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公开(公告)号：US20070073354A1
公开(公告)日：2007-03-29
申请号：US11235947
申请日：2005-09-26
Applicant: Mark Knudson , Adrianus Donders , Timothy Conrad
Inventor： Mark Knudson , Adrianus Donders , Timothy Conrad
IPC: A61N1/00
CPC classification number: A61N1/36071 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/36064 , A61N1/36067
Abstract: A method and apparatus are disclosed for treating a variety of conditions include treating a disorder associated with neural activity near a region of a brain. In such condition, the method includes placing an electrode to create a field near said region, creating said field with parameters selected to at least partially block neural activity within said field. For treating a tissue sensation, the method includes identifying a target area of tissue to be treated and placing an electrode to create a field near the target area, and creating the field with parameters selected to at least partially block neural activity within the target area. For treating a condition associated with neural activity of a spinal cord, the method includes placing an electrode to create a field near a nerve associated with the spinal cord, and creating the field with parameters selected to at least partially block neural activity within the nerve.
Abstract translation: 公开了用于治疗各种病症的方法和装置，包括治疗与脑区域附近的神经活动相关的病症。 在这种情况下，该方法包括放置电极以在所述区域附近产生场，产生具有选择以至少部分地阻止所述场内的神经活动的参数的所述场。 为了治疗组织感觉，所述方法包括识别待治疗的组织的靶区域并放置电极以在目标区域附近产生场，以及创建具有选择以至少部分阻断目标区域内的神经活动的参数的场。 为了治疗与脊髓的神经活动相关的病症，所述方法包括放置电极以产生与脊髓相关的神经附近的场，以及创建具有选择以至少部分阻断神经内的神经活动的参数的场。
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公开(公告)号：US20050070974A1
公开(公告)日：2005-03-31
申请号：US10756176
申请日：2004-01-12
Applicant: Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
Inventor： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
CPC classification number: A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36085
Abstract: A method and apparatus for treating patients suffering from obesity or eating disorders by applying a predetermined stimulating signal to the patient's vagus nerve appropriate to alleviate the condition and by applying a neural conduction block to the vagus nerve at a blocking site with the neural conduction block selected to at least partially block nerve impulses on the vagus nerve at the blocking site.
Abstract translation: 一种用于通过将预定的刺激信号施加到患者的迷走神经以适当减轻病症并通过在所选择的神经传导阻滞的阻塞部位向迷走神经应用神经传导阻滞来治疗患有肥胖或进食障碍的患者的方法和装置 至少部分阻断阻塞部位的迷走神经上的神经冲动。
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公开(公告)号：US20050028830A1
公开(公告)日：2005-02-10
申请号：US10938255
申请日：2004-09-09
Applicant: Mark Knudson , Timothy Conrad , Jerry Griffin
Inventor： Mark Knudson , Timothy Conrad , Jerry Griffin
CPC classification number: A61F5/566
Abstract: A method and apparatus for treating snoring of a patient includes providing an implant for altering a dynamic response of a soft palate of the patient to airflow past the soft palate. The implant is embedded in the soft palate to alter the dynamic response. For example, the implant has a mass, stiffness or dampening sufficient to alter the dynamic response following the implantation without substantially impairing a function of the soft palate to close a nasal passage of the patient during swallowing.
Abstract translation: 用于治疗患者打鼾的方法和装置包括提供植入物，用于改变患者的软腭的动态响应以使气流通过软腭。 植入物嵌入软腭以改变动态反应。 例如，植入物具有足以改变植入后的动态响应的质量，刚度或阻尼，而基本上不会损伤软腭在吞咽期间关闭患者鼻通道的功能。
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4.发明申请公开(公告)号：US20080021512A1
公开(公告)日：2008-01-24
申请号：US11891770
申请日：2007-08-13
Applicant: Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
Inventor： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
IPC: A61N1/00
CPC classification number: A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
Abstract: At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
Abstract translation: 通过刺激患者的肠神经系统来治疗多种胃肠道疾病中的至少一种，以增强肠神经系统的功能性色调。 治疗包括在靠近胃肠器官的迷走神经支配的至少一个部位的刺激部位电刺激患者的迷走神经。 电刺激包括在刺激部位施加刺激信号。 在靠近刺激部位的近端阻塞位置，将可选的近端电阻塞信号施加到迷走神经。 选择近端阻塞信号以至少部分阻断近端阻塞部位处的神经冲动。
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公开(公告)号：US20050268919A1
公开(公告)日：2005-12-08
申请号：US11196690
申请日：2005-08-03
Applicant: Mark Knudson , Timothy Conrad
Inventor： Mark Knudson , Timothy Conrad
CPC classification number: A61F5/56 , A61F2/0077 , A61F2/20 , A61M31/002 , A61M37/00
Abstract: A patient's pharyngeal wall is treated by inserting an expander member into the airway and positioning an active portion of the expander member in opposition to portions of the pharyngeal wall to be treated. The expander member is activated to urge the wall portions outwardly to an outwardly displaced position. The expander member is then deactivated while leaving the wall portions in the outwardly placed position and the expander member is removed from said airway. A further aspect of the treatment includes stabilization of at least a portion of the pharyngeal wall after compression of portions of the wall.
Abstract translation: 通过将膨胀器构件插入气道并将膨胀器构件的有效部分定位成与待治疗的咽壁的部分相对，来治疗患者的咽壁。 膨胀器构件被启动以将壁部分向外推动到向外移位的位置。 然后使膨胀器构件停止，同时将壁部分留在向外放置的位置，并且膨胀器构件从所述气道中移除。 治疗的另一方面包括在压缩壁的部分之后稳定咽壁的至少一部分。
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Patent Agency Ranking
公开(公告)号：US20050098184A1
公开(公告)日：2005-05-12
申请号：US11011741
申请日：2004-12-14
Applicant: Timothy Conrad , Mark Knudson
Inventor： Timothy Conrad , Mark Knudson
CPC classification number: A61F5/566
Abstract: A method and apparatus for treating snoring of a patient includes providing an implant for altering a dynamic response of a soft palate of the patient to airflow past the soft palate. The implant is embedded in the soft palate to alter the dynamic response. The implant has multiple fibers braided along a length of the implant.
Abstract translation: 用于治疗患者打鼾的方法和装置包括提供植入物，用于改变患者的软腭的动态响应以使气流通过软腭。 植入物嵌入软腭以改变动态反应。 植入物沿着植入物的长度编织多根纤维。
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公开(公告)号：US20050268923A1
公开(公告)日：2005-12-08
申请号：US11197271
申请日：2005-08-03
Applicant: Mark Knudson , Katherine Tweden , Timothy Conrad
Inventor： Mark Knudson , Katherine Tweden , Timothy Conrad
CPC classification number: A61F5/56 , A61F2/0059
Abstract: A patient's upper airway condition such as snoring and sleep apnea is treated by selecting a particulate material selected for limited migration within tissue and for encouraging a fibrotic response of tissue to the material. A bolus of the particulate material is injected into the tissue area to structurally stiffen the tissue.
Abstract translation: 患者的上呼吸道状况如打鼾和睡眠呼吸暂停通过选择在组织内选择用于有限迁移的颗粒材料并促进组织对该材料的纤维化反应来治疗。 将大量颗粒材料注入组织区域以使组织结构变硬。
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公开(公告)号：US20050251255A1
公开(公告)日：2005-11-10
申请号：US11179184
申请日：2005-07-12
Applicant: Anja Metzger , Brian Erickson , John Sopp , Mark Knudson , Timothy Conrad
Inventor： Anja Metzger , Brian Erickson , John Sopp , Mark Knudson , Timothy Conrad
CPC classification number: A61F5/56 , A61F2/04 , A61F2/20 , A61F2002/046 , A61M31/002 , A61M37/00
Abstract: A pharyngeal airway having a pharyngeal wall of a patient at least partially surrounding and defining the airway is treated by selecting an implant dimensioned so as to be implanted at or beneath a mucosal layer of the pharyngeal wall and extending transverse to said wall. The implant has mechanical characteristics for the implant, at least in combination with a fibrotic tissue response induced by the implant, to stiffen said pharyngeal wall to resist radial collapse. The implant is implanted into the pharyngeal wall transverse to a longitudinal axis of the airway.
Abstract translation: 具有至少部分地围绕和限定气道的患者的咽壁的咽气道通过选择尺寸设置成植入在咽壁的粘膜层上或下方并且横向于所述壁延伸的植入物来治疗。 植入物具有用于植入物的机械特征，至少与由植入物引起的纤维化组织反应相结合，以加强所述咽壁以抵抗径向塌陷。 将植入物植入到垂直于气道纵轴的咽壁中。
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公开(公告)号：US20050038484A1
公开(公告)日：2005-02-17
申请号：US10881045
申请日：2004-06-30
Applicant: Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
Inventor： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
CPC classification number: A61N1/36085 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36178
Abstract: A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
Abstract translation: 用于治疗至少部分由迷走神经活动表征的多种疾病中的至少一种的方法包括将电极定位在由迷走神经支配的身体器官周围。 将电信号施加到电极以调节迷走神经活性。 电信号被施加在为信号选择的频率上，以向迷走神经产生神经传导阻滞，其中神经传导阻滞被选择以至少部分阻断迷走神经上的脉冲。 电信号的应用被停止。 重复信号的应用和信号的中断，并且选择停止和应用的持续时间来治疗疾病。
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公开(公告)号：US20070135858A1
公开(公告)日：2007-06-14
申请号：US11656132
申请日：2007-01-22
Applicant: Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
Inventor： Mark Knudson , Richard Wilson , Katherine Tweden , Timothy Conrad
IPC: A61N1/32
CPC classification number: A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
Abstract: At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.
Abstract translation: 至少部分由至少部分由迷走神经活动支配至少一个患者的多个器官的患者的障碍中的至少一种通过包括将神经刺激器载体定位在患者的身体器官周围的方法来治疗， 器官由至少一个迷走神经树干支配。 电极设置在载体上并位于迷走神经干线处。 将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。 该信号可以是阻塞或刺激信号。
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