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公开(公告)号：US20210292759A1
公开(公告)日：2021-09-23
申请号：US16346251
申请日：2017-11-01
Inventor： Won Jong KIM , Jeong Hun KIM , Jihyun LEE , Byung Joo LEE
IPC: C12N15/115 , A61K31/713 , A61K47/61 , A61P35/00 , A61P27/02
Abstract: The present invention relates to a method for producing dextran polymer-based amplified nucleic acid aptamer nanoconstructs which efficiently and selectively capture a specific target molecule, the method comprising linking a short nucleic acid sequence or a complementary sequence for formation of nanoconstructs and a nucleic acid aptamer sequence for capture of the specific target molecule to a dextran polymer by a chemical reaction, mixing the resulting polymer/nucleic acid substances with each other to form nanostructures, subjecting the nanostructures to rolling circle amplification, thereby forming a nucleic acid aptamer having a repeated structure. The dextran polymer-based amplified nucleic acid aptamer nanoconstructs have the effect of efficiently and selectively capturing a specific target molecule.
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公开(公告)号：US20210371863A1
公开(公告)日：2021-12-02
申请号：US16963315
申请日：2018-04-13
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Won Jong KIM , Ji Hyun LEE
IPC: C12N15/115 , A61K31/713 , C12Q1/6886
Abstract: The present invention relates to a highly efficient aptamer complex comprising a branched DNA and an aptamer, and a pharmaceutical use thereof. More specifically, the aptamer complex of the present invention relates to a highly efficient aptamer complex including a Y-shaped DNA as the branched DNA and using vascular endothelial growth factor (VEGF) as a target molecule. The aptamer complex of the present invention and a pharmaceutical composition comprising the same as an active ingredient are expected to be widely used in the medical field since the binding efficiency with the target molecule is more remarkable than that of the conventional aptamer.
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公开(公告)号：US20170274098A1
公开(公告)日：2017-09-28
申请号：US15337252
申请日：2016-10-28
Inventor： Won Jong KIM , Jinhwan KIM
CPC classification number: A61K48/0041 , C08B37/003 , C08G69/10 , C08G73/0206
Abstract: Provided is a gene delivery including a polymer network formed by binding phenylboronic acid, sugar, and a low-molecular weight branched polymer. The gene delivery may be stably maintained in vivo and efficiently deliver a gene specifically to cancer cells, such that the gene delivery system may be usefully used as a gene delivery system for chemotherapy.
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Patent Agency Ranking
公开(公告)号：US20210275574A1
公开(公告)日：2021-09-09
申请号：US17182504
申请日：2021-02-23
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Won Jong KIM , Ji Won Yeo
IPC: A61K31/785 , A61K9/06 , A61K9/00
Abstract: The invention relates to a nitric oxide-responsive acrylamide-based polymer, and more particularly, to an acrylamide-based polymer that is produced using an acrylamide-based monomer and a nitric oxide-sensitive crosslinking agent and allows prevention or treatment of a disease or illness caused by overexpression of nitric oxide.
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公开(公告)号：US20200040145A1
公开(公告)日：2020-02-06
申请号：US16606143
申请日：2018-04-18
Inventor： Won Jong KIM , Junghong PARK
Abstract: The present invention relates to a polymeric gel comprising crosslink points, which are dissociated in response to nitrogen monoxide, and to a method for preparing a hydrogel, the method comprising the steps of: a) polymerizing a mixture of monomers comprising a monofunctional hydrophilic monomer and a monomer comprising a plurality of functional groups comprising an o-phenylenediamine residue; and b) separating a hydrogel formed by the polymerization.
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公开(公告)号：US20150260678A1
公开(公告)日：2015-09-17
申请号：US14698955
申请日：2015-04-29
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Jin Kon KIM , Sangshin JANG , Seung Yun YANG , Gumhye JEON , Won Jong KIM , Sejin SON , Hyunwoo KIM
IPC: G01N27/40 , G01N27/447
CPC classification number: G01N27/40 , B32B3/12 , B32B3/266 , B32B27/08 , B32B27/302 , B32B2333/12 , B82Y30/00 , B82Y40/00 , G01N27/44791 , G01N33/48721 , Y10T428/24149 , Y10T428/24273 , Y10T428/249978 , Y10T428/249979 , Y10T428/24998
Abstract: A nanoporous membrane according to the present invention includes a support member and a polymer layer disposed on the support member and including a plurality of nano pores each having an inner wall formed of a block-structured polymer material of which the end thereof is substituted by a functional group.
Abstract translation: 根据本发明的纳米多孔膜包括支撑构件和设置在支撑构件上的聚合物层，并且包括多个纳米孔，每个纳米孔具有由嵌段结构的聚合物材料形成的内壁，其末端被 功能组。
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7.发明申请公开(公告)号：US20170145040A1
公开(公告)日：2017-05-25
申请号：US15359474
申请日：2016-11-22
Inventor： Won Jong KIM , Jihoon KIM , Hyung Woo CHOI
CPC classification number: C07F7/1804 , A61K31/655 , A61K31/695 , A61K33/00 , A61K47/54 , A61K47/6923 , A61K47/6929 , B01J20/048 , B01J20/22 , B82Y5/00 , C01B21/24
Abstract: Provided is a method of controlling release of nitric oxide, and more particularly, to a method of selectively releasing nitric oxide depending on a change in pH using calcium phosphate.The method of selectively releasing nitric oxide according to the present invention may stably deliver nitric oxide to a desired site, and induce release of nitric oxide by a change in pH, thereby making it possible to improve a therapeutic effect while preventing a loss of nitric oxide.
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8.发明申请METHOD OF PREPARING COATING FILM CONTAINING NITROGEN MONOXIDE ON SURFACE OF MATERIAL USING CATECHOLAMINE 有权使用羧甲基纤维素制备含有氮氧化物的材料表面涂层膜的方法公开(公告)号：US20140127277A1
公开(公告)日：2014-05-08
申请号：US13860899
申请日：2013-04-11
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Won Jong KIM , Jihoon KIM , Haeshin LEE , Seonki HONG
CPC classification number: A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/114
Abstract: A method of coating surfaces of various body-implantable materials with control-releasable nitrogen monoxide using a catecholamine, more particularly, technology of preparing a coating film containing a diazeniumdiolate functional group on a surface of a material to be coated using a catecholamine, is provided. The coating film prepared by the method has advantages in that nitrogen monoxide can be stably supplied under an in vivo environment, and can be suitably used in a living body without causing cytotoxicity. Therefore, among the materials having a coating film formed on a surface thereof, the body-implantable material is especially expected to be widely used for medical and health applications including treatment of ischemic disorders such as arteriosclerosis through controlled release of nitrogen monoxide, regulation of penile erections, antibacterial and antiviral effects, and wound healing.
Abstract translation: 提供一种使用儿茶酚胺涂覆具有对照可释放一氧化氮的各种身体可植入材料的表面的方法，更具体地说，提供了使用儿茶酚胺在待涂覆的材料的表面上制备含有二氮烯鎓二硫酸盐官能团的涂膜的技术 。 通过该方法制备的涂膜具有能够在体内环境下稳定地供给一氧化氮的优点，可以适当地用于生物体而不引起细胞毒性。 因此，在其表面形成有涂膜的材料中，特别期望体内植入材料广泛用于医疗和健康应用，包括通过控制释放一氧化氮来治疗缺血性疾病如动脉硬化，调节阴茎 勃起，抗菌和抗病毒作用以及伤口愈合。
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