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公开(公告)号：US07750151B2
公开(公告)日：2010-07-06
申请号：US11547113
申请日：2005-04-05
Applicant: Mark T. Bilodeau , Chixu Chen , Nicholas D. P. Cosford , Brian W. Eastman , John C. Hartnett , Essa H. Hu , Peter J. Manley , Lou Anne Neilson , Lida R. Tehrani , Zhicai Wu
Inventor： Mark T. Bilodeau , Chixu Chen , Nicholas D. P. Cosford , Brian W. Eastman , John C. Hartnett , Essa H. Hu , Peter J. Manley , Lou Anne Neilson , Lida R. Tehrani , Zhicai Wu
IPC: C07D471/04 , C07D413/12 , C07D521/00 , C07D401/14 , C07D487/08 , A61P35/00
CPC classification number: C07D471/04 , C07D519/00
Abstract: The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
Abstract translation: 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代萘啶的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。
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2.发明申请SUBSTITUTED 1,2,4-OXADIAZOLES AND ANALOGS THEREOF AS CB2 RECEPTOR MODULATORS, USEFUL IN THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES 审中-公开作为CB2受体调节剂的替代的1,2,4-OXADIAZOLES及其类似物，有助于治疗疼痛，呼吸和非呼吸系统疾病公开(公告)号：US20100227845A1
公开(公告)日：2010-09-09
申请号：US12738192
申请日：2008-10-14
Applicant: Zhicai Wu , John C. Hartnett
Inventor： Zhicai Wu , John C. Hartnett
IPC: A61K31/4439 , C07D413/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P37/00 , C07D413/14 , A61K31/4545 , A61K31/496 , C07D417/14 , A61K31/541
CPC classification number: C07D413/04 , C07D401/04 , C07D413/14
Abstract: The present invention relates to compounds represented by Formula (I), Formula (II) and Formula (III) and pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical compositions comprising the instant compounds. This invention further provides methods to treat and prevent pain, respiratory and non-respiratory diseases.
Abstract translation: 本发明涉及由式（I），式（II）和式（III）表示的化合物及其药学上可接受的盐。 本发明还提供包含本发明化合物的药物组合物。 本发明还提供了治疗和预防疼痛，呼吸和非呼吸道疾病的方法。
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3.发明申请IMIDAZOPYRIDINE ANALOGS AS CB2 RECEPTOR MODULATORS, USEFUL IN THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES 审中-公开作为CB2受体调节剂的咪唑吡啶类似物，有助于治疗疼痛，呼吸和非呼吸系统疾病公开(公告)号：US20090325936A1
公开(公告)日：2009-12-31
申请号：US12519789
申请日：2007-12-14
Applicant: Mark T. Bilodeau , Christopher S. Burgey , Zhengwu James Deng , Nathan R. Kett , Jeffrey Melamed , Peter M. Munson , Kausik K. Nanda , Wayne Thompson , B. Wesley Trotter , Zhicai Wu , John C. Hartnett
Inventor： Mark T. Bilodeau , Christopher S. Burgey , Zhengwu James Deng , Nathan R. Kett , Jeffrey Melamed , Peter M. Munson , Kausik K. Nanda , Wayne Thompson , B. Wesley Trotter , Zhicai Wu , John C. Hartnett
IPC: A61K31/437 , C07D471/04 , A61K31/506 , A61K31/497 , A61K31/5377 , A61K31/551 , A61K31/541 , A61P19/00 , A61P25/00
CPC classification number: C07D471/04
Abstract: The present invention relates to compounds represented by Formula (I) and Formula (II): (I) (II) or pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical compositions comprising the instant compounds. This invention further provides methods to treat and prevent pain, respiratory and non-respiratory diseases.
Abstract translation: 本发明涉及由式（I）和式（II）表示的化合物：（I）（II）或其药学上可接受的盐。 本发明还提供包含本发明化合物的药物组合物。 本发明还提供了治疗和预防疼痛，呼吸和非呼吸道疾病的方法。
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公开(公告)号：US20080280899A1
公开(公告)日：2008-11-13
申请号：US11547113
申请日：2005-04-05
Applicant: Mark T. Bilodeau , Chixu Chen , Nicholas D.P. Cosford , Brian W. Eastman , John C. Hartnett , Essa H. Hu , Peter J. Manley , Lou Anne Neilson , Lida R. Tehrani , Zhicai Wu
Inventor： Mark T. Bilodeau , Chixu Chen , Nicholas D.P. Cosford , Brian W. Eastman , John C. Hartnett , Essa H. Hu , Peter J. Manley , Lou Anne Neilson , Lida R. Tehrani , Zhicai Wu
IPC: A61K31/519 , C07D471/04 , A61K31/4375 , A61P35/00 , A61K31/5377 , C07D413/12
CPC classification number: C07D471/04 , C07D519/00
Abstract: The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
Abstract translation: 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代萘啶的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。
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公开(公告)号：US07223738B2
公开(公告)日：2007-05-29
申请号：US10510069
申请日：2003-04-04
Applicant: Mark T. Bilodeau , Mark E. Duggan , John C. Hartnett , Craig W. Lindsley , Peter J. Manley , Zhicai Wu , Zhijian Zhao
Inventor： Mark T. Bilodeau , Mark E. Duggan , John C. Hartnett , Craig W. Lindsley , Peter J. Manley , Zhicai Wu , Zhijian Zhao
IPC: A01N43/04 , A01N43/58 , A01N43/60 , A01N43/42 , A61K31/70 , A61K31/50 , A61K31/495 , A61K31/52 , A61K31/47 , C07D487/00 , C07D491/00 , C07H15/00 , C07H17/00 , C07H17/02 , C09B25/00
CPC classification number: C07D401/10 , A61K31/498 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D409/14 , C07D417/14 , C07D471/04
Abstract: The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
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Patent Agency Ranking
公开(公告)号：US07579355B2
公开(公告)日：2009-08-25
申请号：US10554001
申请日：2004-04-20
Applicant: Mark T. Bilodeau , Mark E. Duggan , John C. Hartnett , Craig W. Lindsley , Zhicai Wu , Zhijian Zhao
Inventor： Mark T. Bilodeau , Mark E. Duggan , John C. Hartnett , Craig W. Lindsley , Zhicai Wu , Zhijian Zhao
IPC: A61K31/52 , C07D401/14
CPC classification number: C07F9/65583 , A61K45/06 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: The present invention is directed to compounds which contain a substituted pyridine moeity which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
Abstract translation: 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代吡啶甲氧基化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。
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公开(公告)号：US07544677B2
公开(公告)日：2009-06-09
申请号：US11659606
申请日：2005-08-19
Applicant: Mark T. Bilodeau , Nicholas D. P. Cosford , John C. Hartnett , Yiwei Li , Jun Liang , Peter J. Manley , Lou Anne Neilson , Tony Siu , Zhicai Wu
Inventor： Mark T. Bilodeau , Nicholas D. P. Cosford , John C. Hartnett , Yiwei Li , Jun Liang , Peter J. Manley , Lou Anne Neilson , Tony Siu , Zhicai Wu
IPC: A61K31/541 , A61K31/5355 , A61K31/519 , C07D471/04 , C07D519/00 , A61P35/00
CPC classification number: C07D471/04
Abstract: The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
Abstract translation: 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代的5-取代哌啶部分的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。
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公开(公告)号：US07414055B2
公开(公告)日：2008-08-19
申请号：US10554187
申请日：2004-04-20
Applicant: Mark E. Duggan , Craig W. Lindsley , Zhicai Wu , Zhijian Zhao , John C. Hartnett
Inventor： Mark E. Duggan , Craig W. Lindsley , Zhicai Wu , Zhijian Zhao , John C. Hartnett
IPC: A61K31/44 , C07D401/02
CPC classification number: C07D213/85 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
Abstract: The present invention is directed to compounds which contain a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
Abstract translation: 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代的吡啶部分的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。
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公开(公告)号：US20140088124A1
公开(公告)日：2014-03-27
申请号：US14123246
申请日：2012-06-01
Applicant: Robert J. DeVita , QingMei Hong , Zhong Lai , Kevin D. Dykstra , Yang Yu , Jian Liu , Donald M. Sperbeck , Tianying Jian , Deodial Guiadeen , Ginger Xu-qiang Yang , Zhicai Wu , Shuwen He , Pauline C. Ting , Robert Aslanian , Jeffrey T. Kuethe , James Balkovec , Rongze Kuang , Gang Zhou , Heping Wu
Inventor： Robert J. DeVita , QingMei Hong , Zhong Lai , Kevin D. Dykstra , Yang Yu , Jian Liu , Donald M. Sperbeck , Tianying Jian , Deodial Guiadeen , Ginger Xu-qiang Yang , Zhicai Wu , Shuwen He , Pauline C. Ting , Robert Aslanian , Jeffrey T. Kuethe , James Balkovec , Rongze Kuang , Gang Zhou , Heping Wu
IPC: C07D401/14 , C07D417/14 , C07D493/04 , C07D471/04
CPC classification number: C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04
Abstract: Described herein are compounds of formula (I), The compounds of formula I act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.
Abstract translation: 本文描述的是式（I）的化合物。式I化合物作为DGAT1抑制剂，可用于预防，治疗或作为高脂血症，糖尿病和肥胖症的补救剂。
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公开(公告)号：US20070254901A1
公开(公告)日：2007-11-01
申请号：US11659606
申请日：2005-08-19
Applicant: Mark Bilodeau , Nicolas Cosford , John Hartnett , Yiwei Li , Jun Liang , Peter Manley , Lou Neilson , Tony Siu , Zhicai Wu
Inventor： Mark Bilodeau , Nicolas Cosford , John Hartnett , Yiwei Li , Jun Liang , Peter Manley , Lou Neilson , Tony Siu , Zhicai Wu
IPC: A61K31/519 , A61P35/00 , C07D471/04
CPC classification number: C07D471/04
Abstract: The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
Abstract translation: 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代的5-取代哌啶部分的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。
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