-
公开(公告)号：US07241845B2
公开(公告)日：2007-07-10
申请号：US10805494
申请日：2004-03-22
Applicant: Neil Bonnette Graham , Christopher Raymond Moran
Inventor： Neil Bonnette Graham , Christopher Raymond Moran
IPC: C08G65/32
CPC classification number: C08G81/024 , A61K47/34 , C08G18/4808 , C08G18/6685 , C08G65/33348 , C08G81/00 , C08G2210/00
Abstract: A linear random block copolymer comprising segments of polyethylene oxide and a relatively more hydrophobic polymer, e.g. polypropylene oxide connected by hydrophobic segments containing urethane and urea groups formed from the reaction of a di-isocyanate and a diamine, wherein the diamine comprises less than 2% by weight of the total weight of the reactants used in the preparation of the copolymer.
Abstract translation: 线性无规嵌段共聚物，其包含聚环氧乙烷和相对较疏水的聚合物的链段， 通过含有由二异氰酸酯和二胺反应形成的氨基甲酸酯和脲基的疏水部分连接的聚环氧丙烷，其中二胺占共聚物制备中使用的反应物总重量的小于2重量％。
-
公开(公告)号：US20120302656A1
公开(公告)日：2012-11-29
申请号：US13505418
申请日：2010-11-02
Applicant: Abdul Rashid , Roderick William Jonathan Bowers , Wade Tipton , Neil Bonnette Graham
Inventor： Abdul Rashid , Roderick William Jonathan Bowers , Wade Tipton , Neil Bonnette Graham
CPC classification number: C08G18/4833 , C08G18/6674 , C08G2220/00 , G02B1/043 , C08L75/08
Abstract: The present invention relates to a thermoplastic polyurethane contact lens prepared from a mixture comprising: (a) at least one polyethylene glycol; (b) at least one di-isocyanate; and (c) at least one diol of formula (I): wherein n is an integer from 1 to 25; wherein the polyethylene glycol, di-isocyanate and diol are reacted under substantially anhydrous conditions. Further aspects of the invention relate to a process for preparing a contact lens. The invention also relates to a process for preparing a polyurethane xerogel in the form of a molded article, said process comprising the steps of: (i) preparing a reaction mixture comprising at least one polyethylene glycol, at least one di-isocyanate and at least one diol of formula I as described above; (ii) reacting the reaction mixture formed in step (i) under substantially anhydrous conditions to form a polyurethane xerogel; (iii) injection molding the polyurethane xerogel to form a molded article, (iv) hydrating the xerogel molded article to form a contact lens.
Abstract translation: 本发明涉及由以下混合物制备的热塑性聚氨酯隐形眼镜：（a）至少一种聚乙二醇; （b）至少一个二异氰酸酯; 和（c）至少一种式（I）的二醇：其中n是1至25的整数; 其中聚乙二醇，二异氰酸酯和二醇在基本无水条件下反应。 本发明的其它方面涉及一种制备隐形眼镜的方法。 本发明还涉及一种制备模制品形式的聚氨酯干凝胶的方法，所述方法包括以下步骤：（i）制备包含至少一种聚乙二醇，至少一种二异氰酸酯和至少一种二异氰酸酯的反应混合物 如上所述的一种式I的二醇; （ii）在基本上无水条件下使步骤（i）中形成的反应混合物反应形成聚氨酯干凝胶; （iii）注射成型聚氨酯干凝胶以形成模塑制品，（iv）将干凝胶模塑制品保湿以形成隐形眼镜。
-
公开(公告)号：US09000065B2
公开(公告)日：2015-04-07
申请号：US13505416
申请日：2010-11-02
Applicant: Abdul Rashid , Roderick William Jonathan Bowers , Wade Tipton , Neil Bonnette Graham
Inventor： Abdul Rashid , Roderick William Jonathan Bowers , Wade Tipton , Neil Bonnette Graham
IPC: C08G18/61 , C08G18/48 , C08G18/66 , G02B1/04 , C08G101/00
CPC classification number: C08G18/61 , C08G18/4833 , C08G18/6674 , C08G2101/0091 , G02B1/043 , C08L75/04 , C08L83/04
Abstract: The present invention relates to a polyurethane prepared from a mixture comprising: (a) at least one polyethylene glycol; (b) at least one di-isocyanate; (c) at least one polydialkyl siloxane diol; and (d) at least one diol of formula (I) wherein n is an integer from 1 to 25; wherein the polyethylene glycol, di-isocyanate, polydialkyl siloxane diol and diol are reacted under substantially anhydrous conditions. Further aspects of the invention relate to a process for preparing a polyurethane. The invention also relates to a process for preparing a polyurethane xerogel in the form of a molded article, said process comprising the steps of: (i) preparing a reaction mixture comprising at least one polyethylene glycol, at least one di-isocyanate, at least one polydialkyl siloxane diol and at least one diol of formula I as described above; (ii) reacting the reaction mixture formed in step (i) under substantially anhydrous conditions to form a polyurethane xerogel; and (iii) injection molding the polyurethane xerogel to form a molded article.
Abstract translation: 本发明涉及由以下混合物制备的聚氨酯：（a）至少一种聚乙二醇; （b）至少一种二异氰酸酯; （c）至少一种聚二烷基硅氧烷二醇; 和（d）至少一种式（I）的二醇，其中n是1至25的整数; 其中聚乙二醇，二异氰酸酯，聚二烷基硅氧烷二醇和二醇在基本无水条件下反应。 本发明的其它方面涉及一种制备聚氨酯的方法。 本发明还涉及一种制备模制品形式的聚氨酯干凝胶的方法，所述方法包括以下步骤：（i）制备包含至少一种聚乙二醇，至少一种二异氰酸酯的反应混合物，至少一种 一种聚二烷基硅氧烷二醇和至少一种如上所述的式I的二醇; （ii）在基本上无水条件下使步骤（i）中形成的反应混合物反应形成聚氨酯干凝胶; 和（iii）注射成型聚氨酯干凝胶以形成模塑制品。
-
公开(公告)号：US20130274370A1
公开(公告)日：2013-10-17
申请号：US13821154
申请日：2011-10-24
Applicant: Rashid Abdul , Neil Bonnette Graham
Inventor： Rashid Abdul , Neil Bonnette Graham
IPC: C08L75/08
CPC classification number: C08L75/08 , C08G18/10 , C08G18/12 , C08G18/4833 , C08G2210/00 , G02B1/043 , C08L71/02 , C08L75/04
Abstract: The present invention relates to a polyurethane polymer composition prepared by reacting a mixture comprising: a} at least one polyethylene glycol, and either b) at least one poly-isocyanate, having a functionality greater than 2 or c) at least one di-isocyanate and at least one polyol or at least one macropolyol having a functionality greater than 2, wherein the polyol or macropolyol is present at an amount of 0.1 to 9 wt % of the mixture. The invention also relates to a process for preparing a polyurethane xero-gel in the form of a moulded article, said process comprising the steps of: i.) preparing said mixture; ii. ) dispensing the reaction mixture formed in step i) into a mould; iii. ) allowing the reaction mixture to react and cure; iv. ) removing the moulded article from the mould; and v. ) hydrating the moulded article.
Abstract translation: 本发明涉及一种聚氨酯聚合物组合物，其通过使包含：a}至少一种聚乙二醇和b）至少一种官能度大于2的聚异氰酸酯或c）至少一种二异氰酸酯 和至少一种多元醇或至少一种官能度大于2的大多元醇，其中所述多元醇或大多元醇的含量为所述混合物的0.1至9重量％。 本发明还涉及一种制备模塑制品形式的聚氨酯纯化凝胶的方法，所述方法包括以下步骤：i）制备所述混合物; ii。 ）将步骤i）中形成的反应混合物分配到模具中; iii。 ）使反应混合物反应和固化; iv。 ）将模制品从模具中取出; 和v）水合该模制品。
-
公开(公告)号：US20120316256A1
公开(公告)日：2012-12-13
申请号：US13505403
申请日：2010-11-02
Applicant: Abdul Rashid , Roderick William Jonathan Bowers , Wade Tipton , Neil Bonnette Graham
Inventor： Abdul Rashid , Roderick William Jonathan Bowers , Wade Tipton , Neil Bonnette Graham
CPC classification number: C08G71/04 , C08G18/4825 , C08G18/4829 , C08G18/4833 , C08G18/61 , C08G2101/0091 , C08G2210/00 , G02B1/043 , C08L69/00
Abstract: The present invention relates to a polyurethane polymer composition comprising polyethyleneglycol dialkyl ether. There is also provided a process for preparing a polyurethane. The invention also relates to a process for preparing a polyurethane xerogel in the form of a molded article, said process comprising the steps of: i. preparing a mixture of a. at least one polyethylene glycol or at least one polyol of formula (I), wherein at least three Of X1, X2, X3, X4 and X5 are each independently an OH-terminated group, and the remainder of X1, X2, X3, X4 and X5 are each independently H or absent, and Z is a central linking unit, a. at least one di- or poly-isocyanate, b. optionally at least one OH-terminated chain extender, and c. at least one polyethyleneglycol dialkyl ether; ii. dispensing the reaction mixture formed in step i) into a mold; iii. allowing the reaction mixture to react and cure; iv. removing the molded article from the mold; and v. hydrating the molded article.
Abstract translation: 本发明涉及包含聚乙二醇二烷基醚的聚氨酯聚合物组合物。 还提供了制备聚氨酯的方法。 本发明还涉及一种制备模制品形式的聚氨酯干凝胶的方法，所述方法包括以下步骤： 准备一种混合物。 至少一种聚乙二醇或至少一种式（I）的多元醇，其中X 1，X 2，X 3，X 4和X 5中的至少三个各自独立地是OH-封端的基团，其余的X 1，X 2，X 3，X 4 和X 5各自独立地为H或不存在，Z为中心连接单元，a。 至少一种二异氰酸酯或多异氰酸酯，b。 任选地至少一个OH-封端的扩链剂，和c。 至少一种聚乙二醇二烷基醚; ii。 将步骤i）中形成的反应混合物分配到模具中; iii。 使反应混合物反应并固化; iv。 将模制品从模具中取出; 和v。水合成型制品。
-
Patent Agency Ranking
公开(公告)号：US09243102B2
公开(公告)日：2016-01-26
申请号：US13505418
申请日：2010-11-02
Applicant: Abdul Rashid , Roderick William Jonathan Bowers , Wade Tipton , Neil Bonnette Graham
Inventor： Abdul Rashid , Roderick William Jonathan Bowers , Wade Tipton , Neil Bonnette Graham
CPC classification number: C08G18/4833 , C08G18/6674 , C08G2220/00 , G02B1/043 , C08L75/08
Abstract: The present invention relates to a thermoplastic polyurethane contact lens prepared from a mixture comprising: (a) at least one polyethylene glycol; (b) at least one di-isocyanate; and (c) at least one diol of formula (I): wherein n is an integer from 1 to 25; wherein the polyethylene glycol, di-isocyanate and diol are reacted under substantially anhydrous conditions. Further aspects of the invention relate to a process for preparing a contact lens. The invention also relates to a process for preparing a polyurethane xerogel in the form of a molded article, said process comprising the steps of: (i) preparing a reaction mixture comprising at least one polyethylene glycol, at least one di-isocyanate and at least one diol of formula I as described above; (ii) reacting the reaction mixture formed in step (i) under substantially anhydrous conditions to form a polyurethane xerogel; (iii) injection molding the polyurethane xerogel to form a molded article, (iv) hydrating the xerogel molded article to form a contact lens.
Abstract translation: 本发明涉及由以下混合物制备的热塑性聚氨酯隐形眼镜：（a）至少一种聚乙二醇; （b）至少一种二异氰酸酯; 和（c）至少一种式（I）的二醇：其中n是1至25的整数; 其中聚乙二醇，二异氰酸酯和二醇在基本无水条件下反应。 本发明的其它方面涉及一种制备隐形眼镜的方法。 本发明还涉及一种制备模制品形式的聚氨酯干凝胶的方法，所述方法包括以下步骤：（i）制备包含至少一种聚乙二醇，至少一种二异氰酸酯和至少一种二异氰酸酯的反应混合物 如上所述的一种式I的二醇; （ii）在基本上无水条件下使步骤（i）中形成的反应混合物反应形成聚氨酯干凝胶; （iii）注射成型聚氨酯干凝胶以形成模塑制品，（iv）将干凝胶模塑制品保湿以形成隐形眼镜。
-
公开(公告)号：US20130053511A1
公开(公告)日：2013-02-28
申请号：US13505410
申请日：2010-11-02
Applicant: Abdul Rashid , Roderick William Jonathan Bowers , Wade Tipton , Neil Bonnette Graham
Inventor： Abdul Rashid , Roderick William Jonathan Bowers , Wade Tipton , Neil Bonnette Graham
CPC classification number: C08G18/61 , C08G18/4829 , C08G18/4833 , C08G18/4883 , C08G2210/00 , G02B1/043 , C08L75/04
Abstract: The present invention relates to a polyurethane polymer prepared from a mixture comprising: (a) at least one polyol of formula (I), wherein at least three of X1, X2, X3, X4 and X5 are each independently an OH-terminated polyoxyalkylene group, and the remainder of X1, X2, X3. X4 and X5 are each independently H or absent, and Z is a central linking unit; (b) at least one di- or poly-isocyanate; and (c) optionally at least one OH-terminated chain extender. Further aspects of the invention relate to a process for preparing a polyurethane, and to a process for preparing a contact lens.
Abstract translation: 本发明涉及由以下混合物制备的聚氨酯聚合物：（a）至少一种式（I）的多元醇，其中X 1，X 2，X 3，X 4和X 5中的至少三个各自独立地为OH封端的聚氧化烯基 ，余数为X1，X2，X3。 X4和X5各自独立地为H或不存在，Z为中心连接单元; （b）至少一种二异氰酸酯或多异氰酸酯; 和（c）任选的至少一个OH-封端的扩链剂。 本发明的其它方面涉及一种制备聚氨酯的方法以及一种制备隐形眼镜的方法。
-
公开(公告)号：US20120302661A1
公开(公告)日：2012-11-29
申请号：US13505416
申请日：2010-11-02
Applicant: Abdul Rashid , Roderick William Jonathan Bowers , Wade Tipton , Neil Bonnette Graham
Inventor： Abdul Rashid , Roderick William Jonathan Bowers , Wade Tipton , Neil Bonnette Graham
CPC classification number: C08G18/61 , C08G18/4833 , C08G18/6674 , C08G2101/0091 , G02B1/043 , C08L75/04 , C08L83/04
Abstract: The present invention relates to a polyurethane prepared from a mixture comprising: (a) at least one polyethylene glycol; (b) at least one di-isocyanate; (c) at least one polydialkyl siloxane diol; and (d) at least one diol of formula (I) wherein n is an integer from 1 to 25; wherein the polyethylene glycol, di-isocyanate, polydialkyl siloxane diol and diol are reacted under substantially anhydrous conditions. Further aspects of the invention relate to a process for preparing a polyurethane. The invention also relates to a process for preparing a polyurethane xerogel in the form of a molded article, said process comprising the steps of: (i) preparing a reaction mixture comprising at least one polyethylene glycol, at least one di-isocyanate, at least one polydialkyl siloxane diol and at least one diol of formula I as described above; (ii) reacting the reaction mixture formed in step (i) under substantially anhydrous conditions to form a polyurethane xerogel; and (iii) injection molding the polyurethane xerogel to form a molded article.
Abstract translation: 本发明涉及由以下混合物制备的聚氨酯：（a）至少一种聚乙二醇; （b）至少一种二异氰酸酯; （c）至少一种聚二烷基硅氧烷二醇; 和（d）至少一种式（I）的二醇，其中n是1至25的整数; 其中聚乙二醇，二异氰酸酯，聚二烷基硅氧烷二醇和二醇在基本无水条件下反应。 本发明的其它方面涉及一种制备聚氨酯的方法。 本发明还涉及一种制备模制品形式的聚氨酯干凝胶的方法，所述方法包括以下步骤：（i）制备包含至少一种聚乙二醇，至少一种二异氰酸酯的反应混合物，至少一种 一种聚二烷基硅氧烷二醇和至少一种如上所述的式I的二醇; （ii）在基本上无水条件下使步骤（i）中形成的反应混合物反应形成聚氨酯干凝胶; 和（iii）注射成型聚氨酯干凝胶以形成模塑制品。
-
公开(公告)号：US20100013114A1
公开(公告)日：2010-01-21
申请号：US12282235
申请日：2007-03-12
Applicant: Roderick William Jonathan Bowers , Neil Bonnette Graham , Abdul Rashid
Inventor： Roderick William Jonathan Bowers , Neil Bonnette Graham , Abdul Rashid
IPC: B29D11/00
Abstract: The present invention relates to a method of using non-macrogelled polymer-solvent combinations to form devices, in particular medical devices and/or cosmetic devices, more specifically contact lenses. The method of using polymer solvent combinations is suitable for forming useful 3D dimensionally stable structures which may include curved surfaces, which may be significantly different to those curved surfaces achieved by using simple meniscus effects.
Abstract translation: 本发明涉及使用非聚凝胶聚合物 - 溶剂组合来形成装置，特别是医疗装置和/或化妆品装置，更具体地说是隐形眼镜的方法。 使用聚合物溶剂组合的方法适用于形成有用的3D尺寸稳定的结构，其可以包括弯曲表面，其可以与通过使用简单的弯月面效应实现的那些曲面显着不同。
-
公开(公告)号：US5994492A
公开(公告)日：1999-11-30
申请号：US930652
申请日：1997-12-11
Applicant: Neil Bonnette Graham , Jianwen Mao
Inventor： Neil Bonnette Graham , Jianwen Mao
CPC classification number: A61K9/2031 , C08G18/0852 , C08G18/6677 , C08G18/758 , C08G2210/00
Abstract: A microgel is produced by a two-stage process wherein the monomers are first polymerized in the absence of solvent for a controlled period, and in a second stage solvent is added and polymerization is completed. The polymer is preferably a polyurethane formed from a polyalkylene glycol, a triol and a diisocyanate. The molecular weight is typically 100,000 to 200,000. The microgels form granules which may be compressed into solid form. Such solid forms containing an active agent, such as a protein, are useful as sustained delivery devices.
Abstract translation: PCT No.PCT / GB96 / 00863 Sec。 371 1997年12月11日第 102（e）日期1997年12月11日PCT提交1996年4月4日PCT公布。 公开号WO96 / 31551 日期：1996年10月10日通过两阶段方法生产微凝胶，其中单体首先在不存在溶剂的条件下进行聚合，在第二阶段加入溶剂并进行聚合。 聚合物优选为由聚亚烷基二醇，三醇和二异氰酸酯形成的聚氨酯。 分子量通常为100,000至200,000。 微凝胶形成可压缩成固体形式的颗粒。 含有活性剂如蛋白质的这种固体形式可用作持续递送装置。
-
-
-
-
-
-
-
-
-
Search Results
15
records
(took 0.038 seconds)
