公开(公告)号：US20220194894A1

公开(公告)日：2022-06-23

申请号：US17429183

申请日：2020-02-10

申请人： Nogra Pharma Limited

发明人： Salvatore Demartis ,  Francesca Viti ,  Marie McNulty

IPC分类号： C07C231/02 ,  C07C201/12 ,  C07C205/56 ,  C07C233/54

摘要： The disclosure provides a process for the preparation of 3-(4′-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof, contemplated to be capable of modulating the activity of receptors, e.g., PPARs receptors.

公开(公告)号：US12071623B2

公开(公告)日：2024-08-27

申请号：US18246845

申请日：2022-05-17

申请人： Nogra Pharma Limited

发明人： Francesca Viti ,  Marie McNulty ,  Salvatore Bellinvia

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/113

CPC分类号： C12N15/1136 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/3341

摘要： Disclosed herein polynucleotides complementary to IL-34, including IL-34 antisense oligonucleotides and IL-34 NAs, and methods for treating inflammatory diseases, such as an inflammatory bowel disease, and/or fibrosis, associated with elevated activity or expression of IL-34. Also disclosed are pharmaceutical compositions containing a polynucleotide complementary to IL-34, for example, an IL-34 antisense oligonucleotide or an IL-34 siRNA, useful for treating inflammatory diseases and/or fibrosis and manufacture of medicaments containing a disclosed polynucleotide to be used in treating inflammatory diseases and/or fibrosis.

公开(公告)号：US20230002770A1

公开(公告)日：2023-01-05

申请号：US17755943

申请日：2020-11-16

申请人： Nogra Pharma Limited

发明人： Francesca Viti ,  Marie McNulty ,  Salvatore Bellinvia

IPC分类号： C12N15/113 ,  A61P1/00

摘要： Disclosed herein are IL-34 inhibitors, including IL-34 antisense oligonucleotide sequences, and methods for treating inflammatory diseases, such as an inflammatory bowel disease, and/or fibrosis, associated with elevated activity or expression of IL-34. Also disclosed are pharmaceutical compositions containing an IL-34 inhibitor, for example, a IL-34 antisense oligonucleotide, useful for treating inflammatory diseases and/or fibrosis and manufacture of medicaments containing a disclosed IL-34 inhibitor to be used in treating inflammatory diseases and/or fibrosis.

公开(公告)号：US20190046490A1

公开(公告)日：2019-02-14

申请号：US16078555

申请日：2017-02-27

申请人： Nogra Pharma Limited

发明人： Marie McNulty ,  Francesca Viti ,  Salvatore Bellinvia

IPC分类号： A61K31/201 ,  A61P1/00

摘要： Disclosed herein in part are methods for treating lactose intolerance, including administering fatty acid compounds that modulate PPARγ receptors.

公开(公告)号：US11905232B2

公开(公告)日：2024-02-20

申请号：US17429183

申请日：2020-02-10

申请人： Nogra Pharma Limited

发明人： Salvatore Demartis ,  Francesca Viti ,  Marie McNulty

IPC分类号： C07C231/10 ,  C07C201/12 ,  C07C205/56 ,  C07C231/18 ,  C07C233/54 ,  C07C231/02 ,  C07C227/04 ,  C07C303/28

CPC分类号： C07C231/10 ,  C07C201/12 ,  C07C205/56 ,  C07C227/04 ,  C07C231/02 ,  C07C231/18 ,  C07C233/54 ,  C07C303/28 ,  C07C201/12 ,  C07C205/56 ,  C07C303/28 ,  C07C309/66 ,  C07C227/04 ,  C07C229/42 ,  C07C231/02 ,  C07C233/54

摘要： The disclosure provides a process for the preparation of 3-(4′-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof, contemplated to be capable of modulating the activity of receptors, e.g., PPARs receptors.

公开(公告)号：US20180338992A1

公开(公告)日：2018-11-29

申请号：US15778688

申请日：2016-11-25

申请人： Nogra Pharma Limited

发明人： Marie McNulty ,  Francesca Viti ,  Salvatore Bellinvia

IPC分类号： A61K31/711 ,  A61P1/00 ,  A61K9/00 ,  C12N15/113

摘要： Disclosed herein are antisense oligonucleotide sequences against IL-34 and methods for treating inflammatory diseases, such as inflammatory bowel disease, and/or fibrosis, associated with elevated activity or expression of IL-34. Also disclosed are pharmaceutical compositions containing an IL-34 antisense oligonucleotide useful for treating inflammatory diseases and/or fibrosis and manufacture of medicaments containing a disclosed IL-34 antisense oligonucleotide to be used in treating inflammatory diseases and/or fibrosis.

公开(公告)号：US20240093197A1

公开(公告)日：2024-03-21

申请号：US18246845

申请日：2022-05-17

申请人： Nogra Pharma Limited

发明人： Francesca Viti ,  Marie McNulty ,  Salvatore Bellinvia

IPC分类号： C12N15/113

CPC分类号： C12N15/1136 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/3341

摘要： Disclosed herein polynucleotides complementary to IL-34, including IL-34 antisense oligonucleotides and IL-34 NAs, and methods for treating inflammatory diseases, such as an inflammatory bowel disease, and/or fibrosis, associated with elevated activity or expression of IL-34. Also disclosed are pharmaceutical compositions containing a polynucleotide complementary to IL-34, for example, an IL-34 antisense oligonucleotide or an IL-34 siRNA, useful for treating inflammatory diseases and/or fibrosis and manufacture of medicaments containing a disclosed polynucleotide to be used in treating inflammatory diseases and/or fibrosis.

公开(公告)号：US20230212582A1

公开(公告)日：2023-07-06

申请号：US17996505

申请日：2021-04-23

申请人： Nogra Pharma Limited

发明人： Francesca Viti ,  Giovanni Monteleone ,  Salvatore Demartis ,  Salvatore Bellinvia ,  Marie McNulty

IPC分类号： C12N15/113 ,  G01N33/68 ,  A61P1/12

CPC分类号： C12N15/1136 ,  G01N33/6863 ,  A61P1/12 ,  C12N2310/3341 ,  C12N2310/315 ,  C12N2310/322

摘要： The present disclosure relates to compositions of oligonucleotide (e.g., SMAD7 antisense oligonucleotide diastereomers) and methods of manufacturing, assessing efficacy, and using the compositions.