公开(公告)号：US20240261520A1

公开(公告)日：2024-08-08

申请号：US18603017

申请日：2024-03-12

Applicant: MannKind Corporation

Inventor： Chad C. Smutney ,  P. Spencer Kinsey ,  Carl R. Sahi ,  Benoit Adamo ,  John M. Polidoro ,  Scott McLean ,  Dennis Overfield ,  Anthony Bryant

IPC: A61M15/00 ,  A61K9/00 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K38/26 ,  A61K38/28 ,  A61K47/22

CPC classification number: A61M15/0045 ,  A61K9/0075 ,  A61K38/1709 ,  A61K38/22 ,  A61K38/26 ,  A61K38/28 ,  A61K47/22 ,  A61M15/0021 ,  A61M15/0023 ,  A61M15/0028 ,  A61M15/0043 ,  A61M15/0048 ,  A61M15/0086 ,  A61M15/0091 ,  A61K38/00 ,  A61M2202/064 ,  A61M2205/6081 ,  A61M2206/20

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.

公开(公告)号：US20230201489A1

公开(公告)日：2023-06-29

申请号：US18117823

申请日：2023-03-06

Applicant: MannKind Corporation

Inventor： Chad C. Smutney ,  Benoit Adamo ,  Brendan F. Laurenzi ,  P. Spencer Kinsey

IPC: A61M15/00 ,  A61M11/00

CPC classification number: A61M15/00 ,  A61M11/001 ,  A61M15/0005 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/0028 ,  A61M15/0025 ,  A61M15/0065 ,  A61M2202/064 ,  A61M2205/076 ,  A61M2206/14 ,  A61M2206/16 ,  A61M2206/20 ,  A61M2016/0027

Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity.

公开(公告)号：US20230098083A1

公开(公告)日：2023-03-30

申请号：US17983915

申请日：2022-11-09

Applicant: MannKind Corporation

Inventor： P. Spencer Kinsey ,  Brendan Laurenzi ,  Chad C. Smutney ,  Benoit Adamo ,  Joseph Guarneri ,  John J. Freeman, JR.

IPC: A61M15/00 ,  A61K9/00 ,  A61K31/352 ,  A61K31/495 ,  A61K31/661

Abstract: A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.

公开(公告)号：US20210244897A1

公开(公告)日：2021-08-12

申请号：US17244730

申请日：2021-04-29

Applicant: MannKind Corporation

Inventor： Chad C. Smutney ,  Benoit Adamo ,  John M. Polidoro ,  P. Spencer Kinsey ,  Dennis Overfield ,  Carl R. Sahi ,  Christine Billings ,  Mark T. Marino

IPC: A61M15/00 ,  A61K38/28 ,  A61K9/00

Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.

公开(公告)号：US20210146071A1

公开(公告)日：2021-05-20

申请号：US17158997

申请日：2021-01-26

Applicant: MannKind Corporation

Inventor： P. Spencer Kinsey ,  Brendan Laurenzi ,  Chad C. Smutney ,  Benoit Adamo ,  Joseph Guarneri ,  John J. Freeman, JR.

IPC: A61M15/00 ,  A61K9/00 ,  A61K31/352 ,  A61K31/495 ,  A61K31/661

Abstract: A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.

公开(公告)号：US20200345957A1

公开(公告)日：2020-11-05

申请号：US16932520

申请日：2020-07-17

Applicant: MannKind Corporation

Inventor： Chad C. Smutney ,  P. Spencer Kinsey ,  Carl R. Sahi ,  Benoit Adamo ,  John M. Polidoro

IPC: A61M15/00 ,  A61K47/22 ,  A61K9/00 ,  A61K38/17 ,  A61K38/22 ,  A61K38/26 ,  A61K38/28

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.

公开(公告)号：US10751488B2

公开(公告)日：2020-08-25

申请号：US15098219

申请日：2016-04-13

Applicant: MannKind Corporation

Inventor： Chad C. Smutney ,  P. Spencer Kinsey ,  Carl R. Sahi ,  Benoit Adamo ,  John M. Polidoro

IPC: A61M15/00 ,  A61K47/22 ,  A61K9/00 ,  A61K38/17 ,  A61K38/22 ,  A61K38/26 ,  A61K38/28 ,  A61K38/00

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

公开(公告)号：US20160287820A1

公开(公告)日：2016-10-06

申请号：US15182503

申请日：2016-06-14

Applicant: MannKind Corporation

Inventor： Chad C. Smutney ,  Beniot Adamo ,  John M. Polidoro ,  P. Spencer Kinsey ,  Dennis Overfield ,  Carl R. Sahi ,  Christine Billings ,  Mark T. Marino

IPC: A61M15/00 ,  A61K38/28 ,  A61K9/00

CPC classification number: A61M15/0091 ,  A61K9/0075 ,  A61K38/28 ,  A61M15/0021 ,  A61M15/0028 ,  A61M15/0043 ,  A61M2202/064 ,  A61M2205/6081

Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.

Abstract translation: 公开了一种肺部药物递送系统，包括呼吸动力的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以配备药物递送制剂，其包含例如二酮哌嗪和活性成分，包括肽和蛋白质如胰岛素和胰高血糖素样肽1，用于治疗内分泌疾病，例如糖尿病和 /或肥胖。

公开(公告)号：US20160228659A1

公开(公告)日：2016-08-11

申请号：US15098219

申请日：2016-04-13

Applicant: MannKind Corporation

Inventor： Chad C. Smutney ,  P. Spencer Kinsey ,  Carl R. Sahi ,  Benoit Adamo ,  John M. Polidoro

IPC: A61M15/00

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

公开(公告)号：US12233206B2

公开(公告)日：2025-02-25

申请号：US18603017

申请日：2024-03-12

Applicant: MannKind Corporation

Inventor： Chad C. Smutney ,  P. Spencer Kinsey ,  Carl R. Sahi ,  Benoit Adamo ,  John M. Polidoro ,  Scott McLean ,  Dennis Overfield ,  Anthony Bryant

IPC: A61M15/00 ,  A61K9/00 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K38/26 ,  A61K38/28 ,  A61K47/22

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.