公开(公告)号：US20230248722A1

公开(公告)日：2023-08-10

申请号：US17996706

申请日：2021-04-30

Applicant: MANNKIND CORPORATION

Inventor： Thomas Hofmann ,  Stefan Ufer ,  John J. Freeman, JR.

IPC: A61K31/498 ,  A61K9/00 ,  A61K47/26 ,  A61K47/10 ,  A61K47/12

CPC classification number: A61K31/498 ,  A61K9/0075 ,  A61K9/0078 ,  A61K47/26 ,  A61K47/10 ,  A61K47/12

Abstract: Disclosed herein are methods of treatment and/or prophylaxis of viral infections. In particular, the method is for the administration by inhalation of a pharmaceutically effective dose of clofazimine, which is provided in the form of a solution, suspension, or as a dry powder, in formulations suitable for inhalation.

公开(公告)号：US20200375984A1

公开(公告)日：2020-12-03

申请号：US16994425

申请日：2020-08-14

Applicant: MannKind Corporation

Inventor： Marshall L. Grant ,  Grayson W. Stowell ,  Paul Menkin ,  John J. Freeman, JR.

IPC: A61K31/495 ,  A61K9/00 ,  A61K9/16 ,  A61K9/19 ,  A61K9/14 ,  A61K38/28 ,  A61K45/06 ,  A61M15/00 ,  C07D241/08 ,  A61K31/5575 ,  A61K38/19

Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.

公开(公告)号：US20170189395A1

公开(公告)日：2017-07-06

申请号：US15462559

申请日：2017-03-17

Applicant: MannKind Corporation

Inventor： Marshall L. Grant ,  Grayson W. Stowell ,  Paul Menkin ,  John J. Freeman, JR.

IPC: A61K31/495 ,  A61K38/19 ,  A61K9/00 ,  A61K45/06 ,  A61K31/5575

Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.

公开(公告)号：US20230181573A1

公开(公告)日：2023-06-15

申请号：US18106948

申请日：2023-02-07

Applicant: MannKind Corporation

Inventor： Marshall L. Grant ,  Grayson W. Stowell ,  Paul Menkin ,  John J. Freeman, JR.

IPC: A61K31/495 ,  A61K9/00 ,  A61K9/16 ,  A61K9/19 ,  A61K9/14 ,  A61K38/28 ,  A61K45/06 ,  A61M15/00 ,  C07D241/08 ,  A61K31/5575 ,  A61K38/19

CPC classification number: A61K31/495 ,  A61K9/0075 ,  A61K9/1617 ,  A61K9/1694 ,  A61K9/19 ,  A61K9/145 ,  A61K38/28 ,  A61K45/06 ,  A61M15/0028 ,  A61M15/0091 ,  C07D241/08 ,  A61K31/5575 ,  A61K38/193 ,  Y10T428/2982 ,  A61K38/00

Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.

公开(公告)号：US20230098083A1

公开(公告)日：2023-03-30

申请号：US17983915

申请日：2022-11-09

Applicant: MannKind Corporation

Inventor： P. Spencer Kinsey ,  Brendan Laurenzi ,  Chad C. Smutney ,  Benoit Adamo ,  Joseph Guarneri ,  John J. Freeman, JR.

IPC: A61M15/00 ,  A61K9/00 ,  A61K31/352 ,  A61K31/495 ,  A61K31/661

Abstract: A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.

公开(公告)号：US20210146071A1

公开(公告)日：2021-05-20

申请号：US17158997

申请日：2021-01-26

Applicant: MannKind Corporation

Inventor： P. Spencer Kinsey ,  Brendan Laurenzi ,  Chad C. Smutney ,  Benoit Adamo ,  Joseph Guarneri ,  John J. Freeman, JR.

IPC: A61M15/00 ,  A61K9/00 ,  A61K31/352 ,  A61K31/495 ,  A61K31/661

Abstract: A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.