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    Compositions and methods for stabilizing susceptible compounds
    1.
    发明授权
    Compositions and methods for stabilizing susceptible compounds 有权

    公开(公告)号：US11028361B2

    公开(公告)日：2021-06-08

    申请号：US16801668

    申请日：2020-02-26

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Richard Fike ,  Bruce Branchaud ,  Shawn Barrett

    IPC: C12N5/18 ,  C12N5/00

    Abstract: Methods for increasing the stability of, or protecting, labile components such as ethanolamine, growth factors, vitamins, etc., in compositions such as a cell culture medium. Stability of the labile compound is increased either, by derivatization of the labile compound with chemicals, or by sequestering the labile compound. Sequestering can be done either by encapsulation within a microcapsule, or by the use of sequestering agents. Encapsulation includes the encapsulation of dendrimers complexes of susceptible compounds within the microcapsule, thereby providing the controlled release of the susceptible compound that was protected.
    These methods may improve and extend storage conditions of compositions comprising the labile compounds, improve shipping and handling of compositions comprising the labile compounds, such as dry media formulations, at room temperature rather than at lower temperatures thereby decreasing shipping costs. Stabilization of labile compounds in compositions such as dry format media can be viewed as a contribution to green technology.

    CELL CULTURE MEDIA AND METHODS
    4.
    发明申请
    CELL CULTURE MEDIA AND METHODS 有权
    细胞培养基和方法

    公开(公告)号：US20150064785A1

    公开(公告)日：2015-03-05

    申请号：US14367413

    申请日：2012-12-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Richard Fike ,  Shawn Barrett ,  Zhou Jiang ,  David Judd

    IPC: C12N5/00 ,  B29C67/24

    CPC classification number: C12N5/005 ,  B01J13/06 ,  B01J13/22 ,  B29C67/24 ,  B29L2009/00 ,  C12N5/0018 ,  C12N2500/30 ,  C12N2500/38 ,  C12N2511/00 ,  C12N2533/40 ,  C12N2533/74

    Abstract: Compositions and methods are described for preparing media, feeds, and supplements. Such methods and medias may display increased stability of labile components and may use, for example, microsuspension and/or encapsulation technologies, chelation, and optionally, coating and/or mixing the labile compounds with anti-oxidants. The compositions may withstand thermal and/or irradiation treatment and have reduced virus number. These techniques may result in product with extended shelf-life, extended release of their internal components into culture, or in product that can be added aseptically into a bioreactor using minimal volumes. The compositions and methods may optimize the bioproduction workflow and increase efficiency.

    Abstract translation: 描述了制备培养基，饲料和补品的组合物和方法。 这样的方法和介质可以显示不稳定组分的增加的稳定性，并且可以使用例如微悬浮和/或封装技术，螯合，以及任选地，将不稳定化合物与抗氧化剂包衣和/或混合。 组合物可以承受热和/或照射治疗并且具有减少的病毒数量。 这些技术可能导致产品具有延长的保质期，将其内部组分延长释放到培养物中，或可以无菌地添加到生物反应器中使用最小体积的产品中。 组合物和方法可以优化生物生产工作流程并提高效率。

    Cell culture media and methods
    5.
    发明授权
    Cell culture media and methods 有权

    公开(公告)号：US10066200B2

    公开(公告)日：2018-09-04

    申请号：US15198237

    申请日：2016-06-30

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Richard Fike ,  Shawn Barrett ,  Zhou Jiang ,  David Judd

    IPC: C12N5/00 ,  B29C67/24 ,  B29L9/00 ,  B01J13/06 ,  B01J13/22

    Abstract: Compositions and methods are described for preparing media, feeds, and supplements. Such methods and medias may display increased stability of labile components and may use, for example, microsuspension and/or encapsulation technologies, chelation, and optionally, coating and/or mixing the labile compounds with anti-oxidants. The compositions may withstand thermal and/or irradiation treatment and have reduced virus number. These techniques may result in product with extended shelf-life, extended release of their internal components into culture, or in product that can be added aseptically into a bioreactor using minimal volumes. The compositions and methods may optimize the bioproduction workflow and increase efficiency.

    Cell culture media and methods
    6.
    发明授权
    Cell culture media and methods 有权
    细胞培养基和方法

    公开(公告)号：US09410118B2

    公开(公告)日：2016-08-09

    申请号：US14367413

    申请日：2012-12-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Richard Fike ,  Shawn Barrett ,  Zhou Jiang ,  David Judd

    IPC: B29C67/24 ,  B29L9/00 ,  C12N5/00

    CPC classification number: C12N5/005 ,  B01J13/06 ,  B01J13/22 ,  B29C67/24 ,  B29L2009/00 ,  C12N5/0018 ,  C12N2500/30 ,  C12N2500/38 ,  C12N2511/00 ,  C12N2533/40 ,  C12N2533/74

    Abstract: Compositions and methods are described for preparing media, feeds, and supplements. Such methods and medias may display increased stability of labile components and may use, for example, microsuspension and/or encapsulation technologies, chelation, and optionally, coating and/or mixing the labile compounds with anti-oxidants. The compositions may withstand thermal and/or irradiation treatment and have reduced virus number. These techniques may result in product with extended shelf-life, extended release of their internal components into culture, or in product that can be added aseptically into a bioreactor using minimal volumes. The compositions and methods may optimize the bioproduction workflow and increase efficiency.

    Abstract translation: 描述了制备培养基，饲料和补品的组合物和方法。 这样的方法和介质可以显示不稳定组分的增加的稳定性，并且可以使用例如微悬浮和/或封装技术，螯合，以及任选地，将不稳定化合物与抗氧化剂包衣和/或混合。 组合物可以承受热和/或照射治疗并且具有减少的病毒数量。 这些技术可能导致产品具有延长的保质期，将其内部组分延长释放到培养物中，或可以无菌地添加到生物反应器中使用最小体积的产品中。 组合物和方法可以优化生物生产工作流程并提高效率。

    Cell culture media and methods
    7.
    发明授权
    Cell culture media and methods 有权

    公开(公告)号：US12203095B2

    公开(公告)日：2025-01-21

    申请号：US16918838

    申请日：2020-07-01

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Richard Fike ,  Shawn Barrett ,  Zhou Jiang ,  David Judd

    IPC: C12N5/00 ,  B01J13/06 ,  B01J13/22 ,  B29C67/24 ,  B29L9/00

    Abstract: Compositions and methods are described for preparing media, feeds, and supplements. Such methods and medias may display increased stability of labile components and may use, for example, microsuspension and/or encapsulation technologies, chelation, and optionally, coating and/or mixing the labile compounds with anti-oxidants. The compositions may withstand thermal and/or irradiation treatment and have reduced virus number. These techniques may result in product with extended shelf-life, extended release of their internal components into culture, or in product that can be added aseptically into a bioreactor using minimal volumes. The compositions and methods may optimize the bioproduction workflow and increase efficiency.

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