公开(公告)号：US20140127277A1

公开(公告)日：2014-05-08

申请号：US13860899

申请日：2013-04-11

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Won Jong KIM ,  Jihoon KIM ,  Haeshin LEE ,  Seonki HONG

IPC: A61L31/10 ,  A61L27/54 ,  A61L29/16 ,  A61L27/34 ,  A61L31/16 ,  A61L29/08

CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/114

Abstract: A method of coating surfaces of various body-implantable materials with control-releasable nitrogen monoxide using a catecholamine, more particularly, technology of preparing a coating film containing a diazeniumdiolate functional group on a surface of a material to be coated using a catecholamine, is provided. The coating film prepared by the method has advantages in that nitrogen monoxide can be stably supplied under an in vivo environment, and can be suitably used in a living body without causing cytotoxicity. Therefore, among the materials having a coating film formed on a surface thereof, the body-implantable material is especially expected to be widely used for medical and health applications including treatment of ischemic disorders such as arteriosclerosis through controlled release of nitrogen monoxide, regulation of penile erections, antibacterial and antiviral effects, and wound healing.

Abstract translation: 提供一种使用儿茶酚胺涂覆具有对照可释放一氧化氮的各种身体可植入材料的表面的方法，更具体地说，提供了使用儿茶酚胺在待涂覆的材料的表面上制备含有二氮烯鎓二硫酸盐官能团的涂膜的技术 。 通过该方法制备的涂膜具有能够在体内环境下稳定地供给一氧化氮的优点，可以适当地用于生物体而不引起细胞毒性。 因此，在其表面形成有涂膜的材料中，特别期望体内植入材料广泛用于医疗和健康应用，包括通过控制释放一氧化氮来治疗缺血性疾病如动脉硬化，调节阴茎 勃起，抗菌和抗病毒作用以及伤口愈合。