公开(公告)号：US20230201354A1

公开(公告)日：2023-06-29

申请号：US17998761

申请日：2021-05-14

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Hakan Demirci ,  Nicholas Kotov ,  Yichun Wang

IPC: A61K47/52 ,  A61K9/00 ,  A61K45/06 ,  A61K49/00 ,  A61K47/69 ,  C01B32/159

CPC classification number: A61K47/52 ,  A61K9/0019 ,  A61K45/06 ,  A61K9/0092 ,  A61K49/0095 ,  A61K49/0017 ,  A61K47/6929 ,  C01B32/159 ,  C01B2202/36 ,  C01B2202/34 ,  B82Y5/00

Abstract: Disclosed herein are compositions and methods for injecting compounds into a vitreous body. Carbon nanotubes can be functionalized with a variety of agents, such as therapeutic agents and/or diagnostic agents, which can be injected into a vitreous body for treatment or detection of ocular tumors such as retinoblastoma. The carbon nanotubes can effectively penetrate the ocular tumor, making them effective carriers for the therapeutic and/or diagnostic agents.

公开(公告)号：US12036000B2

公开(公告)日：2024-07-16

申请号：US16304805

申请日：2017-05-25

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Hakan Demirci ,  Guan Xu

IPC: A61B5/00 ,  A61B8/10 ,  G01N29/24 ,  G01N29/34 ,  A61B8/00 ,  G01N21/17 ,  G01N29/46

CPC classification number: A61B5/0095 ,  A61B8/10 ,  G01N29/2418 ,  G01N29/348

Abstract: A method of diagnosing intraocular tumors including illuminating a tissue sample using a pulsed light source resulting in output of heat and thermoelastic expansion of the tissue sample. The thermoelastic expansion of the tissue sample produces propagating waves in ultrasonic frequencies. The propagating waves are acquired using an ultrasound system and back-projection reconstruction, thereby mapping anatomies with optical contrast at ultrasonic resolution to image intraocular tumors.

公开(公告)号：US20220211545A1

公开(公告)日：2022-07-07

申请号：US17612156

申请日：2021-05-21

Applicant: The Regents of the University of Michigan ,  The Penn State Research Foundation

Inventor： Lauro V. Ojeda ,  Jeffrey M. Sundstrom ,  Justin T. Holmer ,  Alan Cruz ,  Minghui Huang ,  Anant Bhamri ,  Hakan Demirci ,  Thomas Gardner ,  Russ Miller ,  Peter Nguyen

IPC: A61F9/007 ,  A61B10/02 ,  A61B10/00

Abstract: Provided herein are devices, systems, and methods for biological sample collection. In particular, provided herein are devices, systems, and methods that employ small, hand-held devices that collect small volumes of biological samples, such as vitreous from the eye, for diagnostic and other purposes.