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公开(公告)号：US20240019360A1
公开(公告)日：2024-01-18
申请号：US18453533
申请日：2023-08-22
Applicant: PROTEIN DYNAMIC SOLUTIONS, INC.
Inventor： Belinda Pastrana-Rios
CPC classification number: G01N21/39 , G01N33/6806 , G01N2201/1248 , G01N2021/3595
Abstract: The disclosure relates to methods and systems for the analysis of compounds in a crystalline state and/or undergoing crystallization. Two-dimensional correlation (2DCOS) and co-distribution analysis (2 DCDS) analysis plots can be generated and analyzed. Asynchronous plots can aid in establishing a sequential order of events. Positive cross peaks that correlate with auto peaks associated with aggregation can be identified. The auto peaks can be referenced to quickly discern the regions of the molecule most perturbed, which would indicate a driver for the crystallization state of the molecule. One can define which functional group types (e.g., region) are most perturbed (positive, intense auto peak) and observe how the different auto peaks begin to have greatest intensity change. These changes in auto peaks in the synchronous plots for the different stages of crystallization can provide information as to the dynamics of the process from amorphous to crystalline state.
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公开(公告)号：US20120078532A1
公开(公告)日：2012-03-29
申请号：US12889656
申请日：2010-09-24
Applicant: David Edward Forsyth , Wayne Kenneth Miller
Inventor： David Edward Forsyth , Wayne Kenneth Miller
IPC: G06F19/00
CPC classification number: G01N21/3504 , G01N21/274 , G01N21/61 , G01N2201/1218 , G01N2201/1248
Abstract: Non-dispersive infrared (NDIR) sensing systems employ a NDIR sensor coupled to a microprocessor to determine gas concentrations by employing slope-based methodologies that compensate for pressure variations, temperature variations, or both, which may compare NDIR signals with calibrated data. NDIR sensor systems may employ means for limiting the system peak current demand providing for the portability and scalability of the system. In NDIR sensor systems calculating gas concentrations using calibration data, the phase of the change in the NDIR output signal in response to a change in the infrared source emitter level may be measured as part of the calibration process.
Abstract translation: 非分散红外（NDIR）感测系统使用耦合到微处理器的NDIR传感器来通过采用补偿压力变化，温度变化或两者的基于斜率的方法来确定气体浓度，这可以将NDIR信号与校准数据进行比较。 NDIR传感器系统可以采用用于限制系统峰值电流需求的装置，以提供系统的可移植性和可扩展性。 在使用校准数据计算气体浓度的NDIR传感器系统中，响应于红外源发射极电平的变化，NDIR输出信号的变化的相位可以作为校准过程的一部分来测量。
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公开(公告)号：US07142296B2
公开(公告)日：2006-11-28
申请号：US10180647
申请日：2002-06-26
Applicant: Brian T. Cunningham , Peter Y. Li , Frank DeFilippi
Inventor： Brian T. Cunningham , Peter Y. Li , Frank DeFilippi
IPC: G01J3/28
CPC classification number: G01N21/253 , B01L3/5085 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G01N2201/0635 , G01N2201/08 , G01N2201/0833 , G01N2201/0846 , G01N2201/1248 , G02B5/1809 , G02B5/1814 , G02B21/06
Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
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公开(公告)号：US20170336320A1
公开(公告)日：2017-11-23
申请号：US15520051
申请日：2015-10-20
Inventor： Azer P. YALIN
IPC: G01N21/3504 , G01J3/42 , G01N21/39
CPC classification number: G01N21/3504 , G01J3/42 , G01J2003/2869 , G01J2003/423 , G01N21/39 , G01N2201/1248
Abstract: Systems and methods are disclosed to determine the concentration of a species within a sample. An example method may include collecting optical loss data over a range of frequencies from the sample using a spectroscopy system; placing the optical loss data into a plurality of bins, each bin having a defined frequency width; determining an average optical loss data value for the optical loss values within each bin that have an optical loss value less than a threshold value; removing the optical loss data within each bin having a value outside a tolerance range bounding the average optical loss data value for the respective bin; fitting a spectral curve to the remaining optical loss data; and determining the concentration of the species within the sample based on the spectral curve.
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公开(公告)号：US09606055B2
公开(公告)日：2017-03-28
申请号：US13737179
申请日：2013-01-09
Applicant: PPG Industries Ohio, Inc.
Inventor： Alison M. Norris
CPC classification number: G01N21/55 , G01J3/462 , G01J3/504 , G01N21/255 , G01N21/8422 , G01N21/8851 , G01N2021/8877 , G01N2201/1245 , G01N2201/1248
Abstract: A computer implemented method. The method includes obtaining, using a processor, spectral reflectance data from a coated surface having a target coating theron; and determining, using the processor, whether the data includes any outlier data points. The method also includes removing, using the processor, at least one of the outlier data points to produce final spectral reflectance data; and calculating, using the processor, a characteristic of the target coating based at least in part on the final spectral reflectance data.
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Patent Agency Ranking
公开(公告)号：US20060181705A1
公开(公告)日：2006-08-17
申请号：US11404430
申请日：2006-04-13
Applicant: Brian Cunningham , Peter Li , Frank DeFilippi
Inventor： Brian Cunningham , Peter Li , Frank DeFilippi
IPC: G01J3/28
CPC classification number: G01N21/253 , B01L3/5085 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G01N2201/0635 , G01N2201/08 , G01N2201/0833 , G01N2201/0846 , G01N2201/1248 , G02B5/1809 , G02B5/1814 , G02B21/06
Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
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公开(公告)号：US07327454B2
公开(公告)日：2008-02-05
申请号：US11404485
申请日：2006-04-13
Applicant: Brian T. Cunningham , Peter Y. Li , Frank DiFilippi
Inventor： Brian T. Cunningham , Peter Y. Li , Frank DiFilippi
IPC: G01J3/28
CPC classification number: G01N21/253 , B01L3/5085 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G01N2201/0635 , G01N2201/08 , G01N2201/0833 , G01N2201/0846 , G01N2201/1248 , G02B5/1809 , G02B5/1814 , G02B21/06
Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
Abstract translation: 用于检测生物分子相互作用的方法和装置。 不需要使用标签，并且可以以高通量的方式执行方法。 用于检测在生物传感器的表面上发生的生物化学相互作用的装置包括光源。 第一光纤耦合到光源并照亮生物传感器。 第二光纤检测从生物传感器反射的波长。 光谱仪确定来自生物传感器的反射信号的光谱。
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公开(公告)号：US20070252987A1
公开(公告)日：2007-11-01
申请号：US11506639
申请日：2006-08-18
Applicant: Brian Cunningham , Peter Li , Frank DiFilippi
Inventor： Brian Cunningham , Peter Li , Frank DiFilippi
IPC: G01J3/28
CPC classification number: G01N21/253 , B01L3/5085 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G01N2201/0635 , G01N2201/08 , G01N2201/0833 , G01N2201/0846 , G01N2201/1248 , G02B5/1809 , G02B5/1814 , G02B21/06
Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
Abstract translation: 用于检测生物分子相互作用的方法和装置。 不需要使用标签，并且可以以高通量的方式执行方法。 用于检测在生物传感器的表面上发生的生物化学相互作用的装置包括光源。 第一光纤耦合到光源并照亮生物传感器。 第二光纤检测从生物传感器反射的波长。 光谱仪确定来自生物传感器的反射信号的光谱。
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公开(公告)号：US07158230B2
公开(公告)日：2007-01-02
申请号：US11404158
申请日：2006-04-13
Applicant: Brian T. Cunningham , Peter Y. Li , Frank DiFilippi
Inventor： Brian T. Cunningham , Peter Y. Li , Frank DiFilippi
IPC: G01J3/28
CPC classification number: G01N21/253 , B01L3/5085 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G01N2201/0635 , G01N2201/08 , G01N2201/0833 , G01N2201/0846 , G01N2201/1248 , G02B5/1809 , G02B5/1814 , G02B21/06
Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
Abstract translation: 用于检测生物分子相互作用的方法和装置。 不需要使用标签，并且可以以高通量的方式执行方法。 用于检测在生物传感器的表面上发生的生物化学相互作用的装置包括光源。 第一光纤耦合到光源并照亮生物传感器。 第二光纤检测从生物传感器反射的波长。 光谱仪确定来自生物传感器的反射信号的光谱。
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公开(公告)号：US20240201103A1
公开(公告)日：2024-06-20
申请号：US18220985
申请日：2023-07-12
Applicant: SAMSUNG ELECTRONICS CO., LTD
Inventor： Myunggeun SONG , Sarah KIM , Changyul KIM , Younghoon KIM , Jaeyong PARK , Sungil CHO , Taeil CHO
IPC: G01N21/94
CPC classification number: G01N21/94 , G01N2201/1248
Abstract: An inspection method includes extracting a first similarity by comparing first data of a first optical signal with reference data of a reference optical signal, generating a first normal distribution of the first similarity, extracting a second similarity by comparing second data of a second optical signal with the reference data of the reference optical signal, generating a second normal distribution of the second similarity, and comparing the first normal distribution with the second normal distribution. The extracting of the first similarity includes deriving the first data of the first optical signal.
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