公开(公告)号：US4423061A

公开(公告)日：1983-12-27

申请号：US454106

申请日：1982-12-28

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/107 ,  A61K31/40 ,  A61P7/08 ,  B01F17/14 ,  C07D207/10

CPC分类号： C07D207/10 ,  Y10S514/832

摘要： A perfluorocycloamine emulsion preparation having oxygen carrying ability containing a perfluorocycloamine of the general formula: ##STR1## wherein any position may optionally be substituted with a perfluoromethyl group as an oxygen carrying component.

摘要翻译： 一种全氟环丙胺乳液制剂，其具有含有以下通式的全氟环丙胺的含氧载体：其中任何位置可任选被全氟甲基取代为携氧组分。

公开(公告)号：US4414336A

公开(公告)日：1983-11-08

申请号：US306647

申请日：1981-09-29

申请人： Ryozo Watanabe ,  Keiichi Kawasumi ,  Shoichi Maeda ,  Takashi Shoji

发明人： Ryozo Watanabe ,  Keiichi Kawasumi ,  Shoichi Maeda ,  Takashi Shoji

IPC分类号： G01N33/50 ,  G01N33/579 ,  G01N33/96 ,  G01N33/48 ,  G01N33/54

CPC分类号： G01N33/96 ,  G01N33/50 ,  G01N33/579 ,  G01N2333/81 ,  Y10S436/825 ,  Y10T436/255

摘要： (1) A method for preparing a sample for use in the endotoxin test which comprises subjecting a sample of plasma or blood preparation to a contact with water-insoluble anti-human .alpha..sub.2 -macroglobulin antibody and to a gel filtration by means of a gel of allyl dextran crosslinked with N,N'-methylenebis acrylamide or a gel of polyvinyl alcohol having many hydrophilic hydroxyl groups, and recovering the maximum molecular weight fraction.(2) A kit for preparing a sample for use in the endotoxin test consisting of a set of a sample-developing column prepared by packing a water-insoluble anti-human .alpha..sub.2 -macroglobulin antibody and a gel of allyl dextran crosslinked with N,N'-methylenebis acrylamide or a gel of polyvinyl alcohol having many hydrophilic hydroxyl groups, both equilibrated with a buffer solution of pH 7.0-7.4, into a column and tightly sealing the column, an aqueous solution of a high molecular colored substance to be added to the sample and a buffer solution for use in developing the sample.

摘要翻译： （1）一种制备用于内毒素试验的样品的方法，其包括使血浆或血液制剂的样品与不溶于水的抗人α2-巨球蛋白抗体接触并通过凝胶进行凝胶过滤 的与N，N'-亚甲基双丙烯酰胺交联的烯丙基葡聚糖或具有许多亲水性羟基的聚乙烯醇凝胶，并回收最大分子量分数。 （2）一种用于制备用于内毒素测试的样品的试剂盒，其由一组通过包装不溶于水的抗人α2-巨球蛋白抗体和与N交联的烯丙基葡聚糖凝胶制备的样品显影柱组成， N'-亚甲基双丙烯酰胺或具有许多亲水性羟基的聚乙烯醇凝胶，两者都用pH 7.0-7.4的缓冲溶液平衡，并将柱紧密密封，加入高分子色素物质的水溶液 到样品和用于开发样品的缓冲溶液。

公开(公告)号：US4340594A

公开(公告)日：1982-07-20

申请号：US260607

申请日：1981-05-06

申请人： Yutaka Mizushima ,  Kazumasa Yokoyama ,  Kiichiro Nabeta ,  Noboru Yamada ,  Tadakazu Suyama

发明人： Yutaka Mizushima ,  Kazumasa Yokoyama ,  Kiichiro Nabeta ,  Noboru Yamada ,  Tadakazu Suyama

IPC分类号： A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K31/57 ,  A61K31/704 ,  A61P29/00 ,  A61K31/56

CPC分类号： A61K9/1075 ,  A61K31/57

摘要： A fat emulsion containing a steroid having an anti-inflammatory activity, comprising an effective quantity of a steroid having an anti-inflammatory activity, 5 to 50% (W/V) of soybean oil, a phospholipid in a weight ratio of 1-50 to 100 of said soybean oil, and a proper quantity of water. This fat emulsion exhibits a long-lasting activity in the region of inflammation and is especially useful in the therapeutic or prophylactic treatment of rheumatism, immunological hemolytic anemia, idiopathic thrombocytopenic purpura, and Paget disease, or in conjunction with kidney transplantation.

摘要翻译： 含有具有抗炎活性的类固醇的脂肪乳剂，其包含有效量的具有抗炎活性的类固醇，大豆油为5〜50％（W / V），重量比为1〜50的磷脂 至100份所述大豆油，并加入适量的水。 这种脂肪乳剂在炎症区域表现出持久的活性，特别可用于治疗或预防性治疗风湿病，免疫性溶血性贫血，特发性血小板减少性紫癜和佩吉特病，或与肾移植有关。

公开(公告)号：US4327086A

公开(公告)日：1982-04-27

申请号：US245971

申请日：1981-03-20

申请人： Tsunekazu Fukushima ,  Tomiyuki Matsunaga ,  Satoshi Funakoshi

发明人： Tsunekazu Fukushima ,  Tomiyuki Matsunaga ,  Satoshi Funakoshi

IPC分类号： A61K35/14 ,  A61K35/16 ,  A61K35/50 ,  A61K38/00 ,  A61K38/16 ,  A61L2/00 ,  C12N9/10 ,  A61K37/00 ,  A61K35/48

CPC分类号： C12N9/1044 ,  A61L2/0023 ,  A61K38/00

摘要： A process for heat treatment to inactive hepatitis virus in human blood coagulation factor XIII compositions, which is characterized in that the heat treatment at 50.degree. to 80.degree. C. of an aqueous solution containing the human blood coagulation factor XIII is carried out for 3 to 15 hours in the presence of 10% (W/V) or more of at least one principal stabilizer selected from the group consisting of neutral amino acids, monosaccharides and sugar alcohols and 10% (W/V) or more of at least one auxiliary stabilizer selected from the group consisting of salts of organic carboxylic acids having 3 to 10 carbon atoms.

摘要翻译： 一种在人血液凝固因子XIII组合物中对无活性肝炎病毒进行热处理的方法，其特征在于在含有人血液凝固因子XIII的水溶液中在50〜80℃下进行热处理3次 在10％（W / V）以上的至少一种选自中性氨基酸，单糖和糖醇的主要稳定剂和10％（W / V）以上的至少一种辅助剂 选自具有3-10个碳原子的有机羧酸盐的稳定剂。

公开(公告)号：US4306025A

公开(公告)日：1981-12-15

申请号：US179783

申请日：1980-08-20

申请人： Eichi Hasegawa ,  Takashi Kobayashi

发明人： Eichi Hasegawa ,  Takashi Kobayashi

IPC分类号： B65B5/02 ,  C12N9/08

CPC分类号： B65B5/02 ,  Y10S435/816

摘要： Myeloperoxidase can be separated and recovered from a supernatant liquid of an aqueous dispersion of a disintegration product of human myelogenous leukocytes, which dispersion has been admixed with at least one member selected from the group consisting of manganese salts and protamine sulfate. The recovered myeloperoxidase in combination with an alkali metal halide can be used as a pharmaceutical composition effective against microorganisms deficient or diminished in catalase synthesizing activity.

摘要翻译： 髓过氧化物酶可以从人骨髓白质细胞的崩解产物的水性分散体的上清液中分离回收，该分散体已经与选自锰盐和鱼精蛋白硫酸盐的至少一种混合。 回收的髓过氧化物酶与碱金属卤化物的组合可以用作对过氧化氢酶合成活性缺乏或减少的微生物有效的药物组合物。

公开(公告)号：US4286063A

公开(公告)日：1981-08-25

申请号：US105116

申请日：1979-12-19

申请人： Tadakazu Suyama

发明人： Tadakazu Suyama

IPC分类号： A61K38/00 ,  C12N9/72

CPC分类号： C12N9/6462 ,  C12Y304/21073 ,  A61K38/00 ,  Y10S435/814 ,  Y10S435/815

摘要： A method for producing a thrombolytic preparation characterized in that among treatment conditions in the urokinase production pH is maintained within the neutral or weakly alkaline range throughout each treatment step to produce a thrombolytic preparation containing urokinase having a molecular weight of 54,000.+-.10,000 as major ingredient.

摘要翻译： 一种血栓溶解制剂的制造方法，其特征在于，在每个处理步骤中，在尿激酶产生pH的处理条件下，保持在中性或弱碱性范围内，以产生含有分子量为54,000 +/- 10,000的尿激酶的血栓溶解制剂作为主要 成分。

公开(公告)号：US4285933A

公开(公告)日：1981-08-25

申请号：US091245

申请日：1979-11-02

申请人： Tunekazu Fukushima ,  Satoshi Funakoshi

发明人： Tunekazu Fukushima ,  Satoshi Funakoshi

IPC分类号： C07K14/745 ,  A61K35/50 ,  A61K38/00 ,  A61K38/16 ,  A61K38/43 ,  A61L2/00 ,  C07K14/435 ,  C12N9/10 ,  A61K35/48

CPC分类号： C12N9/1044 ,  A61L2/0023 ,  A61K38/00

摘要： The invention relates to a process for concentrating blood coagulation Factor XIII (Fibrin stabilizing factor) which comprises removing a fraction precipitated at a pH of 6 to 9 in a concentration of 4 to 9% (W/V) of an alkylenoxide polymer or copolymer having a molecular weight of 2,000 to 20,000 from a crude globulin fraction obtained from human placentae by separating in albumin fraction therefrom, and then collecting the fraction precipitated in the concentration of 20 to 30% (W/V) of said polymer or copolymer, thereby obtaining easily said blood coagulation Factor XIII free from pyrogen in good yield.

摘要翻译： 本发明涉及一种浓缩凝血因子XIII（纤维蛋白稳定因子）的方法，其包括以4至9％（W / V）的浓度在6至9的pH下除去沉淀的级分的亚烷基氧化物聚合物或共聚物 通过从白蛋白馏分中分离从人胎盘获得的粗球蛋白部分分子量为2,000〜20,000，然后收集以所述聚合物或共聚物的20〜30％（W / V）的浓度沉淀的级分，从而得到 容易地说凝血因子XIII不含热原，产率良好。

公开(公告)号：US4265888A

公开(公告)日：1981-05-05

申请号：US110753

申请日：1980-01-08

申请人： Yoshio Kagitani ,  Takashi Imagawa ,  Hirohisa Inahara ,  Ryozo Watanabe

发明人： Yoshio Kagitani ,  Takashi Imagawa ,  Hirohisa Inahara ,  Ryozo Watanabe

IPC分类号： A61K9/08 ,  A61K9/00 ,  A61K9/14 ,  A61K31/60 ,  A61K47/02 ,  A61K31/615

CPC分类号： A61K31/621 ,  A61K31/60 ,  A61K47/02 ,  A61K9/0019

摘要： Acetylsalicylates with basic amino acids such as DL-lysine is stabilized in the form of solid preparation by admixing anhydrous calcium chloride therewith. The preparation containing calcium chloride is prevented from hydrolysis and can be stored for a long period of time even at a relatively high room temperature. The preparation is further prevented from discarolation when glycine is added thereto.

摘要翻译： 具有碱性氨基酸如DL-赖氨酸的乙酰水杨酸酯通过将无水氯化钙与其混合而稳定化为固体制剂的形式。 含有氯化钙的制剂被防止水解，并且即使在相对较高的室温下也可以长期储存。 当加入甘氨酸时，进一步防止了该制备。

公开(公告)号：US4230697A

公开(公告)日：1980-10-28

申请号：US37515

申请日：1979-05-09

申请人： Masayuki Nishida ,  Satoshi Funakoshi ,  Katsuhiro Ogasa ,  Morio Kuboyama ,  Nobuya Yanai ,  Muneo Yamada

发明人： Masayuki Nishida ,  Satoshi Funakoshi ,  Katsuhiro Ogasa ,  Morio Kuboyama ,  Nobuya Yanai ,  Muneo Yamada

IPC分类号： A61K35/22 ,  A61K38/00 ,  C07K14/52 ,  A61K37/00 ,  C07C103/52

CPC分类号： A61K35/22 ,  C07K14/52 ,  A61K38/00 ,  Y10S530/83 ,  Y10S530/834 ,  Y10S530/851

摘要： A colony-stimulating factor having definite physical and chemical properties and a function of stimulating activity on human bone marrow cells to proliferate and differentiate, thereby forming granulocyte colonies, is obtained from human urine by concentrating the urine with respect to proteins contained therein by adsorption chromatography with silica gel, salting out with ammonium sulfate and other means, then removing impurities by adsorption on cation exchanger, and further purifying by ion exchanging chromatography on anion exchanger, gel filtrating chromatography with highly crosslinked gels, affinity chromatography with sugar affinitive adsorbents and electrophoresis. This substance is stable in the presence of a stabilizer such as albumin or urinary proteins, against heat-treatment of virus-inactivation and can be used as a leukopenia curative which is precluded from fear of virus-infection.

摘要翻译： 具有确定的物理和化学性质以及刺激人骨髓细胞活性增殖和分化，从而形成粒细胞集落的功能的集落刺激因子通过浓缩尿液相对于其中所含蛋白质的吸附色谱从人尿中获得 用硅胶盐析，用硫酸铵等方法盐析，然后通过阳离子交换器上的吸附除去杂质，进一步通过阴离子交换柱上的离子交换色谱，高度交联凝胶的凝胶过滤色谱，糖亲和性吸附剂的亲和层析和电泳进行纯化。 这种物质在稳定剂如白蛋白或尿蛋白存在下是稳定的，用于病毒灭活的热处理，并且可以用作免于病毒感染的白细胞减少症治疗剂。

公开(公告)号：US4168303A

公开(公告)日：1979-09-18

申请号：US913493

申请日：1978-06-07

申请人： Masayuki Nishida ,  Sadao Yabushita ,  Shigeru Fujita ,  Toshiyuki Saki

发明人： Masayuki Nishida ,  Sadao Yabushita ,  Shigeru Fujita ,  Toshiyuki Saki

IPC分类号： A61K39/395 ,  A61K9/14 ,  A61K9/19 ,  C07K16/06 ,  A61K37/06

CPC分类号： C07K16/06 ,  Y10S530/83 ,  Y10S530/831

摘要： Freeze-drying of an aqueous solution of human native gamma globulin having an anticomplementary activity of 20 (C'H50) or less in the presence of 0.06 to 0.26 part by weight of a neutral inorganic salt for 1 part by weight of the gamma globulin gives an immunoactive lyophilized native gamma globulin preparation which has undergone neither increase in anticomplementary activity nor deterioration in antibody activity during the freeze-drying and is safe for use in intravenous administration.

摘要翻译： 在0.1重量份的γ球蛋白的存在下，在0.06至0.26重量份的中性无机盐的存在下，将具有20（C'H50）或更小的抗互补活性的人天然γ球蛋白水溶液冷冻干燥， 免疫活性的冻干天然γ球蛋白制剂在冷冻干燥过程中既没有增加抗补体活性也没有降低抗体活性，并且安全地用于静脉内给药。