公开(公告)号：US11229658B2

公开(公告)日：2022-01-25

申请号：US15555168

申请日：2016-03-04

Applicant: NESTEC S.A.

Inventor： Norbert Sprenger ,  Dominique Brassart ,  Delphine Egli

IPC: A61K31/702 ,  A61K9/00 ,  A23L33/00 ,  A23L33/21 ,  A23L33/125 ,  A61K35/741 ,  A61K35/00

Abstract: The present invention relates to a nutritional composition comprising at least one fucosylated oligosaccharide and at least one N-acetylated oligosaccharide in particular amounts, for use in preventing and/or treating infections and/or inflammations of the lower respiratory tract and/or of the ear in an infant or a young child.

公开(公告)号：US11179405B2

公开(公告)日：2021-11-23

申请号：US16328782

申请日：2017-08-24

Applicant: NESTEC S.A.

Inventor： Bernard Berger ,  Norbert Sprenger ,  Dominik Grathwohl

IPC: A61K31/702 ,  A23L33/00 ,  A23L33/21 ,  A61K45/06 ,  A61P31/04 ,  A61P1/00 ,  A61K9/00

Abstract: The present invention relates to nutritional compositions for infants or young children and their health effects, that comprise at least one fucosylated oligosaccharide and at least one N-acetylated oligosaccharide. These nutritional compositions are for use to prevent and/or treat infection in an infant or young child, by promoting and/or reducing specific microbiota communities in an infant or young child.

公开(公告)号：US10821125B2

公开(公告)日：2020-11-03

申请号：US16415618

申请日：2019-05-17

Applicant: NESTEC S.A.

Inventor： Carlos Antonio De Castro ,  Norbert Sprenger ,  Sagar Thakkar

IPC: A61K31/702 ,  C07H3/06 ,  C07H5/06 ,  A23L33/00 ,  A23L33/10

Abstract: A nutritional composition contains Fut2-dependent oligosaccharides for promoting brain growth and development in infants in the very early postnatal period. The nutritional composition contains Fut2-dependent oligosaccharides and Lacto-N-neotetraose and is specifically for use in promoting brain catch-up growth in preterm infants or infants with low-birth weight. A kit can include at least two of these nutritional compositions.

公开(公告)号：US20190046545A1

公开(公告)日：2019-02-14

申请号：US16071729

申请日：2017-01-26

Applicant: NESTEC S.A.

Inventor： Aristea Binia ,  Chiara Nembrini ,  Norbert Sprenger ,  Ornella Avanti Nigro

IPC: A61K31/702 ,  A23L33/00 ,  A23L33/21 ,  A61P3/04

Abstract: The present invention relates to a nutritional composition comprising an oligosaccharide mixture, said oligosaccharide mixture comprising at least one N-acetylated oligosaccharide, one galacto-oligosaccharide and one sialylated oligosaccharide for use in reducing and/or avoiding excessive fat mass accumulation and/or in preventing any related later in life health disorders in an infant or a young child such as later in life obesity and related comorbidities, by increasing colonic SCFA production and/or GLP-1 secretion/releasein said infant or young child.

公开(公告)号：US20180143186A1

公开(公告)日：2018-05-24

申请号：US15573690

申请日：2016-05-18

Applicant: NESTEC S.A.

Inventor： Dominique Brassart ,  Norbert Sprenger

IPC: G01N33/53

CPC classification number: G01N33/5308 ,  A23C9/206 ,  A23L33/40 ,  A23V2002/00 ,  G01N2333/42 ,  G01N2400/02 ,  G01N2400/12 ,  A23V2200/32 ,  A23V2200/324 ,  A23V2250/284

Abstract: Described is a matrix to identify mother's milk missing fucosyltransferase-2 (FUT2) dependent glycans which comprise a line of a glycan binding protein such as a lectin or antibody suitable to bind 2′fucosyl-glycans and a line of a positive control to bind a mother's milk protein. For instance, this matrix is porous and allows for transport by capillary force of compounds of mother's milk such as glycoproteins. Especially, the glycan binding protein is the plant lectin from Ulex europaeus. A diagnostic kit comprising one or more of such matrices and a device suitable to receive such a matrix provided with a milk application window and a read-out window has been described as well. Finally a kit-of-parts comprising such a diagnostic kit and one or more feeding doses of 2′fucosyl-glycans has been disclosed.

公开(公告)号：US20180078573A1

公开(公告)日：2018-03-22

申请号：US15554738

申请日：2016-03-04

Applicant: NESTEC S.A.

Inventor： Norbert Sprenger ,  Dominique Brassart ,  Delphine Egli

IPC: A61K31/702 ,  A23L33/125 ,  A23L33/135 ,  A23L33/00 ,  A61K35/741

Abstract: The present invention relates to a nutritional composition comprising at least one fucosylated oligosaccharide for use in preventing and/or treating constipation and/or in improving stool consistency/frequency in an infant or a young child.

公开(公告)号：US09254303B2

公开(公告)日：2016-02-09

申请号：US13963581

申请日：2013-08-09

Applicant: NESTEC S.A.

Inventor： Norbert Sprenger

IPC: A61K38/00 ,  A61K35/747 ,  A23L1/30 ,  A23L1/308 ,  A61K31/702 ,  A61K31/7016

CPC classification number: A61K35/747 ,  A23L33/10 ,  A23L33/135 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A23Y2220/73 ,  A61K31/7016 ,  A61K31/702 ,  Y02A50/473 ,  A23V2200/3204 ,  A23V2200/3202 ,  A23V2200/32 ,  A23V2250/1882 ,  A23V2250/70 ,  A23V2250/704 ,  A23V2250/156 ,  A61K2300/00

Abstract: This invention relates to a preparation comprising N-acetyl-lactosamine and/or an oligosaccharide containing N-acetyl-lactosamine and a probiotic Lactobacillus sp. The invention extends to nutritional compositions comprising said preparation and to the use of the preparation in the prevention and treatment of pathogenic infections of the gastro-intestinal and upper respiratory tracts.

公开(公告)号：US10821124B2

公开(公告)日：2020-11-03

申请号：US15554738

申请日：2016-03-04

Applicant: NESTEC S.A.

Inventor： Norbert Sprenger ,  Dominique Brassart ,  Delphine Egli

IPC: A61K31/702 ,  A61P1/00 ,  A23L33/00 ,  A23L33/135 ,  A23L33/21 ,  A23L33/125 ,  A61K9/00 ,  A61K35/741 ,  A61K35/00

Abstract: The present invention relates to a nutritional composition comprising at least one fucosylated oligosaccharide for use in preventing and/or treating constipation and/or in improving stool consistency/frequency in an infant or a young child.

公开(公告)号：US20190269710A1

公开(公告)日：2019-09-05

申请号：US16415618

申请日：2019-05-17

Applicant: NESTEC S.A.

Inventor： Carlos Antonio De Castro ,  Norbert Sprenger ,  Sagar Thakkar

IPC: A61K31/702 ,  A23L33/10 ,  A23L33/00

Abstract: A nutritional composition contains Fut2-dependent oligosaccharides for promoting brain growth and development in infants in the very early postnatal period. The nutritional composition contains Fut2-dependent oligosaccharides and Lacto-N-neotetraose and is specifically for use in promoting brain catch-up growth in preterm infants or infants with low-birth weight. A kit can include at least two of these nutritional compositions.

公开(公告)号：US10328091B2

公开(公告)日：2019-06-25

申请号：US15522575

申请日：2015-10-29

Applicant: NESTEC S.A.

Inventor： Carlos Antonio De Castro ,  Norbert Sprenger ,  Sagar Thakkar

IPC: A61K31/702 ,  A23L33/00 ,  A23L33/10

Abstract: This invention relates to the use of a nutritional composition comprising Fut2-dependent oligosaccharides for promoting brain growth and development in infants in the very early postnatal period. The nutritional composition comprises Fut2-dependent oligosaccharides and Lacto-N-neotetraose and is specifically for use in promoting brain catch-up growth in preterm infants or infants with low-birth weight. The invention further relates to a kit comprising at least two of these nutritional compositions.