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    Recombinant Adenoviral Vector Expressing Zika Antigen with Improved Productivity
    95.
    发明申请
    Recombinant Adenoviral Vector Expressing Zika Antigen with Improved Productivity 有权

    公开(公告)号：US20210317477A1

    公开(公告)日：2021-10-14

    申请号：US17261436

    申请日：2019-07-19

    申请人： Janssen Vaccines & Prevention B.V.

    发明人： Taco Gilles Uil

    IPC分类号： C12N15/86 ,  C07K14/005 ,  A61K39/12 ,  A61P31/14

    摘要： Provided herein are adenoviral vectors comprising nucleotide sequences encoding a Zika virus M and Env antigen, wherein the nucleotide sequence encoding the Zika virus M and Env antigen is operably linked to a cytomegalovirus (CMV) promoter comprising at least one tetracycline operator (TetO) motif. Also provided herein are pharmaceutical compositions comprising the adenoviral vectors, methods of producing the adenoviral vectors, methods of preventing Zika virus or the progression of Zika virus in a subject in need thereof, and kits comprising the adenoviral vectors and host cells.

    Binding molecules directed against influenza hemagglutinin and uses thereof
    96.
    发明授权
    Binding molecules directed against influenza hemagglutinin and uses thereof 有权

    公开(公告)号：US11136379B2

    公开(公告)日：2021-10-05

    申请号：US16946092

    申请日：2020-06-05

    申请人： Janssen Vaccines & Prevention B.V.

    发明人： Boerries Brandenburg ,  Ronald Vogels ,  Joost A. Kolkman ,  Robert Heinz Edward Friesen

    IPC分类号： C07K16/08 ,  A61K39/145 ,  C07K16/10 ,  G01N33/569 ,  A61K39/00

    摘要： Multimeric binding molecules that are capable of specifically binding to hemagglutinin (HA) of at least two influenza A virus strains, said strains comprising HA of two different HA subtypes from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza B virus strain are provided. The binding molecules preferably are also capable of neutralizing at least two influenza A virus strains from phylogenetic group 2; or capable of neutralizing at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically neutralizing at least one influenza B virus strain.

    STABILIZED FILOVIRUS GLYCOPROTEIN TRIMERS
    97.
    发明申请
    STABILIZED FILOVIRUS GLYCOPROTEIN TRIMERS 有权

    公开(公告)号：US20210292371A1

    公开(公告)日：2021-09-23

    申请号：US17266404

    申请日：2019-08-13

    申请人： JANSSEN VACCINES & PREVENTION B.V.

    发明人： Johannes LANGEDIJK ,  Lucy RUTTEN ,  Sven BLOKLAND

    IPC分类号： C07K14/005 ,  A61K39/12

    摘要： Filovirus glycoprotein mutations that stabilize the trimeric form of the glycoprotein are provided. The Filovirus glycoproteins have certain amino acid substitutions at specified positions in the glycoprotein sequence. The Filovirus glycoproteins described herein have an improved percentage of trimer formation and/or an improved trimer yield as compared to a Filovirus glycoprotein that does not have one or more of the indicated amino acid substitutions. Also provided are nucleic acid molecules and vectors encoding the Filovirus glycoproteins, as well as compositions containing the Filovirus glycoproteins, nucleic acid, and vectors.