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1.发明申请IMAGING AND TREATMENT OF PATHOPHYSIOLOGIC CONDITIONS BY CERENKOV RADIATION 审中-公开通过CERENKOV辐射成像和治疗病理状况公开(公告)号：US20170007724A1
公开(公告)日：2017-01-12
申请号：US15115457
申请日：2015-02-02
Applicant: WASHINGTON UNIVERSITY
Inventor： Samuel Achilefu , Nalinikanth Kotagiri
CPC classification number: A61K49/0056 , A61K41/0038 , A61K41/0057 , A61K49/0013 , A61K49/0021 , A61K51/0474 , A61K51/0482
Abstract: The present disclosure discloses methods and compositions for A administering Cerenkov radiation-induced therapy (GRIT). In an aspect, the invention encompasses a composition comprising at least two radiation-sensitive molecules. In another aspect, the invention encompasses a composition comprising a radiation-sensitive molecule and a targeting agent. In still another aspect, the invention encompasses a method for administering Gerenkov radiation-induced therapy (GRIT) to a target tissue in a subject. The method comprises administering to the subject an effective amount of a composition B comprising at least one radiation-sensitive molecule and administering to the subject an amount of a Gerenkov radiation (GR)-emitting radionuclide effective to activate the radiation-sensitive molecule, thereby administering GRIT to the target tissue in the subject.
Abstract translation: 本公开公开了用于施用切伦科夫辐射诱导疗法（GRIT）的方法和组合物。 一方面，本发明包括包含至少两种辐射敏感分子的组合物。 在另一方面，本发明包括包含辐射敏感分子和靶向剂的组合物。 另一方面，本发明包括用于给受试者的靶组织施用格伦科夫辐射诱导疗法（GRIT）的方法。 该方法包括向受试者施用有效量的包含至少一种辐射敏感分子的组合物B，并向受试者施用一定量的有效激活辐射敏感分子的Gerenkov辐射（GR）发射放射性核素，由此施用 GRIT到受试者的靶组织。
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公开(公告)号：US12178886B2
公开(公告)日：2024-12-31
申请号：US17449766
申请日：2021-10-01
Applicant: Washington University
Inventor： Samuel Achilefu , Nalinikanth Kotagiri
Abstract: The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT).
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公开(公告)号：US20220202961A1
公开(公告)日：2022-06-30
申请号：US17449766
申请日：2021-10-01
Applicant: Washington University
Inventor： Samuel Achilefu , Nalinikanth Kotagiri
Abstract: The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT).
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公开(公告)号：US11135316B2
公开(公告)日：2021-10-05
申请号：US15115457
申请日：2015-02-02
Applicant: Washington University
Inventor： Samuel Achilefu , Nalinikanth Kotagiri
Abstract: The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT). In an aspect, the invention encompasses a composition comprising at least two radiation-sensitive molecules. In another aspect, the invention encompasses a composition comprising a radiation-sensitive molecule and a targeting agent. In still another aspect, the invention encompasses a method for administering Cerenkov radiation-induced therapy (CRIT) to a target tissue in a subject. The method comprises administering to the subject an effective amount of a composition B comprising at least one radiation-sensitive molecule and administering to the subject an amount of a Cerenkov radiation (CR)-emitting radionuclide effective to activate the radiation-sensitive molecule, thereby administering CRIT to the target tissue in the subject.
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