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公开(公告)号：US20180055876A1
公开(公告)日：2018-03-01
申请号：US15690020
申请日：2017-08-29
发明人： Vlad Bogin , Thomas Ichim
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/0073
摘要： Disclosed are means of preventing, reducing and/or treating pregnancy associated complications by administration of Noble Gas mixtures, directly by inhalation, or by other means of direct or indirect introduction, with the intended effect of reducing immunological/inflammatory events associated with said complications. In one embodiment the invention teaches the modulation of the maternal-fetal unit from a Th1/Th17 predisposition towards a Th2/Treg environment by inhalation of a combination of 30% xenon gas admixed with air, or combinations of medical grade oxygen and nitrogen.
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公开(公告)号：US20170341980A1
公开(公告)日：2017-11-30
申请号：US15610362
申请日：2017-05-31
发明人： Vlad Bogin , Thomas Ichim , Santos Kesari
CPC分类号： C01B21/24 , A61K33/00 , A61K2300/00
摘要： Disclosed are means of inducing neuroregeneration and/or neuroprotection in patients with damage to the nervous system. In one embodiment, Noble Gas containing compositions are administered to a patient suffering from a neurological injury, said therapy is administered alone, or in combination with other therapies useful in the induction of neuronal protection/stimulation of neurogenesis. In one specific embodiment, patients are treated with Noble Gas compositions to restore neural function subsequent to radiation therapy or chemotherapy for neoplasia of the brain. In another embodiment, Noble Gas compositions are administered prior to, concurrent with or after radiation and chemotherapy in order to induce a protective effect on non-malignant cells without substantially interfering with efficacy of radiation and chemotherapy.
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公开(公告)号：US10376539B2
公开(公告)日：2019-08-13
申请号：US15598268
申请日：2017-05-17
发明人： Vlad Bogin , Thomas Ichim , Santosh Kesari
摘要： Disclosed are methods of inhibiting progression, stabilizing and reversing amyotrophic lateral sclerosis and neuromuscular degenerative diseases including spinal muscular atrophy, by administration of xenon, or noble gas compositions at a sufficient frequency and concentration to evoke anti-inflammatory, immunomodulatory, and regenerative processes in a patient in need of therapy. In one embodiment, xenon is administered as a pharmaceutical preparation at a concentration of 5 to 90% by volume, more preferably for certain embodiments, at 5 to 30% by volume, wherein said pharmaceutical preparation additionally contains oxygen, argon, nitrogen and/or air. In other embodiments argon is utilized together, or as a replacement for xenon. Furthermore, the use of xenon and/or other noble gas combinations are disclosed for augmentation of therapies that augment endogenous regenerative cells.
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公开(公告)号：US20170333473A1
公开(公告)日：2017-11-23
申请号：US15598268
申请日：2017-05-17
发明人： Vlad Bogin , Thomas Ichim , Santosh Kesari
CPC分类号： A61K33/00 , A61K35/28 , A61K35/51 , A61K2035/124
摘要： Disclosed are methods of inhibiting progression, stabilizing and reversing amyotrophic lateral sclerosis and neuromuscular degenerative diseases including spinal muscular atrophy, by administration of xenon, or noble gas compositions at a sufficient frequency and concentration to evoke anti-inflammatory, immunomodulatory, and regenerative processes in a patient in need of therapy. In one embodiment, xenon is administered as a pharmaceutical preparation at a concentration of 5 to 90% by volume, more preferably for certain embodiments, at 5 to 30% by volume, wherein said pharmaceutical preparation additionally contains oxygen, argon, nitrogen and/or air. In other embodiments argon is utilized together, or as a replacement for xenon. Furthermore, the use of xenon and/or other noble gas combinations are disclosed for augmentation of therapies that augment endogenous regenerative cells.
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公开(公告)号：US20170281685A1
公开(公告)日：2017-10-05
申请号：US15465514
申请日：2017-03-21
发明人： Vlad Bogin , Thomas Ichim
IPC分类号： A61K35/28 , C12N5/0775
CPC分类号： A61K35/28 , C12N5/0663 , C12N5/0668 , C12N2500/02 , C12N2500/05
摘要： The current invention discloses compositions of matter, therapeutic protocols, and combination therapies utilizing previously unknown activity of Xenon alone or in combination with other Noble gases to augment therapeutic activity of regenerative cells, in one embodiment said regenerative cells comprising of mesenchymal stem cells. In one embodiment the invention provides use of xenon-pretreatment of cells prior to in vivo application in order to allow for enhanced efficacy of said cells. In other embodiments xenon alone, or in combination with other gases is utilized to modulate regenerative activity of cells in vivo.
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公开(公告)号：US20170196906A1
公开(公告)日：2017-07-13
申请号：US15402177
申请日：2017-01-09
发明人： Vlad Bogin , Thomas Ichim
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/007
摘要： The invention discloses means of utilizing Noble Gases for inhibition of pathogenic processes associated with Alzheimer's Disease progression, as well as reversal of Alzheimer's Disease. In one embodiment compositions containing xenon gas are administered alone or together with therapeutic interventions for treatment of Alzheimer's Disease. In another embodiment, taupathies such as chronic traumatic encephalopathy are treated by administration of xenon or Noble Gas containing mixtures.
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公开(公告)号：US20170348349A1
公开(公告)日：2017-12-07
申请号：US15615912
申请日：2017-06-07
发明人： Vlad Bogin , Thomas Ichim , Daqing Ma
CPC分类号： A61K33/00 , A61G10/026 , A61K9/0019 , A61K9/007 , A61K9/0073 , A61K9/127 , A61M5/00 , A61M16/12 , A61M37/0092 , A61M2005/006 , A61M2016/1035 , A61M2202/0208 , A61M2202/0291 , A61M2202/0007 , A61K2300/00
摘要： Disclosed are the unique and unexpected findings that xenon gas possesses the ability to directly inhibited amyloid beta associated toxicity, inhibit production of amyloid beta, and stimulate synthesis of soluble, free-form amyloid beta. The invention teaches the use of xenon gas, as well as various combinations of Noble Gases, for the prevention, amelioration, and treatment of Alzheimer's Disease and other pathologies associated with generation of insoluble aggregates containing amyloid beta.
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