-
公开(公告)号：US11125514B2
公开(公告)日：2021-09-21
申请号：US17045415
申请日：2019-04-04
申请人： The Research Foundation for The State University of New York , Wisconsin Alumni Research Foundation
发明人： Qiaoqiang Gan , Haomin Song , Zongfu Yu , Ming Zhou
摘要： Disclosed herein are systems and methods for passively cooling water vapor to enable efficient condensation, and methods of making such systems. A passive cooler can include a thermally conductive substrate having a first side and a second side opposite the first side, a coating disposed on at least a portion of the first side of the substrate, and a housing having one or more insulative walls. The insulative walls may define a vapor flow channel from an inlet to an outlet of the housing such that the second side of the substrate is exposed to water vapor flowing through the vapor flow channel.
-
96.发明申请公开(公告)号：US20210269601A1
公开(公告)日：2021-09-02
申请号：US17189868
申请日：2021-03-02
发明人： Juntao Luo , Xu Wang , Changying Shi
摘要： Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.
-
公开(公告)号：US20210256406A1
公开(公告)日：2021-08-19
申请号：US16973319
申请日：2019-07-08
发明人： Klaus MUELLER , Jun WANG
摘要： A system and method associated with generating an interactive visualization of causal models used in analytics of data is disclosed. The system performs various operations that include receiving time series data in the analytics of time-based phenomena associated with a data set. The system generates a visual representation to specify an effect associated with a causal relation. A causal hypothesis is determined using at least one of an effect variable and a cause variable associated with the visual representation. Causal events are identified in a new visual representation with a time shift being set. A statistical significance is determined using at least one time window within the new visual representation. An updated visual representation is generated including one or more updated causal models.
A corresponding method and computer-readable medium are also disclosed.-
公开(公告)号：US20210254869A1
公开(公告)日：2021-08-19
申请号：US17269117
申请日：2019-08-19
申请人： The Research Foundation for The State University of New York , Wisconsin Alumni Research Foundation
发明人： Qiaoqiang GAN , Lyu ZHOU , Zongfu YU , Haomin SONG
摘要： A passive cooler of the disclosure includes a thermal emitter having a substrate and a coating disposed on at least a portion of a first side of the substrate. The cooler has a beam guide made from a material having a high absorption to solar wavelengths and high reflectance at mid-infrared wavelengths. The beam guide is configured such that at least a portion of incident light is acted on by the beam guide before reaching the thermal emitter. In some embodiments, the beam guide has a graded optical index.
-
公开(公告)号：US11083782B2
公开(公告)日：2021-08-10
申请号：US16091425
申请日：2017-04-05
发明人： Sathy Balu-Iyer , Richard Bankert , Radha Ramakrishnan , Robert Dingman , Vandana Iyer , Jennifer Schneider , Fiona Yau Glassman , Nhan Hanh Nguyen
IPC分类号： A61K39/395 , A61K39/00 , A61K39/39 , A61K9/10 , A61K9/00 , A61K47/24 , A61K9/127 , A61P37/06 , A61K31/436
摘要： Compositions and methods for inducing immune tolerance to proteins and subsequence administration of the proteins are disclosed. Compositions comprise proteins complexed with liposomes comprising PS and PC, wherein at least part of the PS is present as lyso-PS.
-
公开(公告)号：US11072633B2
公开(公告)日：2021-07-27
申请号：US16097558
申请日：2017-04-28
发明人： Nicole Sampson , Xinxin Yang , Tianao Yuan
摘要： The present invention provides a compound having the structure: for use in combination with an anti-tuberculosis drug for treating a subject infected with M. tuberculosis.
-
-
-
-
-
-
-
-
-
搜索结果
1446 条记录 (耗时 0.053 秒)
